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Herald Scholarly Open Access, 2561 Cornelia Road, #205, Herndon, VA (2025)

08/29/2025

🆕𝐑𝐞𝐟𝐫𝐚𝐦𝐢𝐧𝐠 𝐄𝐦𝐞𝐫𝐠𝐞𝐧𝐜𝐲 𝐂𝐚𝐫𝐞 𝐟𝐨𝐫 𝐆𝐞𝐫𝐢𝐚𝐭𝐫𝐢𝐜 𝐏𝐚𝐭𝐢𝐞𝐧𝐭𝐬: 𝐓𝐡𝐞 𝐂𝐞𝐧𝐭𝐫𝐚𝐥 𝐑𝐨𝐥𝐞 𝐨𝐟 𝐅𝐫𝐚𝐢𝐥𝐭𝐲

📌Source: Journal of Gerontology & Geriatric Medicine
📌Published Date: Aug 28, 2025

✅Background: Frailty is a multidimensional syndrome characterized by a reduced physiological reserve, exposing older adults to the dangerous adverse consequences of acute illness or injury. In the Emergency Department (ED), traditional assessment models often fail to detect and estimate vulnerability, leading to undertriage, delayed or inappropriate interventions, and poor outcomes.

✅Objective: To advocate for the systematic integration of frailty assessment in emergency medicine using the ABCDE-F framework. The addition of "Frailty" as the "F" in the emergency care patient primary survey (Airway, Breathing, Circulation, Disability, Exposure, and ABCDE) reflects a growing consensus that frailty must be addressed as a core clinical concern in acute care.

✅Methods: This review synthesizes the recent literature on the impact of frailty assessment in geriatric ED patients and its implications for ethical, efficient, and patient-centered emergency care.

✅Results: Integrating frailty into ED workflows improves risk stratification, aligns treatment with patient goals, and reduces unnecessary admissions and intervention. The ABCDEF model offers a structured and actionable framework for emergency physicians.

✅Conclusion: Early recognition of frailty is crucial in acute care settings. The application of the ABCDE-F model had a significant transformative impact on emergency care for older adults. Its integration is expected to enhance the outcomes and management of geriatric patients in the emergency department.

Read this & more via link in comments👇

07/31/2025

𝐄𝐯𝐚𝐥𝐮𝐚𝐭𝐢𝐨𝐧 𝐨𝐟 𝐏𝐫𝐞𝐯𝐚𝐥𝐞𝐧𝐭 𝐁𝐫𝐞𝐚𝐬𝐭 𝐂𝐚𝐧𝐜𝐞𝐫 𝐑𝐢𝐬𝐤 𝐅𝐚𝐜𝐭𝐨𝐫𝐬 𝐚𝐧𝐝 𝐭𝐡𝐞𝐢𝐫 𝐂𝐨𝐫𝐫𝐞𝐥𝐚𝐭𝐢𝐨𝐧 𝐰𝐢𝐭𝐡 𝐃𝐞𝐦𝐨𝐠𝐫𝐚𝐩𝐡𝐢𝐜 𝐂𝐡𝐚𝐫𝐚𝐜𝐭𝐞𝐫𝐢𝐬𝐭𝐢𝐜𝐬 𝐢𝐧 𝐖𝐞𝐬𝐭𝐞𝐫𝐧 𝐒𝐮𝐝𝐚𝐧

📌Source: Journal of Cancer Biology & Treatment
📌Published Date: Jul 31, 2025

𝐀𝐛𝐬𝐭𝐫𝐚𝐜𝐭

🔹Background: A variety of factors, including lifestyle choices, hormonal levels, and environmental exposure, determine the chance of developing breast cancer. This study aimed to evaluate the prevalent risk factors for breast cancer risk factors and their correlation with demographic characteristics in Western Sudan.

🔹Methodology: This is a prospective descriptive using data collected from 201 Sudanese volunteers between December 15, 2024, and January 25, 2025. Participants were chosen at random, regardless of age, education level, occupation, or other demographic variables.

