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Herald Scholarly Open Access, 2561 Cornelia Road, #205, Herndon, VA (2026)

12/24/2025

📍Published Date: Dec 17, 2025
📍Journal of Reproductive Medicine Gynaecology & Obstetrics

We recorded 3436 deliveries during the collection period, including 307 cases of placental abruption, i.e. a frequency of placental abruption of 8.93%. Among these deliveries, there were 269 primiparous women with 50 patients admitted for placental abruption, i.e. a frequency of placental abruption in primiparous women of 18.6%.

Placental abruption remains a major obstetric emergency, particularly in primiparous women, and requires close monitoring of identifiable risk factors.

👉This study highlights that the absence of prenatal follow-up and inadequate management of risk factors considerably increase the probability of occurrence of this pathology. Maternal-fetal prognosis depends directly on the speed of diagnosis and management. It is essential to strengthen prenatal monitoring to prevent complications associated with placental abruption and improve outcomes for mothers and newborns.

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12/16/2025

𝐑𝐞𝐬𝐢𝐥𝐢𝐞𝐧𝐭 𝐛𝐲 𝐃𝐞𝐬𝐢𝐠𝐧: 𝐁𝐮𝐢𝐥𝐝𝐢𝐧𝐠 𝐀𝐝𝐚𝐩𝐭𝐢𝐯𝐞 𝐂𝐚𝐩𝐚𝐜𝐢𝐭𝐲 𝐢𝐧 𝐆𝐥𝐨𝐛𝐚𝐥 𝐔𝐧𝐢𝐯𝐞𝐫𝐬𝐢𝐭𝐲 𝐄𝐝𝐮𝐜𝐚𝐭𝐢𝐨𝐧

✅Universities face multifaceted risks that threaten academic, financial and operational integrity.

✅This paper develops a comprehensive resilience framework for higher education institutions, identifies key risk domains and offers strategic recommendations for global implementation.

✅Drawing on international frameworks and institutional case studies, the research emphasises integrated governance, adaptive capacity and proactive planning to sustain core missions during disruption.

✅Methods combined qualitative document analysis and expert consultations to synthesise resilience domains, validate framework components and derive actionable recommendations.

✅Findings highlight governance, integrated risk management, digital and cyber resilience, equity and community engagement and academic continuity as core domains.

✅Recommendations include embedding resilience indicators into executive reporting, establishing cross-functional resilience teams, routine horizon scanning, scalable blended learning infrastructure and expanded psychological resilience programs.

✅The framework aims to guide universities in embedding resilience into strategic architecture to navigate uncertainty and support societal stability.

Read latest study in comments 👇

12/09/2025

𝐑𝐞𝐥𝐚𝐭𝐢𝐨𝐧 𝐛𝐞𝐭𝐰𝐞𝐞𝐧 𝐌𝐚𝐭𝐞𝐫𝐧𝐚𝐥 𝐕𝐢𝐭𝐚𝐦𝐢𝐧 𝐃 𝐂𝐨𝐧𝐜𝐞𝐧𝐭𝐫𝐚𝐭𝐢𝐨𝐧 𝐝𝐮𝐫𝐢𝐧𝐠 𝐓𝐡𝐢𝐫𝐝 𝐓𝐫𝐢𝐦𝐞𝐬𝐭𝐞𝐫 𝐚𝐧𝐝 𝐌𝐚𝐭𝐞𝐫𝐧𝐚𝐥 𝐚𝐧𝐝 𝐍𝐞𝐨𝐧𝐚𝐭𝐚𝐥 𝐇𝐞𝐚𝐥𝐭𝐡 𝐎𝐮𝐭𝐜𝐨𝐦𝐞𝐬

✅Background: Vitamin D is a key nutritional factor for maintenance of maternal and fetal . Fetal vitamin D acquisition is entirely dependent on the availability of the mother’s 25-hydroxyvitamin D, VitaminD regulates parathyroid hormone level and increases calcium absorption, critical factors in fetal development.

✅Objective: Vitamin D deficiency occurs frequently in pregnancy and may lead to preeclampsia, gestational diabetes, postpartum depression, and stillbirth. Therefore, it is necessary to establish the risk factors for during pregnancy to enable a preliminary and predictable diagnosis of vitamin D deficiency and its complications.

