Journal of General Physiology

Journal of General Physiology The Journal of General Physiology publishes research in physiological problems at cellular and molecular level. Published by Rockefeller University Press.
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The Journal of General Physiology publishes peer-reviewed research in physiological problems at the cellular and molecular level. Est. 1918, published by The Rockefeller University Press.

The Journal of General Physiology publishes peer-reviewed research in physiological problems at the cellular and molecular level. Est. 1918, published by The Rockefeller University Press.

Mission: The mission of JGP is to publish articles that elucidate basic biological, chemical, or physical mechanisms of broad physiological importance. GENERAL PHYSIOLOGY is the study of biological mechanisms through analytical investigations, which decipher the molecular and cellular mechanisms underlying biological function at all levels of organization.

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JGP is pleased to present a special collection of articles on Ion Channels & Transporters in Immunity, to accompany the ...
09/11/2020
Journal of General Physiology (JGP) | Rockefeller University Press

JGP is pleased to present a special collection of articles on Ion Channels & Transporters in Immunity, to accompany the Society of General Physiologists online symposium today (https://www.sgp2020.com).

The collection highlights articles published in JGP that are of interest to the community and are focused on understanding the structure and function of these fundamental proteins. We hope you enjoy reading the collection and welcome your comments!

JGP is pleased to present a special collection of articles on ion channels and transporters that play roles in the physiology of immune cells and inflammation. The collection highlights articles published in JGP that are of intere...

The voltage-gated proton channel (HV1) resembles the voltage sensors of other channels, but its movement during channel ...
09/09/2020
Engineered high-affinity zinc binding site reveals gating configurations of a human proton channel | Journal of General Physiology | Rockefeller University Press

The voltage-gated proton channel (HV1) resembles the voltage sensors of other channels, but its movement during channel opening remains controversial. Vladimir Cherny, Thomas DeCoursey and colleagues establish open and closed gating configurations of HV1 by analyzing the interactions of Zn2+ with an introduced histidine residue.

JGP is pleased to present a special collection of articles on ion channels and transporters that play roles in the physi...
09/09/2020
Journal of General Physiology (JGP) | Rockefeller University Press

JGP is pleased to present a special collection of articles on ion channels and transporters that play roles in the physiology of immune cells and inflammation, to coincide with the Society of General Physiologists's first online symposium on Ion Channels & Transporters in Immunity, Inflammation & Antitumor Immunity (https://www.sgp2020.com). The collection highlights articles published in JGP that are of interest to the community and are focused on understanding the structure and function of these fundamental proteins. We hope you enjoy reading the collection and welcome your comments!

JGP is pleased to present a special collection of articles on ion channels and transporters that play roles in the physiology of immune cells and inflammation. The collection highlights articles published in JGP that are of intere...

Our September cover shows map of STIM1:Orai1 ratio from the basal surface of a transfected HEK 293A cell. Circles repres...
09/08/2020

Our September cover shows map of STIM1:Orai1 ratio from the basal surface of a transfected HEK 293A cell. Circles represent Orai1 channel clusters (puncta); STIM1:Orai1 ratio is color coded from blue (low) to red (high). Gradi¬ents in STIM1:Orai1 ratio, combined with optical and electrical recording of Orai1-GCaMP6f channel activity, reveal functional heterogeneity in Orai1 puncta and enable system¬atic study of STIM1-Orai1 channel states. Image © Dynes et al., 2020. Read the article: https://bit.ly/3hnCn0Q Read the Issue: https://bit.ly/2YZYbIL

Our September cover shows map of STIM1:Orai1 ratio from the basal surface of a transfected HEK 293A cell. Circles repres...
09/07/2020

Our September cover shows map of STIM1:Orai1 ratio from the basal surface of a transfected HEK 293A cell. Circles represent Orai1 channel clusters (puncta); STIM1:Orai1 ratio is color coded from blue (low) to red (high). Gradi¬ents in STIM1:Orai1 ratio, combined with optical and electrical recording of Orai1-GCaMP6f channel activity, reveal functional heterogeneity in Orai1 puncta and enable system¬atic study of STIM1-Orai1 channel states. Image © Dynes et al., 2020. Read the article: https://bit.ly/3hnCn0Q Read the Issue: https://bit.ly/2YZYbIL

K+ binding to mammalian glutamate transporters is essential for the import and release of glutamate into cells. Using MD...
08/21/2020
Mechanism and potential sites of potassium interaction with glutamate transporters | Journal of General Physiology | Rockefeller University Press

K+ binding to mammalian glutamate transporters is essential for the import and release of glutamate into cells. Using MD simulations and site-directed mutagenesis, Jiali Wang, Christof Grewer and colleagues (at Binghamton University) identify two K+ binding sites in the transporter EAAC1, one of which appears to catalyze the relocation step of the transport cycle.

