Clinical Oncology News

Clinical Oncology News An independent source of unbiased, accurate, reliable news and in-depth expert analysis on issues oncologists and hematologist/oncologists care about most.

Commentary: The prostate cancer screening landscape has shifted from an absolute against PSA screening back to an indivi...
07/10/2017
PSA and Prostate Ca Metastases: The Task at Hand

Commentary: The prostate cancer screening landscape has shifted from an absolute against PSA screening back to an individual discussion about the risks and benefits of PSA screening

Prostate cancer is the most commonly diagnosed cancer in US men, with an estimated 161,360 new cases and 26,730 deaths projected for 2017.

In the 1980s, up to 70% of cancer patients reported pain. Thirty years later, cancer pain prevalence has not changed not...
06/29/2017
Challenges to Cancer Pain Management Are Multifactorial

In the 1980s, up to 70% of cancer patients reported pain. Thirty years later, cancer pain prevalence has not changed noticeably

In the 1980s, up to 70% of cancer patients reported pain. Thirty years later, cancer pain prevalence has not changed noticeably, reported Julie Waldfogel, PharmD, at the 2017 annual meeting of the Hematology/Oncology Pharmacy Association.

Being perfectly proficient at drawing blood or starting an IV line in an inanimate simulator does not mean you will feel...
06/28/2017
The Marginalization of the Medical Student

Being perfectly proficient at drawing blood or starting an IV line in an inanimate simulator does not mean you will feel completely competent or at ease drawing blood from your first few patients

If you went to medical school before 1980, you probably remember a lot of learning-by-doing in real human beings.

06/22/2017
Contralateral Risk For DCIS Patients Low

New research shows the risk for contralateral breast cancer in DCIS patients is too low to justify prophylactic mastectomy

Las Vegas—The rate of contralateral prophylactic mastectomy in women with ductal carcinoma in situ more than doubled in the past decade, but new research shows their risk for contralateral breast cancer is too low to justify that preventive option.

“As our population ages, it’s important that surgeons know which patients will have good surgical outcomes. Since ag...
06/20/2017
Even Some Frailty Predicts Poor Outcomes in Older GI Ca Pts

“As our population ages, it’s important that surgeons know which patients will have good surgical outcomes. Since age alone does not predict outcomes, we’ve been looking at the idea of frailty,” said Molly Garland, MD

In older gastrointestinal cancer patients, whose health often is compromised by comorbidities as well as poor performance status and malnutrition, even a very low modified frailty index (mFI) score can indicate poor postoperative outcomes, according to a new study.

Darzalex is approved in combination with pomalidomide and dexamethasone for third-line multiple myeloma
06/20/2017
Darzalex Approved With Pomalyst and Dex for Third-Line MM

Darzalex is approved in combination with pomalidomide and dexamethasone for third-line multiple myeloma

Approved in combination with pomalidomide (Pomalyst, Celgene) and dexamethasone for patients with multiple myeloma (MM) who have received ≥2 prior therapies, including lenalidomide (Revlimid, Celgene) and a proteasome inhibitor.

“Enabling a woman to preserve her hair during chemotherapy is empowering,” said lead investigator Tessa Cigler, MD, ...
06/19/2017
Evidence Builds for Scalp Cooling

“Enabling a woman to preserve her hair during chemotherapy is empowering,” said lead investigator Tessa Cigler, MD, MPH

Growing evidence suggests that scalp cooling can alleviate chemotherapy-induced hair loss. The most recent data come from a study in which two-thirds of patients who underwent scalp cooling retained half or more of their hair.

ANGPT2 shows promise as a biomarker for checkpoint response
06/15/2017
ANGPT2: Promising Biomarker for Checkpoint Response

ANGPT2 shows promise as a biomarker for checkpoint response

Early results show that angiopoietin-2 (ANGPT2), a serum-based protein, may provide an easy way to identify which patients with metastatic melanoma will respond to immune checkpoint therapy, according to investigators at the Dana-Farber Cancer Institute, in Boston.

ASCO Report: Pertuzumab plus trastuzumab yields small benefit at steep price
06/14/2017
Pertuzumab Plus Trastuzumab Yields Small Benefit at Steep Price

ASCO Report: Pertuzumab plus trastuzumab yields small benefit at steep price

Adding pertuzumab to trastuzumab for women with HER2-positive breast cancer reduced the risk for invasive breast cancer by 1% at three years of follow-up, according to results of a Phase III trial.

