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Journal of General Physiology

Journal of General Physiology The Journal of General Physiology publishes research in physiological problems at cellular and molecular level. Published by Rockefeller University Press.

The Journal of General Physiology publishes peer-reviewed research in physiological problems at the cellular and molecular level. Est. 1918, published by The Rockefeller University Press.

The Journal of General Physiology publishes peer-reviewed research in physiological problems at the cellular and molecular level. Est. 1918, published by The Rockefeller University Press.

Operating as usual

Happy #PeerReviewWeek22! In the theme of “#ResearchIntegrity: Creating and supporting trust in research,” we are highlig...
09/21/2022
Editorial Policies | Journal of General Physiology | Rockefeller University Press

Happy #PeerReviewWeek22! In the theme of “#ResearchIntegrity: Creating and supporting trust in research,” we are highlighting JGP’s policies, including Materials and Data Sharing here: https://rupress.org/jgp/pages/editorial-policies#data-sharing

Editorial Policies | Journal of General Physiology | Rockefeller University Press

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This week, we celebrate #PeerReviewWeek22 by thanking all of those who have served their communities! This year’s theme ...
09/20/2022
Editorial Policies | Journal of General Physiology | Rockefeller University Press

This week, we celebrate #PeerReviewWeek22 by thanking all of those who have served their communities! This year’s theme is “#ResearchIntegrity: Creating and supporting trust in research.” Learn about JGP’s policies on Data Integrity & more here: https://rupress.org/jgp/pages/editorial-policies#data-integrity

Editorial Policies | Journal of General Physiology | Rockefeller University Press

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We join in celebrating #PeerReviewWeek22 by thanking all of those who have served their communities by reviewing papers!...
09/19/2022

We join in celebrating #PeerReviewWeek22 by thanking all of those who have served their communities by reviewing papers! We encourage all to check out the activities at Peer Review Week 2022: https://bit.ly/397sZMb

📢  Call For Papers: JGP invites you to submit papers on the topic Ion Channels in Context: Structure and Function in Nat...
09/14/2022
Call for Papers: Ion Channels in Context | Journal of General Physiology | Rockefeller University Press

📢 Call For Papers: JGP invites you to submit papers on the topic Ion Channels in Context: Structure and Function in Native Cells and Macromolecular Complexes to be published throughout the year and highlighted in a special issue.

The review process will be overseen by JGP Associate Editors Jeanne Nerbonne and Crina Nimigean. They will be joined by subject experts Cathy Proenza and Matt Trudeau, organizers of the Society of General Physiologists' 75th Annual Symposium, which will take place September 7–11, 2022 in Woods Hole, Massachusetts.
Learn more and submit your research👇

Call for Papers: Ion Channels in Context | Journal of General Physiology | Rockefeller University Press

A new University of California, Irvine-led study reveals how mechanical forces and tissue mechanics influence the morpho...
09/08/2022
Surprising discovery by UCI-led team links Piezo1 and cholesterol during brain development

A new University of California, Irvine-led study reveals how mechanical forces and tissue mechanics influence the morphology of the developing brain, and establishes a direct link in neural stem cells between Piezo1, a mechanically-activated ion channel, and intracellular cholesterol levels during neural development. The study in JGP from Nourse, Pathak et al. (https://bit.ly/3xqBFdt) may provide avenues for novel treatment of diseases like Alzheimer's.

A new University of California, Irvine-led study reveals how mechanical forces and tissue mechanics influence the morphology of the developing brain, and establishes a direct link in neural stem cells between Piezo1, a mechanically-activated ion channel, and intracellular cholesterol levels during n...

PIEZO1, a mechanically gated ion channel, transduces mechanical cues in neural stem cells. Here, Jamison Nourse, Medha P...
09/07/2022
Piezo1 regulates cholesterol biosynthesis to influence neural stem cell fate during brain development | Journal of General Physiology | Rockefeller University Press

PIEZO1, a mechanically gated ion channel, transduces mechanical cues in neural stem cells. Here, Jamison Nourse, Medha Pathak and colleagues (University of California, Irvine) show the impact of Piezo1 knockout on neural development in vivo and find that cholesterol biosynthesis and lipid membrane composition are regulated by Piezo1.

