Monthly Prescribing Reference

Monthly Prescribing Reference eMPR provides daily drug news, medication safety alerts & recalls, and industry-supported drug information & education. Prescribing Reference, Inc.

(PRI) is a subsidiary of Haymarket Media Group of London, England. Established in 1984, PRI's goal was to provide healthcare professionals in the United States with a version of Monthly Index of Medical Specialties® (MIMS), the United Kingdom's leading monthly drug reference. This reference would be concise, compact, easy-to-use and updated frequently. In June of 1985, PRI launched Monthly Prescribing Reference® (MPR), its first and main publication. MPR is distributed on a controlled basis to primary care physicians throughout the U.S.

Mission: MPR and its website, http://www.eMPR.com, provide concise and up-to-date drug information for healthcare professionals.

Operating as usual

Study examines risk of aortic aneurysm, dissection with fluoroquinolone treatment, while taking into account any confoun...
09/14/2020
Risk of Aortic Aneurysm, Dissection With Fluoroquinolones Examined

Study examines risk of aortic aneurysm, dissection with fluoroquinolone treatment, while taking into account any confounding by indication and bias due to differences in surveillance.

Fluoroquinolones may slightly increase the risk of aortic aneurysm or aortic dissection, however the benefits of these drugs, when used appropriately, may outweigh this potential risk.

A large study identified almost 2 million singleton pregnancies resulting in live births, to examine the association bet...
09/14/2020
Modafinil in Early Pregnancy Not Tied to Congenital Malformations - MPR

A large study identified almost 2 million singleton pregnancies resulting in live births, to examine the association between modafinil use in early pregnancy and malformations in exposed infants.

Overall, 133 of the 1,917,605 pregnancies in the study were exposed to modafinil during early pregnancy.

🎧 We've reached episode 50! This week we go over:🔬 AstraZeneca's trial pause;🔹 Steroid Tx for COVID-19;🔹 Higher doses of...
09/11/2020
MPR Weekly Dose Podcast Episode 50 - MPR

🎧 We've reached episode 50! This week we go over:
🔬 AstraZeneca's trial pause;
🔹 Steroid Tx for COVID-19;
🔹 Higher doses of diabetes drug approved;
🔹 First non-hormonal contraceptive;
✉️ FDA warning letter for pain devices.
🎬 And, of course, movie trivia! 🎬

We cover AstraZeneca’s decision to pause their COVID-19 vaccine trial; New studies indicate benefits for steroid therapy in COVID patients; Higher doses of diabetes treatment gain approval; The first non-hormonal contraceptive is launched; The FDA issues a letter regarding spinal cord stimulators;...

Accelerated approved granted to treatment that targets tumor-specific gene alteration in non-small cell lung cancer.
09/09/2020
Gavreto Approved for Metastatic RET Fusion-Positive NSCLC - MPR

Accelerated approved granted to treatment that targets tumor-specific gene alteration in non-small cell lung cancer.

The FDA has approved Gavreto™ (pralsetinib; Blueprint Medicines and Genentech) for the treatment of adults with metastatic RET fusion-positive NSCLC.

The Company noted that the actions being taken are considered “routine” when a potentially unexplained illness is report...
09/09/2020
AstraZeneca Pauses COVID-19 Vaccine Trials - MPR

The Company noted that the actions being taken are considered “routine” when a potentially unexplained illness is reported.

AstraZeneca's clinical trial program evaluating its investigational vaccine for COVID-19, AZD1222, has been temporarily paused.

Recommendations put forth promote choosing evidence-based care, improving the quality of care patients receive, and redu...
09/02/2020
AAP: Choosing Wisely Recs on Pediatric Pulmonology, Sleep Medicine

Recommendations put forth promote choosing evidence-based care, improving the quality of care patients receive, and reducing medical waste.

Prior to utilizing medical therapies and practices to manage asthma and sleep disorders in children, pediatricians and families should review the new guidance from Choosing Wisely, according to the American Academy of Pediatrics.

