05/11/2025
Going without food for just 24 hours may sound harmless, but a new simulation reveals shocking changes your body undergoes in a single day of fasting. Within the first few hours, your body starts using stored glucose for energy, keeping your brain and muscles functioning. As time passes, your insulin levels drop, prompting your body to burn fat for fuel.
By around 12 hours, glycogen stores are significantly depleted, and your body begins producing ketones as an alternative energy source. This can lead to increased mental clarity for some, but also irritability or fatigue for others. Your metabolism slightly shifts, conserving energy while prioritising vital organs.
Simulations also show changes in hormones like ghrelin, which spikes and triggers hunger signals, explaining those intense cravings. By the 24-hour mark, your body enters a mild fasting state, improving cellular repair processes and promoting autophagy, where your cells start cleaning out damaged components. However, prolonged fasting without preparation can stress your heart, kidneys, and other organs.
Understanding these changes can help people approach fasting safely, whether for health reasons or intermittent fasting practices. While 24 hours can be manageable for many healthy adults, listening to your body and staying hydrated is crucial. Science continues to uncover how fasting affects our physiology, offering insight into how the body adapts when food is temporarily unavailable.