✅Materials and Methods: This cross-sectional was conducted between February 2017 and January 2019 in a referral tertiary hospital in Beijing, China. All data were extracted from the hospital’s patient information system. Vitamin D deficiency was defined as total serum 25-hydroxyvitamin-D concentration less than 20 ng/ml, whereas concentrations between 20 and 30 ng/ml were classified as vitamin D insufficiency.

✅Results: We included 306 participants with singleton pregnancies. The prevalence of vitamin D deficiency was 57.51% (176/306). A significant correlation was found between vitamin D concentration and the gestational week of delivery (P ≤0.001).

✅Conclusion: Vitamin D deficiency is a common phenomenon among pregnant women in the Chinese mainland, and the concentration of vitamin D in their bodies is significantly correlated with the progress of .

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📊Figure: Linear relationship between serum 25(OH)-D and birth week.

12/05/2025

Latest research by Christian Chess, et al. RUH Bath
"𝐎𝐩𝐭𝐢𝐦𝐢𝐬𝐢𝐧𝐠 𝐃𝐢𝐬𝐭𝐚𝐥 𝐅𝐞𝐦𝐨𝐫𝐚𝐥 𝐅𝐫𝐚𝐜𝐭𝐮𝐫𝐞𝐬 𝐢𝐧 𝐎𝐥𝐝𝐞𝐫 𝐀𝐝𝐮𝐥𝐭𝐬: 𝐀𝐧 𝐌𝐃𝐓 𝐚𝐧𝐝 𝐎𝐫𝐭𝐡𝐨𝐠𝐞𝐫𝐢𝐚𝐭𝐫𝐢𝐜 𝐌𝐨𝐝𝐞𝐥" make a difference in the lives of elderly patients.

👉Distal Femoral Fractures (DFFs) are an often overlooked and under-appreciated source of morbidity and mortality in elderly patients. They present a high level of surgical complexity, with multiple treatment options available (nailing, plating, arthroplasty and combination), compounded by challenging perioperative optimisation and frequently inadequate system-level support.

✅The typical DFF patient is elderly, frail and multimorbid, presenting with osteoporosis, sarcopenia and managing significant polypharmacy alongside pre-existing functional dependency.

✅This profound vulnerability is starkly reflected in clinical outcomes: Loosen et al., reported 64% perioperative morbidity and a 26-35% one-year mortality (median age 86.5) following treatment for DFFs, with 62% of previously independent, home-dwelling patients failing to return home and requiring long-term residential care.

✅Clinically and demographically, DFFs mirror hip fractures, yet historically have lacked the same structured care pathways with orthogeriatric input, national audit, and aligned financial incentives, resulting in preventable disparities in outcomes. Encouragingly, this landscape is changing.

✅NHS England has extended the Best Practice Tariff (BPT) to distal femoral fractures, and the National Hip Fracture Database (NHFD) has begun explicit case capture of DFFs.

✅This article presents a Formalised Multidisciplinary Team (MDT) pathway for the assessment and management of fragility distal femoral fractures.

👉By standardising care across pre-operative, intraoperative, and postoperative phases, the approach closes performance gaps, integrates medical and surgical optimisation, and delivers measurable improvements in clinical outcomes.

Find out more about Distal Femoral Fractures (DFFs) via the link in comments 💬

📊Figure: Radiograph of a left distal femoral plate fixation.
(a) - Anterior View. (b) - Lateral View.

12/01/2025

🌿𝐍𝐚𝐭𝐮𝐫𝐚𝐥 𝐏𝐫𝐨𝐝𝐮𝐜𝐭𝐬 𝐏𝐫𝐨𝐭𝐞𝐜𝐭 𝐋𝐮𝐧𝐠 𝐃𝐢𝐬𝐞𝐚𝐬𝐞𝐬 𝐛𝐲 𝐓𝐚𝐫𝐠𝐞𝐭𝐢𝐧𝐠 𝐭𝐡𝐞 𝐇𝐢𝐩𝐩𝐨 𝐒𝐢𝐠𝐧𝐚𝐥𝐢𝐧𝐠 𝐏𝐚𝐭𝐡𝐰𝐚𝐲

Respiratory illness and diseases are common problems worldwide. Natural products have become a source of drug discovery for respiratory diseases. The Hippo signaling pathway is a highly conserved evolutionary .

