Rockefeller University Press

Rockefeller University Press We publish The Journal of Cell Biology, The Journal of Experimental Medicine, and The Journal of General Physiology.
The Rockefeller University Press (RUP) is committed to quality and integrity in scientific publishing. Our goal is to publish excellent science using the latest technologies. We carry out rigorous peer review, applying the highest standards of novelty, mechanistic insight, data integrity, and general interest. In the internet age, the ability to distribute information is no longer restricted to publishers, and everyone is overloaded with information. Thus, the current value of a scientific publisher is that we carry out peer review, and by doing so we publish only those papers reporting significant conceptual advances. The review process for all three RUP journals is carried out in conjunction with academic editors.

Excess inflammation caused by IL-17 has been implicated in autoimmune disorders such as rheumatoid arthritis, psoriasis,...
06/06/2019
Phosphorylation of Regnase-1 lets IL-17 run amok

Excess inflammation caused by IL-17 has been implicated in autoimmune disorders such as rheumatoid arthritis, psoriasis, and multiple sclerosis. Because of this destructive side of IL-17, a research team led by Osaka University decided to examine exactly how mRNA-degrading protein Regnase-1 helps rein in the unruly cytokine. In an article published in the Journal of Experimental Medicine (https://bit.ly/2WvDpBK), the researchers describe how their results could provide some relief for patients suffering from IL-17-associated diseases.

When considering the role of the key immune molecule interleukin (IL)-17, the phrase "too much of a good thing" springs to mind. Because unlike some of its more sedate cytokine cousins which studiously direct the immune response to destroy invading pathogens, IL-17 can get a little carried away. So....

JGP poster award winners from the 2019 Biophysical Society of Canada Annual Meeting (from left to right): Daniel Nino, S...
06/04/2019

JGP poster award winners from the 2019 Biophysical Society of Canada Annual Meeting (from left to right): Daniel Nino, Sarah Bickers, and Rashik Ahmed.

A team of researchers discovered the COMMD3/8 complex as a molecule involved in immune cell migration, clarifying that t...
06/04/2019
COMMD3/8 protein complex: a potential drug target for treating inflammatory diseases

A team of researchers discovered the COMMD3/8 complex as a molecule involved in immune cell migration, clarifying that the complex plays a critical role in the establishment of immune responses. Their research results were published in the Journal of Experimental Medicine (https://bit.ly/2wccmM4).

A team of researchers led by Kazuhiro Suzuki from the Immunology Frontier Research Center at Osaka University discovered the COMMD3/8 complex as a molecule involved in immune cell migration, clarifying that the complex plays a critical role in the establishment of immune responses. Their research re...

The Journal of Experimental Medicine is pleased to present a special collection of articles (https://bit.ly/2YXZDJf) to ...
05/30/2019
Immunometabolism 2019

The Journal of Experimental Medicine is pleased to present a special collection of articles (https://bit.ly/2YXZDJf) to coincide with the 4th International Conference on ImmunoMetabolism: Molecular and Cellular Immunology of Metabolism.

Interested in discussing your latest research with JEM editors and learning how we are making the publishing process easier for authors? Meet Senior Scientific Editor Alejo Chorny at this workshop.

Cancer researchers have discovered surprising new functions for a protein called MYC, a powerful oncogene that drives th...
05/29/2019

Cancer researchers have discovered surprising new functions for a protein called MYC, a powerful oncogene that drives the development of almost half a million new cancer cases in the US every year. The study, which was published in the Journal of Experimental Medicine (https://bit.ly/2YVZMNo), shows that MYC affects the efficiency and quality of protein production in lymphoma cells, fueling their rapid growth and altering their susceptibility to immunotherapy. Read the press release here: https://bit.ly/2YV2HWm

A study, conducted at The University of Chicago and published in the Journal of Experimental Medicine (https://bit.ly/2E...
05/28/2019
Antibiotics may help curb Alzheimer's symptoms

A study, conducted at The University of Chicago and published in the Journal of Experimental Medicine (https://bit.ly/2EdIJOX), demonstrated how long-term antibiotic use could reduce inflammation and slow the growth of amyloid plaques in male mice.

A new study in mice suggests that a combination of antibiotics may reduce the buildup of amyloid plaques, but only in male brains.

A toxic protein linked to Huntington's disease can move from neuron to neuron through a nanotube tunnel whose constructi...
05/24/2019
Nanotubes enable travel of Huntington’s disease protein | Scripps Research

A toxic protein linked to Huntington's disease can move from neuron to neuron through a nanotube tunnel whose construction is initiated by a protein called Rhes. The research was published in the Journal of Cell Biology (https://bit.ly/2WFnqwQ).

