http://apc.aast.edu/ojs/index.php/AMPDR/

Advances in Medical, Pharmaceutical and Dental Research Journal, 9 Abou Qear, Abu Qir Al Gharbeyah, Alexandria Governorate, Montaza 2 (2025)

30/07/2025

Advances in Medical, Pharmaceutical and Dental Research
Vol 5, No 1 (2025)
https://apc.aast.edu/.../inde.../AMPDR/issue/view/85/showToc

Advanced Research in Pharmaceutical Sciences
Knowledge, attitude, and practice towards voluntary counseling and testing services among university students in Kigali, Rwanda: a cross-sectional study PDF
John Bayingana M., Papias Kanani, Raissah Igiribambe, Japheths Ogendi
DOI: https://dx.doi.org/10.21622/AMPDR.2025.05.1.1129

Abstract

Background

Voluntary Counseling and Testing (VCT) is recommended as effective in reducing risks in sexually active young adults, such as college students.

Objective: This study was aimed to assess the level of knowledge, attitude and practice towards VCT service among University students in Kigali City, Rwanda.
Method:

A cross-sectional study was conducted using stratified sampling method from March to August 2021. A total of 374 participants filled a structured questionnaire to gather information. A chi-square test was used to determine an association between a number of independent factors and dependent variables.

Result

A total of 374 participants were interviewed. Majority, 278(74.3%) were in the age bracket of 20-24 years. A total of 223(59.6%) students demonstrated good knowledge on VCT; 219(58.6%) had positive attitude towards VCT for HIV. Less than half 160(42.8%) reported that they had VCT for HIV within the past one year. Respondents age, religion, income-category, level of education and occupation were among the sociodemographic variables that were significantly associated with practices of HIV prevention and control. The ignorance of the VCT center was reported as main barriers for VCT uptake.
Conclusion

The findings show positive views on VCT, but over half didn't get tested due to lack of knowledge about VCT centers.

22/07/2025

Advances in Medical, Pharmaceutical and Dental Research
Vol 5, No 1 (2025)
https://apc.aast.edu/ojs/index.php/AMPDR/issue/view/85/showToc

Advanced Research in Pharmaceutical Sciences
Piper guineense (Swhan and Thon) Inhibits Lanosterol-14α-demethylase in Multi-Drug Resistant Non-albicans Candida Species: In vitro and In silico Studies
Olumide Oluyele, Damilola Alex Omoboyowa, Ayomide Esther Aderogba, Koffi Adusa Osei
DOI: https://dx.doi.org/10.21622/AMPDR.2025.05.1.1060

Abstract

Candida species are globally recognized for invasive infections with poor prognosis. Burgeoning quest for the discovery of novel therapeutics has increased the scientific scrutiny of several medicinal plants. This study assessed the efficacy of Piper guineense crude extract and fractions against selected multi-drug resistant non- albicans Candida species. Both the crude and fractionated extracts of P. guineense elicited marked anti-candidal activity. Overall, the crude extract showed better efficacy over the fractions with the highest inhibition zone (25.0mm) recorded against Candida tropicalis; amongst the fractions, n-hexane fraction (F2) produced the highest inhibition zone (23mm) against Candida glabrata. The MIC ranged from 25mg/ml to 50mg/ml; while the MBC ranged between 100 mg/ml to 200 mg/ml. HPLC analysis revealed the presence of 14 compounds in the extract, with prominent members being quercetin, ellagic acid, persin, catechin, p-coumaric acid, and lutein. The binding affinity and free binding energy results reveal that most of these bioactive compounds were better than the standard drug (Fluconazole). Conclusively, P. guineense extracts demonstrated impressive anti-candidal properties against the tested multi-drug resistant non-albicans Candida species and could have potential as new drug lead for the treatment of infections resulting from these pathogens.