🔹Results: Approximately 14.2% of the cases have a family history of breast cancer (FBC). The majority of cases were between the ages of 21 and 29, accounting for 53.3%. Menarche occurs in approximately 15.2% of children under the age of 12 years. Approximately 75% of them were now older than 25 years. Approximately 10.2% and 29.5% reported their first complete pregnancy at ages over 25 and under 18 years, respectively. Approximately 60.6% reported non-breastfeeding, with 54.9% under the age of 25 years.

🔹Conclusion: The majority of Sudanese women are exposed to a combination of breast cancer risk factors. Use of contraceptive pills is a risk for subsequent development of benign breast lesions. More research is needed to determine the significance of these factors in contributing to early start.

Discover more via the link in comments below. 👇

📊Figure: Describes the research population based on demographic data.

07/29/2025

𝐄𝐭𝐢𝐨𝐩𝐚𝐭𝐡𝐨𝐠𝐞𝐧𝐞𝐬𝐢𝐬, 𝐒𝐜𝐫𝐞𝐞𝐧𝐢𝐧𝐠, 𝐃𝐢𝐚𝐠𝐧𝐨𝐬𝐢𝐬 𝐚𝐧𝐝 𝐌𝐚𝐧𝐚𝐠𝐞𝐦𝐞𝐧𝐭 𝐨𝐟 𝐕𝐢𝐫𝐚𝐥 𝐎𝐫𝐢𝐠𝐢𝐧 𝐏𝐨𝐬𝐭-𝐓𝐫𝐚𝐧𝐬𝐩𝐥𝐚𝐧𝐭 𝐌𝐚𝐥𝐢𝐠𝐧𝐚𝐧𝐜𝐢𝐞𝐬

📌Source: Journal of Nephrology & Renal Therapy
📌Published Date: Jul 23, 2025

Kidney transplant is the treatment of choice for patients with end-stage renal disease. It confers significantly better survival outcomes and an improved quality of life. Despite improved one-year and graft and patient survival, the long-term survival of transplant recipients remains a bleak prospect, owing in large part to cardiovascular disease, infections and malignancies.

Certain malignancies occur at higher rates in transplant recipients, negatively impacting the recipient’s quality of life and, more importantly, their survival. While the development of these cancers involves multiple contributing factors, the majority are linked to oncogenic viruses. Chronic immunosuppression is also instrumental in the increased risk of post-transplantation malignancies – this double-edged sword causes impaired T-cell function, immunosurveillance, and control of oncogenic viruses.

This review examines the multifactorial pathogenesis, which involves impaired immune surveillance, chronic immunosuppression, and environmental exposures, with a focus on viral oncogenesis.

The author also discusses the diagnosis and management of viral origin post-transplant malignancies, including emerging therapies such as adoptive immunity, which represent promising avenues for treating both viral infections and related malignancies in transplant recipients.

Discover more via the link in comments below. 👇

𝐅𝐢𝐠𝐮𝐫𝐞: Pathogenesis of virus-induced posttransplant malignancy. VEGF: Vascular endothelial factor, TGF-β: Transforming growth factor-β, IL-6: Interleukin-6, RAS: Rat sarcoma-rapidly accelerated fibrosarcoma, PTLD: Posttransplant lymphoproliferative disease, EBV: Epstein–Barr virus. Adapted from Indian Journal of Transplantation - Postrenal Transplant Malignancy: An Update for Clinicians.

06/05/2025

𝐏𝐨𝐬𝐭𝐩𝐚𝐫𝐭𝐮𝐦 𝐂𝐚𝐭𝐚𝐬𝐭𝐫𝐨𝐩𝐡𝐞: 𝐂𝐞𝐫𝐞𝐛𝐫𝐚𝐥 𝐕𝐞𝐧𝐨𝐮𝐬 𝐒𝐢𝐧𝐮𝐬 𝐓𝐡𝐫𝐨𝐦𝐛𝐨𝐬𝐢𝐬 𝐰𝐢𝐭𝐡 𝐈𝐧𝐭𝐫𝐚𝐜𝐫𝐚𝐧𝐢𝐚𝐥 𝐇𝐲𝐩𝐨𝐭𝐞𝐧𝐬𝐢𝐨𝐧

📌Source: Journal of Brain & Neuroscience Research
📌Published Date: May 29, 2025

👉Being a life threatening condition, cerebral venous sinus thrombosis is uncommon. Annual incidence ranges from 1.16 to 2.02 per 100,000 1,2and is more common in females than males, with a female-to-male ratio of 3:13, 4.

