The American Journal of Pathology

The American Journal of Pathology The official journal of the American Society for Investigative Pathology, examining discoveries in basic and translational pathobiology

Operating as usual

Mechanisms of #Endothelial Regeneration and #Vascular Repair and Their Application to #RegenerativeMedicine. Insightful ...
12/22/2020

Mechanisms of #Endothelial Regeneration and #Vascular Repair and Their Application to #RegenerativeMedicine. Insightful review article points the way to new therapies for #atherosclerosis, #sepsis, and other vascular diseases. From authors at Northwestern University Feinberg School of Medicine and Ann & Robert H. Lurie Children's Hospital of Chicago. Full text is FREE to all readers at https://ajp.amjpathol.org/article/S0002-9440(20)30455-7/fulltext. #pathology

Image on the cover is from "Expression, Localization, and Function of the Nucleolar Protein BOP1 in #ProstateCancer Prog...
12/15/2020

Image on the cover is from "Expression, Localization, and Function of the Nucleolar Protein BOP1 in #ProstateCancer Progression", authors from UW Health and University of Wisconsin-Madison.

Full text: https://ajp.amjpathol.org/article/S0002-9440(20)30454-5/fulltext

[Tissue segmentation in prostate cancer identifying epithelium (red) and stroma (green).]

Inhibition of Histone Deacetylase 6 by Tubastatin A Attenuates the Progress of #Osteoarthritis via Improving Mitochondri...
12/11/2020

Inhibition of Histone Deacetylase 6 by Tubastatin A Attenuates the Progress of #Osteoarthritis via Improving Mitochondrial Function. This work by authors at Wenzhou Medical U and Wenzhou Central Hosp and its significance for treatment of OA were showcased in a recent Elsevier press release: http://ow.ly/J6U250CIlNK. FREE full text at https://ajp.amjpathol.org/article/S0002-9440(20)30416-8/fulltext. #pathology
[Inhibition of HDAC6 with tubastatin A reduces reactive oxygen species and matrix degradation in cultured chondrocytes and postpones development of OA in mice.]

Somatic Mutations in LRRK2 Identify a Subset of Invasive Mammary Carcinomas Associated with High Mutation Burden, from A...
12/08/2020

Somatic Mutations in LRRK2 Identify a Subset of Invasive Mammary Carcinomas Associated with High Mutation Burden, from American Society for Investigative Pathology member Dr. Edgardo Parrilla Castellar and colleagues from Duke Health.

Full text: https://ajp.amjpathol.org/article/S0002-9440(20)30410-7/fulltext

[Abundant granular eosinophilic cytoplasm, with mitochondrial-rich
apocrine-like features, prevailed in LRRK2-mutated tumors.]

12/04/2020

#Pathology of Idiopathic #PulmonaryFibrosis Assessed by a Combination of Microcomputed Tomography, Histology, and Immunochemistry. FREE Editor's Choice article is the latest in AJP's new category of #MachineLearning, #ComputationalPathology, and Biophysical Imaging. From authors at University of British Columbia, Kyoto University, Yale School of Medicine, KU Leuven, and Mayo Clinic. https://ajp.amjpathol.org/article/S0002-9440(20)30412-0/fulltext
[3D reconstruction of connection between conducting airways (pink) and honeycomb region (orange) in human IPF sample.]

High-Fat Diet-Induced Functional and Pathologic Changes in #LacrimalGland. High-fat diet provokes lacrimal inflammation ...
11/25/2020

High-Fat Diet-Induced Functional and Pathologic Changes in #LacrimalGland. High-fat diet provokes lacrimal inflammation and reduces tear secretion in mice. FREE Editor's Choice article from authors at Xiamen U, Wenzhou Medical U, and Cardiff University. https://ajp.amjpathol.org/article/S0002-9440(20)30413-2/fulltext #pathology #dryeye
[Pathological changes in lacrimal glands of mice fed high-fat diets (HFD) are partially reversed by the Ppar-alpha agonist fenofibrate.]