Jupiter, FL - A toxic protein linked to Huntington’s disease can move from neuron to neuron through a nanotube tunnel whose construction is initiated by a protein called Rhes, say scientists at Scripps Research.

A new immunodeficiency disease caused by a novel mutation in a gene called IL2RB (encoding interleukin-2 receptor beta) ...
05/23/2019
New disease discovered by CU Anschutz researchers

A new immunodeficiency disease caused by a novel mutation in a gene called IL2RB (encoding interleukin-2 receptor beta) has been identified by researchers at the University of Colorado Anschutz Medical Campus, and published in the Journal of Experimental Medicine (https://bit.ly/2DQ2pbg). See also the articles at https://bit.ly/2VHq2Nz and https://bit.ly/2YrAjLp

A new immunodeficiency disease caused by a novel genetic mutation has been identified by researchers at the University of Colorado Anschutz Medical Campus providing unique insights into cell biology.

In a study recently published in the Journal of Experimental Medicine, Medina et al. (https://bit.ly/2Qeiwo1) explored t...
05/22/2019
Too much of a good thing: why KIT inhibitors stop working

In a study recently published in the Journal of Experimental Medicine, Medina et al. (https://bit.ly/2Qeiwo1) explored the mechanisms behind why Kit inhibition fails as an immunotherapy with chronic use, and investigated strategies that may help to redeem the seemingly promising effects of imatinib on antitumor immunity. Read the highlight by ACIR: https://bit.ly/2wd2K3y

Constitutive signaling from a single mutation in the KIT proto-oncogene can be sufficient to drive the formation of a gastrointestinal stromal tumor (GIST). These tumors constitutively express immunosuppressive IDO, which dampens dendritic cell-primed effector CD8+ T cell responses. Previous studies...

JGP is pleased to present a collection of articles on ligand-gated ion channels (https://bit.ly/2Em80GF). Along with cut...
05/21/2019
Ligand-gated ion channels

JGP is pleased to present a collection of articles on ligand-gated ion channels (https://bit.ly/2Em80GF). Along with cutting-edge Research Articles on the structure and function of glutamate-, acetylcholine-, and ATP-gated ion channels, the collection features a Hypothesis on allosteric regulation of ion channel function by the lipid membrane and a Review of our current understanding of NMDA receptors.

Ligand-gated ion channels are membrane proteins that transduce the binding of a ligand, such as a neurotransmitter, into an electrical response. In recent years, our understanding of the mechanisms by which ligands bind to and open these ion channels has been revolutionized by advances in structural...

A new study in the Journal of Experimental Medicine (https://bit.ly/2EdIJOX) shows that, by altering the gut microbiome,...
05/17/2019

A new study in the Journal of Experimental Medicine (https://bit.ly/2EdIJOX) shows that, by altering the gut microbiome, long-term antibiotic treatment reduces inflammation and slows the growth of amyloid plaques in the brains of male mice, though the same treatment has no effect on female animals. Read the press release here: https://bit.ly/2LPg8FL

A new Journal of Cell Biology study (https://bit.ly/2LJbmcX) reveals that inhibiting PHLPP2 lowered the levels of MYC, a...
05/16/2019

A new Journal of Cell Biology study (https://bit.ly/2LJbmcX) reveals that inhibiting PHLPP2 lowered the levels of MYC, an oncogenic protein that causes many different types of cancer that cannot be targeted by conventional drug therapies. Read the press release here: https://bit.ly/2w15VeD

Journal of Cell Biology (JCB) harmonized its manuscript submission systems with the Journal of Cell Science (JCS) and Mo...
05/16/2019

Journal of Cell Biology (JCB) harmonized its manuscript submission systems with the Journal of Cell Science (JCS) and Molecular Biology of the Cell (MBoC) to reduce the burden on authors and reviewers. Read all about the new option here: https://bit.ly/2W5SwAH

Research published in the Journal of Cell Biology (https://bit.ly/2WFnqwQ) provides insight into how and why Huntington'...
05/14/2019
Here's why Huntington's disease attacks brain cells in human

Research published in the Journal of Cell Biology (https://bit.ly/2WFnqwQ) provides insight into how and why Huntington's disease attacks and destroys certain brain cells in human beings.

