(PRI) is a subsidiary of Haymarket Media Group of London, England. Established in 1984, PRI's goal was to provide healthcare professionals in the United States with a version of Monthly Index of Medical Specialties® (MIMS), the United Kingdom's leading monthly drug reference. This reference would be concise, compact, easy-to-use and updated frequently. In June of 1985, PRI launched Monthly Prescribing Reference® (MPR), its first and main publication. MPR is distributed on a controlled basis to primary care physicians throughout the U.S.
Mission: MPR and its website, http://www.eMPR.com, provide concise and up-to-date drug information for healthcare professionals.
Operating as usual
Study examines risk of aortic aneurysm, dissection with fluoroquinolone treatment, while taking into account any confounding by indication and bias due to differences in surveillance.
Fluoroquinolones may slightly increase the risk of aortic aneurysm or aortic dissection, however the benefits of these drugs, when used appropriately, may outweigh this potential risk.
A large study identified almost 2 million singleton pregnancies resulting in live births, to examine the association between modafinil use in early pregnancy and malformations in exposed infants.
Overall, 133 of the 1,917,605 pregnancies in the study were exposed to modafinil during early pregnancy.
COPD treatment indication expanded to include asthma patients.
The FDA has approved Trelegy Ellipta (fluticasone furoate, umeclidinium, vilanterol; GlaxoSmithKline) for the maintenance treatment of asthma.
🎧 We've reached episode 50! This week we go over:
🔬 AstraZeneca's trial pause;
🔹 Steroid Tx for COVID-19;
🔹 Higher doses of diabetes drug approved;
🔹 First non-hormonal contraceptive;
✉️ FDA warning letter for pain devices.
🎬 And, of course, movie trivia! 🎬
We cover AstraZeneca’s decision to pause their COVID-19 vaccine trial; New studies indicate benefits for steroid therapy in COVID patients; Higher doses of diabetes treatment gain approval; The first non-hormonal contraceptive is launched; The FDA issues a letter regarding spinal cord stimulators;...
A large-scale study aimed to determine the association between medication use and a subsequent diagnosis of cutaneous or systemic lupus erythematosus.
A new case of cutaneous lupus erythematosus or systemic lupus erythematosus could potentially be drug induced.
New prescriptions by specialists who do not typically prescribe hydroxychloroquine increased from 1143 to 75,569 from February to March 2020.
New Rx increased 80-fold among specialists who do not typically prescribe these medications.
Accelerated approved granted to treatment that targets tumor-specific gene alteration in non-small cell lung cancer.
The FDA has approved Gavreto™ (pralsetinib; Blueprint Medicines and Genentech) for the treatment of adults with metastatic RET fusion-positive NSCLC.
The Company noted that the actions being taken are considered “routine” when a potentially unexplained illness is reported.
AstraZeneca's clinical trial program evaluating its investigational vaccine for COVID-19, AZD1222, has been temporarily paused.
Three randomized trials and a meta-analysis show benefits for critically ill patients with severe COVID-19.
Three randomized trials and a meta-analysis show benefits for critically ill patients, severe COVID-19.
Treatment approved for acute myeloid leukemia patients who achieved first complete remission and cannot proceed to intensive curative therapy. https://www.empr.com/home/news/onureg-azacitidine-fda-approved-acute-myeloid-leukemia-aml/
The FDA has approved Onureg® (azacitidine; Bristol Myers Squibb) tablets for the continued treatment of adult patients in first remission with AML.
ICYMI: AstraZeneca begin trial for prospective COVID-19 vaccine in 30,000 adult volunteers.
A phase 3 trial of AstraZeneca’s investigational vaccine candidate, AZD1222, has begun for the prevention of symptomatic COVID-19.
Take this week's Clinical Challenge and see if you can correctly diagnose this dermatological condition. https://www.empr.com/slideshow/slides/clinical-challenge-lesion-on-the-palm/
A 66-year-old man presents for evaluation of a growth on his left palm. He first noted the lesion approximately 1 year ago, and it has increased in size considerably throughout the last 3 to 4 months.
