Nature Genetics

Nature Genetics Nature Genetics is a monthly journal publishing high impact research in all areas of genetics and genomics. http://www.nature.com/ng/index.html

Nature Genetics is a monthly journal publishing high impact research in all areas of genetics and genomics. Nature Genetics is part of the Nature Research portfolio.

Online Nature Rev Genetics Genetics of coronary artery disease by Khera & Kathiresan Sek Kathiresan MD  http://go.nature...
05/17/2017

Online Nature Rev Genetics Genetics of coronary artery disease by Khera & Kathiresan Sek Kathiresan MD http://go.nature.com/2qwtDvV

Transcriptional profiling of human oocytes and preimplantation embryos highlights DUX4-family proteins as activators of ...
05/05/2017

Transcriptional profiling of human oocytes and preimplantation embryos highlights DUX4-family proteins as activators of cleavage-stage genes and repetitive elements. The study shows that Dux expression converts mouse embryonic stem cells into two-cell (2C) embryo-like cells, suggesting that mouse DUX and human DUX4 act as drivers of the mammalian cleavage/2C state. Article by Peter Hendrickson et al: http://go.nature.com/2qptNV4 $

A new study reports that human DUX4, which is linked to facioscapulohumeral dystrophy, and mouse DUX activate genes asso...
05/04/2017
Conservation and innovation in the DUX4-family gene network : Nature Genetics : Nature Research

A new study reports that human DUX4, which is linked to facioscapulohumeral dystrophy, and mouse DUX activate genes associated with cleavage-stage embryos, including retrotransposons, in muscle cells.

Article by Jennifer Whiddon: http://go.nature.com/2qpBEC5 $

Stephen Tapscott and colleagues report that human DUX4, which is linked to facioscapulohumeral dystrophy, and mouse DUX activate genes associated with cleavage-stage embryos, including retrotransposons, in muscle cells. They suggest that the ancestral DUX4-regulated genes characteristic of cleavage-...

Eugene Gladyshev and Nancy Kleckner report that the DNMT1-like cytosine methylase DIM-2 can mediate repeat-induced point...
05/02/2017
DNA sequence homology induces cytosine-to-thymine mutation by a heterochromatin-related pathway in Neurospora : Nature Genetics : Nature Research

Eugene Gladyshev and Nancy Kleckner report that the DNMT1-like cytosine methylase DIM-2 can mediate repeat-induced point mutation through C-to-T mutation of repetitive DNA in Neurospora crassa. They show that this process requires heterochromatin factors and propose a model whereby direct interactions between homologous double-stranded DNA can initiate the formation of heterochromatin. http://go.nature.com/2qw4LTR $

Eugene Gladyshev and Nancy Kleckner report that the DNMT1-like cytosine methylase DIM-2 can mediate RIP (repeat-induced point mutation) through cytosine-to-thymine mutation of repetitive DNA in Neurospora crassa. They show that this process requires heterochromatin factors and propose a model whereb...

The genome sequence of the golden orb-weaver spider provides new insights into how spiders create silk for building thei...
05/01/2017
The Nephila clavipes genome highlights the diversity of spider silk genes and their complex expression : Nature Genetics : Nature Research

The genome sequence of the golden orb-weaver spider provides new insights into how spiders create silk for building their webs

Article by Paul Babb et al.: go.nature.com/2pPcFeK (Open)
Image Credit: Charles J Sharp via Wikipedia: https://tinyurl.com/l3v3ys8

Benjamin Voight and colleagues report the annotated genome of the golden orb-weaver spider. They describe 28 spider silk genes (spidroins), characterize their expression in distinct silk gland types and identify non-spidroin genes with expression patterns suggesting potential roles in silk productio...

News and Views article by Silvana Gaudieri & Michaela Lucas highlights a study reporting genome-to-genome analysis of ho...
04/28/2017
Innate and adaptive immunity shape circulating HCV strains : Nature Genetics : Nature Research

News and Views article by Silvana Gaudieri & Michaela Lucas highlights a study reporting genome-to-genome analysis of host-HCV genetic interactions http://go.nature.com/2oLUC4B

An unbiased genome-to-genome analysis in chronic hepatitis C virus (HCV) infection confirms the innate and adaptive arms of the immune system as drivers of viral evolution. Viral adaptation has a critical role in the interaction between host and pathogen and has important clinical implications for i...

