Journal of Experimental Medicine

Journal of Experimental Medicine The Journal of Experimental Medicine publishes immunology, cancer, stem cells, microbial pathogenesis, vascular biology, and neurobiology research.
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The Journal of Experimental Medicine (JEM) features peer-reviewed research on immunology, cancer biology, stem cell biology, microbial pathogenesis, vascular biology, and neurobiology. All editorial decisions are made by research-active scientists in conjunction with in-house scientific editors. JEM provides free online access to many article types immediately, with complete archival content freel

The Journal of Experimental Medicine (JEM) features peer-reviewed research on immunology, cancer biology, stem cell biology, microbial pathogenesis, vascular biology, and neurobiology. All editorial decisions are made by research-active scientists in conjunction with in-house scientific editors. JEM provides free online access to many article types immediately, with complete archival content freel

The host-derived regulatory network that controls mucus secretion and thereby changes gut microbiota has not been fully ...
07/21/2021
Foxo1 controls gut homeostasis and commensalism by regulating mucus secretion | Journal of Experimental Medicine | Rockefeller University Press

The host-derived regulatory network that controls mucus secretion and thereby changes gut microbiota has not been fully illustrated. Zuojia Chen, Chuan Wu, Vijay K. Kuchroo and colleagues reveal that Forkhead box protein O1 (Foxo1) is critical for gut commensalism and intestinal barrier integrity by regulating goblet cell function. https://bit.ly/3kKYiDE

The host-derived regulatory network that controls mucus secretion and thereby changes gut microbiota has not been fully illustrated. Here, we identify that Fork

Roberto Vendramin, Jean-Christophe Marine, Eleonora Leucci and colleagues (KU Leuven) demonstrate that the integrated st...
07/21/2021
Activation of the integrated stress response confers vulnerability to mitoribosome-targeting antibiotics in melanoma | Journal of Experimental Medicine | Rockefeller University Press

Roberto Vendramin, Jean-Christophe Marine, Eleonora Leucci and colleagues (KU Leuven) demonstrate that the integrated stress response in melanoma promotes cell plasticity and drives therapy resistance by boosting mitochondrial translation. Therefore, repurposing of mitoribosome-targeting antibiotics offers a salvage strategy for the treatment of patients with limited therapeutic options. https://bit.ly/3eHU7oq

Vendramin et al. demonstrate that the integrated stress response in melanoma promotes cell plasticity and drives therapy resistance by boosting mitochondrial tr

Researchers Weill Cornell Medicine & NewYork-Presbyterian Hospital have discovered that injecting mice with blood vessel...
07/21/2021
Researchers reverse emphysema in mice by injecting blood vessel wall cells

Researchers Weill Cornell Medicine & NewYork-Presbyterian Hospital have discovered that injecting mice with blood vessel wall cells can reverse the symptoms of #emphysema, suggesting new treatments for #COPD. Read the press release https://bit.ly/2Usz2HM or see the full study: https://bit.ly/3hQfTs2

Researchers at Weill Cornell Medicine and NewYork-Presbyterian in New York have discovered that injecting mice with pulmonary endothelial cells--the cells that line the walls of blood vessels in the lung--can reverse the symptoms of emphysema. The study, which will be published July 21 in the Journa...

JEM is pleased to present a special collection of recent articles on hematologic malignancies, to coincide with Federati...
07/21/2021
JEM Hematologic Malignancies Collection 2021 | Journal of Experimental Medicine | Rockefeller University Press

JEM is pleased to present a special collection of recent articles on hematologic malignancies, to coincide with Federation of American Societies for Experimental Biology - FASEB's Hematologic Malignancies Conference.
The collection includes studies that characterize heterogenous disease-propagating stem cells, explore the regulation of translation, metabolism, cell cycle, cell death, and developmental pathways, and develop novel therapies in the context of leukemia and lymphoma. The review articles from our recent Special Focus on Hematopoietic Stem Cells are also featured here. We hope you will enjoy reading this collection and encourage your feedback!

JEM is pleased to present a special collection of articles on hematologic malignancies. The collection includes studies that characterize heterogenous disease-propagating stem cells, explore the regulation of translation, metabolism, cell cycle, cell de...