ASCO report: Head-to-head trial finds PFS varies between TKIs in NSCLC
06/14/2017
Head-to-Head Trial Finds PFS Varies Between TKIs in NSCLC

ASCO report: Head-to-head trial finds PFS varies between TKIs in NSCLC

In patients with ALK-positive NSCLC, the TKI alectinib increases PFS by a year or more relative to crizotinib, according to a multinational trial. The head-to-head Phase III comparison of the TKIs was undertaken in treatment-naive patients with advanced disease.

At five years, 16% of patients with non-small cell lung cancer (NSCLC) treated with a checkpoint inhibitor are still ali...
06/13/2017
Modest Long-Term Survival With Immuno Rx in NSCLC

At five years, 16% of patients with non-small cell lung cancer (NSCLC) treated with a checkpoint inhibitor are still alive

At five years, 16% of patients with non-small cell lung cancer (NSCLC) treated with a checkpoint inhibitor are still alive, according to the longest follow-up to date from an immunotherapy…

ASCO Video: Allyson Ocean, MD, of Weill Cornell Medicine, discusses a new digital platform, “Let’s Win,” which con...
06/13/2017
New Crowdsourcing Platform Connects Pancreatic Cancer Patients to the Latest Studies

ASCO Video: Allyson Ocean, MD, of Weill Cornell Medicine, discusses a new digital platform, “Let’s Win,” which connects patients and healthcare professionals through a shared resource for the latest pancreatic cancer research news

Allyson Ocean, MD, at Weill Cornell Medicine, in New York, discusses a new digital platform, “Let's Win”, which focuses on connecting patients and healthcare professionals through a shared resource for  the latest pancreatic cancer research news.

ASCO Video: Daniel F. Hayes, MD, president of the American Society of Clinical Oncology, discusses the importance of fed...
06/05/2017
ASCO President Daniel F. Hayes, MD, Discusses Federal Funding of Cancer Research

ASCO Video: Daniel F. Hayes, MD, president of the American Society of Clinical Oncology, discusses the importance of federal funding of cancer research #ASCO17

Daniel F. Hayes, MD, president of the American Society of Clinical Oncology, shared his thoughts and concerns about the state of federal funding for oncology research. He said that the only way we are going to make progress in tackling cancer is “to catch up and keep up.”

06/02/2017
ASCO Report: Insurance Increases Early Detection of Screenable Cancers

ASCO Report: Insurance coverage increases early detection of screenable cancers goo.gl/8HI94s

Patients who develop cancer that can be detected by screening are more likely to get an early-stage diagnosis if they have adequate insurance coverage, such as the kind provided through the Affordable Care Act.

SABRINA trial indicates subcutaneous rituximab equivalent to IV form goo.gl/P1WPSR
06/01/2017
SABRINA Trial Indicates Subcutaneous Rituximab Equivalent to IV Form

SABRINA trial indicates subcutaneous rituximab equivalent to IV form goo.gl/P1WPSR

A formulation of rituximab administered by subcutaneous injection appears to be just as safe and effective in the treatment of follicular lymphoma as IV rituximab, according to a Phase III multinational trial.

Dr. Scott Tagawa discusses risk factors and outcomes of prostate cancer goo.gl/Zgy1tn
05/31/2017
Dr. Scott Tagawa Discusses Risk Factors and Outcomes of Prostate Cancer

Dr. Scott Tagawa discusses risk factors and outcomes of prostate cancer goo.gl/Zgy1tn

Dr. Tagawa explains the evidence that inadequate sleep is a risk factor for worse outcomes in men with prostate cancer. After a review of the studies, he explains how he incorporates this information into his own care of prostate cancer patients.

Debra Patt, MD, shares how adopting the Oncology Care Model has shaped Texas Oncology's approach to cancer care goo.gl/1...
05/24/2017
COA: Debra Patt, MD Discusses the Oncology Care Model

Debra Patt, MD, shares how adopting the Oncology Care Model has shaped Texas Oncology's approach to cancer care goo.gl/1TCuOy

Dr. Debra Patt sat down with Clinical Oncology News at the 2017 Community Oncology Alliance meeting to discuss what her practice has learned after adopting  the Oncology Care Model and how it has shaped their approach to cancer care.