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Journal of General Physiology (JGP), in partnership with the Society of General Physiologists, is now accepting applicat...
08/20/2020

Journal of General Physiology (JGP), in partnership with the Society of General Physiologists, is now accepting applications for the 2020 Junior Faculty Networking Cohort. The program is designed to support and connect junior faculty in the first stage of their independent careers. Up to nine junior faculty will be matched with Rajini Rao, Director of the Graduate Program in Cellular and Molecular Medicine and Professor of Physiology at Johns Hopkins Medicine for group discussions. Learn more & apply: https://bit.ly/2EgPzmo

Stress increases the permeability of the mitochondrial inner membrane by activating permeability transition pores (PTPs)...
08/18/2020
The very low number of calcium-induced permeability transition pores in the single mitochondrion | Journal of General Physiology | Rockefeller University Press

Stress increases the permeability of the mitochondrial inner membrane by activating permeability transition pores (PTPs), likely composed of ATP synthase or the adenine nucleotide translocator. By measuring water flux during calcium-activated mitochondrial swelling, Neginskaya, Pavlov at NYU College of Dentistry et al. estimate that if these proteins are involved in PTP, only a small fraction becomes transformed into the pore on a single mitochondrion. #mitochondria

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JGP invites you to submit papers on the topic of #Myofilament Function to be included in a special issue. Submissions of...
08/17/2020
Call for Papers: Myofilament Function

JGP invites you to submit papers on the topic of #Myofilament Function to be included in a special issue. Submissions of Research Articles, Communications, Hypotheses, or Methods and Approaches are specifically invited, in any format. For more info, visit:

Call for Papers: Myofilament Function Call for Papers: Myofilament Function JGP invites you to submit papers on the topic of Myofilament Function by September 30, 2020 to be included in a special issue of JGP. The issue will be edited by Christine Cremo, JGP Editorial Advisory Board member and Profe...

JGP invites you to submit papers on the topic of #Myofilament Function to be included in a special issue edited by Chris...
08/11/2020
Call for Papers: Myofilament Function

JGP invites you to submit papers on the topic of #Myofilament Function to be included in a special issue edited by Christine Cremo, Henk Granzier, Richard Moss. We'll waive $2,000 publication fee for these specific articles, if submitted before September 30th! More info:

Call for Papers: Myofilament Function Call for Papers: Myofilament Function JGP invites you to submit papers on the topic of Myofilament Function by September 30, 2020 to be included in a special issue of JGP. The issue will be edited by Christine Cremo, JGP Editorial Advisory Board member and Profe...

Have you registered yet? Society of General Physiologists 1st online symposium on Ion Channels & Transporters in Immunit...
08/06/2020
Ion Channels & Transporters in Immunity, Inflammation & Antitumor Immunity

Have you registered yet? Society of General Physiologists 1st online symposium on Ion Channels & Transporters in Immunity, organized by Stefan Feske & Bimal Desai is coming next month. Registration is free for SGP members, $25 for others. For more info, visit: https://sgp2020.com

Michael Cahalan, PhD (UC Irvine)Th17 cell calcium signaling in the spinal cord during murine autoimmune neuroinflammation

Mice lacking calsequestrin-1 have reduced levels of releasable Ca2+ in the sarcoplasmic reticulum of their skeletal musc...
08/05/2020
Pre-assembled Ca2+ entry units and constitutively active Ca2+ entry in skeletal muscle of calsequestrin-1 knockout mice | Journal of General Physiology | Rockefeller University Press

Mice lacking calsequestrin-1 have reduced levels of releasable Ca2+ in the sarcoplasmic reticulum of their skeletal muscles. Antonio Michelucci, Robert T. Dirksen, Feliciano Protasi and colleagues reveal that this is compensated by constitutive assembly of STIM1 & Orai1 into Ca2+ entry units, promoting both constitutive and store-operated Ca2+ entry.

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Our August cover shows a temperature mapping of HeLa cells on ratiometric thermometer nanosheets. From top to bottom: Br...
08/03/2020

Our August cover shows a temperature mapping of HeLa cells on ratiometric thermometer nanosheets. From top to bottom: Bright-field image, EuTTA fluorescence image, Rh101 fluorescence image, and the EuTTA/Rh101 ratio image. Left , center, and right columns indicate live, fixed, and skinned cells after fixation, respectively. Dashed lines on top indicate the outlines of cells. Image © Oyama et al., 2020. Read the JGP Issue 8: https://bit.ly/2Xjm0uc

The α7 nicotinic acetylcholine receptor (nAChR) is highly abundant in the brain but is frequently located at extra-synap...
07/23/2020
Mechanism of calcium potentiation of the α7 nicotinic acetylcholine receptor | Journal of General Physiology | Rockefeller University Press

The α7 nicotinic acetylcholine receptor (nAChR) is highly abundant in the brain but is frequently located at extra-synaptic regions where the concentration of ACh is low. Steven M. Sine, Cecilia Bouzat, Kathiresan Natarajan, Nuriya Mukhtasimova and colleagues reveal that at low ACh concentrations, calcium potentiates α7 channel opening by binding to a novel structural motif.