Type 2 cytokines promote epithelial changes that help to expel worms during intestinal helminth infection. Oyebola O. Oy...
07/20/2021
PGD2 and CRTH2 counteract Type 2 cytokine–elicited intestinal epithelial responses during helminth infection | Journal of Experimental Medicine | Rockefeller University Press

Type 2 cytokines promote epithelial changes that help to expel worms during intestinal helminth infection. Oyebola O. Oyesola, Elia Tait Wojno et al. (University of Washington) show that prostaglandin D2 and its receptor CRTH2 are novel negative regulators of this response, dampening the Type 2 cytokine–mediated program. https://bit.ly/3kD1rpd

Type 2 cytokines promote epithelial changes that help to expel worms during intestinal helminth infection. Oyesola et al. show that prostaglandin D2 and its rec

Gautham Yepuri, Ravichandran Ramasamy et al. discuss a recent study by Cheng et al. (https://bit.ly/2V0BZ1Q) describing ...
07/20/2021
Macrophage-adipocyte communication and cardiac remodeling | Journal of Experimental Medicine | Rockefeller University Press

Gautham Yepuri, Ravichandran Ramasamy et al. discuss a recent study by Cheng et al. (https://bit.ly/2V0BZ1Q) describing how #adipocytes & #macrophages collaborate to foster cardiac fibrosis through the actions of angiotensin II in #obesity: https://bit.ly/3Boyhjp

A recent study published in JEM describes the adipocyte–macrophage collaboration to foster cardiac fibrosis through the actions of angiotensin II in obesity.

The regulatory mechanisms controlling natural killer (NK) cells maturation remain unknown. Siyu Tan, Chunhong Ma and col...
07/19/2021
Transcription factor Zhx2 restricts NK cell maturation and suppresses their antitumor immunity | Journal of Experimental Medicine | Rockefeller University Press

The regulatory mechanisms controlling natural killer (NK) cells maturation remain unknown. Siyu Tan, Chunhong Ma and colleagues (Shandong University) report that Zhx2 acts as a key negative regulator of NK cell maturation by controlling IL-15 signaling and transcription of Zeb2.

The regulatory mechanisms controlling natural killer (NK) cell maturation remain unknown. In this article, Tan et al. report that Zhx2 acts as a key negative re

Through skin index-sorted single-cell RNA sequencing, Satoshi Nakamizo, Florent Ginhoux (Agency for Science, Technology ...
07/19/2021
Single-cell analysis of human skin identifies CD14+ type 3 dendritic cells co-producing IL1B and IL23A in psoriasis | Journal of Experimental Medicine | Rockefeller University Press

Through skin index-sorted single-cell RNA sequencing, Satoshi Nakamizo, Florent Ginhoux (Agency for Science, Technology and Research (A*STAR)) and colleagues reveal that the transcriptional landscape of macrophages and dendritic cells in atopic and psoriatic skin and identifies CD14+ type 3 dendritic cells co-producing IL1B and IL23A in psoriatic skin.

Skin index-sorted single-cell RNA sequencing reveals the transcriptional landscape of macrophages and dendritic cells in atopic and psoriatic skin and identifie

Hongwei Su, Sabine Ehrt et al. (Weill Cornell Medicine) show that transient genetic depletion of essential proteins in M...
07/16/2021
Genetic models of latent tuberculosis in mice reveal differential influence of adaptive immunity | Journal of Experimental Medicine | Rockefeller University Press

Hongwei Su, Sabine Ehrt et al. (Weill Cornell Medicine) show that transient genetic depletion of essential proteins in Mycobacterium tuberculosis leads to the establishment of latent infection in mice that reproducibly reactivates in a stable proportion of infected mice, mimicking aspects of latent tuberculosis and tuberculosis relapse in humans.

Transient genetic depletion of essential proteins in Mycobacterium tuberculosis leads to the establishment of latent infection in mice that reproducibly reactiv

Using single cell analysis of whole blood and intestinal tissue, Oluwabunmi O. Olaloye, Peng Liu, Liza Konnikova (Yale M...
07/16/2021
CD16+CD163+ monocytes traffic to sites of inflammation during necrotizing enterocolitis in premature infants | Journal of Experimental Medicine | Rockefeller University Press

Using single cell analysis of whole blood and intestinal tissue, Oluwabunmi O. Olaloye, Peng Liu, Liza Konnikova (Yale Medicine) and colleagues identify disease-specific immune dysregulation in necrotizing enterocolitis.

Using single-cell analysis of whole blood and intestinal tissue, Olaloye et al. identify a population of inflammatory monocytes that are potentially pathogenic

This study from Anna-Lena Neehus, Anne Puel, Jacinta Bustamante (The Rockefeller University) and colleagues describes a ...
07/15/2021

This study from Anna-Lena Neehus, Anne Puel, Jacinta Bustamante (The Rockefeller University) and colleagues describes a decreased production of reactive oxygen species by phagocytes of PKCδ-deficient patients as a possible mechanism by which inherited human PKCδ deficiency contributes to susceptibility to infectious diseases.

