American Journal of Ophthalmology

American Journal of Ophthalmology American Journal of Ophthalmology is a peer-reviewed medical journal. It was established in 1884 and is published monthly by Elsevier. Follow us on Twitter @AmJOphthalmol.

The American Journal of Ophthalmology is a peer-reviewed, scientific publication that welcomes the submission of original, previously unpublished manuscripts directed to ophthalmologists and visual science specialists describing clinical investigations, clinical observations, and clinically relevant laboratory investigations. Published monthly since 1884, the full text of the American Journal of Ophthalmology and supplementary material are also presented online at www.ajo.com and on ScienceDirect. The Editor in Chief of the Journal is Richard K. Parrish II, MD.

Genetic contribution to corticosteroid-induced ocular hypertension has been suspected for many decades, but only recentl...
02/14/2019
The genetic influence on corticosteroid-induced ocular hypertension: A field positioned for discovery

Genetic contribution to corticosteroid-induced ocular hypertension has been suspected for many decades, but only recently have scientific technologies and tools been advanced enough to comprehensively investigate these genetic influences.

https://www.ajo.com/article/S0002-9394(19)30052-2/fulltext

To provide evidence that corticosteroid-induced ocular hypertension has a genetic component.

Local staphylomata in high myopia reflects ocular asphericity and correlate with extraocular muscles (EOM) paths. Myopic...
02/13/2019
Rectus Extraocular Muscle Paths and Staphylomata in High Myopia

Local staphylomata in high myopia reflects ocular asphericity and correlate with extraocular muscles (EOM) paths. Myopic staphylomata are associated with inferior displacement of LR path and defect of the LR-SR band ligament.

https://www.ajo.com/article/S0002-9394(19)30050-9/fulltext

To investigate the relationship between displacement of extraocular muscles (EOMs) and staphyloma in high myopia using magnetic resonance imaging (MRI).

The multi-step scoring system of chronic ocular features in SJS/TEN sequelae is a useful tool to grade all levels of sev...
02/13/2019
Multi-Step Grading System for Evaluation of Chronic Ocular Sequelae in Patients with Stevens-Johnson Syndrome

The multi-step scoring system of chronic ocular features in SJS/TEN sequelae is a useful tool to grade all levels of severity and may help to evaluate surgical intervention efficacy by comparing preoperative with postoperative ocular grades.

https://www.ajo.com/article/S0002-9394(19)30049-2/fulltext

To propose a new scoring system for grading of chronic ocular sequelae in Stevens-Johnson syndrome (SJS).

Since mutations at various points along exon 4 have divergent consequences, genetic testing alone may be insufficient fo...
02/13/2019
The location of exon 4 mutations in RP1 raises challenges for genetic counselling and gene therapy

Since mutations at various points along exon 4 have divergent consequences, genetic testing alone may be insufficient for counselling, but recessive inheritance should be considered likely in severe early onset cases.

https://www.ajo.com/article/S0002-9394(19)30048-0/fulltext

Mutations in the photoreceptor gene RP1 lead to recessive or dominantly inherited retinitis pigmentosa (RP). Since the dominantly inherited phenotype is generally milder than recessive cases, it raises the possibility that it could arise by haploinsufficiency, however most mutations are in the termi...

Dry Eye Disease (DED) overall prevalence, annual prevalence and incidence increase over time for all demographics, which...
02/11/2019
Estimated Prevalence and Incidence of Dry Eye Disease Based on Coding Analysis of a Large, All-age United States Health Care System

Dry Eye Disease (DED) overall prevalence, annual prevalence and incidence increase over time for all demographics, which stresses the importance for continued research and treatment development.

https://www.ajo.com/article/S0002-9394(19)30047-9/fulltext

To assess overall prevalence, annual prevalence and incidence of dry eye disease (DED) in a large, representative population in the US.

Characterization of cataracts with the LOCS III after irradiation may help to further fill gaps in the current understan...
02/11/2019
The Lens Opacities Classification System III grading in irradiated uveal melanomas to characterize proton induced cataracts

Characterization of cataracts with the LOCS III after irradiation may help to further fill gaps in the current understanding of the mechanisms of radiation-induced cataracts.

https://www.ajo.com/article/S0002-9394(19)30046-7/fulltext

To evaluate the use of the Lens Opacities Classification System III Grading (LOCS III) for the characterization of radiation-induced cataract, and to correlate the proton beam projection onto the lens with cataract location and grade as defined by the LOCS III.

