Journal of General Physiology

Journal of General Physiology The Journal of General Physiology publishes research in physiological problems at cellular and molecular level. Published by Rockefeller University Press.

The Journal of General Physiology publishes peer-reviewed research in physiological problems at the cellular and molecular level. Est. 1918, published by The Rockefeller University Press.

The Journal of General Physiology publishes peer-reviewed research in physiological problems at the cellular and molecular level. Est. 1918, published by The Rockefeller University Press.

Operating as usual

JGP study by Mamidi, Holmes, Stelzer, and colleagues (https://bit.ly/2Sq4cyw) shows that the phosphorylation state of cM...
06/14/2021
cMyBPC phosphorylation alters response to heart failure drug | Journal of General Physiology | Rockefeller University Press

JGP study by Mamidi, Holmes, Stelzer, and colleagues (https://bit.ly/2Sq4cyw) shows that the phosphorylation state of cMyBPC modulates the ability of omecamtiv mecarbil to enhance myocardial force generation. In our latest Research News:

JGP study shows that the phosphorylation state of cMyBPC modulates the ability of omecamtiv mecarbil to enhance myocardial force generation.

Contractility of smooth muscle is of vital importance. Pütz, Barthel, Frohn, Pfitzer, Schroeter et al. (Universität zu K...
06/11/2021
Caldesmon ablation in mice causes umbilical herniation and alters contractility of fetal urinary bladder smooth muscle | Journal of General Physiology | Rockefeller University Press

Contractility of smooth muscle is of vital importance. Pütz, Barthel, Frohn, Pfitzer, Schroeter et al. (Universität zu Köln) reveal that the actin filament-linked protein caldesmon is indispensable for abdominal wall closure, and that in smooth muscle it promotes a relaxed state and supports the integrity of the contractile apparatus.

Contractility of smooth muscle is of vital importance. Pütz et al. reveal that the actin filament–linked protein caldesmon is indispensable for abdominal wall c

Parameswaran Hariharan and Lan Guan (Texas Tech University Health Sciences Center) find that binding of either melibiose...
06/10/2021
Cooperative binding ensures the obligatory melibiose/Na+ cotransport in MelB | Journal of General Physiology | Rockefeller University Press

Parameswaran Hariharan and Lan Guan (Texas Tech University Health Sciences Center) find that binding of either melibiose or Na+ to their transporter, MelB, may favor MelB open states, while cooperative binding may trigger dehydration and cavity closure, thus enforcing cotransport. Cooperative binding is the core mechanism for their cotransport.

Hariharan and Guan find that binding of either melibiose or Na+ to their transporter, MelB, may favor MelB open states, while cooperative binding may trigger de

We are pleased to present a special collection of recently published articles on cardiac physiology. These articles expl...
06/08/2021
Cardiac Physiology 2021 | Journal of General Physiology | Rockefeller University Press

We are pleased to present a special collection of recently published articles on cardiac physiology. These articles explore both normal cardiac function and the pathology of arrhythmias and other cardiomyopathies. Topics include the biophysics of cardiomyocyte contraction and the mechanobiology of sarcomere proteins such as actin and myosin, ion channel regulation, and the effect of pollutants on cardiac physiology. We hope you enjoy reading the collection and welcome your comments!

JGP is pleased to present this collection of recently published articles on cardiac physiology. These articles explore both normal cardiac function and the pathology of arrhythmias and other cardiomyopathies. Topics include the biophysics of cardiomyocy...

The cover of our June Issue shows lipid distribution around KCNQ1 potassium channel in coarse-grained simulations. Top: ...
06/07/2021

The cover of our June Issue shows lipid distribution around KCNQ1 potassium channel in coarse-grained simulations. Top: Extracellular and intracellular view of KCNQ1 (grey) embedded in a multi-component membrane. Bottom: Contour maps illustrating membrane component distribution around KCNQ1 in membranes enriched with polyunsaturated linoleic acid (LIN), saturated stearic acid (STE), or none of these (FA-FREE). From Yazdi et al. (https://bit.ly/3pf2MCO).
Read JGP June Issue: https://bit.ly/3ceeA2N

The cover of our June Issue shows lipid distribution around KCNQ1 potassium channel in coarse-grained simulations. Top: Extracellular and intracellular view of KCNQ1 (grey) embedded in a multi-component membrane. Bottom: Contour maps illustrating membrane component distribution around KCNQ1 in membranes enriched with polyunsaturated linoleic acid (LIN), saturated stearic acid (STE), or none of these (FA-FREE). From Yazdi et al. (https://bit.ly/3pf2MCO).
Read JGP June Issue: https://bit.ly/3ceeA2N

Matthew Rook, David M. MacLean (University of Rochester School of Medicine & Dentistry) and colleagues assess how mutati...
06/01/2021
Mutation of a conserved glutamine residue does not abolish desensitization of acid-sensing ion channel 1 | Journal of General Physiology | Rockefeller University Press

Matthew Rook, David M. MacLean (University of Rochester School of Medicine & Dentistry) and colleagues assess how mutations in acid-sensing ion channel 1 (ASIC1) affect channel desensitization. They establish that, contrary to previous reports, a glutamine to glycine substitution does not abolish desensitization, but causes complex pH-dependent effects on channel desensitization.