✅Common risk factors are pro-thrombotic conditions, either genetic or acquired, obesity, oral contraceptives, pregnancy and the puerperium, malignancy, infection, and head injury and mechanical precipitants.

✅ venous sinus (CVST) has been associated with intracranial hypotension in postpartum cases, though this connection is relatively rare. After childbirth, women may experience changes in fluid dynamics and hormonal fluctuations that can predispose them to both conditions.

✅In these cases, timely diagnosis is crucial. Magnetic Resonance Imaging and Magnetic Resonance venography can help identify both SIH and CVST. Treatment typically involves addressing the underlying CSF leak, often through epidural blood patches, along with anticoagulation therapy for CVST.

👉Close monitoring is essential to prevent complications and ensure optimal recovery.

Here we are reporting a case of postpartum CVST with Intracranial

Link to in comments

06/03/2025

𝐀 𝐂𝐨𝐦𝐩𝐚𝐫𝐢𝐬𝐨𝐧 𝐨𝐟 𝐑𝐞𝐭𝐢𝐧𝐚𝐥 𝐎𝐱𝐲𝐠𝐞𝐧 𝐒𝐚𝐭𝐮𝐫𝐚𝐭𝐢𝐨𝐧 𝐰𝐢𝐭𝐡 𝐑𝐞𝐭𝐢𝐧𝐚𝐥 𝐚𝐧𝐝 𝐂𝐡𝐨𝐫𝐨𝐢𝐝𝐚𝐥 𝐓𝐡𝐢𝐜𝐤𝐧𝐞𝐬𝐬 𝐢𝐧 𝐂𝐡𝐢𝐧𝐞𝐬𝐞 𝐀𝐝𝐮𝐥𝐭𝐬 𝐰𝐢𝐭𝐡 𝐚 𝐖𝐢𝐝𝐞 𝐑𝐚𝐧𝐠𝐞 𝐨𝐟 𝐌𝐲𝐨𝐩𝐢𝐚

🔓Source: Journal of Ophthalmology & Clinical Research | ISSN 2378-8887

🌐Since 2000 the global prevalence of and high myopia have increased significantly. It is projected that 𝐛𝐲 𝟐𝟎𝟓𝟎, 𝟒𝟗.𝟖% 𝐨𝐟 𝐭𝐡𝐞 𝐰𝐨𝐫𝐥𝐝 𝐩𝐨𝐩𝐮𝐥𝐚𝐭𝐢𝐨𝐧 𝐰𝐢𝐥𝐥 𝐛𝐞 𝐦𝐲𝐨𝐩𝐢𝐜 and almost 10% of the world population will have high myopia

👉𝑲𝒆𝒚 𝑺𝒖𝒎𝒎𝒂𝒓𝒚 𝑷𝒐𝒊𝒏𝒕𝒔

Why carry out this study?

✅Current research indicates that certain changes in the fundus blood flow dynamics are due to differences in refractive error and axial length.
✅We further investigated the changes in retinal oxygen saturation in patients with myopia and elucidated the possible factors related to axial length.

What was learned from the study?

✅There is a significant correlation between both retinal and choroidal thickness and retinal oxygen saturation across a wide range of myopia.
✅This may be due to changes in retinal and choroidal vascular lumen composition caused by axial length elongation and this needs further investigation.

Link to PDF ( ) in comments

05/28/2025

🌿 Discover the Healing Power of Ganoderma lucidum (Reishi Mushroom)! 🌿

Did you know that polysaccharides from Ganoderma lucidum can help regulate your gut microbiota and support your body against diseases like diabetes, heart disease, and liver problems?

Recent research reveals how these natural compounds balance your intestinal flora, boost immunity, and improve metabolism — all with minimal side effects!