A combination of metrics from combined Dual Scheimpflug/Placido device provided a useful model for differentiating norma...
02/08/2019
Distinguishing Highly Asymmetric Keratoconus Eyes Using Dual Scheimpflug/Placido Analysis

A combination of metrics from combined Dual Scheimpflug/Placido device provided a useful model for differentiating normal corneas from the clinically normal eyes of patients with highly asymmetric keratoconus.

https://www.ajo.com/article/S0002-9394(19)30044-3/fulltext

To identify the best metrics or combination of metrics that provide the highest predictive power between normal eyes and the clinically unaffected eye of patients with highly asymmetric keratoconus using data from a Dual Scheimpflug/Placido device

Cataract surgery does not slow the apparent rate of glaucomatous visual field (VF) decay as compared to rates measured d...
02/07/2019
Cataract Surgery and Rate of Visual Field Progression in Primary Open-Angle Glaucoma

Cataract surgery does not slow the apparent rate of glaucomatous visual field (VF) decay as compared to rates measured during the progression of the cataract.

https://www.ajo.com/article/S0002-9394(19)30040-6/fulltext

To test the hypothesis that cataract surgery slows the apparent rate of visual field (VF) decay in primary open-angle glaucoma patients compared with rates measured during cataract progression.Design: Retrospective cohort study.

There is a significant burden of vascular risk factors, associated with an increased risk of in-hospital stroke, acute M...
02/06/2019
Acute Vascular Ischemic Events in Patients with Central Retinal Artery Occlusion in the United States: A Nationwide Study 2003-2014

There is a significant burden of vascular risk factors, associated with an increased risk of in-hospital stroke, acute MI and death in central retinal artery occlusion (CRAO) patients.

https://www.ajo.com/article/S0002-9394(19)30022-4/fulltext

Central retinal artery occlusion (CRAO) confers a high risk of acute vascular ischemic events, including stroke and myocardial infarction (MI). Understanding the burden and risk factor profile of these ischemic events can serve as a valuable guide for ophthalmologists in the management and appropria...

High repeatability of corneal epithelial thickness measurements may be achieved in both keratoconus and healthy eyes wit...
02/05/2019
Corneal Epithelial Thickness Intrasubject Repeatability and its Relation with Visual Limitation in Keratoconus

High repeatability of corneal epithelial thickness measurements may be achieved in both keratoconus and healthy eyes with the placido disc MS-39 (CSO, Firenze, Italy) .

https://www.ajo.com/article/S0002-9394(19)30028-5/fulltext

To evaluate intra-subject repeatability of anterior segment optical coherence tomography (AS-OCT) combined with placido disc MS-39 (CSO, Firenze, Italy) and correlate epithelial thickness measurements and the degree of visual limitation in keratoconus patients.

A deep learning network can be trained to quantify the amount of neuroretinal damage on optic disc photographs using SDO...
02/05/2019
A Deep Learning Algorithm to Quantify Neuroretinal Rim Loss from Optic Disc Photographs

A deep learning network can be trained to quantify the amount of neuroretinal damage on optic disc photographs using SDOCT minimum rim width relative to Bruch’s membrane opening (BMO-MRW) as a reference.

https://www.ajo.com/article/S0002-9394(19)30024-8/fulltext

To train a deep learning (DL) algorithm that quantifies glaucomatous neuroretinal damage on fundus photographs using the minimum rim width relative to Bruch’s membrane opening (BMO-MRW) from spectral domain-optical coherence tomography (SDOCT).

Lesions occurring near or at the optic nerve are associated with a more severe degree of pigmentary changes and retinal ...
02/04/2019
Peripapillary versus macular combined hamartoma of the retina and retinal pigment epithelium: Imaging characteristics

Lesions occurring near or at the optic nerve are associated with a more severe degree of pigmentary changes and retinal disruption than those located in the macula.

https://www.ajo.com/article/S0002-9394(19)30030-3/fulltext

To compare clinical, optical coherence tomography (OCT), and fundus autofluorescence (FAF) characteristics of peripapillary versus (vs.) macular variants of combined hamartoma of the retina and retinal pigment epithelium (combined hamartoma).

Increased PCD values in diabetics without clinical retinopathy likely represent an autoregulatory response to increased ...
02/01/2019
Earliest Evidence of Preclinical Diabetic Retinopathy Revealed using OCT Angiography (OCTA) Perfused Capillary Density

Increased PCD values in diabetics without clinical retinopathy likely represent an autoregulatory response to increased metabolic demand, while the decrease in PCD that follows in NPDR and PDR results largely from an incremental loss of capillary segments.

https://www.ajo.com/article/S0002-9394(19)30025-X/fulltext

To compare perfused capillary density (PCD) in diabetic patients and healthy controls using optical coherence tomography angiography (OCTA).

Tips from the Editor in Chief and three Editors of the AJO to help you determine if your article is right for the Journa...
02/01/2019
What the American Journal of Ophthalmology Wants to Publish

Tips from the Editor in Chief and three Editors of the AJO to help you determine if your article is right for the Journal:

https://www.ajo.com/article/S0002-9394(18)30674-3/fulltext

Conceptualizing a study, doing the research, and pulling the study together are certainly the most labor-intensive parts of getting a paper published, but finding the perfect home for that study can be equally challenging and important. And since our knowledge of pathophysiology improves and new tre...