The cover image is from "Lymphatic Proliferation Ameliorates Pulmonary Fibrosis after Lung Injury", authors at UCSF Medi...
11/23/2020

The cover image is from "Lymphatic Proliferation Ameliorates Pulmonary Fibrosis after Lung Injury", authors at UCSF Medical Center, UCSF, and the University of Southern California.

Full text: https://ajp.amjpathol.org/article/S0002-9440(20)30448-X/fulltext

[Macrophages (red) and Prox1-EGFP (green) in lymphatics and cardiac muscle of large pulmonary veins at 28 days after bleomycin administration.]

#Kidney Tertiary Lymphoid Structures in #Lupus #Nephritis Develop into Large Interconnected Networks and Resemble Lymph ...
11/12/2020

#Kidney Tertiary Lymphoid Structures in #Lupus #Nephritis Develop into Large Interconnected Networks and Resemble Lymph Nodes in Gene Signature. From authors at UiT Norges arktiske universitet. Full text FREE to all readers at https://ajp.amjpathol.org/article/S0002-9440(20)30374-6/fulltext. #pathology #SLE
[Tertiary lymphoid structures (yellow) develop near large arteries (red) and veins (blue) in kidneys of lupus-prone mice.]

Knockout of the Tachykinin Receptor 1 in the Mdr2-/- Mouse Model of Primary Sclerosing #Cholangitis Reduces Biliary Dama...
11/06/2020

Knockout of the Tachykinin Receptor 1 in the Mdr2-/- Mouse Model of Primary Sclerosing #Cholangitis Reduces Biliary Damage and #Liver Fibrosis. FREE Editor's Choice article from The University of Vermont Medical Center, Sapienza Università di Roma, @IUMedicine, @VAIndianapolis, and @tamu. https://ajp.amjpathol.org/article/S0002-9440(20)30341-2/fulltext. American Society for Investigative Pathology member authors include Heather Francis, Lindsey Kennedy, Konstantina Kyritsi, Vik Meadows, Shannon Glaser, and AJP Editorial Board member Gianfranco Alpini. #pathology
[Loss of tachykinin neurokinin 1 receptor (NK1R) reduces damage in livers of Mdr2-/- mice.]

Insulin Promotes Corneal Nerve Repair and Wound Healing In Type I Diabetic Mice by Enhancing Wnt/Beta-Catenin Signaling....
11/03/2020

Insulin Promotes Corneal Nerve Repair and Wound Healing In Type I Diabetic Mice by Enhancing Wnt/Beta-Catenin Signaling. FREE Editor's Choice article from authors at Zhejiang University, Shandong First Medical U, and U of Science & Technology Wuhan. https://ajp.amjpathol.org/article/S0002-9440(20)30380-1/fulltext. #diabetes #pathology #cornea
[Insulin and Wnt signaling pathways mediate corneal repair.]

Universal Precautions Provide Appropriate Protection during Autopsies of Patients with Infectious Diseases. This Biologi...
10/29/2020

Universal Precautions Provide Appropriate Protection during Autopsies of Patients with Infectious Diseases. This Biological Perspectives article by Michael Kritselis and former American Society for Investigative Pathology President Daniel Remick at @BUMedicine provides timely insights into safely performing autopsies in the era of COVID-19. FREE to all readers at https://ajp.amjpathol.org/article/S0002-9440(20)30379-5/fulltext. #autopsy #pathology #SARSCoV2

#Kupffer Cells: Inflammation Pathways and Cell-Cell Interactions in Alcohol-Associated #LiverDisease. FREE Review includ...
10/23/2020

#Kupffer Cells: Inflammation Pathways and Cell-Cell Interactions in Alcohol-Associated #LiverDisease. FREE Review includes discussion of novel ALD therapies that target Kupffer cells. From Veteran Health Indiana, Università di Roma Tor Vergata, UNT Health Science Center, Baylor Scott & White Health, University of Northern Colorado, UNC, @TAMUMedicine, and @IUMedicine. https://ajp.amjpathol.org/article/S0002-9440(20)30417-X/fulltext. Authors include six American Society for Investigative Pathology members: Konstantina Kyritsi, Victoria Meadows, Lindsey Kennedy, Shannon Glaser, Heather Francis, and Gianfranco Alpini (also on the AJP Editorial Board).
[Imbalance between M1 and M2 polarization of Kupffer cells contributes to ALD.]