Rook et al. assess how mutations in acid-sensing ion channel 1 (ASIC1) affect channel desensitization. They establish that, contrary to previous reports, a glut

Peter Proks, Stephen Tucker and colleagues (University of Oxford) show that the antidepressant norfluoxetine affects the...
05/25/2021
Norfluoxetine inhibits TREK-2 K2P channels by multiple mechanisms including state-independent effects on the selectivity filter gate | Journal of General Physiology | Rockefeller University Press

Peter Proks, Stephen Tucker and colleagues (University of Oxford) show that the antidepressant norfluoxetine affects the behavior of TREK-2 two-pore domain K+ channels by regulating the equilibrium between their open and closed states as well as their filter gating.

Proks et al. show that the antidepressant norfluoxetine affects the behavior of TREK-2 two-pore domain K+ channels by regulating the equilibrium between their o

Our latest Research News: JGP study by Eef Dries, Cesare Terracciano and colleagues (https://bit.ly/3eXJRaW) shows that ...
05/24/2021
Regional differences in arrhythmogenesis | Journal of General Physiology | Rockefeller University Press

Our latest Research News: JGP study by Eef Dries, Cesare Terracciano and colleagues (https://bit.ly/3eXJRaW) shows that the subendocardium is more susceptible to spontaneous Ca2+ release events that can initiate arrhythmias, and this may be reduced by local CaMKII inhibition.

JGP study shows that the subendocardium is more susceptible to spontaneous Ca2+ release events that can initiate arrhythmias, and this may be reduced by local C

Tibor G. Szanto, Gyorgy Panyi and colleagues (University of Debrecen) use heavy water and Shaker-IR K+ channel mutants t...
05/21/2021
Shaker-IR K+ channel gating in heavy water: Role of structural water molecules in inactivation | Journal of General Physiology | Rockefeller University Press

Tibor G. Szanto, Gyorgy Panyi and colleagues (University of Debrecen) use heavy water and Shaker-IR K+ channel mutants to establish that structural water molecules contribute to the inactivation of the selectivity filter of the channel. Their experimental evidence supports previous predictions stemming from molecular dynamics simulations.

Szanto et al. use heavy water and Shaker-IR K+ channel mutants to establish that structural water molecules contribute to the inactivation of the selectivity fi

Using mutations associated with cardiomyopathy, Yoel H. Sitbon, Danuta Szczesna-Cordary and colleagues (University of Mi...
05/20/2021
Cardiomyopathic mutations in essential light chain reveal mechanisms regulating the super relaxed state of myosin | Journal of General Physiology | Rockefeller University Press

Using mutations associated with cardiomyopathy, Yoel H. Sitbon, Danuta Szczesna-Cordary and colleagues (University of Miami Miller School of Medicine) study the transition between the super relaxed state of myosin and the disordered-relaxed state. Their findings suggest that the N terminus of myosin essential light chain controls the transition between these two states.

Using mutations associated with cardiomyopathy, Sitbon et al. study the transition between the super relaxed state of myosin and the disordered-relaxed state. T

Hana Inoue, Utako Yokoyama and colleagues (Tokyo Medical University) use site-directed mutagenesis and reconstitution ex...
05/17/2021
The zinc-binding motif of TRPM7 acts as an oxidative stress sensor to regulate its channel activity | Journal of General Physiology | Rockefeller University Press

Hana Inoue, Utako Yokoyama and colleagues (Tokyo Medical University) use site-directed mutagenesis and reconstitution experiments to uncover critical residues within the zinc-binding motif of TRPM7 that are essential for the Mg2+-dependent regulation of the channel activity in conditions of oxidative stress.

Inoue et al. use site-directed mutagenesis and reconstitution experiments to uncover critical residues within the zinc-binding motif of TRPM7 that are essential

Inwardly rectifying potassium channels are generally thought to achieve their physiological voltage dependence via an "e...
05/06/2021
Unconventional voltage sensing in an inwardly rectifying potassium channel | Journal of General Physiology | Rockefeller University Press

Inwardly rectifying potassium channels are generally thought to achieve their physiological voltage dependence via an "extrinsic" mechanism involving voltage-dependent block by polyamines. Harley T. Kurata discusses a surprising finding of polyamine-independent gating of Kir4.1/Kir5.1 heteromeric channels (https://bit.ly/2RzjoIs) by Marmolejo-Murillo and colleagues, which suggests a mechanism of voltage dependence arising from interactions with permeating ions.

Inwardly rectifying potassium channels are generally thought to achieve their physiological voltage dependence via an “extrinsic” mechanism involving voltage-de

Eef Dries, Cesare M. Terracciano and colleagues (Imperial College London) show that injured myocardial slices from the s...
05/06/2021
CaMKII inhibition reduces arrhythmogenic Ca2+ events in subendocardial cryoinjured rat living myocardial slices | Journal of General Physiology | Rockefeller University Press

Eef Dries, Cesare M. Terracciano and colleagues (Imperial College London) show that injured myocardial slices from the subendocardium are more susceptible to spontaneous Ca2+ release events and whole-slice contractions than those from the subepicardium, and that this is reduced by CaMKII inhibition.