American Society of Clinical Oncology Report: Adherence to healthy lifestyle guidelines provides big benefits in colon c...
05/24/2017
ASCO Report: Adherence to Healthy Lifestyle Guidelines Provides Big Benefits in Colon Cancer

American Society of Clinical Oncology Report: Adherence to healthy lifestyle guidelines provides big benefits in colon cancer goo.gl/1w0l3z

Patients with colorectal cancer who follow the healthy lifestyle guidelines of the American Cancer Society’s Nutrition and Physical Activity Guidelines for Cancer Survivors have a longer disease-free and overall survival than those who don’t.

American Society of Clinical Oncology Report: Gefitinib beats chemo after surger in NSCLC goo.gl/FhEbUR
05/23/2017
ASCO Report: Gefitinib Beats Chemo After Surgery in NSCLC

American Society of Clinical Oncology Report: Gefitinib beats chemo after surger in NSCLC goo.gl/FhEbUR

Results from a Phase III trial demonstrate that the EGFR-targeted therapy gefitinib is more effective than chemotherapy in preventing recurrence after surgery in patients with EGFR mutant stage II-IIIA non-small cell lung cancer.

The top killer in breast cancer may surprise you goo.gl/PuhYdb
05/23/2017
The Top Killer In Breast Cancer May Surprise You

The top killer in breast cancer may surprise you goo.gl/PuhYdb

Women in their 40s and 50s are experiencing heart failure and other cardiotoxicities after treatment with radiation, anthracyclines and HER2 receptor antagonists.

AACR: Padmanee Sharma, MD, discusses boosting checkpoint inhibitors in metastatic renal cancer
05/17/2017
AACR: Dr. Padmanee Sharma Discusses Boosting Checkpoint Inhibitors

AACR: Padmanee Sharma, MD, discusses boosting checkpoint inhibitors in metastatic renal cancer

Dr. Sharma, an oncologist at The University of Texas M.D Anderson Cancer Center, in Houston, discusses her recent success in boosting the benefit of a checkpoint inhibitor in metastatic renal cancer with the addition of the VEGF-inhibitor bevacizumab. She goes on to explain why the immunotherapy fie...

05/17/2017
Evidence Grows for Watch-and-Wait in Rectal Cancer

Evidence grows for watch-and-wait in rectal cancer

San Francisco—Data are accumulating for a watch-and-wait approach for many patients with locally advanced rectal cancer, according to an analysis from the International Watch & Wait Database.

For sedation in colonoscopy, Phase III trial shows new agent has many advantages goo.gl/wT2sTe
05/16/2017
For Sedation in Colonoscopy, Phase III Trial Shows New Agent Has Many Advantages

For sedation in colonoscopy, Phase III trial shows new agent has many advantages goo.gl/wT2sTe

The short-acting experimental benzodiazepine remimazolam performed impressively in outpatient colonoscopy, with rapid-onset sedation and far faster recovery than midazolam, according to results from a Phase III trial.

Sudden diabetes seen before 50% of pancreatic cancer cases goo.gl/NpwLev
05/16/2017
Sudden Diabetes Seen Before 50% Of Pancreatic Ca Cases

Sudden diabetes seen before 50% of pancreatic cancer cases goo.gl/NpwLev

Patients and their physicians should be aware that the rapid onset of diabetes at an older age, or a rapid deterioration in existing diabetes that requires more aggressive treatment, could be a sign of early, hidden pancreatic cancer.

Pregnancy-associated breast cancer has been associated with a worse prognosis, but the reasons are not clear goo.gl/ixWn...
05/15/2017
Studies Shed Light on Pregnancy-Associated Breast Ca

Pregnancy-associated breast cancer has been associated with a worse prognosis, but the reasons are not clear goo.gl/ixWnUh

Pregnancy-associated breast cancer (PABC) has been associated with worse prognosis, but the reasons for that have not been clear.

Antibiotics may hamper effectiveness of immunotherapy
05/14/2017
Antibiotics May Hamper Effectiveness of Immunotherapy

Antibiotics may hamper effectiveness of immunotherapy

A small retrospective study suggests that immunotherapy may be less effective in patients who have received antibiotics within a month of starting their therapy. The findings were reported at the 2017 Genitourinary Cancers Symposium.

Q&A with C. Ola Landgren, MD, PhD: Evolving strategies in the treatment of smoldering multiple myeloma
05/13/2017
Q&A: Evolving Strategies in Treatment of Smoldering MM

Q&A with C. Ola Landgren, MD, PhD: Evolving strategies in the treatment of smoldering multiple myeloma

A substantial body of evidence indicates that patients with smoldering multiple myeloma (SMM) who have high-risk features benefit from therapy. Although no therapies are approved yet for this indication, numerous ongoing studies are expected to guide treatment choices.