Recent study conducted on mice has given more insight into how and why Huntington's disease attacks and destroys certain brain cells in human beings.The study was published in the Journal of Cell Biology."We are excited about this result because it

Smoking has long been the biggest cause of cancer in the United States, but obesity, now the second leading cause, has b...
05/10/2019
Obesity reprograms immune cells in breasts to promote tumor formation

Smoking has long been the biggest cause of cancer in the United States, but obesity, now the second leading cause, has been gaining ground. A new study from researchers at the University of Chicago, published in the Journal of Experimental Medicine (https://bit.ly/2YhgrKS) finds that women with breast cancer, the most common cancer among women, are at even higher risk from obesity.

Macrophages in adipose tissue (fat) link obesity to triple-negative breast cancer. Instead of fighting breast cancer, these immune cells actually promote it.

Explore the Journal of Cell Biology's collection of exciting new immunology, microbiology, and virology research.
05/09/2019
Special Collection: Immune cell biology

Explore the Journal of Cell Biology's collection of exciting new immunology, microbiology, and virology research.

We are delighted to present this selection of cutting-edge research about immune cell biology, microbiology, and virology recently published in JCB.

This Journal of Experimental Medicine special collection (https://bit.ly/2vPKOf3) exhibits recent and exciting advances ...
05/08/2019
JEM Immunology Collection 2019

This Journal of Experimental Medicine special collection (https://bit.ly/2vPKOf3) exhibits recent and exciting advances in immunology, celebrating our commitment to publishing outstanding basic immunology as well as innovative studies at the intersection of immunology with other fields such as neuroscience, cancer, and metabolism.

The Journal of Experimental Medicine (JEM) has been publishing exceptional and enduring studies for over 120 years. Many of these seminal studies have helped to define the field of immunology and progress it to the forefront of science, where major progress is being made in the development of new th...

In this special collection (https://bit.ly/2VQOtrG), JCB Editorial Board member Johanna Ivaska and Senior Scientific Edi...
05/07/2019
Special Collection: Cell Adhesion

In this special collection (https://bit.ly/2VQOtrG), JCB Editorial Board member Johanna Ivaska and Senior Scientific Editor Melina Casadio selected recent JCB content delving into the mechanisms of migration, cell–cell, and cell–matrix adhesions.

The adhesion machinery and interactions with the cellular microenvironment play essential roles in regulating cell function—including proliferation, migration, differentiation—in development and disease.

Deadline extended to May 13! We are seeking candidates for the Editor-in-Chief position of the Journal of General Physio...
05/03/2019
Call for Applications: JGP Editor-in-Chief

Deadline extended to May 13!
We are seeking candidates for the Editor-in-Chief position of the Journal of General Physiology for a renewable three-year term, beginning January 1, 2020. The Editor-in-Chief will work with RUP to create and implement the strategic vision of the journal, establish editorial policies, oversee peer review of journal content, encourage submission of high quality manuscripts, and select Associate Editors and new Editorial Advisory Board members. Learn more about this opportunity: https://bit.ly/2D38Zef

Rockefeller University Press (RUP) seeks candidates for the Editor-in-Chief position of the

A joint team from Hokkaido University and Keio University has identified a gut protein essential for neonatal mice to fi...
04/25/2019
Identifying a key player in gut defense development

A joint team from Hokkaido University and Keio University has identified a gut protein essential for neonatal mice to fight infections, according to research published in the Journal of Experimental Medicine (https://bit.ly/2VwOihT). The insight could help understand how infants develop their own intestinal immune systems after weaning.

Scientists have identified a protein critical to the immune system development and antibody production in mice, which could contribute to understanding the gut defense mechanism in infants.

We are seeking candidates for the Editor-in-Chief position of the Journal of General Physiology (JGP) for a renewable th...
04/24/2019
Call for Applications: JGP Editor-in-Chief | JGP

We are seeking candidates for the Editor-in-Chief position of the Journal of General Physiology (JGP) for a renewable three-year term, beginning January 1, 2020. The Editor-in-Chief (EIC) will work with RUP to create and implement the strategic vision of the journal, establish editorial policies, oversee peer review of journal content, encourage submission of high quality manuscripts, and select Associate Editors and new Editorial Advisory Board members. Learn more about this opportunity and apply by April 30, 2019: https://bit.ly/2D38Zef

Rockefeller University Press (RUP) seeks candidates for the Editor-in-Chief position of the Journal of General Physiology (JGP) for a renewable three-year term, beginning January 1, 2020.

New North Carolina State University research, published in the Journal of Cell Biology (https://bit.ly/2GhmoBt), shows t...
04/23/2019
Cell-Killing Proteins Suppress Listeria Without Killing Cells

New North Carolina State University research, published in the Journal of Cell Biology (https://bit.ly/2GhmoBt), shows that key proteins known for their ability to prevent viral infections by inducing cell death can also block certain bacterial infections without triggering the death of the host cells.

