14/09/2026
📢 New Research Article Published!
🔬 Identification PDF as a biomarker of “cold” CRC using integrated bioinformatics and machine learning
In this study, Chen et al. identify peptide deformylase (PDF) as a potential biomarker of “cold” colorectal cancer (CRC) through integrated bioinformatics and machine-learning analyses.
The findings show that high PDF expression is associated with poor prognosis, reduced immune infiltration, and enhanced oxidative phosphorylation (OXPHOS), providing new insights into the mechanisms underlying immune suppression in CRC.
The study further proposes a potential PCBP1–PDF–OXPHOS axis, offering a promising direction for understanding and potentially targeting immune-refractory colorectal tumors.
🔗 Read the full article on ELSPublishing.