29/09/2025
Pancreatic cancer is one of the most lethal cancers, with a five-year survival rate of about 13 percent. Because symptoms often appear only in the late stages, finding early biological risk factors is a major research priority.
A large prospective study analyzed oral wash samples and health data from over 120,000 individuals in the United States, tracking them for nearly a decade. Researchers compared those who eventually developed pancreatic cancer with matched controls who did not. They found that specific oral microbes, including Porphyromonas gingivalis, Eubacterium nodatum, Parvimonas micra, and the fungus Candida tropicalis, were strongly associated with higher pancreatic cancer risk.
When researchers combined these microbial signatures into a “microbial risk score,” individuals with the highest scores were more than three times as likely to develop pancreatic cancer compared to those with lower scores. Interestingly, the study also identified some bacteria linked to lower risk, suggesting that the balance of microbes in the mouth may influence disease development.
The findings do not prove causation but point to a strong association. Scientists believe oral microbes could influence cancer risk by traveling into the digestive tract, triggering chronic inflammation, or interacting with immune responses. The researchers emphasize that oral health and regular care, such as brushing and flossing, may play a role in prevention, though further studies are needed to confirm the mechanisms involved.
Source
Meng, Q., et al. (2025). Oral Microbes Linked to Increased Risk of Pancreatic Cancer. JAMA Oncology. DOI: 10.1001/jamaoncol.2025.2073