Cover image is from "Pyruvate Kinase M2 Tetramerization Protects against Hepatic Stellate Cell Activation and Liver Fibr...
10/19/2020

Cover image is from "Pyruvate Kinase M2 Tetramerization Protects against Hepatic Stellate Cell Activation and Liver Fibrosis"

Full text: https://ajp.amjpathol.org/article/S0002-9440(20)30372-2/fulltext

[Double immunofluorescence staining with PKM2 (red), a-SMA (green), and DAPI (blue) showing reduced proliferation and migration of primary hepatic stellate cells 7 days after being pre-treated with TEPP-46 for 24 hours.]

The deadline for Abstract submission to #PISA2020 has been extended!  Submissions will be accepted until 10/21/2020.  Ab...
10/16/2020
American Society for Investigative Pathology

The deadline for Abstract submission to #PISA2020 has been extended! Submissions will be accepted until 10/21/2020. Abstract topic categories, as well as the link to submit, can be found online here: https://pisa20.asip.org/abstracts/abstract-topic-categories/

The #PISA2020 Deadline has been extended! You still have time to apply for awards and submit your abstract! Submit your science by 10.21.20 for this #ASIPVirtual Experience! #Pathology

Hepatic Stellate Cell-Specific Platelet-Derived Growth Factor Receptor-a Loss Reduces Fibrosis and Promotes Repair after...
10/08/2020

Hepatic Stellate Cell-Specific Platelet-Derived Growth Factor Receptor-a Loss Reduces Fibrosis and Promotes Repair after Hepatocellular Injury, new from American Society for Investigative Pathology member Dr. Paul Monga and colleagues from the Pittsburgh Liver Research Center, University of Pittsburgh and UPMC.

Full text: https://ajp.amjpathol.org/article/S0002-9440(20)30297-2/fulltext

[Confocal coimmunofluorescence imaging showing increased expression of PDGFR-a (green) co-localizing with a-smooth muscle actin (a-SMA)epositive (red) myofibroblasts in mice subjected to 8 weeks of carbon tetrachloride.]

10/07/2020
American Society for Investigative Pathology

Abstract submission for the American Society for Investigative Pathology #PISA2020 is still open! Submit today and your abstract will also be published in AJP as part of an online supplement.

Submit here: https://rb.gy/jzud90

Registration for #PISA2020 is Open! 📂 Registration rates are significantly discounted for members and #graduatestudents, #undergraduatestudents & #postdocs are #FREE! #Trainee and Young Faculty Scholar #Awards are available! Register Today! #Pathology #ASIPVirtual 🧪 Register today! https://pisa20.asip.org/registration/registration-rates/
.
.
.
#instascience
#Atherosclerosis
#Cardiovascular
#BreastCancer
#Cancer
#CellInjury
#CellRepair
#Epithelial
#Mucosal
#Pathobiology
#Gut Microbiome
#Disease
#InfectiousDiseases
#Inflammation
#Immunity
#Neuropathology
#Patholobiology
#Liver #Kidney
#Pulmonary
#Pathology
#Stem Cells and #RegenerativeMedicine

#PISA2020 Plenary Session: Symposia: Molecular Diagnostics: The Liquid Biopsy💉This session will give an overview of the ...
10/02/2020

#PISA2020 Plenary Session: Symposia: Molecular Diagnostics: The Liquid Biopsy💉This session will give an overview of the current applications of liquid biopsy to solid tumors. The liquid biopsy has been shown to be a surrogate for tissue biopsy in several scenarios and could be used more frequently to monitor response to therapy and disease progression. To date these applications seem very promising but liquid biopsy testing has yet to become routine practice in part due to the non-standardization of this technology and lack of clear clinical interpretation of low allelic frequency variants. This session will feature two invited speakers (Dr John Iafrate from Massachusetts General Hospital and Dr. Joshua Coleman from ARUP Laboratories), as well as several abstract-driven talks. Dr. Iafrate will discuss circulating #tumor #DNA and possible applications for detection of such in non-invasive cancer molecular diagnostics. Dr. Coleman will discuss the liquid biopsy and its value in detection of solid #cancers. The abstract-driven talks will be based upon submitted research in the area of #cancer molecular diagnostics. Speakers from Massachusetts General Hospital | ARUP Laboratories
.
.
.
#pathology
#moleculardiagnostics
#biopsy
#research
#anatomicpathology
#liquidbiopsy
#pathology #pathologyexperience #pathologyrotation #pathologist #futurepathologist #labtests #researchpathology #investigativepathology #pathologyresidency #medicalresidency #medicalspecialty #medicalschool