16/07/2025

Advances in Medical, Pharmaceutical and Dental Research
Volume 5, Issue 1, June 2025
https://apc.aast.edu/ojs/index.php/AMPDR/issue/view/85/showToc

Table of Contents
Articles
Advanced Research in Pharmaceutical Sciences
1. Piper guineense (Swhan and Thon) Inhibits Lanosterol-14α-demethylase in Multi-Drug Resistant Non-albicans Candida Species: In vitro and In silico Studies
Olumide Oluyele, Damilola Alex Omoboyowa, Ayomide Esther Aderogba, Koffi Adusa Osei
DOI: https://dx.doi.org/10.21622/AMPDR.2025.05.1.1060

2. Knowledge, attitude, and practice towards voluntary counseling and testing services among university students in Kigali, Rwanda: a cross-sectional study
John Bayingana M., Papias Kanani, Raissah Igiribambe, Japheths Ogendi
DOI: https://dx.doi.org/10.21622/AMPDR.2025.05.1.1129

3. Unveiling the multi-targeted therapeutic potentials of vernonia amygdalina: a comprehensive review of bioactive compounds, molecular mechanisms, and clinical opportunities
Emmanuel Okoro Enyi, Obiageri Florence Ajah
DOI: https://dx.doi.org/10.21622/AMPDR.2025.05.1.1233

4. A primer on fabricating bioactive regenerative scaffolds – from materials and surface properties to microenvironment
Mai M. Ali
DOI: https://dx.doi.org/10.21622/AMPDR.2025.05.1.1282

5.Dose-dependent response of metformin in enhancing motor performance and dopamine release in C57BL/6 mice afflicted by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)
Daha Umar Ishaq, Binta Garba Kurfi, Solomon Ojodemi Oguche
DOI: https://dx.doi.org/10.21622/AMPDR.2025.05.1.1248

Selected Topics in Biological and Pharmacological Sciences
6.Context-dependent autophagy in cancer: deciphering cytoprotective vs. cytotoxic roles and therapeutic modulation strategies
Samer Osama Kostandy, Salwa Aburageh Abuiessa, Mai Mostafa Helmy, Maged Wasfy Helmy
DOI: https://dx.doi.org/10.21622/AMPDR.2025.05.1.1251

7.Modeling schizophrenia endophenotypes in drosophila melanogaster: effects of ketamine on anxiety, aggression, locomotion and inflammatory responses
Abdulrahman Adesola Bello, Royhaan Olamide Folarin
DOI: https://dx.doi.org/10.21622/AMPDR.2025.05.1.1202

Medical and Clinical Research
8. New developments in the optometrist’s assessment and treatment of common headaches
Maduabuchukwu Innocent Nkollo, Aghogho Odogu
DOI: https://dx.doi.org/10.21622/AMPDR.2025.05.1.1116

9. Age and pattern of cervical smear cytology in Federal Medical Centre Asaba – a five year review
Daniel Nnaemeka Onwusulu, Samuel okwuchukwu ilikannu, Chikodili Ogugwa Ochuba, Valentine Idama, Emmanuel Egboduku, Adeniyi Johnson Fagbemi, Sunday Emmanuel Jombo
DOI: https://dx.doi.org/10.21622/AMPDR.2025.05.1.1209

10. Current advances in bispecific T cell–engaging therapies
Emmanuel Owusu Ansah, Benard Ansong, Foster Kyei
DOI: https://dx.doi.org/10.21622/AMPDR.2025.05.1.1222

11. Pancytopenia in epidemic dropsy: a case report
Ashish Gautam, Poonam Gupta, Jitendra Shukla, Ajeet Chaurasia
DOI: https://dx.doi.org/10.21622/AMPDR.2025.05.1.1229

Read the full issue at:
https://apc.aast.edu/ojs/index.php/AMPDR/issue/view/85/showToc

09/07/2025

We’re excited to announce that the June issue of the Advances in Medical, Pharmaceutical and Dental Research Journal (AMPDR), Volume 5, Issue 1, has been officially published
Read the full issue here: https://apc.aast.edu/ojs/index.php/AMPDR/issue/view/85/showToc