This study from Anna-Lena Neehus, Anne Puel, Jacinta Bustamante (The Rockefeller University) and colleagues describes a decreased production of reactive oxygen species by phagocytes of PKCδ-deficient patients as a possible mechanism by which inherited human PKCδ deficiency contributes to susceptibility to infectious diseases.

Andrea-Hermina Györfi, Alexandru-Emil Matei, Jörg H.W Distler and colleagues (FAU Germany) show that Engrailed 1 (EN1) i...
07/14/2021
Engrailed 1 coordinates cytoskeletal reorganization to induce myofibroblast differentiation | Journal of Experimental Medicine | Rockefeller University Press

Andrea-Hermina Györfi, Alexandru-Emil Matei, Jörg H.W Distler and colleagues (FAU Germany) show that Engrailed 1 (EN1) is a key mediator of TGFβ-induced myofibroblast differentiation and fibrotic tissue remodeling. Mechanistically, EN1 induces a profibrotic gene expression profile by modulating the activity of SP transcription factors to coordinate the microtubule-stress fiber cytoskeletal rearrangements required for fibroblast activation in a ROCK-dependent manner.

This work shows that Engrailed 1 (EN1) is a key mediator of TGFβ-induced myofibroblast differentiation and fibrotic tissue remodeling. Mechanistically, EN1 indu

Duancheng Guo, Yi Zhao, Zeng-jie Yang (Fox Chase Cancer Center) and colleagues show that tumor cells can generate their ...
07/13/2021
Tumor cells generate astrocyte-like cells that contribute to SHH-driven medulloblastoma relapse | Journal of Experimental Medicine | Rockefeller University Press

Duancheng Guo, Yi Zhao, Zeng-jie Yang (Fox Chase Cancer Center) and colleagues show that tumor cells can generate their supporting cells-astrocytes to facilitate tumor recurrence in medulloblastoma.

BMP-Sox9 signaling drives tumor cells to transdifferentiate into astrocytes, which contributes to the recurrence of SHH-driven medulloblastoma, a common type of

To accompany the Lysophospholipid and Related Mediators Conference (Federation of American Societies for Experimental Bi...
07/13/2021
Lipid Mediators in Immunity | Journal of Experimental Medicine | Rockefeller University Press

To accompany the Lysophospholipid and Related Mediators Conference (Federation of American Societies for Experimental Biology - FASEB), JEM is pleased to present a special collection of recent articles that uncover the roles of lysophospholipids & other signaling lipids in immunity, from modulating B cell & T cell function to mediating pathogen recognition.

We hope you enjoy the collection and and encourage your feedback!

Lipid molecules represent major structural elements of the cell as well as fuel reserves. However, lipids are also signaling molecules able to affect immune cell activity and even trigger cell death. In this special collection, we present recent JEM art...

Yu-Wen Cheng, Ze-Bei Zhang, Cheng-Chao Ruan et al. (Shanghai Institute of Hypertension) uncover a new interaction patter...
07/08/2021
PDGF-D activation by macrophage-derived uPA promotes AngII-induced cardiac remodeling in obese mice | Journal of Experimental Medicine | Rockefeller University Press

Yu-Wen Cheng, Ze-Bei Zhang, Cheng-Chao Ruan et al. (Shanghai Institute of Hypertension) uncover a new interaction pattern between macrophage and adipocyte: that macrophage-derived uPA activates adipocyte-secreted PDGF-D, which finally accelerates AngII-induced cardiac remodeling in obese mice. Targeting the uPA/PDGF-D pathway might be a potential therapeutic tool for prevention of hypertensive cardiac injury during obesity.

The authors uncover a new interaction pattern between macrophage and adipocyte: that macrophage-derived uPA activates adipocyte-secreted PDGF-D, which finally a

On the cover of our July issue: the antigen-presenting molecule CD1a (white) binds long chain sphingomyelin (blue), whic...
07/05/2021

On the cover of our July issue: the antigen-presenting molecule CD1a (white) binds long chain sphingomyelin (blue), which protrudes to the CD1a surface and blocks the approach of T cell receptors (orange and pink). This original image was made by Dr. Erica Tandori, who is an artist in residence at Monash University. She has worked together with Marcin Wegrecki and Jamie Rossjohn to generate an image that captures the main message of the paper by Cotton et al. (https://bit.ly/3fvY8vG).
Read JEM July Issue: https://bit.ly/3jou3BG