🍀Plants or herbs containing natural compounds have been used for centuries in and have made significant contributions to the pharmacological treatment of various diseases.

🍀Natural products have emerged as a valuable source of novel bioactive lead compounds in drug discovery, characterized by multi-target effects, stable therapeutic efficacy, low side effects and no drug dependence.

🌴Over the years, natural products have been the subject of extensive investigation for their potential in the treatment of lung diseases, with a particular focus on their impact on different classical signaling pathways.

🍀EA (Ellagic Acid) has been shown to significantly suppress fibroblast activation and ECM (Extracellular Matrix) production through inhibition of the Wnt/Akt and Erk signaling pathways. Tripterine and procyanidin B2 improve the occurrence and the development of lung diseases through the pathway.

✅The Hippo signaling pathway has been reported to play an important role in lung development and alveolar differentiation. Beyond impaired alveolar differentiation, lung diseases involve multiple pathological processes.

✅ Chronic inflammation drives tissue damage through cytokine release and immune cell infiltration. Fibrosis, characterized by excessive extracellular matrix deposition (e.g., collagen), disrupts lung architecture in conditions like idiopathic pulmonary fibrosis, YAZ/TAP induces myofibroblast differentiation and excessive extracellular matrix deposition, leading to tissue scarring. Vascular remodeling—including endothelial dysfunction and pulmonary —compromises gas exchange.

✅Airway remodeling features goblet cell , smooth muscle hypertrophy, and submucosal gland enlargement in obstructive diseases such as asthma and , the Hippo signaling pathway function is associated with defective alveolar epithelial regeneration and airspace enlargement.

✅Additionally, oxidative stress, protease-antiprotease imbalances, and epithelial-mesenchymal transition contribute to progressive tissue injury and functional decline. We will summarize the role and mechanism of natural products in Pulmonary Hypertension (PAH), asthma and Acute Lung Injury (ALI) through the Hippo signaling pathway.

📑This article summarizes the protective role of natural products in lung diseases such as pulmonary arterial , acute lung injury, pulmonary arterial hypertension and idiopathic pulmonary and explains how they exert protective effects through the Hippo signaling pathway.

📊 Read full article in comments 👇

09/04/2025

𝐀𝐈-𝐃𝐫𝐢𝐯𝐞𝐧 𝐏𝐞𝐫𝐬𝐨𝐧𝐚𝐥𝐢𝐳𝐞𝐝 𝐍𝐮𝐭𝐫𝐢𝐭𝐢𝐨𝐧 𝐟𝐨𝐫 𝐌𝐞𝐭𝐚𝐛𝐨𝐥𝐢𝐜 𝐂𝐚𝐫𝐞: 𝐀 𝐏𝐞𝐫𝐬𝐩𝐞𝐜𝐭𝐢𝐯𝐞 𝐨𝐧 𝐄𝐪𝐮𝐢𝐭𝐚𝐛𝐥𝐞 𝐃𝐢𝐠𝐢𝐭𝐚𝐥 𝐇𝐞𝐚𝐥𝐭𝐡 𝐒𝐨𝐥𝐮𝐭𝐢𝐨𝐧𝐬

📌Source: Journal of Food Science & Nutrition | ISSN: 2470-1076
📌Published Date: Aug 20, 2025

Metabolic diseases, including and , pose a growing public health and economic burden worldwide. Conventional dietary guidelines often fail to address individual nutritional needs or to achieve adherence in resource-constrained settings.

This Perspective highlights an integrative framework that leverages Large Language Models (LLMs), Retrieval-Augmented Generation (RAG), and federated learning to enable culturally sensitive, privacy-preserving, and scalable dietary interventions. Building on prior simulation studies demonstrating over 80% compliance with clinical nutrition targets such as DASH and EASD guidelines, this approach supports real-time, explainable nutrition guidance through virtual nutritionist systems.

The framework aligns with clinical nutrition practices, emphasizes sustainable and localized dietary strategies, and has the potential to enhance equity by extending evidence-based nutritional support to underserved populations. Future real-world validation and long-term studies are needed to assess the public health impact of such -driven systems.