PIEZO1, a mechanically gated ion channel, transduces mechanical cues in neural stem cells. Here, we show the impact of Piezo1 knockout on neural development in

To coincide with this week's 75th Annual Symposium of the Society of General Physiologists #SGP2022, JGP is pleased to p...
09/06/2022
Ion Channels Update 2022 | Journal of General Physiology | Rockefeller University Press

To coincide with this week's 75th Annual Symposium of the Society of General Physiologists #SGP2022, JGP is pleased to present a special collection of recent articles, exploring how various factors, including the lipid bilayer, hormones, mechanical signals, and molecular motors, influence the function of ion channels in a range of cell types and organisms, from cardiomyocytes to photoreceptors. We hope you enjoy reading the collection and welcome your feedback!

This collection explores how various factors, including the lipid bilayer, hormones, mechanical signals, and molecular motors, influence the function of ion channels in a range of cell types and organisms, from cardiomyocytes to photoreceptors. The coll...

This month, we present a special thematic issue (https://bit.ly/32aBOou) on the excitation–contraction coupling in cardi...
09/05/2022
Excitation–contraction coupling in cardiac, skeletal, and smooth muscle | Journal of General Physiology | Rockefeller University Press

This month, we present a special thematic issue (https://bit.ly/32aBOou) on the excitation–contraction coupling in cardiac, skeletal, and smooth muscle. Read the editorial from Robert Dirksen, David A. Eisner, Eduardo Ríos & Karin Sipido:

The term “excitation–contraction (EC) coupling” was introduced by Alexander Sandow (Sandow, 1952) as “the entire sequence of reactions--excitation, inward acting

On our September cover: the transduction from electrical excitation at TT membrane level to release of Ca2+ in skeletal ...
09/05/2022

On our September cover: the transduction from electrical excitation at TT membrane level to release of Ca2+ in skeletal muscle. (M. Buonarotti, Rome, 1512; W. Melzer, Ulm, 2022) (https://bit.ly/3Q2I329).
Read JGP’s September Issue: https://bit.ly/32aBOou

Compared to the “ventricular” essential myosin light chain MLC1sb/v, the longer and more positively charged MLC1sa prese...
09/02/2022
Myosin essential light chain 1sa decelerates actin and thin filament gliding on β-myosin molecules

Compared to the “ventricular” essential myosin light chain MLC1sb/v, the longer and more positively charged MLC1sa present in slow-twitch M. soleus fibers decelerates actin filament gliding on β-myosin molecules presumably by a decreased dissociation rate from actin filaments. A new study from Jennifer Osten, Maral Mohebbi, Tim Scholz (Medizinische Hochschule Hannover/ MHHnova) and colleagues

Compared to the “ventricular” essential myosin light chain MLC1sb/v, the longer and more positively charged MLC1sa present in slow-twitch M. soleus fibers decel

📣 We're hiring! Rockefeller University Press seeks a talented Scientific Editor to contribute equally to two journals, J...
08/25/2022

📣 We're hiring! Rockefeller University Press seeks a talented Scientific Editor to contribute equally to two journals, Journal of Experimental Medicine (JEM) and Journal of General Physiology (JGP). Join our team in #NYC! Learn more and apply 👉 https://bit.ly/3z0h8gJ

Using a novel assay chamber to inject myosin light chain phosphatase during laser trap measurements, tonic smooth muscle...
08/24/2022
Molecular-level evidence of force maintenance by smooth muscle myosin during LC20 dephosphorylation

Using a novel assay chamber to inject myosin light chain phosphatase during laser trap measurements, tonic smooth muscle force maintenance is observed at the myosin molecular level, marking an important step toward elucidating the underlying mechanisms of the latch state. A new study from Megan Jean Hammell, Anne-Marie Lauzon and colleagues (McGill University):

Using a novel assay chamber to inject myosin light chain phosphatase during laser trap measurements, tonic smooth muscle force maintenance is observed at the my

📣 We're hiring! Rockefeller University Press seeks a talented Scientific Editor to contribute equally to two journals, J...
08/23/2022

📣 We're hiring! Rockefeller University Press seeks a talented Scientific Editor to contribute equally to two journals, Journal of Experimental Medicine (JEM) and Journal of General Physiology (JGP). Join our team in #NYC! Learn more and apply 👉 https://bit.ly/3z0h8gJ

