
03/10/2025
Ever wonder how reparative dentin is formed at the molecular level? 🔬
The pulpal response to mild/moderate caries begins with the sprouting of sympathetic and somatosensory fibers in the dentin near the caries site, clinically producing dentinal hypersensitivity. Neuropeptides such as SP, CGRP, NKA, and NPY are released, inducing a reversible inflammatory reaction with vascular changes of vasoconstriction and vasodilation. PBF is not affected due to activation of the para-sympathetic system, and VIP is released as a compensatory mechanism of vasodilation for control of the vascular tone of the pulp. SP, CGRP, and NPY stimulate endothelial cells, fibroblasts, and inflammatory cells to induce angiogenesis, a mechanism by which hypoxic areas in the pulpal tissue are controlled. These neuropeptides, through their NK1, CGRP1, and NPY Y1 receptors, bind to odontoblasts and fibroblasts to induce them to produce reparative dentin as a defense mechanism.
Dive into the fascinating world of dental pulp in the third edition of Seltzer and Bender’s Dental Pulp Revisited, edited by Scott B. McClanahan and Ronald Ordinola Zapata: https://www.quintessence-publishing.com/gbr/en/product/seltzer-and-benders-dental-pulp-revisited