07/23/2025
🧠 Not just a gender gap, this study shows a reproductive stage gap.
A new study (Battillo & Malin, 2025) found that TMAO, a compound linked to heart disease risk, is significantly higher in postmenopausal women than in both premenopausal women and age- and BMI-matched men.
🔬 TMAO (trimethylamine N-oxide) is produced when gut bacteria metabolize nutrients like choline and carnitine—found in red meat, eggs, and dairy. High TMAO levels are associated with arterial stiffness, inflammation, and atherosclerosis.
What’s striking here isn’t just the gender difference,it’s the reproductive stage difference.
📊 Key findings:
✔️ Postmenopausal women had the highest TMAO levels, even though men had more dietary precursors (choline, carnitine).
✔️ TMAO levels in postmenopausal women were independent of blood pressure, insulin sensitivity, and cardiorespiratory fitness.
✔️ This suggests that menopause itself—not just aging—alters how the body processes key metabolites related to heart disease.
This isn’t just another metabolic study, it’s a window into how the loss of estrogen rewires female physiology. And it reinforces what so many of us in midlife health already know: menopause is a whole-body shift, not a side note.
✨ I’m encouraged to see research that finally separates women by reproductive stage, not just by age or s*x. That distinction changes everything.
➡️ If you’re postmenopausal and wondering why heart disease risk goes up even with a healthy lifestyle, part of the answer may lie in emerging metabolic markers like TMAO.
📣 We need more research like this—research that treats midlife women as biologically distinct, not just smaller versions of men. Reproductive aging matters. Hormones matter. And science must catch up.
Reference:
Battillo DJ, Malin SK. Trimethylamine N-oxide is elevated in postmenopausal women relative to age-matched men and premenopausal women among individuals with obesity. Exp Physiol. 2025. doi:10.1113/EP092550