📣 We're hiring! Rockefeller University Press seeks a talented Scientific Editor to contribute equally to two journals, J...
08/18/2022

📣 We're hiring! Rockefeller University Press seeks a talented Scientific Editor to contribute equally to two journals, Journal of Experimental Medicine (JEM) and Journal of General Physiology (JGP). Join our team in #NYC! Learn more and apply 👉 https://bit.ly/3z0h8gJ

Our latest Research News: Study from Idoux et al. (https://bit.ly/3A5HqNT) reveals that adult zebrafish skeletal muscle ...
08/18/2022
Superfast fish show superfast coupling | Journal of General Physiology | Rockefeller University Press

Our latest Research News: Study from Idoux et al. (https://bit.ly/3A5HqNT) reveals that adult zebrafish skeletal muscle fibers display the fastest kinetics of excitation–contraction coupling ever measured in vertebrate locomotor muscles.

JGP study reveals that adult zebrafish skeletal muscle fibers display the fastest kinetics of excitation–contraction coupling ever measured in vertebrate locomo

This review by Daniela Rossi, Vincenzo Sorrentino and colleagues (Università degli Studi di Siena) provides an up-to-dat...
08/18/2022
Mutations in proteins involved in E-C coupling and SOCE and congenital myopathies | Journal of General Physiology | Rockefeller University Press

This review by Daniela Rossi, Vincenzo Sorrentino and colleagues (Università degli Studi di Siena) provides an up-to-date overview of current knowledge on myopathies caused by mutations in proteins participating in excitation–contraction coupling and store-operated Ca2+ entry mechanisms in skeletal muscle.

This review provides an up-to-date overview of current knowledge on myopathies caused by mutations in proteins participating in excitation–contraction coupling

📣 We're hiring! Rockefeller University Press seeks a talented Scientific Editor to contribute equally to two journals, J...
08/16/2022

📣 We're hiring! Rockefeller University Press seeks a talented Scientific Editor to contribute equally to two journals, Journal of Experimental Medicine (JEM) and Journal of General Physiology (JGP). Join our team in #NYC! Learn more and apply 👉 https://bit.ly/3z0h8gJ

📣 We're hiring! Rockefeller University Press seeks a talented Scientific Editor to contribute equally to two journals, J...
08/12/2022

📣 We're hiring! Rockefeller University Press seeks a talented Scientific Editor to contribute equally to two journals, Journal of Experimental Medicine and Journal of General Physiology. Join our team in #NYC! Learn more and apply 👉 https://bit.ly/3z0h8gJ

📣 We're hiring! Rockefeller University Press seeks a talented Scientific Editor to contribute equally to two journals, J...
08/10/2022

📣 We're hiring! Rockefeller University Press seeks a talented Scientific Editor to contribute equally to two journals, Journal of Experimental Medicine and Journal of General Physiology. Join our team in #NYC! Learn more and apply 👉 https://bit.ly/3z0h8gJ

A numerical modeling study from Anna V. Maltsev (Queen Mary University of London), Michael D. Stern and Victor A. Maltse...
08/09/2022
Disorder in Ca2+ release unit locations confers robustness but cuts flexibility of heart pacemaking

A numerical modeling study from Anna V. Maltsev (Queen Mary University of London), Michael D. Stern and Victor A. Maltsev (National Institute on Aging - NIH) shows that disorder in locations of Ca release units in cardiac pacemaker cells has substantial functional impact by creating release clusters, similar to Poisson clumping, and opportunity of Ca release to propagate within the clusters.

The present numerical modeling study shows that disorder in locations of Ca release units in cardiac pacemaker cells has substantial functional impact by creati

García-Castañeda, Michelucci, Dirksen and colleagues (UR Medicine) show that postdevelopmental, muscle-specific ablation...
08/08/2022
Postdevelopmental knockout of Orai1 improves muscle pathology in a mouse model of Duchenne muscular dystrophy | Journal of General Physiology | Rockefeller University Press

García-Castañeda, Michelucci, Dirksen and colleagues (UR Medicine) show that postdevelopmental, muscle-specific ablation of Orai1 in mdx mice abolishes excessive constitutive and store-operated Ca2+ entry, improves muscular dystrophy pathology, and promotes sarcolemmal integrity, thus demonstrating an important role of enhanced Orai1-mediated Ca2+ entry in exacerbating the dystrophic phenotype.

