Future Pharmacology

31/07/2025

Vargas et al. studied with PEO or PPO backbones loaded with diclofenac sodium, showing drug release rates correlate with polymer hydrophilicity and water absorption, offering insights for designing advanced with properties.

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To evaluate possible structural changes and thermal stability of the polyurea unloaded and loaded with diclofenac sodium, polyurea networks based on polyetheramine containing polypropylene oxide (PPO) or polyethylene oxide (PEO) and hexamethylene diisocyanate trimer-HDI were synthesized. The formati...

31/07/2025

📢 We are delighted to announce that Prof. Dr. Richard DiMarchi from Indiana University, USA, will serve as the plenary speaker for the 5th Medicinal Chemistry Symposium ( 2026): New Trends in Chemical Biology and Drug Discovery, which will be held in , China, from May 14 to 17, 2026.

🎤 Prof. Dr. Richard DiMarchi is a Distinguished Professor of Chemistry and Gill Chair in Biomolecular Sciences at Indiana University. He is recognized for his contributions to the discovery and development of rDNA-derived Humulin®, Humalog®, rGlucagon®, and Forteo®. His academic research has broadened the understanding of glucagon and incretin physiology and pioneered the discovery of single molecule multi-mechanism agonists for the treatment of diabetes and obesity.

Don’t miss this golden opportunity to interact with Prof. DiMarchi!
📝 Submit your abstracts here: https://brnw.ch/21wUApH

31/07/2025

Wang et al. reveal that - , linked to TP53-p21 dysregulation and Wnt/β-catenin activation, drives keloid pathogenesis, highlighting SRP as a novel for therapeutic intervention in treatment. 💊

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Senescence-resumed proliferation (SRP) is proposed to be a mechanism associated with the escape of p21-mediated senescence and the activation of Wnt/β-catenin pathways that enhance malignancy. The keloid genomic landscape shows heavy intersections between TP53 and TGF-β signaling. The machinery to...

31/07/2025

Oliveira et al. synthesized 22 4-aryl-1,4- and found three compounds selectively cytotoxic against HeLa and MCF-7 cancer cells, highlighting their potential as for developing new agents with improved potency and selectivity. 🧪

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We have synthesized 22 symmetric and asymmetric 4-aryl-1,4-dihydropyridines (1,4-DHPs) by a “green” microwave-assisted one-pot multicomponent Hantzsch reaction and evaluated their cytotoxicity to three human cancer cell lines regarding U-251MG (human glioblastoma), HeLa 229 (human cervical adeno...

30/07/2025

Covella et al. review emerging therapies for , highlighting new targeting , improved delivery methods, longer efficacy, and gene therapy approaches aiming for a potential cure. 💊

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Hereditary angioedema (HAE) is a rare disease caused by a genetic alteration of the SERPING1 gene and characterized by recurrent attacks of angioedema that involve the skin, and the mucosae of the gastrointestinal tract and upper airways, which significantly affect the quality of life of patients. N...

30/07/2025

Silva et al. evaluated leaf essential oil for and potential. While standalone antifungal activity was low, synergy with fluconazole and activity against T. vaginalis highlight its therapeutic promise. 💊🦠

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As microbes develop resistance to various drugs, the treatment of infections becomes increasingly challenging, leading to prolonged illness, heightened severity of infections, elevated mortality rates, and increased healthcare costs. Essential oils are lipophilic and volatile mixtures of compounds t...

30/07/2025

Stamatiou et al. review systemic for , focusing on CSF1R inhibitors and antibodies as alternatives to surgery, highlighting emerging pharmacological strategies to reduce recurrence and morbidity. 🧪

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Tenosynovial giant cell tumor (TGCT) is a rare and locally aggressive benign tumor arising from the synovium of joints, bursae, and tendon sheaths. It is classified into localized (L-TGCT) and diffuse (D-TGCT) forms based on the extent of involvement. Surgical resection is the primary treatment, tho...

29/07/2025

Dedoni et al. explore acid signaling in and disorders, highlighting its role in neuronal development and its potential as a for novel in Alzheimer’s, Parkinson’s, and schizophrenia. 💊🧪

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Individuals suffering from diverse neuropsychiatric and neurodegenerative disorders often have comparable symptoms, which may underline the implication of shared hereditary influences and the same biological processes. Lysophosphatidic acid (LPA) is a bioactive phospholipid and a crucial regulator o...

29/07/2025

Dimitrakopoulos et al. used –protein and –target networks, weighted by RNA-Seq data, to identify repurposable drugs for ’s disease, supporting cost-effective, network-based precision therapy approaches. 💊🧠

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Alzheimer’s disease is one of the leading causes of death globally, significantly impacting countless families and communities. In parallel, recent advancements in molecular biology and network approaches, guided by the Network Medicine perspective, offer promising outcomes for Alzheimer’s disea...

29/07/2025

Cocorullo et al. review recent efforts to combat , highlighting preclinical and clinical and early-stage molecules aimed at improving efficacy and shortening current lengthy, low-success treatments. 🦠🧪

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Mycobacterium abscessus is an emerging opportunistic pathogen that infects mainly the respiratory tract of individuals with pre-existing clinical pictures. In recent years, the incidence of infections of this microorganism has risen, in particular in patients with cystic fibrosis, leading to an exac...

28/07/2025

Di Leo et al. review current and emerging treatments, from ACEi/ARBs and glucocorticoids to novel targeting mucosal immunity, complement activation, and kidney fibrosis in patients at risk of progression.

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IgA Nephropathy (IgAN) is the most common form of primary glomerulonephritis and is one of the most common causes of end-stage kidney disease (ESKD) worldwide. The immunopathogenic mechanism underlying IgAN is poorly identified. Currently, the mainstay treatment of IgAN is centered on the optimizati...

28/07/2025

Saiti et al. apply and network analysis to uncover gene–miRNA–drug links in type 2 , advancing and enabling more precise, personalized treatment strategies in clinical care.

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Diabetes mellitus type-2 (DMT2) molecular pathophysiology is still challenging since the disease represents a complex, multifactorial metabolic disease caused by polygenic defects and environmental factors. In addition, the resulting secondary organ complications can be affected by various environme...