Investigational small interfering RNA treatment shows reduction in LDL-C levels, in 17 month study.
09/01/2020
Consistent LDL-C Lowering Reported With Twice-Yearly Inclisiran - MPR

Investigational small interfering RNA treatment shows reduction in LDL-C levels, in 17 month study.

Treatment with twice-yearly inclisiran consistently reduced LDL-C levels over a period of 17 months, according to a post-hoc analysis of pooled data from the two phase 3 trials presented at the European Society of Cardiology Congress 2020.

Some hand sanitizers are being marketed in packaging that resembles food and drink products, leading the FDA to issue a ...
08/31/2020
FDA Warns of Hand Sanitizers in Food-Like Packaging - MPR

Some hand sanitizers are being marketed in packaging that resembles food and drink products, leading the FDA to issue a warning.

Reports received by the FDA include hand sanitizer sold in a pouch that resembled a snack.

Long-acting human insulin analogue available for glycemic control in adults and pediatric patients with diabetes.
08/31/2020
Semglee Now Available for Patients With Diabetes - MPR

Long-acting human insulin analogue available for glycemic control in adults and pediatric patients with diabetes.

The long-acting human insulin analogue has an identical amino acid sequence to Lantus® (insulin glargine; Sanofi).

ICYMI: A Boxed Warning for amputation risk was removed from a diabetes treatment as new data emerged.
08/30/2020
Boxed Warning Removed From Canagliflozin Labeling - MPR

ICYMI: A Boxed Warning for amputation risk was removed from a diabetes treatment as new data emerged.

The FDA has removed the Boxed Warning for canagliflozin (Invokana, Invokamet, Invokamet XR; Janssen) regarding the risk of lower limb amputation.

Results from a trial of the device found that the Pearl Index (pregnancy rate) for the 6th year of use was 0.35, based o...
08/30/2020
Mirena Approved for Pregnancy Prevention for Up to 6 Years - MPR

Results from a trial of the device found that the Pearl Index (pregnancy rate) for the 6th year of use was 0.35, based on 1 pregnancy that occurred during year 6, within 7 days after device removal.

Mirena (levonorgestrel-releasing intrauterine system; Bayer) approval extends contraceptive use for up to 6 years.

New topical treatment for acne vulgaris.
08/28/2020
Winlevi Cream Approved for Acne Vulgaris - MPR

New topical treatment for acne vulgaris.

The FDA has approved Winlevi® (clascoterone; Cassiopea) cream 1% for the topical treatment of acne vulgaris in patients aged 12 years and older.

🎧 Latest MPR Podcast is up! Included:🔹 ACIP vaccination guidelines;🔹 Convalescent plasma;🔹 New 15-minute test;🔹 Expanded...
08/28/2020
MPR Weekly Dose Podcast Episode 49 - MPR

🎧 Latest MPR Podcast is up! Included:
🔹 ACIP vaccination guidelines;
🔹 Convalescent plasma;
🔹 New 15-minute test;
🔹 Expanded indication for intrauterine device;
🔹 Hydrochlorothiazide label change.
📽️ And of course, movie trivia! 🤓

The ACIP release guidelines for the 2020-2021 vaccination recommendations; In COVID, there’s developments in convalescent plasma authorization, a 15 minute test, and ethnobotanist’s give a stark warning concerning a plant that some are touting as a cure. In other news an intrauterine device gain...

Impurities found in rifampin and rifapentine; to avoid a potential shortages, the FDA is allowing temporarily distributi...
08/27/2020
FDA: Tuberculosis Drugs May Contain Nitrosamine Impurities - MPR

Impurities found in rifampin and rifapentine; to avoid a potential shortages, the FDA is allowing temporarily distribution of products with impurities above the acceptable intake limits.

Nitrosamine impurities have been identified in samples of rifampin and rifapentine, according to the Food and Drug Administration (FDA).

A Boxed Warning for leg and foot amputation risk has been removed from a diabetes treatment following the emergence of n...
08/26/2020
Boxed Warning Removed From Canagliflozin Labeling - MPR

A Boxed Warning for leg and foot amputation risk has been removed from a diabetes treatment following the emergence of new data.

The FDA has removed the Boxed Warning for canagliflozin (Invokana, Invokamet, Invokamet XR; Janssen) regarding the risk of lower limb amputation.