02/07/2025

Advances in Medical, Pharmaceutical and Dental Research Journal
Vol 4, No 1 (2024)
https://apc.aast.edu/.../inde.../AMPDR/issue/view/80/showToc

Experimental and Applied Dental research
Effect of platelet rich fibrin on post-operative sequelae following mandibular third molar surgery a prospective comparative study
Chayan Kumar Kundu, Pratyaee Mallick, Sudip Chakraborty
DOI: https://dx.doi.org/10.21622/AMPDR.2024.04.2.1031

Abstract

Objectives: The purpose of this study is to estimate the effect of Platelet Rich Fibrin (PRF) on the control of post-operative sequalae i.e. Pain, Trismus, Swelling and Incidence of Alveolar Osteitis (AO) following mandibular third molar surgery

Material and Methods: 26 patients divided into two groups. Group I getting PRF after extraction of third molar while Group II did not get any PRF. Post-surgical Pain, Swelling, Trismus, Incidence of AO was evaluated.

Results: It was found that Group II had greater pain scores than Group I assessed by VAS, with statistically significant greater score after 2 hours (P=0.0014) and 12 hours (P=0.0063). In case of swelling, Site II shown statistically significant difference in 7th day (P=0.007), and 14th day (P=0.04), Site III shown statistically significant difference in 3rd day (P=0.005), 7th day (P=0.03), and Site IV shown statistically significant difference in only in 3rd day (P=0.004). Inter-incisal distance was higher for Group I than Group II, statistically significant on 7th day (P=0.0069) and 14th day (P=0.0008). This study did not find any incidence of AO in both groups

Conclusions: PRF appears to be beneficial and effective in lowering postoperative sequalae in mandibular third molar surgery. PRF effectively decreases Pain, Swelling and Trismus when compared with case and control group. However, this study cannot comment on effectiveness of PRF on incidence of alveolar osteitis

25/06/2025

Advances in Medical, Pharmaceutical and Dental Research Journal
Vol 4, No 1 (2024)
https://apc.aast.edu/.../inde.../AMPDR/issue/view/80/showToc

Experimental and Applied Dental research
A clinical and microbiological assessment of the efficacy of chemo-mechanical caries removal versus conventional caries removal methods in children: a randomized controlled clinical trial
Mutasim Babiker Zainelabdin Elbashir, Nadia Moustafa Mahmoud Farrag, Ahmed Hamdy Wahba
DOI: https://dx.doi.org/10.21622/AMPDR.2024.04.2.956

Abstract

Background: Effective caries removal in pediatric dentistry is vital for reducing discomfort and
maintaining oral health. Traditional methods like drilling can be invasive, prompting interest in
alternatives such as the chemo-mechanical caries removal method.
Aim: This study aimed to compare the efficacy, pain and satisfaction, treatment time, and
microbiological outcomes of a sodium hypochlorite-based chemo-mechanical caries removal
method (CarieMove® Gel) with conventional drilling in pediatric patients.
Methods: A randomized controlled clinical trial involved 30 children aged 7-9 years with a
bilateral class 1 caries in first permanent molars, as per the International Caries Detection and
Assessment System (ICDAS)No 4, with no pulp involvement. CarieMove® Gel was randomly
applied to one side for caries removal, while the conventional drilling method was used on the
other side. Caries removal efficacy, pain and satisfaction, caries excavation time and microbial
presence before and after treatment were registered. Data were collected, and tabulated statiscally
analyzed at a 5% significance level (p ≤0.05).
Results: Comparative analysis showed similar overall efficacy between the chemo-mechanical
and conventional methods, with no significant difference (p=0.083). Pain and patient satisfaction
pain perception were significantly higher with the chemo-mechanical method (p

17/06/2025

Advances in Medical, Pharmaceutical and Dental Research Journal
Vol 4, No 1 (2024)
https://apc.aast.edu/.../inde.../AMPDR/issue/view/80/showToc