👉Dive into the full article to learn what’s new in this fascinating field:
https://www.heraldopenaccess.us/openaccess/overview-of-ganoderma-lucidum-polysaccharides-on-various-diseases-by-regulating-intestinal-microbiota-what-is-new

Have you ever tried Reishi mushroom supplements? Share your experience or questions below! 👇

05/21/2025

𝐆𝐥𝐮𝐜𝐨𝐬𝐞 𝐆𝐫𝐚𝐝𝐢𝐞𝐧𝐭 𝐂𝐨𝐦𝐛𝐢𝐧𝐞𝐝 𝐰𝐢𝐭𝐡 𝐏𝐥𝐞𝐮𝐫𝐚𝐥 𝐄𝐟𝐟𝐮𝐬𝐢𝐨𝐧 𝐕𝐨𝐥𝐮𝐦𝐞 𝐎𝐛𝐬𝐞𝐫𝐯𝐚𝐭𝐢𝐨𝐧 𝐢𝐧 𝐏𝐥𝐞𝐮𝐫𝐨-𝐏𝐞𝐫𝐢𝐭𝐨𝐧𝐞𝐚𝐥 𝐂𝐨𝐦𝐦𝐮𝐧𝐢𝐜𝐚𝐭𝐢𝐨𝐧: 𝐏𝐫𝐞𝐬𝐞𝐧𝐭𝐚𝐭𝐢𝐨𝐧 𝐨𝐟 𝐓𝐰𝐨 𝐂𝐚𝐬𝐞𝐬

🔓Source: Journal of Alternative Complementary & Integrative Medicine
📅Publish Date: May 06, 2025

✅Peritoneal Dialysis (PD) is an established effective renal Replacement Therapy (KRT) for patients with End-Stage Renal Disease (ESRD). PD accounts for 9% of all KRT and 11% of all dialysis worldwide.

✅An uncommon but well-recognized complication is hydrothorax due to Pleuroperitoneal Communication (PPC) occurring in 1.6–10% of PD patients . An increased intra-abdominal pressure results in dialysate leaking across the diaphragm into the pleural space causing PPC. It is most commonly to be right-sided. Some PPCs appear rapidly. Some exist with long-term PD.

✅Origin of PPC can be detected via contrast CT peritoneography and peritoneal scintigraphy using Technetium-99m tagged macro aggregated albumin or Tc-99m sulfur colloid. Thoracentesis is consistent with a transudative effusion with a high glucose concentration (50 mg/dL greater than simultaneous blood glucose). However, glucose measurement may be equivocal if prolonged effusion results in significant glucose absorption.

✅Here we reported two cases of PPC verified by glucose gradient combined with pleural effusion volume observation, which might provide an easy, reliable, and cost-effective method for diagnosing PPC.

PDF link in comments: 👇

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05/19/2025

𝐋𝐞𝐚𝐫𝐧𝐢𝐧𝐠 𝐂𝐚𝐭𝐚𝐫𝐚𝐜𝐭 𝐒𝐮𝐫𝐠𝐞𝐫𝐲: 𝐄𝐱𝐩𝐞𝐜𝐭𝐞𝐝 𝐚𝐧𝐝 𝐔𝐧𝐞𝐱𝐩𝐞𝐜𝐭𝐞𝐝 𝐄𝐱𝐩𝐞𝐫𝐢𝐞𝐧𝐜𝐞 𝐢𝐧 𝐚 𝐒𝐢𝐧𝐠𝐥𝐞 𝐂𝐞𝐧𝐭𝐞𝐫, 𝐒𝐢𝐧𝐠𝐥𝐞 𝐓𝐞𝐚𝐜𝐡𝐞𝐫, 𝐒𝐢𝐧𝐠𝐥𝐞 𝐒𝐮𝐫𝐠𝐞𝐨𝐧 𝐒𝐞𝐭𝐭𝐢𝐧𝐠

📌Source: Archives of Surgery and Surgical Education
📆Published Date: Mar 21, 2025

✅To examine the learning behaviour of surgeons undergoing cataract surgery training in an ambulant, single-centre, single-teacher setting.

✅This was a retrospective study to examine the process quality. Cataract surgeries were performed at an eye clinic in Bruchsal, Germany, using manual phacoemulsification technique under local anesthesia or sedation. Surgeon training involved stepwise instruction and practice on porcine eyes and surgical simulators before progressing to complete surgeries. Length of procedure, complication rates and visual outcomes were analysed to assess the effectiveness of the training. Shewhart control charts to assess process quality and detect systematic errors.

