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24/05/2025
That’s great
24/05/2025

That’s great

Japanese scientists have begun human trials of a new drug designed to regrow human teeth, offering a potential alternative to traditional implants and dentures. The drug, TRG-035, works by inhibiting the USAG-1 protein, which suppresses tooth development.

In animal trials, it successfully activated dormant tooth buds and led to new tooth growth in mice and ferrets. The initial human trial, underway at Kyoto University Hospital, involves 30 adults aged 30 to 64 who are missing at least one tooth. This first phase will assess the drug’s safety before moving to pediatric trials targeting children with congenital tooth agenesis, a condition where permanent teeth never form.

If successful, the researchers hope to launch the treatment commercially by 2030, positioning it as a revolutionary biological solution to tooth loss and a potential replacement for artificial implants.

01/05/2025

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