American Journal of Ophthalmology

American Journal of Ophthalmology American Journal of Ophthalmology is a peer-reviewed medical journal. It was established in 1884 and is published monthly by Elsevier. Follow us on Twitter @AmJOphthalmol.

The American Journal of Ophthalmology is a peer-reviewed, scientific publication that welcomes the submission of original, previously unpublished manuscripts directed to ophthalmologists and visual science specialists describing clinical investigations, clinical observations, and clinically relevant laboratory investigations. Published monthly since 1884, the full text of the American Journal of Ophthalmology and supplementary material are also presented online at www.ajo.com and on ScienceDirect. The Editor in Chief of the Journal is Richard K. Parrish II, MD.

Our September 2019 issue is now online, featuring a Perspective on Oxygenation-Based Hypoperfusion Maculopathy by McLeod...
09/18/2019

Our September 2019 issue is now online, featuring a Perspective on Oxygenation-Based Hypoperfusion Maculopathy by McLeod, an open-access investigation on preventing IOP increase in glaucomatous eyes after cataract surgery by Hayashi et al, and AOS theses from Milman and Buys.

https://www.ajo.com/issue/S0002-9394(19)X0007-0

Antiviral intravitreal injections could improve the prognosis of treated acute retinal necrosis patients by decreasing t...
09/06/2019
Acute retinal necrosis: virological features using quantitative PCR, therapeutic management, and clinical outcomes

Antiviral intravitreal injections could improve the prognosis of treated acute retinal necrosis patients by decreasing the risk of retinal detachment and improving visual acuity. Quantitative real-time polymerase chain reaction (qPCR) enables monitoring response to treatment and can provide evidence for resistance to antiviral treatment.

https://www.ajo.com/article/S0002-9394(19)30398-8/fulltext

To evaluate outcomes of patients treated with intensive intravitreal therapy and to describe the evolution of quantitative real-time polymerase chain reaction (qPCR) in patients treated for acute retinal necrosis (ARN) syndrome.

Elevated IOP seen in the uveitic glaucoma/OHT eyes (3-6 attacks) was due to reduced tonographic outflow facility.
09/02/2019
Aqueous humour dynamics in uveitic eyes

Elevated IOP seen in the uveitic glaucoma/OHT eyes (3-6 attacks) was due to reduced tonographic outflow facility.

To investigate aqueous humor dynamics in uveitic eyes

Cluster analysis has demonstrated that corneal thickness and front surface sagittal curvature follow concentric patterns...
08/28/2019
Modelling changes in corneal parameters with age: implications for corneal disease detection

Cluster analysis has demonstrated that corneal thickness and front surface sagittal curvature follow concentric patterns of aging, and the robust quartic and cubic regression models describing aging variations in CT and FSSC respectively suggest that these parameters are influenced by hormonal variations.

To apply computational methods to model normal age-related changes in corneal parameters and establish their association with demographic factors, thereby providing a framework for improved detection of subclinical corneal ectasia (SCE).

Ophthalmic Clinical Trials: We've Come a Long Way, BabyAn Editorial by Alfred Sommer, MD, MHSc
08/20/2019
Ophthalmic Clinical Trials: We've Come a Long Way, Baby

Ophthalmic Clinical Trials: We've Come a Long Way, Baby
An Editorial by Alfred Sommer, MD, MHSc

What a difference time makes! A total of 45 years has passed since the American Journal of Ophthalmology published my first editorial.1 Then, I had faulted most clinical reports in the ophthalmic literature for ignoring the importance of studying populations of suitable sample size and selection (jo...

Considering time since eye opening may improve reliability of Scheimpflug imaging as clinically advanced Fuchs’ dystroph...
08/13/2019
Diurnal variation in corneal edema in Fuchs’ Endothelial Corneal Dystrophy

Considering time since eye opening may improve reliability of Scheimpflug imaging as clinically advanced Fuchs’ dystrophy corneas are 31 to 58 μm thicker in the morning with edema resolving within 4 hours.

The extent of diurnal variation in corneal edema in Fuchs’ dystrophy is unknown. We measured corneal thickness and posterior profile over the course of the day using Scheimpflug imaging.Design; Prospective cohort study.

A nationwide, general population-based cohort study found greater risk of NAION after cataract surgery compared to those...
08/13/2019
Risk of Nonarteritic Anterior Ischemic Optic Neuropathy after Cataract Surgery

A nationwide, general population-based cohort study found greater risk of NAION after cataract surgery compared to those without cataract surgery, suggesting a causal relationship of NAION and cataract surgery.