✅The study included 413 surgeries performed by two trainee surgeons over one year and compared their outcomes with those of an experienced supervisor. Operator A showed a typical learning trajectory, stabilising after 100 operations, whereas Operator B faced challenges, possibly exacerbated by disruptions caused by the COVID-19 pandemic. Both operators showed comparable visual outcomes but differed in complication trends.

KEY HIGHLIGHTS
✅The importance of a consistent practice environment and suggests the integration of cataract surgery training into the ambulatory setting to reduce the training burden and increase accessibility

Read the full article here:
👉 https://tinyurl.com/Learning-Cataract-Surgery

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05/16/2025

A study in Journal of Gerontology & Geriatric Medicine aimed to evaluate the prevalence and characteristics of suspected antibiotic allergy in patients over 65 years residing in a long-term care facility,

Link to research in comments.👇

05/15/2025

𝐐𝐮𝐚𝐧𝐭𝐢𝐭𝐚𝐭𝐢𝐯𝐞 𝐀𝐧𝐚𝐥𝐲𝐬𝐢𝐬 𝐨𝐟 𝐍𝐮𝐜𝐥𝐞𝐢𝐜 𝐀𝐜𝐢𝐝 𝐂𝐨𝐧𝐭𝐞𝐧𝐭 𝐢𝐧 𝐒𝐩𝐢𝐤𝐞𝐯𝐚𝐱 (𝐌𝐨𝐝𝐞𝐫𝐧𝐚) 𝐚𝐧𝐝 𝐁𝐍𝐓𝟏𝟔𝟐𝐛𝟐 (𝐏𝐟𝐢𝐳𝐞𝐫) 𝐂𝐎𝐕𝐈𝐃-𝟏𝟗 𝐕𝐚𝐜𝐜𝐢𝐧𝐞 𝐋𝐨𝐭𝐬

👉Originally published in Journal of Angiology & Vascular Surgery, on May 13, 2025

Read this powerful article by Richard M Fleming, PhD, MD, JD , which highlights key findings regarding the oligonucleotide content of Spikevax (Moderna) and BNT162b2 (Pfizer) COVID-19 vaccines.

Infectious processes, including that caused by Severe Acute Respiratory Syndrome Coronavirus number 2 (SARS-CoV-2) result in an Inflammo Thrombotic Immunologic Response (ITIR) Disease (ITIRD), in this instance Coronavirus Disease first described in 2019 (COVID-19). While medical management is possible, enhancement of immunity can be acquired through the administration of vaccines.

The development of mRNA-based COVID-19 vaccines, such as Spikevax (Moderna) and BNT162b2 (Pfizer), has been pivotal in mitigating the global pandemic. These vaccines rely on modified messenger RNA (mRNA) molecules to instruct cells to produce the SARS-CoV-2 spike (S) protein, triggering an immune response.

While mRNA vaccines underwent rigorous clinical evaluation, emerging concerns have prompted further examination of their nucleic acid content and batch consistency. In particular, discrepancies in genomic material, including the presence of undeclared DNA sequences, have raised questions about manufacturing integrity and potential biological risks.

This study was conducted in response to a formal request by Peter Kotlár, MD, Plenipotentiary for the Government of the Slovak Republic, to assess the nucleic acid content in multiple lots of Spikevax and BNT162b2 vaccines. The analysis aimed to:

✅Identify the nucleic acids present in the vaccine preparations.
✅Quantify nucleic acid content across multiple lots.
✅Evaluate batch homogeneity.
✅Determine whether undeclared genetic material was present.
✅Assess potential biological implications of unexpected nucleic acids.
✅Examine the effects of expired storage conditions on nucleic acid stability.
✅The findings provide insights into vaccine composition, stability, and manufacturing practices, with implications for public health policy and regulatory oversight.

Full Article PDF link in comments👇. Well worth your time! Share with your colleagues.