Postdevelopmental, muscle-specific ablation of Orai1 in mdx mice abolishes excessive constitutive and store-operated Ca2+ entry, improves muscular dystrophy pat

Epithelial Na+ channels are major regulators of fluid volumes and ultimately blood pressure in terrestrial vertebrates. ...
08/08/2022
Expression of ENaC subunits in epithelia

Epithelial Na+ channels are major regulators of fluid volumes and ultimately blood pressure in terrestrial vertebrates. Gustavo Frindt, Lawrence G. Palmer and colleagues (Weill Cornell Medicine) found that the amounts of protein comprising these channels in the kidneys and colons of rats and mice exceed what is required to explain the transport of Na+ by these tissues. This excess may facilitate regulation of the channels.

Epithelial Na+ channels are major regulators of fluid volumes and ultimately blood pressure in terrestrial vertebrates. We found that the amounts of protein com

Our August cover shows a reconstructed dendrite segment from a hippocampal pyramidal neuron with six dendritic spines of...
08/01/2022

Our August cover shows a reconstructed dendrite segment from a hippocampal pyramidal neuron with six dendritic spines of different morphologies highlighted with their postsynaptic densities denoted in purple (top row). Simulations of stochastic calcium transients are shown in red at 15 ms for simulations in the six spines (bottom row). Bell, Holst, Lee and Rangamani develop a stochastic model for calcium influx in dendritic spines in idealized and realistic geometries. Using this model, they show that spine morphology alters calcium transients and synaptic weight updates (https://bit.ly/3O1BlqE).
Read JGP’s August Issue: https://bit.ly/3OEvUyj

📣 We're hiring! Rockefeller University Press seeks a talented Scientific Editor to contribute equally to two journals, J...
07/22/2022

📣 We're hiring! Rockefeller University Press seeks a talented Scientific Editor to contribute equally to two journals, Journal of Experimental Medicine and Journal of General Physiology. Join our team in #NYC! Learn more and apply 👉 https://bit.ly/3z0h8gJ

Piezo2 is a membrane protein that activates in response to mechanical signals and plays key roles in humans. Lipids in t...
07/21/2022
Characterizing the lipid fingerprint of the mechanosensitive channel Piezo2

Piezo2 is a membrane protein that activates in response to mechanical signals and plays key roles in humans. Lipids in the membrane such as cholesterol and phosphoinositides modulate Piezo2’s function. Yiechang Lin, Amanda Buyan and Ben Corry (The Australian National University) used computational simulations of Piezo2 in a realistic mammalian membrane to investigate how lipids interact with Piezo2.

Piezo2 is a membrane protein that activates in response to mechanical signals and plays key roles in humans. Lipids in the membrane such as cholesterol and phos

Ca2+ release–activated Ca2+ (CRAC) channels mediate store-operated Ca2+ entry (SOCE) in many nonexcitable cells. Liwei W...
07/21/2022
ORAI3 is dispensable for store-operated Ca2+ entry and immune responses by lymphocytes and macrophages

Ca2+ release–activated Ca2+ (CRAC) channels mediate store-operated Ca2+ entry (SOCE) in many nonexcitable cells. Liwei Wang, Noyer Lucile, Yin-Hu Wang, Anthony Y. Tao, Wenyi Li, Stefan Feske and colleagues (NYU Langone Health) show that, in contrast to the CRAC channel subunit ORAI1, its homologue ORAI3 is dispensable for SOCE in lymphocytes and macrophages and not essential for immune cell function.

Ca2+ release–activated Ca2+ (CRAC) channels mediate store-operated Ca2+ entry (SOCE) in many nonexcitable cells. In contrast to the CRAC channel subunit ORAI1,

📣 We're hiring! Rockefeller University Press seeks a talented Scientific Editor to contribute equally to two journals, J...
07/20/2022

📣 We're hiring! Rockefeller University Press seeks a talented Scientific Editor to contribute equally to two journals, Journal of Experimental Medicine and Journal of General Physiology. Join our team in #NYC! Learn more and apply 👉 https://bit.ly/3z0h8gJ

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