/aims: To determine whether the development of nonarteritic anterior ischemic optic neuropathy (NAION) is increased after receiving cataract surgery in a large general population.

Analysis suggests that VF loss occurs faster in glaucoma patients with uveitis than those without uveitis. The risk of p...
08/11/2019
Evaluating the Impact of Uveitis on Visual Field Progression Using Large-Scale Real-World Data

Analysis suggests that VF loss occurs faster in glaucoma patients with uveitis than those without uveitis. The risk of progressing rapidly in glaucoma with uveitis is almost double than in those without uveitis. Early identification of “rapid progressors” may enable targeted intervention to preserve visual function in this high-risk group.

To compare rates of visual field (VF) loss in uveitis patients with glaucoma against patients with primary open-angle glaucoma (POAG) and explore the association between intraocular pressure (IOP) and rate of VF loss.

When comparing glasses to observation for moderately hyperopic 3- to 5-year-olds with normal visual acuity (VA) and bino...
08/11/2019
A Randomized Clinical Trial of Immediate versus Delayed Glasses for Moderate Hyperopia in Children 3 to 5 Years of Age

When comparing glasses to observation for moderately hyperopic 3- to 5-year-olds with normal visual acuity (VA) and binocularity, failure for VA or binocularity was not common, suggesting immediate glasses prescription for these children may not be needed to prevent them.

To compare VA and binocularity outcomes in moderately hyperopic children with normal VA and binocularity assigned to glasses versus observation. Design: Prospective randomized clinical trial (RCT)

Symfony's spectral dependence was observed to affect visual acuity and contrast sensitivity. Although the red filter did...
08/05/2019
The effect of a spectral filter on visual quality in patients with an extended-depth-of-focus intraocular lens

Symfony's spectral dependence was observed to affect visual acuity and contrast sensitivity. Although the red filter did not improve distance vision, it caused visual deterioration at near.

Wavelength dependence of diffractive intraocular lenses (IOLs) was recognized in vitro but not yet assessed in vivo. By examining pseudophakic patients who had extended-depth-of-focus diffractive implants, we clinically measured this spectral effect on their vision. We also tested the lens in vitro.

Quantitative CC analysis with commercially available OCTA is complicated and researchers need to pay close attention to ...
08/02/2019
Quantification of choriocapillaris with OCTA: a comparison study

Quantitative CC analysis with commercially available OCTA is complicated and researchers need to pay close attention to how they conduct such analysis.

To demonstrate the variation in quantitative choriocapillaris (CC) metrics with various binarization approaches using optical coherence tomography angiography (OCTA).

Patients treated with intravitreal therapy for radiation optic neuropathy showed no statistically significant difference...
08/02/2019
Radiation-induced optic neuropathy – observation versus intravitreal treatment

Patients treated with intravitreal therapy for radiation optic neuropathy showed no statistically significant differences compared with patients only observed, related to visual acuity or optic atrophy development.

To compare intravitreal therapy with the natural course of radiation optic neuropathy after primary proton beam therapy for choroidal melanoma with respect to long-term visual acuity and development of optic atrophy

Scheimpflug photography was used to identify preoperative risk predictors for DMEK based on corneal features and develop...
07/30/2019
Preoperative risk assessment for progression to DMEK following cataract surgery in Fuchs Endothelial Corneal Dystrophy.

Scheimpflug photography was used to identify preoperative risk predictors for DMEK based on corneal features and develop a novel scoring system for risk stratification prior to cataract surgery in Fuchs Endothelial Corneal Dystrophy.

To identify preoperative corneal tomographic features that predict progression to Endothelial Keratoplasty (EK) following cataract surgery in Fuchs Endothelial Corneal Dystrophy (FECD) and establish a regression model to identify high-risk patients.

Retinal detachment: Patient perspective and Electronic Medical Records
07/19/2019
Retinal detachment: Patient perspective and Electronic Medical Records

Retinal detachment: Patient perspective and Electronic Medical Records

Two perspectives are provided on the retinal detachment suffered by one of the authors on a national holiday. One perspective is the personal one - a disturbing visual symptom, the surgery, the recovery and the worry about potential long lasting sequelae, and the need to reiterate detailed medical i...

Glucocorticoid receptor α and MKP-1 as candidate biomarkers for treatment response and disease activity in Vogt-Koyanagi...
07/19/2019
Glucocorticoid receptor α and MKP-1 as candidate biomarkers for treatment response and disease activity in Vogt-Koyanagi-Harada disease

Glucocorticoid receptor α and MKP-1 as candidate biomarkers for treatment response and disease activity in Vogt-Koyanagi-Harada disease

To investigate the potential to utilize the expression of genes for glucocorticoid (GC) receptor and mitogen-activated protein kinase phosphatase-1 (MKP1) as biomarkers of corticosteroid (CS) refractoriness and disease activity in patients with Vogt-Koyanagi-Harada disease (VKH).