Genomic analysis of 133 ovarian cancers identifies seven subgroups using point mutation and structural variation signatu...
04/28/2017
Genomic consequences of aberrant DNA repair mechanisms stratify ovarian cancer histotypes : Nature Genetics : Nature Research

Genomic analysis of 133 ovarian cancers identifies seven subgroups using point mutation and structural variation signatures

Article by Yi Kan Wang & Ali Bashashati et al.: http://go.nature.com/2q7U2OS ($)

Sohrab Shah, David Huntsman and colleagues report the genomic analysis of 133 ovarian cancers spanning different subtypes. They identify seven subgroups using point mutation and structural variation signatures and use these genomic features to stratify ovarian cancers both between and within histoty...

News and Views by Brittany Michel & Cigall Kadoch highlights two recent studies reporting a key role for SWI/SNF complex...
04/27/2017
A SMARCD2-containing mSWI/SNF complex is required for granulopoiesis : Nature Genetics : Nature Research

News and Views by Brittany Michel & Cigall Kadoch highlights two recent studies reporting a key role for SWI/SNF complex protiens in granulopoiesis http://go.nature.com/2qeYnQL

Mammalian SWI/SNF complexes have critical roles in development and differentiation, and are implicated in the pathogenesis of several diseases; however, the mechanisms underpinning disease manifestation and the specificity of the subunits mutated are incompletely understood. Newly identified loss-of...

We recommend constant oversight and evaluation of human germline genome editing to balance prudence with discovery, and ...
04/27/2017
The future of human genome editing : Nature Genetics : Nature Research

We recommend constant oversight and evaluation of human germline genome editing to balance prudence with discovery, and risk with progress. http://go.nature.com/2q7Rvbd

With the advent of precision genome editing, the ability to modify living organisms has proceeded with remarkable speed and breadth. Any application of this technology to the human germ line must be tightly coupled to deliberate consideration of the consequences, both scientific and social, of intro...

Analysis of genotype data from ∼370,000 women identifies 389 independent signals that associate with age at menarche, ...
04/27/2017
Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk : Nature Genetics : Nature Research

Analysis of genotype data from ∼370,000 women identifies 389 independent signals that associate with age at menarche, implicating ∼250 genes. These analyses suggest causal inverse associations, independent of BMI, between puberty timing and risks for breast and endometrial cancers in women and prostate cancer in men.

http://go.nature.com/2pt8Yeq ($)

John Perry, Ken Ong and colleagues analyze genotype data on [sim]370,000 women and identify 389 independent signals that associate with age at menarche, implicating [sim]250 genes. Their analyses suggest causal inverse associations, independent of BMI, between puberty timing and risks for breast and...

News and Views by C Neal Stewart Jr highlights a new study on weedy rice evolution http://go.nature.com/2pirymy
04/26/2017
Becoming weeds : Nature Genetics : Nature Research

News and Views by C Neal Stewart Jr highlights a new study on weedy rice evolution http://go.nature.com/2pirymy

A new resequencing analysis of weedy rice (Oryza sativa L.) biotypes illuminates distinct evolutionary paths and outcomes of de-domestication and ferality. This largest effort to date in weedy plant genomics gives a better understanding of weediness while also providing a promising source of alleles...

Nature Ecology & Evolution
04/26/2017
Nature Ecology & Evolution

Nature Ecology & Evolution

Two new papers in Nature Ecology & Evolution explore how new genes are born. One takes an experimental approach, the other a bioinformatic approach. Your can read the stories behind both papers on our community site.

https://natureecoevocommunity.nature.com/users/30793-joanna-masel/posts/16390-de-novo-gene-birth
https://natureecoevocommunity.nature.com/users/34835-rafik-neme/posts/16396-exploring-random-sequence-space-in-the-name-of-de-novo-genes

The May issue of Nature Genetics is online Now! Epigenome energy landscapes, weedy rice evolution, citrus genomes and mo...
04/26/2017

The May issue of Nature Genetics is online Now! Epigenome energy landscapes, weedy rice evolution, citrus genomes and more! http://go.nature.com/2plGhz1

A new study identifies 24 genes that interact with MSI2 protein and are required for leukemia in vivo. Article by Ly Vu ...
04/26/2017
Functional screen of MSI2 interactors identifies an essential role for SYNCRIP in myeloid leukemia stem cells : Nature Genetics : Nature Research

A new study identifies 24 genes that interact with MSI2 protein and are required for leukemia in vivo.

