The 420 Radio Show

The 420 Radio Show is heard LIVE Friday's at 7pm ET. on www.420radio.ca 💨💨✌ along with event listings, news, along with our usual silliness. Got questions???

The 420 Radio Show is a LIVE Internet Radio Show all about the Cannabis Lifestyle made up of a group of medicinal cannabis patients and recreational users from different walks of life. With contributors world wide, we hope to provide a fun, informative way, to learn about Cannabis. With open and candid discussions on its culture, influences in music, the news, the law, and the fight to legalize ca

nnabis. Feel free to ask!!! call in on Skype

is heard LIVE Friday's at 7pm ET. on The Network at www.420radio.ca and www.LifestyleRadio.ca

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and

08/18/2025

Now in our 19th year... Join Co-hosts Al, Marcel, and Marijane, with grow guy Darcy and our Pharmacist Lennie, along with some some news, views, reviews, gro...

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08/06/2025

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🧐 multiple studies confirm that consuming a high fat meal before taking your plant medicine orally can significantly increase absorption and prolong effects?

Canadian researchers found that oral formats (like edibles) ingested after a fatty meal led to slower onset but higher blood levels of THℂ and its metabolite 11-OH-THℂ compared to fasted conditions. On average, systemic exposure increased by 2.5 times when fed.

A trial published in Scientific Reports (2025) showed that taking 70 mg ℂBD with a standardized high fat meal increased peak concentration by 17 fold and total exposure by almost 10 fold compared to fasting. It also created a double peak absorption pattern, which is likely tied to lymphatic transport and delayed metabolism.

🧠Why does this happen? Lipids(fats), specifically long chain triglycerides, in the meal helps cannabinoids form micelles and bind to chylomicrons inside the gut. This allows absorption into the lymphatic system and bypasses some of the liver’s first-pass breakdown/metabolism, boosting the amount of active compound that enters your bloodstream.

👀What's This Means for You? Eating something high in fat before using an edible can delay onset but increase the total exposure to active cannabinoids. That means it may feel like you're getting stronger or longer lasting effects, even if the dose didn’t change.

💡Pro Tip: If using an oral product, consider pairing it with a small fatty meal like yogurt, avocado, nuts, or ice cream. Just remember to start low and go slow, especially when trying for the first time, and consult your healthcare provider if you’re on other medications.

Have you tried using an edible after a fatty meal? How did it compare to taking it on an empty stomach? Let’s talk about it in the comments💬👇



🌐https://pmc.ncbi.nlm.nih.gov/articles/PMC6922062/
🌐https://pmc.ncbi.nlm.nih.gov/articles/PMC5009397/

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Join us LIVE Friday's 7-9pm ET on our website www.420radio.ca.

We are made up of a group of medicinal cannabis patients and recreational users from different walks of life. With contributors world wide, we hope to provide a fun, informative way, to learn about Cannabis. With open and candid discussions on its culture, influences in music, the news, the law, and the fight to legalize cannabis. along with event listings, news, along with our usual silliness. “Think of Us as a Giant Internet Doobie.... Have a listen, if You enjoy us... Puff Puff Passsssss us along.... "