Read more via the link in Comments 💬
Figure: A sociotechnical framework for equitable, personalized nutrition in metabolic care. 👇

08/29/2025

🆕𝐑𝐞𝐟𝐫𝐚𝐦𝐢𝐧𝐠 𝐄𝐦𝐞𝐫𝐠𝐞𝐧𝐜𝐲 𝐂𝐚𝐫𝐞 𝐟𝐨𝐫 𝐆𝐞𝐫𝐢𝐚𝐭𝐫𝐢𝐜 𝐏𝐚𝐭𝐢𝐞𝐧𝐭𝐬: 𝐓𝐡𝐞 𝐂𝐞𝐧𝐭𝐫𝐚𝐥 𝐑𝐨𝐥𝐞 𝐨𝐟 𝐅𝐫𝐚𝐢𝐥𝐭𝐲

📌Source: Journal of Gerontology & Geriatric Medicine
📌Published Date: Aug 28, 2025

✅Background: Frailty is a multidimensional syndrome characterized by a reduced physiological reserve, exposing older adults to the dangerous adverse consequences of acute illness or injury. In the Emergency Department (ED), traditional assessment models often fail to detect and estimate vulnerability, leading to undertriage, delayed or inappropriate interventions, and poor outcomes.

✅Objective: To advocate for the systematic integration of frailty assessment in emergency medicine using the ABCDE-F framework. The addition of "Frailty" as the "F" in the emergency care patient primary survey (Airway, Breathing, Circulation, Disability, Exposure, and ABCDE) reflects a growing consensus that frailty must be addressed as a core clinical concern in acute care.

✅Methods: This review synthesizes the recent literature on the impact of frailty assessment in geriatric ED patients and its implications for ethical, efficient, and patient-centered emergency care.

✅Results: Integrating frailty into ED workflows improves risk stratification, aligns treatment with patient goals, and reduces unnecessary admissions and intervention. The ABCDEF model offers a structured and actionable framework for emergency physicians.

✅Conclusion: Early recognition of frailty is crucial in acute care settings. The application of the ABCDE-F model had a significant transformative impact on emergency care for older adults. Its integration is expected to enhance the outcomes and management of geriatric patients in the emergency department.

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07/31/2025

𝐄𝐯𝐚𝐥𝐮𝐚𝐭𝐢𝐨𝐧 𝐨𝐟 𝐏𝐫𝐞𝐯𝐚𝐥𝐞𝐧𝐭 𝐁𝐫𝐞𝐚𝐬𝐭 𝐂𝐚𝐧𝐜𝐞𝐫 𝐑𝐢𝐬𝐤 𝐅𝐚𝐜𝐭𝐨𝐫𝐬 𝐚𝐧𝐝 𝐭𝐡𝐞𝐢𝐫 𝐂𝐨𝐫𝐫𝐞𝐥𝐚𝐭𝐢𝐨𝐧 𝐰𝐢𝐭𝐡 𝐃𝐞𝐦𝐨𝐠𝐫𝐚𝐩𝐡𝐢𝐜 𝐂𝐡𝐚𝐫𝐚𝐜𝐭𝐞𝐫𝐢𝐬𝐭𝐢𝐜𝐬 𝐢𝐧 𝐖𝐞𝐬𝐭𝐞𝐫𝐧 𝐒𝐮𝐝𝐚𝐧

📌Source: Journal of Cancer Biology & Treatment
📌Published Date: Jul 31, 2025

𝐀𝐛𝐬𝐭𝐫𝐚𝐜𝐭

🔹Background: A variety of factors, including lifestyle choices, hormonal levels, and environmental exposure, determine the chance of developing breast cancer. This study aimed to evaluate the prevalent risk factors for breast cancer risk factors and their correlation with demographic characteristics in Western Sudan.

🔹Methodology: This is a prospective descriptive using data collected from 201 Sudanese volunteers between December 15, 2024, and January 25, 2025. Participants were chosen at random, regardless of age, education level, occupation, or other demographic variables.