Experimental and Applied Dental research
Chemical constituents analysis of blue vitriol, brimstone and black stone using X-ray fluorescence technology and GC-MS: a quest for novel antifungals
Onyekachukwu Izuchukwu Udemezue, Onyekachi Ijeoma Udemezue, Evangeline Chinyere Udenweze, Chijioke Obinna Ezenwelu, Euphemia Afoma Ikegwuonu
DOI: https://dx.doi.org/10.21622/AMPDR.2024.04.2.857

Abstract

New drugs especially antifungals are continually required by healthcare systems to address serious public health challenges such as resistance, toxicity, cost and scarcity. This research aimed at analyzing the chemical constituents of blue vitriol, brimstone and black stone using x-ray fluorescence technology and gas chromatography-mass spectroscopy (GC-MS); a quest for novel antifungal agents. The test isolates were obtained from high vaginal swab samples of patients attending a University Teaching Hospital in Anambra State, Nigeria. The isolates were identified based on their morphological, physiological and molecular characteristics. The minimal inhibitory concentration (MIC) and minimal fungicidal concentration (MFC) were determined using the broth dilution method. The inorganic and organic constituents of the natural compounds were determined using x-ray fluorescence technology and GC-MS respectively. The isolates include Candida albicans, C. tropicalis, C. glabrata and C. parapsilosis. The MIC and MFC of blue vitriol against the isolates ranges from 12.50mg/ml – 100mg/ml, brimstone (50mg/ml – 200mg/ml), black stone (200mg/ml) and ketoconazole(positive control):12.50mg/ml - 50mg/ml. The inorganic components found in blue vitriol include oxides of copper (43.7%), sulphur (29.4%), aluminium (1.2%); while the heavy metals arsenic, lead and nickel (all

02/06/2025

Advances in Medical, Pharmaceutical and Dental Research Journal
Vol 4, No 1 (2024)
https://apc.aast.edu/.../inde.../AMPDR/issue/view/80/showToc

Experimental and Applied Dental research
Integrative dental management of complex patients: a comprehensive care case report
Alaa Mohamed Eltaweel, Reem A. Hassanin
DOI: https://dx.doi.org/10.21622/AMPDR.2024.04.2.1003

Abstract

This Comprehensive Care Case (CCC) report represented a detailed diagnosis and treatment plan to manage a complex dental patient who came to the outdoor dental clinic of the faculty of dentistry, Arab Academy for Science, Technology, and Maritime Transport in Alamein (AAST). Fatma, a 32-year-old female patient, had been presented with continuous dental pain, improper dental functions, and an aesthetic problem. The staff team, comprising specialists in different dental departments supervised this case with the undergraduate student. Together, they have tailored a treatment plan that integrated cumulative phases. Outcomes were assessed through both radiographical and clinical metrics as well as patient-reported outcomes, demonstrating significant improvements in pain relief, dental functions, and aesthetics. This case illustrated the effectiveness of collaborative care models in addressing the complex clinical challenges with an optimum treatment plan that meets the patient's needs and satisfaction.

It also highlighted the importance of departmental cooperation, social communication, and the role of the university in community service. Our findings contribute to the growing body of evidence supporting comprehensive care strategies for complex patients, suggesting implications for clinical practice and future research.

18/05/2025

Advances in Medical, Pharmaceutical and Dental Research Journal
Vol 4, No 1 (2024)
https://apc.aast.edu/.../inde.../AMPDR/issue/view/80/showToc

Experimental and Applied Dental research
A full mouth rehabilitation restoring function and aesthetics (case report)
Muhammad R. Morgan, Ahmed W. Belal, Raneem M. Gamal, Eman M. Soliman
DOI: https://dx.doi.org/10.21622/AMPDR.2024.04.2.979

Abstract

Background: This study presents a clinical case report of a middle-aged patient with pain in the posterior mandibular first molar, especially while eating, multiple edentulous spaces, and bleeding upon brushing. Periodontal therapy, non-surgical extraction, endodontic therapy, restorative treatment, and prosthetic treatment were all included in the multidisciplinary procedure.