On the cover of our July issue: the antigen-presenting molecule CD1a (white) binds long chain sphingomyelin (blue), which protrudes to the CD1a surface and blocks the approach of T cell receptors (orange and pink). This original image was made by Dr. Erica Tandori, who is an artist in residence at Monash University. She has worked together with Marcin Wegrecki and Jamie Rossjohn to generate an image that captures the main message of the paper by Cotton et al. (https://bit.ly/3fvY8vG).
Read JEM July Issue: https://bit.ly/3jou3BG

Hiroyuki Hosokawa, Ellen V. Rothenberg (Caltech) and colleagues show that repression of Spi1 encoding PU.1 is crucial fo...
06/28/2021
Stage-specific action of Runx1 and GATA3 controls silencing of PU.1 expression in mouse pro–T cells | Journal of Experimental Medicine | Rockefeller University Press

Hiroyuki Hosokawa, Ellen V. Rothenberg (Caltech) and colleagues show that repression of Spi1 encoding PU.1 is crucial for early T-cell lineage commitment and depends on GATA3 and Runx1. Stage-specific Runx1 and GATA3 binding during commitment identifies a closed intronic site of mouse Spi1 that substantially contributes to Spi1 repression.

Repression of Spi1 encoding PU.1 is crucial for early T cell lineage commitment and depends on GATA3 and Runx1. Stage-specific Runx1 and GATA3 binding during co

Both normal cells and tumors release vesicles replete with proteins, DNA, RNA and other cargo, which mediate cellular cr...
06/28/2021
Extracellular vesicle– and particle-mediated communication shapes innate and adaptive immune responses | Journal of Experimental Medicine | Rockefeller University Press

Both normal cells and tumors release vesicles replete with proteins, DNA, RNA and other cargo, which mediate cellular crosstalk. However, little is known about the cargo and function of immune cell-derived extracellular vesicles. This review from Pelissier Vatter, Matei, Lyden et al. (Weill Cornell Medicine) provides an overview of the roles played by immune cell-secreted vesicles in normal physiology and disease.

While tumor-derived extracellular vesicles and particles (EVPs) are well characterized, little is known about the cargo and function of immune cell–derived EVPs

Kurt B. Pruner and Marion Pepper (University of Washington) provide a timely literature review detailing the critical, h...
06/24/2021
Local memory CD4 T cell niches in respiratory viral infection | Journal of Experimental Medicine | Rockefeller University Press

Kurt B. Pruner and Marion Pepper (University of Washington) provide a timely literature review detailing the critical, heterogeneous functions of lung resident CD4 memory T cells during respiratory viral infection. Implications for vaccine design and protection from heterologous influenza and SARS-CoV-2 reinfection are discussed.

Pruner and Pepper provide a timely literature review detailing the critical, heterogenous functions of lung resident CD4 memory T cells during respiratory viral

This study by Rui Yang, Jean-Laurent Casanova (The Rockefeller University) and colleagues describes the multiple facets ...
06/23/2021
High Th2 cytokine levels and upper airway inflammation in human inherited T-bet deficiency | Journal of Experimental Medicine | Rockefeller University Press

This study by Rui Yang, Jean-Laurent Casanova (The Rockefeller University) and colleagues describes the multiple facets and molecular basis of excessive TH2 cytokine production by CD4+ αβ T lymphocytes as a possible mechanism underlying persistent upper airway inflammation and blood eosinophilia in a patient with inherited complete T-bet deficiency.

This study describes the multiple facets and molecular basis of excessive Th2 cytokine production by CD4+ αβ T lymphocytes as a possible mechanism underlying pe

Whether and how m6A modifications regulate NK cell immunity remain unknown. Shoubao Ma, Jiazhuo Yan, Jianhua Yu (City of...
06/23/2021
The RNA m6A reader YTHDF2 controls NK cell antitumor and antiviral immunity | Journal of Experimental Medicine | Rockefeller University Press

Whether and how m6A modifications regulate NK cell immunity remain unknown. Shoubao Ma, Jiazhuo Yan, Jianhua Yu (City of Hope) and colleagues show that NK cell proliferation, survival, and effector functions are positively controlled by the RNA m6A reader YTHDF2.

Whether and how m6A modifications regulate NK cell immunity remain unknown. Here, Ma et al. show that NK cell proliferation, survival, and effector functions ar

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The Journal of Experimental Medicine (JEM) features peer-reviewed research on immunology, cancer biology, stem cell biology, microbial pathogenesis, vascular biology, and neurobiology. All editorial decisions are made by research-active scientists in conjunction with in-house scientific editors. JEM provides free online access to many article types from the date of publication and to all archival content. Established in 1896, JEM is published by The Rockefeller University Press. For more information, visit http://jem.rupress.org. Follow us on Twitter: https://twitter.com/JExpMed

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