Journal of Neuro-Oncology

09/27/2025

Shih et al. reported national SRS trends in brain metastases. Despite rising adoption, patients with lower income, public insurance, or non-academic care were less likely to receive SRS, underscoring persistent disparities.

Read more:https://link.springer.com/article/10.1007/s11060-025-05178-8

09/24/2025

Araceli et al. analyzed 539 patients with brain metastases. GTR did not improve survival overall, but conferred significant benefit in solitary BM, younger patients, controlled disease, and those receiving postsurgical systemic or focal RT.

Read more:https://link.springer.com/article/10.1007/s11060-025-05193-9

09/23/2025

Naewwan et al. showed that piperlongumine inhibits meningioma cell growth by inducing G2/M arrest, activating ROS-mediated ER stress, and altering the ubiquitin-proteasome system, leading to apoptotic cell death.

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Purpose Meningiomas, the most common primary tumors of the central nervous system, are curable by surgical resection and radiotherapy. However, systemic therapeutic chemotherapy for meningiomas has not existed. Piperlongumine (PL), a natural alkaloid extracted from the long pepper (Piper longum), ha...

09/22/2025

Doig et al. analyzed PPCR data on children with brain tumors: higher radiation doses to hippocampus, hypothalamus, pituitary, and thalamus correlated with worse HRQoL after proton therapy. Dose minimization may preserve QoL.

Read more:https://link.springer.com/article/10.1007/s11060-025-05211-w

09/21/2025

Guranda et al. performed an IPD meta-analysis of intra-cavitary radiotherapy after brain metastasis resection: IORT and IBT achieved ~95% 1-yr local control, with IORT showing longer OS (39 vs 16 mo) and lower RN/LMD rates.

Read more:https://link.springer.com/article/10.1007/s11060-025-05227-2

09/20/2025

Dr. Sheehan highlighted growth of JNO and announced launch of Journal of Neuro-Oncology: Discovery, led by Editor-in-Chief Dr. Hadjipanayis. JNOD will expand opportunities for high-quality publications and further serve global neuro-oncology community.

https://link.springer.com/article/10.1007/s11060-025-05222-7

09/11/2025

Das et al present consensus-based guidance for CNS tumor care in Ontario, defining minimum hospital services, multidisciplinary coordination, treatment delivery, and provider qualifications to standardize care in province.

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Purpose Patients with primary central nervous system (CNS) tumours require complex, multidisciplinary care from the time of diagnosis to end-of-life. Because of their rarity, investigations and treatments for certain tumours should be provided at facilities with specialized healthcare providers and....

09/09/2025

Pienkowski et al. found grade-specific shifts in vesicle trafficking across gliomas and highlighted its role as a therapeutic target.

Read more:https://link.springer.com/article/10.1007/s11060-025-05151-5

09/08/2025

Chandler et al found KIAA1549::BRAF fusion more frequent in pediatric than adult PA (59.6% vs 23.1%). In children, GTR and cerebellar location predicted longer PRFS; no operative/genomic predictors identified in adults.

Purpose Pilocytic astrocytoma (PA) is rare in adults despite being the most common pediatric brain tumor. KIAA1549::BRAF fusion and BRAF p.V600E mutation are common in PA, yet prognostic impact of these alterations remains uncertain. We highlight clinical characteristics and tumor genomics in PA acr...

09/06/2025

Chen et al. identified PLOD3, COL17A1, FN1, and LAMB3 as key mutated genes in recurrent adamantinomatous craniopharyngioma via whole exome sequencing. COL17A1, FN1, and LAMB3 were overexpressed in keratin nodules of recurrent cases.

Read more:https://link.springer.com/article/10.1007/s11060-025-05061-6

09/04/2025

Hagan et al. found that long-term methylphenidate preserved age-appropriate intellectual development in childhood brain tumor survivors, with strongest benefit to Fluid Reasoning. Chemotherapy-linked decline was prevented with treatment.

Read more:https://link.springer.com/article/10.1007/s11060-025-05177-9

09/03/2025

Nishiwaki et al. show that α-sulfoquinovosyl-acylpropanediol inhibits PI3K/Akt, suppresses hypoxia pathways, and delays DNA repair, enhancing GBM radiosensitivity while sparing normal astrocytes. Supports SQAP as a potential adjunct to RT.

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Purpose Radiotherapy remains a key treatment modality for glioblastoma (GBM), but therapeutic resistance and radiation-induced toxicity severely limit its efficacy. Therefore, the development of novel, safe, and effective radiosensitizers is urgently needed. α-Sulfoquinovosylacylpropandiol (SQAP), ...