AstraZeneca begin trial for prospective COVID-19 vaccine in 30,000 adult volunteers.
A phase 3 trial of AstraZeneca’s investigational vaccine candidate, AZD1222, has begun for the prevention of symptomatic COVID-19.
Recommendations put forth promote choosing evidence-based care, improving the quality of care patients receive, and reducing medical waste.
Prior to utilizing medical therapies and practices to manage asthma and sleep disorders in children, pediatricians and families should review the new guidance from Choosing Wisely, according to the American Academy of Pediatrics.
Non-opioid, postsurgical pain relief treatment gains approval.
The FDA has approved XaraColl® (bupivacaine hydrochloride; Innocoll Holdings Limited) implant for acute postsurgical pain relief for up to 24 hours in adults following open inguinal hernia repair.
"It is imperative that we develop strategies to help clinicians prescribe antibacterials judiciously to hospitalized patients with COVID-19."
Likelihood of receiving antibiotics higher for more severe illness, at for-profit hospitals.
Investigational small interfering RNA treatment shows reduction in LDL-C levels, in 17 month study.
Treatment with twice-yearly inclisiran consistently reduced LDL-C levels over a period of 17 months, according to a post-hoc analysis of pooled data from the two phase 3 trials presented at the European Society of Cardiology Congress 2020.
Some hand sanitizers are being marketed in packaging that resembles food and drink products, leading the FDA to issue a warning.
Reports received by the FDA include hand sanitizer sold in a pouch that resembled a snack.
Remdesivir OK'd for use in all suspected, or lab-confirmed, COVID-19 cases, regardless of severity.
The EUA was expanded based on data from 2 studies that included patients with mild and moderate COVID-19 disease.
Long-acting human insulin analogue available for glycemic control in adults and pediatric patients with diabetes.
The long-acting human insulin analogue has an identical amino acid sequence to Lantus® (insulin glargine; Sanofi).
ICYMI: A Boxed Warning for amputation risk was removed from a diabetes treatment as new data emerged.
The FDA has removed the Boxed Warning for canagliflozin (Invokana, Invokamet, Invokamet XR; Janssen) regarding the risk of lower limb amputation.
Results from a trial of the device found that the Pearl Index (pregnancy rate) for the 6th year of use was 0.35, based on 1 pregnancy that occurred during year 6, within 7 days after device removal.
Mirena (levonorgestrel-releasing intrauterine system; Bayer) approval extends contraceptive use for up to 6 years.
New topical treatment for acne vulgaris.
The FDA has approved Winlevi® (clascoterone; Cassiopea) cream 1% for the topical treatment of acne vulgaris in patients aged 12 years and older.
🎧 Latest MPR Podcast is up! Included:
🔹 ACIP vaccination guidelines;
🔹 Convalescent plasma;
🔹 New 15-minute test;
🔹 Expanded indication for intrauterine device;
🔹 Hydrochlorothiazide label change.
📽️ And of course, movie trivia! 🤓
The ACIP release guidelines for the 2020-2021 vaccination recommendations; In COVID, there’s developments in convalescent plasma authorization, a 15 minute test, and ethnobotanist’s give a stark warning concerning a plant that some are touting as a cure. In other news an intrauterine device gain...
Impurities found in rifampin and rifapentine; to avoid a potential shortages, the FDA is allowing temporarily distribution of products with impurities above the acceptable intake limits.
Nitrosamine impurities have been identified in samples of rifampin and rifapentine, according to the Food and Drug Administration (FDA).
A COVID-19 test that provides results in 15 minutes has been granted Emergency Use Authorization; Abbot expects to ship up to 50 million tests a month by October.
The FDA has issued an Emergency Use Authorization for BinaxNOW™ COVID-19 Ag Card (Abbott), a rapid test for COVID-19.