Dries et al. show that injured myocardial slices from the subendocardium are more susceptible to spontaneous Ca2+ release events and whole-slice contractions th

The cardiac KCNQ1 channel is a promising anti-arrhythmic target. Samira Yazdi, Sara I. Liin, H. Peter Larsson and collea...
05/04/2021
Identification of PUFA interaction sites on the cardiac potassium channel KCNQ1 | Journal of General Physiology | Rockefeller University Press

The cardiac KCNQ1 channel is a promising anti-arrhythmic target. Samira Yazdi, Sara I. Liin, H. Peter Larsson and colleagues report on how PUFAs interact with two binding sites in KCNQ1 to trigger channel activation.

The cardiac KCNQ1 channel is a promising anti-arrhythmic target. Yazdi et al. report on how PUFAs interact with two binding sites in KCNQ1 to trigger channel ac

Call for Papers 📣  We invite you to submit papers on the topic of Mechanotransduction by Membrane Proteins, to be highli...
05/03/2021
Call for Papers Mechanotransduction | Journal of General Physiology | Rockefeller University Press

Call for Papers 📣 We invite you to submit papers on the topic of Mechanotransduction by Membrane Proteins, to be highlighted in a special issue. Guest editors of the special issue are Valeria Vásquez (University of Tennessee Health Science Center); Elizabeth S. Haswell, (Washington University in St. Louis); and Miriam B. Goodman (Stanford University).
Learn more & submit your research:

Call for Papers Mechanotransduction | Journal of General Physiology | Rockefeller University Press


Call for Papers: Mechanotransduction by Membrane Proteins



You are invited you to submit papers on the topic of Mechanotransductio...

Our May cover image shows immunofluorescence images of gene-edited human induced pluripotent stem cells showing the expr...
05/03/2021

Our May cover image shows immunofluorescence images of gene-edited human induced pluripotent stem cells showing the expression of pluripotency markers. From Clippinger, Greenberg, and colleagues (https://bit.ly/3e2fRvo).
Read JGP May Issue: https://bit.ly/3u30tEm

Our May cover image shows immunofluorescence images of gene-edited human induced pluripotent stem cells showing the expression of pluripotency markers. From Clippinger, Greenberg, and colleagues (https://bit.ly/3e2fRvo).
Read JGP May Issue: https://bit.ly/3u30tEm

Call for papers 📣 COMING SOON: JGP invites you to submit papers on the topic of Mechanotransduction by Membrane Proteins...
04/27/2021
Call for Papers Mechanotransduction | Journal of General Physiology | Rockefeller University Press

Call for papers 📣 COMING SOON: JGP invites you to submit papers on the topic of Mechanotransduction by Membrane Proteins, starting May 3, 2021. Guest editors of the special issue are Valeria Vásquez (University of Tennessee Health Science Center), Elizabeth S. Haswell (Washington University in St. Louis) and Miriam B. Goodman (Stanford University). They will be assisted in handling the reviews of submitted manuscripts by JGP Associate Editors Jeanne Nerbonne and Crina Nimigean.
Learn more and sign up for a reminder:

Call for Papers Mechanotransduction | Journal of General Physiology | Rockefeller University Press


Coming Soon: Mechanotransduction by Membrane Proteins



Journal of General Physiology (JGP) will invite you to submit papers starting Ma...

David Rasicci, Christopher Yengo (Penn State) et al. investigate the mechanochemical properties of distinct isoforms of ...
04/26/2021
Impact of regulatory light chain mutation K104E on the ATPase and motor properties of cardiac myosin | Journal of General Physiology | Rockefeller University Press

David Rasicci, Christopher Yengo (Penn State) et al. investigate the mechanochemical properties of distinct isoforms of cardiac myosin carrying the K104E regulatory light chain mutation, previously associated with hypertrophic cardiomyopathy. They demonstrate that the mutation does not affect the ATPase or motor properties of human cardiac myosin subfragment-1 (M2β-S1), but the mutation increases the sliding velocity and disrupts RLC incorporation in full-length α-cardiac myosin.

Rasicci et al. investigate the mechanochemical properties of distinct isoforms of cardiac myosin carrying the K104E regulatory light chain mutation, previously

Beatrice Scellini, Chiara Tesi and colleagues (Università degli Studi di Firenze) show that mavacamten, a preclinical in...
04/26/2021
Mavacamten has a differential impact on force generation in myofibrils from rabbit psoas and human cardiac muscle | Journal of General Physiology | Rockefeller University Press

Beatrice Scellini, Chiara Tesi and colleagues (Università degli Studi di Firenze) show that mavacamten, a preclinical inhibitor of sarcomeric myosins, has a fast and reversible mechanical action on skeletal and cardiac myofibers that is mediated by a shift of motor heads out of a force-generating cycle, with no effect on the kinetics of cardiac force development.

Scellini et al. show that mavacamten, a preclinical inhibitor of sarcomeric myosins, has a fast and reversible mechanical action on skeletal and cardiac myofibe

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