#Lysosome Associated Protein Transmembrane 4B-24 Is the Predominant Protein Isoform in Human Tissues and Undergoes Rapid...
10/02/2020

#Lysosome Associated Protein Transmembrane 4B-24 Is the Predominant Protein Isoform in Human Tissues and Undergoes Rapid, Nutrient-Regulated Turnover. New article from authors at University of Helsinki and Minerva Fndn Inst for Med Res sheds light on an understudied isoform of this cancer-associated protein. FREE full text: https://ajp.amjpathol.org/article/S0002-9440(20)30336-9/fulltext. #pathology
[24 kDa isoform of LAPTM4B predominates in breast (B) and lung (C) cancers and adjacent normal tissue.]

Structural Integrity of the Alveolar-Capillary Barrier in Cynomolgus Monkeys Challenged with Fully Virulent and Toxin-De...
09/30/2020

Structural Integrity of the Alveolar-Capillary Barrier in Cynomolgus Monkeys Challenged with Fully Virulent and Toxin-Deficient Strains of Bacillus anthracis. Editor's Choice article from authors at U.S. Food and Drug Administration. Full text is FREE to all readers at https://ajp.amjpathol.org/article/S0002-9440(20)30298-4/fulltext. #pathology #InfectiousDisease
[Pathological changes in lung due to infection with fully virulent #Bacillusanthracis]

Retinoid-Related Orphan Receptor ROR gamma t in CD4+ T Cell-Mediated Intestinal Homeostasis and Inflammation. Comprehens...
09/28/2020

Retinoid-Related Orphan Receptor ROR gamma t in CD4+ T Cell-Mediated Intestinal Homeostasis and Inflammation. Comprehensive review of this Th17 cell master transcription factor and its potential as a therapeutic target for #IBD. FREE from authors at UAB: https://ajp.amjpathol.org/article/S0002-9440(20)30345-X/fulltext #pathology #CrohnsDisease #UlcerativeColitis
[Regulation of induction of ROR gamma t]

Medical Treatment Can Unintentionally Alter the Regulatory T Cell Compartment in Patients with Widespread Pathophysiolog...
09/25/2020

Medical Treatment Can Unintentionally Alter the Regulatory T Cell Compartment in Patients with Widespread Pathophysiologic Conditions. Authors at University of Miami Miller School of Medicine discuss how #estrogen, #metformin, #statins, and other common medications modulate #Tregs. FREE Review at https://ajp.amjpathol.org/article/S0002-9440(20)30369-2/fulltext.
[Metformin and statins influence metabolic reprogramming of T cells.]

Angiotensin-Converting Enzyme Gene Polymorphism and Severe #LungInjury in Patients with #COVID19. Thought-provoking, tim...
09/23/2020

Angiotensin-Converting Enzyme Gene Polymorphism and Severe #LungInjury in Patients with #COVID19. Thought-provoking, timely Mini-Review from Drs. Zheng and Cao at St. Francis Hospital, The Heart Center. FREE full text at https://ajp.amjpathol.org/article/S0002-9440(20)30344-8/fulltext. #pathology #coronavirus
[Proposed mechanism of ACE DD genotype in severe lung injury due to SARS-CoV-2 infection]

Cover image is from "Tenascin-C Induces Phenotypic Changes in Fibroblasts to Myofibroblasts with High Contractility thro...
09/21/2020

Cover image is from "Tenascin-C Induces Phenotypic Changes in Fibroblasts to Myofibroblasts with High Contractility through the Integrin αvβ1/Transforming Growth Factor β/SMAD Signaling Axis in Human Breast Cancer", authors at 三重大学|Mie University.