Novel, investigative plaque #psoriasis cream shows promise in trial of over 1000 individuals.
Positive results were announced from two phase 3 studies evaluating tapinarof cream (Dermavant Sciences) for plaque psoriasis.
A Boxed Warning for leg and foot amputation risk has been removed from a diabetes treatment following the emergence of new data.
The FDA has removed the Boxed Warning for canagliflozin (Invokana, Invokamet, Invokamet XR; Janssen) regarding the risk of lower limb amputation.
FDA give Priority Review to treatment intended for aggressive form of non-small cell lung cancer.
The FDA has granted Priority Review to tepotinib for metastatic NSCLC whose tumors have a mutation that leads to METex14 skipping.
The granting of Emergency Use Authorization does not mean that plasma therapy for #COVIDー19 has been proven safe and effective.
FDA 'emergency use authorization' does not mean plasma therapy has been proven safe and effective.
Intrauterine device has its indication extended for an extra year. The approval was based on a study of 362 women of reproductive age.
Mirena (levonorgestrel-releasing intrauterine system; Bayer) approval extends contraceptive use for up to 6 years.
A potential COVID-19 treatment is being investigated in 48 patients; the treatment is derived from convalescent patients who were infected with SARS-CoV-2.
A phase 1 study of AstraZeneca’s investigational monoclonal antibody AZD7442 for coronavirus disease 2019 (COVID-19) has been initiated.
New case may suggest that immunity to the new coronavirus may last only a few months in some people.
Suggests that immunity to the new coronavirus may last only a few months in some people.
Researchers examined whether the 41 most commonly used individual antihypertensive drugs were associated with an altered risk for incident depression.
Depression rates down with nine antihypertensive agents, including enalapril, amlodipine, atenolol.
Cancer risk warning added to label of hypertension treatment. The increased risk is predominately for squamous cell carcinoma and in white patients taking large cumulative doses, say the FDA.
The FDA has approved labeling changes for HCTZ to include information regarding an increased risk of non-melanoma skin cancer.
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Uber has launched a healthcare specific ride service...
Physicians who played a video game designed to "improve heuristic thinking in decision-making," showed lower rates of under-triage than physicians who used traditional education.
The 2018 top ten medical innovations list includes advances in oncology, diabetes, ophthalmology, perioperative care and other therapeutic areas.
In 2015 the vascularized composite allotransplantation team at the Children's Hospital of Philadelphia carried out the first bilateral hand transplant on an 8-year-old boy.
A new report has highlighted significant compensation disparities for physicians along gender and geographical lines: goo.gl/ZS770B
Berries from a tree commonly found in Florida may contain an extract with the ability to disarm dangerous antibiotic-resistant staph bacteria.
Coffee and tea add-ins like sugar and cream can have a significant impact on an individual's dietary quality...
A new simulation allows clinicians to take part in a virtual conversation designed to improve communication around antibiotic use. For more information visit: goo.gl/OGnGzR
ICYMI: 100 leading doctors and researchers have chosen their top medical innovations for 2017 ... goo.gl/7X9xtL
This video details the early signs of Alzheimer's disease. Identifying the disease early allows patients to get maximum benefits from available treatments. A list of available pharmacological treatments can be found here: goo.gl/aHNUSz
New clinical guidelines recommend infants receive peanut-containing food as early as four months.Read more here: goo.gl/hjtyec
VIDEO: On World AIDS Day we summarize new research that traces the origin of HIV in the U.S. and dispels the myth of 'Patient Zero'.
Video: MPR's weekly highlights from the world of medicine
The wait is over! Enter our MPR 30th Anniversary Contest for a chance to win an Apple Watch Sport from today through June 30th. #MPR30 Share if you like this! http://bit.ly/1ekZY12
Here's Scott announcing the wining ticket....
We have a winner in our iPad Mini Raffle!