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05/13/2025

Huge congratulations 🤝👏 to Masaki Fujioka on the publication of his latest research : 𝐂𝐡𝐚𝐧𝐠𝐞𝐬 𝐢𝐧 𝐬𝐨𝐜𝐢𝐚𝐥 𝐚𝐜𝐭𝐢𝐯𝐢𝐭𝐲 𝐢𝐧 𝐉𝐚𝐩𝐚𝐧 𝐝𝐮𝐫𝐢𝐧𝐠 𝐭𝐡𝐞 𝐂𝐎𝐕𝐈𝐃-𝟏𝟗 𝐩𝐚𝐧𝐝𝐞𝐦𝐢𝐜 𝐛𝐚𝐬𝐞𝐝 𝐨𝐧 𝐭𝐡𝐞 𝐧𝐮𝐦𝐛𝐞𝐫 𝐨𝐟 𝐭𝐫𝐚𝐮𝐦𝐚 𝐬𝐮𝐫𝐠𝐞𝐫𝐢𝐞𝐬

✅Source: Journal of Emergency Medicine Trauma & Surgical Care
📆 Publish Date: Apr 30, 2025

✅Numbers of trauma surgeries at 12 general hospitals from 2015 to 2023 were extracted and those before and after COVID-19 pandemic were compared.

✅The annual average number of trauma surgery patients before pandemic was 4279, but this decreased to 3825 (-11%) in 2020. There was no significant difference in the number of patients from the following year onwards. Number of patients who underwent surgery with spinal or local anesthesia before the epidemic was 3375, which significantly decreased to 2754 (-16%) in 2020, but no significant difference was observed after 2021.

✅The number of trauma surgeries decreased significantly only in the first year of the pandemic. This was due to a decrease in minor trauma surgeries that could be conducted with local or lumbar anesthesia. The government requested that citizens restrict their activities and asked medical institutions to postpone non-urgent surgeries, but emergency trauma surgeries were performed as usual. The decrease in trauma patients was only seen in the first year of the COVID-19 pandemic, considered to be due to the fact that numbers of accidents and traumas decreased as a result of citizens complying with the behavioral restrictions, but this voluntary behavioral restraint was thought to last only one year.

✅The behavioral restrictions reduced the number of trauma cases, but people’s self-restraint was insufficient from the second year onwards.

Full Research Article in comments👇
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05/09/2025

𝐍𝐨𝐰 𝐢𝐬 𝐭𝐡𝐞 𝐓𝐢𝐦𝐞 𝐭𝐨 𝐏𝐮𝐭 𝐈𝐧𝐯𝐚𝐬𝐢𝐯𝐞 𝐥𝐨𝐛𝐮𝐥𝐚𝐫 𝐂𝐚𝐫𝐜𝐢𝐧𝐨𝐦𝐚 (𝐈𝐋𝐂) 𝐢𝐧 𝐭𝐡𝐞 𝐅𝐫𝐨𝐧𝐭!

📍 Invasive lobular Carcinoma (ILC) is the second most common type of breast cancer, after Invasive Ductal Carcinoma (IDC)

✅Invasive lobular Carcinoma (ILC) is distinguished from Invasive Ductal Carcinoma (IDC) via negative E-cadherin staining. Accumulating data reveal different biological and clinical behavior of ILC in both early and metastatic breast cancer.

✅Thus, IDC usually present as a solid mass while ILC tend to present as non-mass enhancement. Clinically, ILC tends to spread to the ovaries, peritoneum and meninges and is more resistant to chemotherapy. Current international guidelines do not consider ILC separately and do not issue distinct recommendations for this entity. In this work we compare the treatment approach to ILC and IDC in pre and postmenopausal patients.

✅A structured questionnaire was distributed to all breast cancer Oncologists in Israel. Two identical clinical cases were presented, the only difference being ILC or IDC histology.

✅About 80% (n=40) of breast cancer treating oncologists in Israel answered the questionnaire, different approach were noted between IDC and ILC in identical cases. For premenopausal patients with IDC stage II (T2N1MO) Luminal B, 61.0% of the oncologists recommended neoadjuvant chemotherapy (NACT) and 22% opted to upfront surgery, while for ILC only 26.8% initiated NACT and 39.0% chose upfront surgery. The difference was statistically significant (P-0.014). In postmenopausal patients, there was numerically but not statistically significant difference between the treatment approaches.

✅Although international guidelines do not consider ductal and lobular histology separately, oncologists' treatment approach differs between premenopausal patients with IDC versus ILC histology.

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