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Call for papers: submit research in #Myofilament Function by Sept. 30 to be considered for special issue edited by Chris...
07/17/2020
Call for Papers: Myofilament Function

Call for papers: submit research in #Myofilament Function by Sept. 30 to be considered for special issue edited by Christine Cremo, Henk Granzier, & Richard L. Moss. JGP will waive the publication fee of $2,000 for these specific dedicated issue articles. https://bit.ly/3ehkmj6

Call for Papers: Myofilament Function Call for Papers: Myofilament Function JGP invites you to submit papers on the topic of Myofilament Function by September 30, 2020 to be included in a special issue of JGP. The issue will be edited by Christine Cremo, JGP Editorial Advisory Board member and Profe...

On the cover of the Journal of General Physiology's July issue: Slc7a5 is an amino acid transporter with unusual gating ...
07/06/2020

On the cover of the Journal of General Physiology's July issue: Slc7a5 is an amino acid transporter with unusual gating effects on certain Kv channels. Slc7a5 traps Kv1.2 in a nonconducting state that can be relieved by supraphysiological hyperpolarizing voltages, causing disinhibition of channel currents. The image depicts disinhibition in voltage-clamp recordings of Kv1.2 (±Slc7a5) with intermittent depolarizations (+10 mV) from a negative holding potential (−120 mV). Image © Lamothe and Kurata, 2020. Find the associated article here: https://bit.ly/2NrFMyh
Read the JGP July issue: https://bit.ly/31Opwjj

Joseph Dynes, Andriy Yeromin and Michael Cahalan use a fluorescent genetically encoded Ca2+ indicator, GCaMP6f, fused to...
07/01/2020
Cell-wide mapping of Orai1 channel activity reveals functional heterogeneity in STIM1-Orai1 puncta | Journal of General Physiology | Rockefeller University Press

Joseph Dynes, Andriy Yeromin and Michael Cahalan use a fluorescent genetically encoded Ca2+ indicator, GCaMP6f, fused to Orai1 to visualize Ca2+ influx through store-operated Orai1 channels. Combined with whole-cell recording of transfected human cells, this reporter reveals heterogeneity of channel activation and kinetics in STIM1-Orai1 puncta within the same cell.

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We are delighted to support the first online symposium of the Society of General Physiologists on Ion Channels & Transpo...
06/30/2020

We are delighted to support the first online symposium of the Society of General Physiologists on Ion Channels & Transporters in Immunity in September organized by Stefan Feske and Bimal Desai. Registration is free for SGP members, $25 for others. For more info, visit: https://sgp2020.com. Another benefit of SGP membership: a 25% discount on the $2,000 JGP publications fee to all SGP members—a savings of $500. To enable the discount, active members can use a promotional code during invoicing. To receive a promotional code, members must contact SGP. Learn more about SGP membership here: https://www.sgpweb.org/MembershipJGP

Submit your papers on the topic of Myofilament Function by September 30, 2020 to be considered for a special issue of JG...
06/26/2020
Call for Papers: Myofilament Function

Submit your papers on the topic of Myofilament Function by September 30, 2020 to be considered for a special issue of JGP. The issue will be edited by JGP Editors Christine Cremo, Henk Granzier, and Richard L. Moss. JGP will waive the publication fee of $2,000 for these specific dedicated issue articles. Learn more! https://bit.ly/3ehkmj6

Submit by September 30, 2020

Felix Neumaier, Toni Schneider, and colleagues (https://bit.ly/2zN9f2D) reveal that Zn2+ effects on Cav2.3 channels are ...
06/25/2020
Zn2+-induced changes in Cav2.3 channel function: An electrophysiological and modeling study

Felix Neumaier, Toni Schneider, and colleagues (https://bit.ly/2zN9f2D) reveal that Zn2+ effects on Cav2.3 channels are complex, can be either inhibitory or stimulatory, and may persist for several minutes after cessation of the Zn2+ signal. A Markov model is developed that can account for Cav2.3 channel currents in the absence and presence of physiological Zn2+ concentrations.

Loosely bound Zn2+ ions are increasingly recognized as potential modulators of synaptic plasticity and neuronal excitability under normal and pathophysiological conditions.

Valerie Abigail Nirenberg and Ofer Yifrach provide commentary (https://bit.ly/2UXOU1U) on a study by Szanto et al. (http...
06/24/2020
Flow and shortcuts along the Shaker Kv channel slow inactivation gating cycle

Valerie Abigail Nirenberg and Ofer Yifrach provide commentary (https://bit.ly/2UXOU1U) on a study by Szanto et al. (https://bit.ly/3eoNnJh) that addresses flow along the gating cycle of the Shaker-IR channel during the onset of slow inactivation at negative membrane potentials and the consequences of locking open inactivated channels on recovery from slow inactivation.

Closing the cycle of Kv channel slow inactivation gating.

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