What happens when proteins that kill cells as a defense mechanism decide to not kill cells? An NC State study reveals the answer.

In a recent study, described in the Journal of Experimental Medicine (https://bit.ly/2VBGXxA), Nussenzweig and his colle...
04/19/2019
Gene-editing technique opens door for HIV vaccine - News

In a recent study, described in the Journal of Experimental Medicine (https://bit.ly/2VBGXxA), Nussenzweig and his colleagues used CRISPR-Cas9 gene editing technology to modify mouse B cells to make human broadly neutralizing antibodies that can fight HIV.

The human body cannot naturally defend itself against HIV—not usually, at least. But in very rare cases, infected individuals generate broadly neutralizing antibodies, or bNAbs, that fight the virus. Now, Rockefeller scientists have devised a way to grant this HIV-fighting power to otherwise avera...

The Journal of Cell Biology congratulates Academic Editor Elaine Fuchs who has been named a Foreign Member of the Royal ...
04/17/2019
Elaine Fuchs | Royal Society

The Journal of Cell Biology congratulates Academic Editor Elaine Fuchs who has been named a Foreign Member of the Royal Society. Dr. Fuchs was recognized for transforming our understanding of skin stem cells and their application to regenerative medicine, genetic syndromes and cancers, and pioneering reverse genetics. Learn more: https://bit.ly/2GtAzU1

Royal Society Fellow

A study of pregnant women with systemic lupus erythematosus has identified early changes in the RNA molecules present in...
04/16/2019
Researchers identify early indicators of pregnancy complications in lupus patients

A study of pregnant women with systemic lupus erythematosus has identified early changes in the RNA molecules present in the blood that could be used to determine the likelihood of them developing preeclampsia. The study was published in the Journal of Experimental Medicine (https://bit.ly/2VyIULg).

A study of pregnant women with systemic lupus erythematosus has identified early changes in the RNA molecules present in the blood that could be used to determine the likelihood of them developing preeclampsia. The study, which will be published April 8 in the Journal of Experimental Medicine, may a...

We are seeking candidates for the Editor-in-Chief position of the Journal of General Physiology (JGP) for a renewable th...
04/12/2019
Call for Applications: JGP Editor-in-Chief | JGP

We are seeking candidates for the Editor-in-Chief position of the Journal of General Physiology (JGP) for a renewable three-year term, beginning January 1, 2020. The Editor-in-Chief (EIC) will work with RUP to create and implement the strategic vision of the journal, establish editorial policies, oversee peer review of journal content, encourage submission of high quality manuscripts, and select Associate Editors and new Editorial Advisory Board members. Learn more about this opportunity and apply by April 30, 2019: https://bit.ly/2D38Zef

Rockefeller University Press (RUP) seeks candidates for the Editor-in-Chief position of the Journal of General Physiology (JGP) for a renewable three-year term, beginning January 1, 2020.

04/11/2019
Immune cells fighting blood cancer visualized for the first time

One of the strategies used to combat cancer is based on modification of the patient's T lymphocytes to make them recognize the target molecule CD19 expressed by the tumor, so that they can eliminate it. But some patients suffer relapses. To improve therapies in future, scientists from the Institut Pasteur set out to elucidate the precise workings of CAR T cells. Their work was published in the Journal of Experimental Medicine (https://bit.ly/2COyrEh).

When cancer escapes the immune system, our defenses are rendered powerless and are unable to fight against the disease. Chimeric antigen receptor T cells (CAR T cells) represent a promising immunotherapy strategy, developed with the aim of tackling tumors head-on. But the occurrence of relapse in so...

New research in the Journal of Experimental Medicine (https://bit.ly/2G2MQyD) shows a new approach that significantly mi...
04/09/2019
New approach to stroke treatment could minimize brain damage

New research in the Journal of Experimental Medicine (https://bit.ly/2G2MQyD) shows a new approach that significantly minimized brain damage caused by stroke in mouse models. The new approach works by targeting hemichannels—pathways that allow for the flow of chemical ions and small molecules—that are expressed by astrocytes.

A new treatment for a common type of stroke may soon be possible, thanks to a discovery by an international team of researchers led by the University of British Columbia.

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The Rockefeller University Press (RUP) is committed to quality and integrity in scientific publishing. Our goal is to publish excellent science using the latest technologies. We carry out rigorous peer review, applying the highest standards of novelty, mechanistic insight, data integrity, and general interest.

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