JoX MDPI

12/12/2025

Hypertensive disorders in pregnancy remain a major global health concern. This research by Prof. Elisa Cairrão et al. provides mechanistic insights into how DEP exposure can alter vascular resistance in human umbilical arteries, mirroring vascular patterns observed in hypertensive pregnancies.

The study highlights both short-term receptor-mediated effects and long-term signaling pathways—including NO/sGC/cGMP/PKG and L-type Ca²⁺ channels—suggesting a plausible mechanistic link between phthalate exposure and gestational hypertension.

🔗 https://www.mdpi.com/2755888

Hypertensive disorders in pregnancy (HDP) are the most prevalent diseases during pregnancy.

12/12/2025

🔬 How does PGRMC1 influence cytochrome P450 activity and shape both drug metabolism and endogenous biochemical pathways?

This thorough review by Dr. Francisco Esteves et al. explores structural insights, regulatory mechanisms, and emerging challenges in PGRMC1–CYP research.

🔗 https://www.mdpi.com/2774898

Progesterone receptor membrane component 1 (PGRMC1) is one of few proteins that have been recently described as direct modulators of the activity of human cytochrome P450 enzymes (CYP)s. These enzymes form a superfamily of membrane-bound hemoproteins that metabolize a wide variety of physiological,....

11/12/2025

Disinfection in wastewater treatment is essential, but it can also generate numerous byproducts—many still difficult to detect.

This study uses a combined strategy: passive samplers to capture trace chemicals, GC×GC-TOFMS for deep chemical profiling, and an NMF algorithm to help distinguish overlapping signals.

The workflow allowed researchers to identify multiple DBPs, including several brominated compounds linked to coastal influences, and to flag their potential environmental risks.

📄 Screening Disinfection Byproducts in Arid-Coastal Wastewater
Authors: Dr. Deedar Nabi et al.
🔗 https://www.mdpi.com/2774764

Disinfection during tertiary municipal wastewater treatment is a necessary step to control the spread of pathogens; unfortunately, it also gives rise to numerous disinfection byproducts (DBPs), only a few of which are regulated because of the analytical challenges associated with the vast number of....

11/12/2025

Long-term exposure to electronic ci******es may be more harmful to the gut than many expect.

This mouse study shows that both e-cig aerosols and traditional cigarette smoke alter intestinal proliferation, immune function, tight-junction proteins, and microbiota balance.
In other words, e-cigs may pose gut risks comparable to conventional smoking.

📘 Chronic Exposure to Both Electronic and Conventional Ci******es Alters Ileum and Colon Turnover, Immune Function, and Barrier Integrity in Mice
by Dr. Mathilde Body-Malapel et al.
🔗 https://www.mdpi.com/2879640

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Although the effects of cigarette smoke (CS) on the development of several intestinal diseases is well documented, the impact of e-cigarette aerosol (e-cig) on digestive health is largely unknown.

11/12/2025

📖 Welcome Dr. Célia Ventura – Scientific Committee of IOCXe2026! 📖

We are thrilled to announce that Dr. Célia Ventura from National Institute of Health Doutor Ricardo Jorge and NOVA University of Lisbon, Portugal, will be joining the 1st International Online Conference on Xenobiotics (IOCXe2026) as a member of the scientific committee. She specializes in genetic toxicology, genetic susceptibility, epigenomics, transcriptomics, mechanistic toxicology, and nanotoxicology.

📅 Save the Date: 22-23 June 2026, Online, CEST

📢Calling for Submissions📢
📖 Submit your abstract by 24 February 2026: https://bit.ly/44OLly9
🔗 For more information: https://bit.ly/44UxlTH
📧 Inquiries: Reach out at [email protected]

We are excited to welcome you to IOCXe2026 !

11/12/2025

This work explores how 17α-ethinylestradiol (EE2)—a potent synthetic estrogen—affects brown trout liver spheroids at environmentally relevant concentrations. The study shows clear estrogenic responses at higher doses, reinforcing the value of 3D fish hepatocyte spheroids as alternative models for assessing xenoestrogen impacts.

🐟 Estrogenic Responsiveness of Brown Trout Primary Hepatocyte Spheroids to Environmental Levels of 17α-Ethinylestradiol
by Dr. Tânia Vieira Madureira et al.
🔗 https://www.mdpi.com/2901638

Three-dimensional (3D) fish hepatocyte cultures are promising alternative models for replicating in vivo data.

11/12/2025

How do trace elements such as mercury, arsenic, strontium, and others influence IVF success?

This study explores the presence of ten non-essential elements in multiple biofluids and their associations with ovarian response, embryo development, and live birth outcomes.

📘 Associations between Non-Essential Trace Elements in Women’s Biofluids and IVF Outcomes in Euploid Single-Embryo Transfer Cycles
Authors: Dr. Francisco Dominguez et al.
🔗 https://www.mdpi.com/2904204

10/12/2025

🌿 Legacy pollutants in coastal salt marshes

This study by Dr. Ricardo Cruz de Carvalho et al. investigates organochlorine pesticides and PCBs in salt marshes of the Tagus Estuary, revealing how agricultural activity, industrial history, and natural protection influence contamination levels. Evidence of pollutant uptake by Spartina maritima underscores ongoing ecological risks in these systems.

🔗 https://www.mdpi.com/2939022

10/12/2025

🧠 How PFAS affect neuronal signaling

This study by Prof. Francesco Dondero et al. explores the effects of PFOS and PFOA on neuron-like cells, revealing reversible inhibition of GABA receptor-mediated currents and dose-dependent cytotoxicity. The findings offer important insights into the neurotoxic mechanisms of persistent environmental pollutants.

🔗 https://www.mdpi.com/3037948

10/12/2025

🌱Exposure Assessment of Essential and Potentially Toxic Elements (PTEs) from Chia Seeds

Authors: Prof. Carmen Rubio et al.

This article investigates the presence of essential and potentially toxic elements in chia seeds and assesses dietary exposure levels, contributing to the evaluation of food safety and long-term consumption risks.

👉 https://www.mdpi.com/3062858

The increasing consumption of chia seeds is followed by a growing interest in their nutritional and toxicological characterization. To assess the characterization of the essential and PTEs of this novel food, 20 samples of conventional and organic chia seeds available on the European market were ana...

10/12/2025

🌊 Oxidative Stress in Mussel Mytilus trossulus Induced by Different-Sized Plastics

by Mr. Andrey Alexandrovich Mazur et al.

This article examines the effects of polystyrene microparticles and polyethylene macrofragments on oxidative stress responses in marine mussels, using biochemical and cellular biomarkers.

👉 https://www.mdpi.com/3053934

Polyethylene and polystyrene are massively used around the world in various applications and are the most abundant plastic waste.

06/12/2025

✨ Endocrine disruptors—from environmental chemicals to natural products and even physical agents—can interfere with hormone-regulated pathways. This review explores how these factors may influence the male and female genitourinary tracts, discussing development, anatomy, and associated disorders such as bladder and prostate cancer.

🔗 https://www.mdpi.com/3070216

by Dr. Martin Pelletier et al.

Over the last decades, the human species has seen an increase in the incidence of pathologies linked to the genitourinary tract. Observations in animals have allowed us to link these increases, at least in part, to changes in the environment and, in particular, to an increasing presence of endocrine...