04/09/2025
✨ Difference Between Serum and Plasma ✨
🌟 Plasma 🌟
Plasma is the liquid portion of blood obtained by collecting the sample in tubes containing anticoagulants such as EDTA, Heparin, or Citrate, followed by centrifugation.
✅ Contains fibrinogen (a clotting protein)
✅ Commonly used for tests such as CBC, PT, APTT, coagulation studies, and D-dimer
✅ Derived from blood that has not clotted
🌟 Serum 🌟
Serum is the liquid portion of blood obtained after clot formation, using tubes without anticoagulants such as the plain red-top tube or the gold-top serum separator tube (SST), then centrifuged.
❌ Does not contain fibrinogen (consumed during clotting process)
✅ Commonly used for tests such as blood chemistry, hormone assays, antibody detection, and immunological studies
✅ Derived from blood that has been allowed to clot before centrifugation
👉 Summary
🔸 Plasma → collected in tubes with anticoagulants; Serum → collected in tubes without anticoagulants
🔸 Plasma contains fibrinogen, whereas Serum does not contain fibrinogen
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