10/03/2026
📘 Organics – Volume 5, Issue 4 (December 2024)
We’re excited to share another issue of Organics for 2024 — Volume 5, Issue 4 (December 2024) — featuring 17 high-quality research articles advancing the field of organic chemistry.
⭐ We warmly invite you to explore the latest insights and discoveries shaping the future of organic research.
Cover Story: l-(+)-Furanomycin, a crucial substrate for isoleucyl aminoacyl-tRNA synthetase, replaces isoleucine during protein translation and exhibits antibacterial properties in vitro. Various synthetic approaches have been developed to produce l-(+)-Furanomycin and its analogs. This review focuses on total synthesis strategies and the biological significance of Furanomycin, a distinctive antibacterial agent with a non-proteinogenic amino acid core. It covers its isolation and diverse synthetic methodologies, including those using chiral substrates like carbohydrates and amino acids and alternative approaches with achiral starting materials like furans and cyclopentadiene. Methods relying on amino acids are particularly appealing, involving only six to seven steps for a swift and flexible process to access Furanomycin and its analogs.
🔗 Access all articles in this issue (free access):
https://brnw.ch/21x0BKx