🔹Results: Approximately 14.2% of the cases have a family history of breast cancer (FBC). The majority of cases were between the ages of 21 and 29, accounting for 53.3%. Menarche occurs in approximately 15.2% of children under the age of 12 years. Approximately 75% of them were now older than 25 years. Approximately 10.2% and 29.5% reported their first complete pregnancy at ages over 25 and under 18 years, respectively. Approximately 60.6% reported non-breastfeeding, with 54.9% under the age of 25 years.

🔹Conclusion: The majority of Sudanese women are exposed to a combination of breast cancer risk factors. Use of contraceptive pills is a risk for subsequent development of benign breast lesions. More research is needed to determine the significance of these factors in contributing to early start.

Discover more via the link in comments below. 👇

📊Figure: Describes the research population based on demographic data.

07/29/2025

𝐄𝐭𝐢𝐨𝐩𝐚𝐭𝐡𝐨𝐠𝐞𝐧𝐞𝐬𝐢𝐬, 𝐒𝐜𝐫𝐞𝐞𝐧𝐢𝐧𝐠, 𝐃𝐢𝐚𝐠𝐧𝐨𝐬𝐢𝐬 𝐚𝐧𝐝 𝐌𝐚𝐧𝐚𝐠𝐞𝐦𝐞𝐧𝐭 𝐨𝐟 𝐕𝐢𝐫𝐚𝐥 𝐎𝐫𝐢𝐠𝐢𝐧 𝐏𝐨𝐬𝐭-𝐓𝐫𝐚𝐧𝐬𝐩𝐥𝐚𝐧𝐭 𝐌𝐚𝐥𝐢𝐠𝐧𝐚𝐧𝐜𝐢𝐞𝐬

📌Source: Journal of Nephrology & Renal Therapy
📌Published Date: Jul 23, 2025

Kidney transplant is the treatment of choice for patients with end-stage renal disease. It confers significantly better survival outcomes and an improved quality of life. Despite improved one-year and graft and patient survival, the long-term survival of transplant recipients remains a bleak prospect, owing in large part to cardiovascular disease, infections and malignancies.

Certain malignancies occur at higher rates in transplant recipients, negatively impacting the recipient’s quality of life and, more importantly, their survival. While the development of these cancers involves multiple contributing factors, the majority are linked to oncogenic viruses. Chronic immunosuppression is also instrumental in the increased risk of post-transplantation malignancies – this double-edged sword causes impaired T-cell function, immunosurveillance, and control of oncogenic viruses.

This review examines the multifactorial pathogenesis, which involves impaired immune surveillance, chronic immunosuppression, and environmental exposures, with a focus on viral oncogenesis.

The author also discusses the diagnosis and management of viral origin post-transplant malignancies, including emerging therapies such as adoptive immunity, which represent promising avenues for treating both viral infections and related malignancies in transplant recipients.

Discover more via the link in comments below. 👇

𝐅𝐢𝐠𝐮𝐫𝐞: Pathogenesis of virus-induced posttransplant malignancy. VEGF: Vascular endothelial factor, TGF-β: Transforming growth factor-β, IL-6: Interleukin-6, RAS: Rat sarcoma-rapidly accelerated fibrosarcoma, PTLD: Posttransplant lymphoproliferative disease, EBV: Epstein–Barr virus. Adapted from Indian Journal of Transplantation - Postrenal Transplant Malignancy: An Update for Clinicians.

06/05/2025

𝐏𝐨𝐬𝐭𝐩𝐚𝐫𝐭𝐮𝐦 𝐂𝐚𝐭𝐚𝐬𝐭𝐫𝐨𝐩𝐡𝐞: 𝐂𝐞𝐫𝐞𝐛𝐫𝐚𝐥 𝐕𝐞𝐧𝐨𝐮𝐬 𝐒𝐢𝐧𝐮𝐬 𝐓𝐡𝐫𝐨𝐦𝐛𝐨𝐬𝐢𝐬 𝐰𝐢𝐭𝐡 𝐈𝐧𝐭𝐫𝐚𝐜𝐫𝐚𝐧𝐢𝐚𝐥 𝐇𝐲𝐩𝐨𝐭𝐞𝐧𝐬𝐢𝐨𝐧

📌Source: Journal of Brain & Neuroscience Research
📌Published Date: May 29, 2025

👉Being a life threatening condition, cerebral venous sinus thrombosis is uncommon. Annual incidence ranges from 1.16 to 2.02 per 100,000 1,2and is more common in females than males, with a female-to-male ratio of 3:13, 4.