The granting of Emergency Use Authorization does not mean that plasma therapy for #COVIDー19 has been proven safe and eff...
08/26/2020
WHO: Plasma Therapy for COVID-19 Still Experimental - MPR

The granting of Emergency Use Authorization does not mean that plasma therapy for #COVIDー19 has been proven safe and effective.

FDA 'emergency use authorization' does not mean plasma therapy has been proven safe and effective.

Intrauterine device has its indication extended for an extra year. The approval was based on a study of 362 women of rep...
08/25/2020
Mirena Approved for Pregnancy Prevention for Up to 6 Years - MPR

Intrauterine device has its indication extended for an extra year. The approval was based on a study of 362 women of reproductive age.

Mirena (levonorgestrel-releasing intrauterine system; Bayer) approval extends contraceptive use for up to 6 years.

Researchers examined whether the 41 most commonly used individual antihypertensive drugs were associated with an altered...
08/25/2020
Antihypertensive Meds and Depression Risk Examined - MPR

Researchers examined whether the 41 most commonly used individual antihypertensive drugs were associated with an altered risk for incident depression.

Depression rates down with nine antihypertensive agents, including enalapril, amlodipine, atenolol.

Cancer risk warning added to label of hypertension treatment. The increased risk is predominately for squamous cell carc...
08/24/2020
FDA: Small Risk of Skin Cancer With Hydrochlorothiazide Use - MPR

Cancer risk warning added to label of hypertension treatment. The increased risk is predominately for squamous cell carcinoma and in white patients taking large cumulative doses, say the FDA.

The FDA has approved labeling changes for HCTZ to include information regarding an increased risk of non-melanoma skin cancer.

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Vedic Astronomy ( FB Page ) " Saavan Kaal Gananaa ( whose " TIME " does not need Leap Second ) with Mathematical Explaination of/for * 1) Samvatsar , Ahoratra and how Saavan Day differs from Civil ( Solar ) Day * 2.) Equatorial Precession and how prevalent Precession ( Ayanamsha ) which is Ecliptic derived using it with Obliquity of Ecliptic. ( In Vedic Astronomy Star/s for Ayanamsha Mul/Mrug NOT Chitra). * 3) Sidereal ( Nirayan ) and Tropical ( Sayan ) Longitudes of Sun * 4) Calculation of Eccentric Anomaly of Planet from Mean Anomaly and True Anomaly from it without Kepler's Laws * 5) Invariable Plane and Star Positions w.r.t. it . Also their ( Apparent ) motion w.r.t. Earth. * 6) Rikvedic Year of 366 days which is now of 365.25 days ( In Vedic Astronomy Sidereal Period changes Cyclically. )
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Curiosity kills the cat! I went to pharmacy to get another Levalbuterol HFA. I was told they had none and that the called the manufactuer who said they are all out and don't know when they will have more!!! Does anyone know if they are going to continue making this product??? Problem: Albuterol throws me into VFIB! I can't take any of the other rescue inhalers. Finally found a pharmacy in drug store 60 miles from me ( middle of Nowhere MT), and finally found someone going that way tomorrow who can pick it up for me as I am unable to drive. This could be a big problem for me !!!!! Anyone???
A friend had me sign up for MPR several years ago, just the emails that are free as they did not have a laptop at the time. They are a nurse and i am not in the medical field at all. I have tried to figure out how to unsubscribe but it seems every where i go i can subscribe to a paid service but not unsubscribe. to put it bluntly your emails are wasted on me and wasting my time as well. My email is [email protected] please unsubscribe me. Thanks in advance.
I have an ear infection and you have the best ear drops to fix that. How can you charge $200 plus for your medication and still have a heart. The drug is $62.62 in Canada....and that's high too, but a lot better than $200 plus.....I can see you deleting this post because it is negative against your product. I paid the price because I can and it does work....but really $200 Plus???? don't tell me it goes into research.....
Hmmm, some things do come full circle... when nature is allowed an unadulterated course, there maybe many such elements to 'treat' the human condition... of aberration...
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