25/08/2026
High-risk features based on the Thrombolysis in Myocardial Infarction (TIMI) risk score. The TIMI risk score includes the following criteria:
Age >65 years,
Multiple risk factors for coronary heart disease,
ST-segment deviation on admission ECG,
Multiple episodes of angina in the preceding 24 hours,
Aspirin use in the prior 7 days, elevated serum cardiac biomarkers, and prior/known coronary stenosis ≥50%.
Patients with 0-2 of these features are considered low risk, patients with 3-4 are intermediate risk, and patients with 5-7, are at high risk for all-cause mortality, myocardial infarction, and/or severe
recurrent angina requiring urgent revascularization, as seen in the TIMI 11B (Thrombolysis In Myocardial Ischemia trial, phase 11B) and ESSENCE (Efficacy and Safety of Subcutaneous Enoxaparin in Unstable Angina and Non-Q-wave MI) trials . These risk factors are all weighted equally in the risk score, although some features, such as elevated biomarkers and dynamic ECG changes, may have higher absolute risks and specificities for coronary ischemia.