✅Common risk factors are pro-thrombotic conditions, either genetic or acquired, obesity, oral contraceptives, pregnancy and the puerperium, malignancy, infection, and head injury and mechanical precipitants.

✅ venous sinus (CVST) has been associated with intracranial hypotension in postpartum cases, though this connection is relatively rare. After childbirth, women may experience changes in fluid dynamics and hormonal fluctuations that can predispose them to both conditions.

✅In these cases, timely diagnosis is crucial. Magnetic Resonance Imaging and Magnetic Resonance venography can help identify both SIH and CVST. Treatment typically involves addressing the underlying CSF leak, often through epidural blood patches, along with anticoagulation therapy for CVST.

👉Close monitoring is essential to prevent complications and ensure optimal recovery.

Here we are reporting a case of postpartum CVST with Intracranial

Link to in comments

06/03/2025

𝐀 𝐂𝐨𝐦𝐩𝐚𝐫𝐢𝐬𝐨𝐧 𝐨𝐟 𝐑𝐞𝐭𝐢𝐧𝐚𝐥 𝐎𝐱𝐲𝐠𝐞𝐧 𝐒𝐚𝐭𝐮𝐫𝐚𝐭𝐢𝐨𝐧 𝐰𝐢𝐭𝐡 𝐑𝐞𝐭𝐢𝐧𝐚𝐥 𝐚𝐧𝐝 𝐂𝐡𝐨𝐫𝐨𝐢𝐝𝐚𝐥 𝐓𝐡𝐢𝐜𝐤𝐧𝐞𝐬𝐬 𝐢𝐧 𝐂𝐡𝐢𝐧𝐞𝐬𝐞 𝐀𝐝𝐮𝐥𝐭𝐬 𝐰𝐢𝐭𝐡 𝐚 𝐖𝐢𝐝𝐞 𝐑𝐚𝐧𝐠𝐞 𝐨𝐟 𝐌𝐲𝐨𝐩𝐢𝐚

🔓Source: Journal of Ophthalmology & Clinical Research | ISSN 2378-8887

🌐Since 2000 the global prevalence of and high myopia have increased significantly. It is projected that 𝐛𝐲 𝟐𝟎𝟓𝟎, 𝟒𝟗.𝟖% 𝐨𝐟 𝐭𝐡𝐞 𝐰𝐨𝐫𝐥𝐝 𝐩𝐨𝐩𝐮𝐥𝐚𝐭𝐢𝐨𝐧 𝐰𝐢𝐥𝐥 𝐛𝐞 𝐦𝐲𝐨𝐩𝐢𝐜 and almost 10% of the world population will have high myopia

👉𝑲𝒆𝒚 𝑺𝒖𝒎𝒎𝒂𝒓𝒚 𝑷𝒐𝒊𝒏𝒕𝒔

Why carry out this study?

✅Current research indicates that certain changes in the fundus blood flow dynamics are due to differences in refractive error and axial length.
✅We further investigated the changes in retinal oxygen saturation in patients with myopia and elucidated the possible factors related to axial length.

What was learned from the study?

✅There is a significant correlation between both retinal and choroidal thickness and retinal oxygen saturation across a wide range of myopia.
✅This may be due to changes in retinal and choroidal vascular lumen composition caused by axial length elongation and this needs further investigation.

Link to PDF ( ) in comments

05/28/2025

🌿 Discover the Healing Power of Ganoderma lucidum (Reishi Mushroom)! 🌿

Did you know that polysaccharides from Ganoderma lucidum can help regulate your gut microbiota and support your body against diseases like diabetes, heart disease, and liver problems?

Recent research reveals how these natural compounds balance your intestinal flora, boost immunity, and improve metabolism — all with minimal side effects!

👉Dive into the full article to learn what’s new in this fascinating field:
https://www.heraldopenaccess.us/openaccess/overview-of-ganoderma-lucidum-polysaccharides-on-various-diseases-by-regulating-intestinal-microbiota-what-is-new

Have you ever tried Reishi mushroom supplements? Share your experience or questions below! 👇

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