Medical marijuana and the role of the phyisican
05/12/2017
Medical Marijuana and the Role of the Physician

Medical marijuana and the role of the phyisican

Chicago—If an oncology practice hasn’t already started fielding inquiries from patients about medical marijuana, it’s probably only a matter of time, now that last November’s election has pushed the tally of medical marijuana states above 50%.

Study looks at BRCA and overall survival in young breast cancer patients
05/11/2017
Study Looks at BRCA and OS in Young Breast Cancer Patients

Study looks at BRCA and overall survival in young breast cancer patients

BRCA1/2 mutation status does not affect survival in young patients with breast cancer, according to findings from a large study called POSH conducted in the United Kingdom.

Is cabozantinib a standard of care for advanced renal cell carcinoma?
05/10/2017
Is Cabozantinib a Standard of Care for Advanced RCC?

Is cabozantinib a standard of care for advanced renal cell carcinoma?

A final report from the Phase III METEOR trial makes a solid case that cabozantinib is a new standard of care in patients with advanced renal cell carcinoma (RCC) previously treated with antiangiogenic therapy.

Insights in Oncology: The Disappearance of Eye Contact by Bruce Gershenhorn, DO
05/09/2017
The Disappearance of Eye Contact

Insights in Oncology: The Disappearance of Eye Contact by Bruce Gershenhorn, DO

There are a few basic tenets for good communication—the proper handshake (or hug), taking the time to listen, and, of course, eye contact. But the second and third tenets have been decimated in the era of the EHR.

Dark meat fish improves disease-free survival in colorectal cancer goo.gl/qWZMbm
05/09/2017
Dark Meat Fish Improves DFS in Colorectal Cancer

Dark meat fish improves disease-free survival in colorectal cancer goo.gl/qWZMbm

Patients who consumed dark meat fish more than three times per month after a diagnosis of colorectal cancer (CRC) had a 35% improved disease-free survival (DFS) compared with…

Diarrhea not best measure of ImmunoRx-related colitis goo.gl/9go0Q9
05/08/2017
Diarrhea Not Best Measure of ImmunoRx-Related Colitis

Diarrhea not best measure of ImmunoRx-related colitis goo.gl/9go0Q9

The severity of diarrhea is not an accurate predictor of the presence or severity of colitis in a patient receiving immunotherapy, according to a retrospective study from the Netherlands.

Efforts needed to encourage exercise after cancer
05/04/2017
Efforts Needed to Encourage Exercise After Cancer

Efforts needed to encourage exercise after cancer

Roughly three-fourths of patients report decreased physical activity after a cancer diagnosis, according to a survey of 662 patients with common cancers treated at 12 hospitals.

05/02/2017
Higher Rates of Distant Metastasis, Mortality in Breast Cancer Patients

Higher rates of distant metastasis, mortality in breast cancer patients with HR-negative, HER2-negative disease than other cancer types goo.gl/f1QnK0

Rates of distant metastasis and mortality were found to be higher among breast cancer patients with hormone receptor (HR)-negative, HER2-negative disease than other cancer types, in a review of physician-reported clinical information from the Optum Oncology Management Registry.

All bloodstream infections in pediatric hematology/oncology patients should be tracked goo.gl/thnzcH
05/02/2017
All Bloodstream Infections in Pediatric Hematology/Oncology Patients Should Be Tracked

All bloodstream infections in pediatric hematology/oncology patients should be tracked goo.gl/thnzcH

All bloodstream infections in pediatric hematology/oncology patients, not simply central line–associated bloodstream infections, should be actively tracked as part of the Childhood Cancer and Blood Disorders Network’s quality improvement efforts.

Vogl, NY: Adjuvant ovarian function suppression for resected breast cancer revisited goo.gl/owmrX4
05/01/2017
Vogl, NY: Adjuvant OFS for Resected Breast Cancer Revisited

Vogl, NY: Adjuvant ovarian function suppression for resected breast cancer revisited goo.gl/owmrX4

After the results of the Eastern Cooperative Oncology Group (ECOG) 5188 study (Intergroup 0101) were published by Davidson et al, many of us in the field hoped that a study of additional adjuvant ovarian function suppression (OFS) restricted to women with functioning ovaries would demonstrate clearl...

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