Purpose: Restoring appropriate occlusion and enhancing appearance were the goals of the treatment plan.

Methodology: The patient's treatment approach was commenced by clinical and radiographical examination, including panoramic X-ray and multiple periapical X-rays, followed by diagnosis, phases of treatment, the insertion of monolithic zirconia full coverage restorations, and porcelain fused to metal fixed partial denture.

Conclusion: There was an improvement concerning esthetics and function. An integrated treatment strategy is crucial for achieving optimal outcomes in full-mouth rehabilitation. Appropriate treatment planning requires careful assessment of the etiology, history, and factors pertaining to the oral health condition.

15/05/2025

Advances in Medical, Pharmaceutical and Dental Research Journal
Vol 4, No 1 (2024)
https://apc.aast.edu/.../inde.../AMPDR/issue/view/80/showToc

Experimental and Applied Dental research
Complete dental rehabilitation utilizing removable partial dentures and monolithic zirconia crowns (case report)
Hagar Ibrahim, Marwan Aggag
https://dx.doi.org/10.21622/AMPDR.2024.04.2.965

Abstract

Bilateral edentulous areas are a common clinical presentation, and in most of those cases, implant repair may not be possible. As a result, the conventional metallic partial denture is still in use. As our awareness of appearance has grown in our daily life , esthetics became a crucial component of dentistry. consequently, patients ask for aesthetic restorations that also maintain functionality. Zirconia is a widely used material for both functional and aesthetic demands. It has been demonstrated that zirconia can endure occlusal and functional stresses without neglecting the aesthetic appearance that is expected of a tooth-colored restoration. which is why using it as surveyed crowns to support partial dentures is optimal.

Objectives: The goal of this case study is to demonstrate a method for restoring a partially edentulous patient through the use of a metallic partial denture held up by surveyed zirconia crowns using CAD-CAM technology.

29/04/2025

Advances in Medical, Pharmaceutical and Dental Research Journal
Vol 4, No 1 (2024)
https://apc.aast.edu/.../inde.../AMPDR/issue/view/80/showToc

Experimental and Applied Dental research
Monolithic zirconia crowns and fixed partial denture in anterior and posterior regions as a prosthetic solutions (case report)
Ahmed Islam Abourayan, Marwan Aggag
DOI: https://dx.doi.org/10.21622/AMPDR.2024.04.2.964

Abstract

The increase in patient’s demand for an esthetic natural like and a strong functional restoration now days, using of all-ceramic zirconia fixed partial denture for rehabilitation of missing posterior teeth has been increasing in daily dental practice, Although dental implants are the treatment of choice in most of our cases today, but it’s not always executable for all patients due to many reasons such as, chronic smoking, alcoholism, uncontrolled diabetes, and most importantly poor oral hygiene. Monolithic, multilayer zirconia gave the desired mechanical strength that can withstand high masticatory forces, without having a negative effect on its esthetic appearance, which makes it the material of choice in our case.

14/04/2025

Advances in Medical, Pharmaceutical and Dental Research Journal
Vol 4, No 1 (2024)
https://apc.aast.edu/.../inde.../AMPDR/issue/view/80/showToc

Experimental and Applied Dental research
Interdisciplinary approach to unilateral missing maxillary lateral incisor with preparation modification (case report)
Mohamed Shaalan, Ibrahim Allam, Marwan Aggag
DOI: https://dx.doi.org/10.21622/AMPDR.2024.04.2.963

Abstract

Background: In many clinical cases where one or both maxillary lateral incisors are absent, orthodontic treatment with space opening or closure using canine and premolar replacement has led to improved periodontal health and high patient satisfaction however with long treatment period. Preparation modification of the maxillary canine can simulate lateral incisor and first premolar can mimic the canine for appearance. Zirconia crowns have shown they can withstand occlusal and functional stresses while maintaining the required aesthetic appearance.

Objectives: This case highlighted management of unilateral missing maxillary lateral incisor with only preparation modification using digital smile design and CAD- CAM technology.

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