Full text: https://ajp.amjpathol.org/article/S0002-9440(20)30329-1/fulltext

[Immunohistochemical analysis of calponin (green) and tenascin-C (red) in narrow areas adjacent to the basement membrane of ductules. Only a few fibroblasts in these areas are positive. Myoepithelia and capillary vessel walls are positive.]

#PISA2020 Plenary Session: Computational Pathology: Big Data, Big Ideas Translation. Session Description: Big data has r...
09/17/2020

#PISA2020 Plenary Session: Computational Pathology: Big Data, Big Ideas Translation. Session Description: Big data has referred to the means to acquire and analyze new, complex and multi-dimensional sources of information. Novel tools to extract meaning from ‘big data’ have the potential to drive substantive changes in clinical practice, from personalized diagnostics, prognostics and therapeutics to intelligent drug design, population surveillance/screening and the mining of the electronic health record. Successful integration of data analytics and data sciences within platforms for biomedical discovery are expanding further innovations and applications to patient care.
http://ow.ly/Hy7j50BrG5c | Register today https://pisa20.asip.org/registration/registration-rates/
#BigData Brigham and Women's Hospital Pathai PathAI Harvard Medical School Harvard Magazine Harvard University Massachusetts General Hospital
.
.
.

#bigdata #datascience #machinelearning #technology #ai #artificialintelligence #data #iot #analytics #deeplearning #python #tech #innovation #business #programming #cloudcomputing #cloud #blockchain #datascientist #coding #software #automation #datavisualization #cybersecurity #datamining #bigdataanalytics

#PISA2020 Plenary Session: Computational Pathology: Big Data, Big Ideas Translation. Session Description: Big data has r...
09/17/2020

#PISA2020 Plenary Session: Computational Pathology: Big Data, Big Ideas Translation. Session Description: Big data has referred to the means to acquire and analyze new, complex and multi-dimensional sources of information. Novel tools to extract meaning from ‘big data’ have the potential to drive substantive changes in clinical practice, from personalized diagnostics, prognostics and therapeutics to intelligent drug design, population surveillance/screening and the mining of the electronic health record. Successful integration of data analytics and data sciences within platforms for biomedical discovery are expanding further innovations and applications to patient care.
In this symposium we will explore underlying principles of big data approaches, and the translation of findings to clinical applications. Discussions will explore three examples of integrated ‘big data’ and functional discovery approaches, (1) digital imaging and improved pathologic diagnosis, (2) pathogen and microbiome big data approaches to identify new therapeutic targets and implement better prevention methods for pathogens from C. difficile to COVID-19, and (3) single cell sequencing to define genomic and environmental drivers of cancer, and identify targets for new therapeutic approaches. These examples will provide insights into how computational pathology is developing the tools we will be using to care for patients in the future. http://ow.ly/jZq650BrEbF | Register today https://pisa20.asip.org/registration/registration-rates/
#BigData Brigham and Women's Hospital Pathai PathAI Harvard Medical School Harvard Magazine Harvard University Massachusetts General Hospital
.
.
.

#bigdata #datascience #machinelearning #technology #ai #artificialintelligence #data #iot #analytics #deeplearning #python #tech #innovation #business #programming #cloudcomputing #cloud #blockchain #datascientist #coding #software #automation #datavisualization #cybersecurity #datamining #bigdataanalytics

Address


Opening Hours

Monday 09:00 - 17:00
Tuesday 09:00 - 17:00
Wednesday 09:00 - 17:00
Thursday 09:00 - 17:00
Friday 09:00 - 17:00

Telephone

+12402839720

Alerts

Be the first to know and let us send you an email when The American Journal of Pathology posts news and promotions. Your email address will not be used for any other purpose, and you can unsubscribe at any time.

Contact The Business

Send a message to The American Journal of Pathology:

Videos

Nearby media companies

Comments

Työmarkkinat vs. orjamarkkinat Nitä vahvempi tai taitavampi orja oli,sitä parmpaa hintaa isäntä saattoi orjasta pyytää.😟
Lactobacillus reuteri의 긍정적 역할