Pneumatic retinopexy (PR) results in successful anatomic and visual outcomes in both traditional (TPR) and nontraditiona...
01/31/2019
Anatomic, Visual and Financial Outcomes for Traditional and Nontraditional Primary Pneumatic Retinopexy for Retinal Detachment

Pneumatic retinopexy (PR) results in successful anatomic and visual outcomes in both traditional (TPR) and nontraditional (NTPR) repair of primary rhegmatogenous retinal detachment (RD).

https://www.ajo.com/article/S0002-9394(19)30018-2/fulltext

To determine factors predictive of anatomic, visual and financial outcomes after traditional and nontraditional primary pneumatic retinopexy (PR) for rhegmatogenous retinal detachment (RD).

PROSE treatment is feasible in over two-thirds of pediatric patients with chronic ocular surface disease related to SJS/...
01/31/2019
Prosthetic Replacement of the Ocular Surface Ecosystem Treatment for Ocular Surface Disease in Pediatric Patients with Stevens-Johnson Syndrome

PROSE treatment is feasible in over two-thirds of pediatric patients with chronic ocular surface disease related to SJS/TEN and results in significant improvement in vision that is durable over a period of many years.

https://www.ajo.com/article/S0002-9394(19)30015-7/fulltext

To report the outcomes of Prosthetic Replacement of the Ocular Surface Ecosystem (PROSE) treatment in pediatric patients with chronic ocular surface disease associated with Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN).

Evaluating outcomes and disease characteristics in eyes with neovascular age-related macular degeneration that received ...
01/30/2019
Extended (≥q12 Weeks) Dosing Interval With Intravitreal Aflibercept and Ranibizumab in Neovascular AMD: Post Hoc Analysis of VIEW Trials

Evaluating outcomes and disease characteristics in eyes with neovascular age-related macular degeneration that received intravitreal aflibercept injection (IAI) and ranibizumab ≥q12 or

To evaluate outcomes and disease characteristics in eyes with neovascular age-related macular degeneration that received intravitreal aflibercept injection (IAI) and ranibizumab ≥q12 or

In patients with open-angle glaucoma (OAG) and ocular hypertension (OHT), once-daily dosing of netarsudil 0.02% was effe...
01/29/2019
Long-term Safety and Ocular Hypotensive Efficacy Evaluation of Netarsudil Ophthalmic Solution

In patients with open-angle glaucoma (OAG) and ocular hypertension (OHT), once-daily dosing of netarsudil 0.02% was effective, consistently lowering IOP through 12 months, and was tolerated by the majority of patients.

https://www.ajo.com/article/S0002-9394(19)30012-1/fulltext

Evaluate netarsudil 0.02% ophthalmic solution in patients with open-angle glaucoma (OAG) and ocular hypertension (OHT).Design; Double-masked, randomized, multi-center, parallel-group, non-inferiority clinical study.

Nod-1 expression was increased in the conjunctiva of Dry Eye (DE), especially Sjögren syndrome (SS)-DE, and was associa...
01/28/2019
Expression of Nod-like Receptors and Clinical Correlations in Patients with Dry Eye Disease

Nod-1 expression was increased in the conjunctiva of Dry Eye (DE), especially Sjögren syndrome (SS)-DE, and was associated with the disease severity.

https://www.ajo.com/article/S0002-9394(19)30011-X/fulltext

To investigate the expression pattern of nucleotide-binding oligomerization domain (Nod)-like receptors that detects “danger” intracellular signaling and its correlation with clinical dry eye (DE) markers.

Pediatric Eye Questionnaires for separately assessing functional vision and ER-QOL domains in children of any age and wi...
01/28/2019
Development of pediatric eye questionnaires for children with eye disease

Pediatric Eye Questionnaires for separately assessing functional vision and ER-QOL domains in children of any age and with any eye condition

https://www.ajo.com/article/S0002-9394(19)30010-8/fulltext

To develop patient-derived Pediatric Eye Questionnaires (PedEyeQ) to separately assess eye-related quality of life (ER-QOL) and functional vision in children with eye conditions.Design: Questionnaire development study.

Did you follow the AJO Centennial celebration through 2018? All of our featured editorials, perspectives, historical rep...
01/25/2019
American Journal of Ophthalmology

Did you follow the AJO Centennial celebration through 2018? All of our featured editorials, perspectives, historical reprints, and vintage advertisements are now in one place:

https://www.ajo.com/Centennial

Journal Launch The AJO lays claim to being both the first and the longest continuously published ophthalmology journal based outside of Europe. But what we currently refer to as the AJO—colloquially named the "yellow journal" because of its characteristic color in print—is actually the third ite...

Children with lower BCVA, bilateral glaucoma and those who had undergone three or more glaucoma surgeries had significan...
01/25/2019
Functional Visual Ability and Quality of Life in Children with Glaucoma

Children with lower BCVA, bilateral glaucoma and those who had undergone three or more glaucoma surgeries had significantly lower functional visual ability and vision-related quality of life (VR QoL).

https://www.ajo.com/article/S0002-9394(19)30007-8/fulltext

To evaluate the effect of glaucoma and its management on the functional visual ability (FVA) and the vision related quality of life (VR QoL) in children 8 to 18 years of age.

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