What does the American Journal of Ophthalmology want to publish? In this free-access editorial, Editor in Chief Richard ...
07/18/2019
What the American Journal of Ophthalmology Wants to Publish

What does the American Journal of Ophthalmology want to publish? In this free-access editorial, Editor in Chief Richard K. Parrish II and three of the Journal's editors outline questions and formatting tips you can use to shape your Journal submissions.

Conceptualizing a study, doing the research, and pulling the study together are certainly the most labor-intensive parts of getting a paper published, but finding the perfect home for that study can be equally challenging and important. And since our knowledge of pathophysiology improves and new tre...

The April 2019 issue of the AJO is online featuring Open Access to the full length article, "Long-term Safety and Ocular...
07/18/2019
Table of Contents page - American Journal of Ophthalmology

The April 2019 issue of the AJO is online featuring Open Access to the full length article, "Long-term Safety and Ocular Hypotensive Efficacy Evaluation of Netarsudil Ophthalmic Solution: Rho Kinase Elevated IOP Treatment Trial (ROCKET-2)"

The June 2019 issue of the AJO is now online, featuring a historical look at fluorescein angiography and OCT in the Jour...
07/18/2019
Table of Contents page - American Journal of Ophthalmology

The June 2019 issue of the AJO is now online, featuring a historical look at fluorescein angiography and OCT in the Journal's first 100 years and a perspective on how genetics influence corticosteroid-induced ocular hypertension.

The July 2019 issue of the AJO is now online, featuring three theses for the American Ophthalmological Society and Open ...
07/18/2019
Table of Contents page - American Journal of Ophthalmology

The July 2019 issue of the AJO is now online, featuring three theses for the American Ophthalmological Society and Open Access to "A Deep Learning System for Automated Angle-Closure Detection in Anterior Segment Optical Coherence Tomography Images"

Genetic contribution to corticosteroid-induced ocular hypertension has been suspected for many decades, but only recentl...
02/14/2019
The genetic influence on corticosteroid-induced ocular hypertension: A field positioned for discovery

Genetic contribution to corticosteroid-induced ocular hypertension has been suspected for many decades, but only recently have scientific technologies and tools been advanced enough to comprehensively investigate these genetic influences.

https://www.ajo.com/article/S0002-9394(19)30052-2/fulltext

To provide evidence that corticosteroid-induced ocular hypertension has a genetic component.

Local staphylomata in high myopia reflects ocular asphericity and correlate with extraocular muscles (EOM) paths. Myopic...
02/13/2019
Rectus Extraocular Muscle Paths and Staphylomata in High Myopia

Local staphylomata in high myopia reflects ocular asphericity and correlate with extraocular muscles (EOM) paths. Myopic staphylomata are associated with inferior displacement of LR path and defect of the LR-SR band ligament.

https://www.ajo.com/article/S0002-9394(19)30050-9/fulltext

To investigate the relationship between displacement of extraocular muscles (EOMs) and staphyloma in high myopia using magnetic resonance imaging (MRI).

The multi-step scoring system of chronic ocular features in SJS/TEN sequelae is a useful tool to grade all levels of sev...
02/13/2019
Multi-Step Grading System for Evaluation of Chronic Ocular Sequelae in Patients with Stevens-Johnson Syndrome

The multi-step scoring system of chronic ocular features in SJS/TEN sequelae is a useful tool to grade all levels of severity and may help to evaluate surgical intervention efficacy by comparing preoperative with postoperative ocular grades.

https://www.ajo.com/article/S0002-9394(19)30049-2/fulltext

To propose a new scoring system for grading of chronic ocular sequelae in Stevens-Johnson syndrome (SJS).

Since mutations at various points along exon 4 have divergent consequences, genetic testing alone may be insufficient fo...
02/13/2019
The location of exon 4 mutations in RP1 raises challenges for genetic counselling and gene therapy

Since mutations at various points along exon 4 have divergent consequences, genetic testing alone may be insufficient for counselling, but recessive inheritance should be considered likely in severe early onset cases.

https://www.ajo.com/article/S0002-9394(19)30048-0/fulltext

Mutations in the photoreceptor gene RP1 lead to recessive or dominantly inherited retinitis pigmentosa (RP). Since the dominantly inherited phenotype is generally milder than recessive cases, it raises the possibility that it could arise by haploinsufficiency, however most mutations are in the termi...

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