Article by Ly Vu et al.: http://go.nature.com/2q7CTVN ($)

Michael Kharas and colleagues characterize the MSI2 protein interactome in leukemia cells and subsequently perform a functional screen identifying 24 genes required for leukemia in vivo. They focus on the RNA-binding protein SYNCRIP, showing that it regulates Hoxa9 and other transcripts involved in…

Adiposity significantly amplifies the effects of some genetic variants on nonalcoholic fatty liver disease.Article by St...
04/25/2017
Adiposity amplifies the genetic risk of fatty liver disease conferred by multiple loci : Nature Genetics : Nature Research

Adiposity significantly amplifies the effects of some genetic variants on nonalcoholic fatty liver disease.

Article by Stefan Stender et al.: http://go.nature.com/2paI7kf ($)

Jonathan Cohen, Helen Hobbs and colleagues show that adiposity significantly amplifies the effects of PNPLA3, TM6SF2, and GCKR sequence variants on nonalcoholic fatty liver disease. They find that synergy between adiposity and genotype influences the full spectrum of the disease, from steatosis to h...

New blog post from the Nature Genetics editors highlights a classic paper from our archives by Eric Lander & Leonid Krug...
04/20/2017
From the archives (1995): Guidelines for interpreting and reporting linkage results : Free Association

New blog post from the Nature Genetics editors highlights a classic paper from our archives by Eric Lander & Leonid Kruglyak from 1995. http://go.nature.com/2oTMSyy #NatGen25

, recommending clear statistical guidelines for reporting linkage results for complex traits. The paper had an immediate impact, setting the bar for what could or could not be called “significant” in the literature. Although originally focused on human genetic linkage studies, the guidelines set for...

Kaoru Ito, Yoichiro Kamatani, Toshihiro Tanaka and colleagues report a genome-wide association study for atrial fibrilla...
04/20/2017
Identification of six new genetic loci associated with atrial fibrillation in the Japanese population : Nature Genetics

Kaoru Ito, Yoichiro Kamatani, Toshihiro Tanaka and colleagues report a genome-wide association study for atrial fibrillation in the Japanese population. They identify six new loci, five of which are not associated with atrial fibrillation in individuals of European ancestry, suggesting that they may be specific to the Japanese population.

Article by Siew-Kee Low et al.: http://go.nature.com/2oie3SG #SharedIt

A new study reports complete genome assemblies based on long-read sequencing of 7 Saccharomyces cerevisiae and 5 Sacchar...
04/18/2017
Contrasting evolutionary genome dynamics between domesticated and wild yeasts : Nature Genetics : Nature Research

A new study reports complete genome assemblies based on long-read sequencing of 7 Saccharomyces cerevisiae and 5 Saccharomyces paradoxus strains to compare the evolutionary dynamics between these domesticated and wild yeast species.

Article by Jia-Xing Yue et al.: http://go.nature.com/2oESf4E

Jia-Xing Yue, Gianni Liti and colleagues use long-read sequencing to generate complete genome assemblies of 7 Saccharomyces cerevisiae and 5 Saccharomyces paradoxus strains. They use these data to define boundaries between chromosomal core and subtelomeric regions and to compare the evolutionary dyn...

Don't miss your chance to present at the NYU Nature Conference on Neurogenetics! Abstract submissions due April 19: go.n...
04/14/2017
NYU Nature Conference on Neurogenetics

Don't miss your chance to present at the NYU Nature Conference on Neurogenetics! Abstract submissions due April 19: go.nature.com/2picYLA #neurogen17

August 9-11, 2017
Kimmel Center for University Life, New York University, New York, NY

Genomic studies of citrus suggest that regions containing energy- and reproduction-associated genes may be under selecti...
04/10/2017
Genomic analyses of primitive, wild and cultivated citrus provide insights into asexual reproduction : Nature Genetics : Nature Research

Genomic studies of citrus suggest that regions containing energy- and reproduction-associated genes may be under selection in cultivated citrus

Article by Xia Wang, Yuantao Xu, Siqi Zhang, Li Cao et al.:
http://go.nature.com/2oYlpy2 #openacces
Image credit: Scott Bauer, USDA (via Wikipedia)

Qiang Xu and colleagues sequence four citrus species de novo, along with 100 accessions, including primitive, wild and cultivated citrus. Their genomic analyses associate the CitRWP gene with polyembryony and suggest that regions harboring energy- and reproduction-associated genes are probably under...

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