Bioequivalence & Bioavailability International Journal, 28475 Witherspoon Drive, Novi, MI (2026)

Bioequivalence & Bioavailability International Journal (BEBA) is specifically designed to provide researchers around the world in the field of Bioequivalence & Bioavailability.We invites authors to submit their original articles, reviews, opinions,etc.

06/14/2024

Natural Radiance Unveiled: A Comprehensive Review of Herbal Cosmetics and their Transformative Effects

https://medwinpublishers.com/BEBA/natural-radiance-unveiled-a-comprehensive-review-of-herbal-cosmetics-and-their-transformative-effects.pdf

Authors: Dudhat K*

DOI: 10.23880/beba-16000235

Abstract:

The use of herbal cosmetics has gained popularity due to their natural composition and perceived benefits over synthetic products. This comprehensive review explores the transformative effects of herbal cosmetics on skin, hair, nails, and oral hygiene. The benefits of using natural cosmetics include their safety, suitability for all skin types, lack of animal testing, absence of negative side effects, and affordability. Cosmeceuticals, a combination of cosmetics and pharmaceuticals, are also discussed, highlighting their various mechanisms of action and examples of active ingredients. The classification of herbal cosmetics based on dosage form and the body part to be applied on is presented, along with specific examples of herbal ingredients used in skin care, hair care, and oral care products. The study of drugs used in cosmetics is examined, featuring plants such as soapnut, amla, henna, hibiscus, tea, aloe, and liquorice. This review provides valuable insights into the world of herbal cosmetics and their potential in enhancing beauty and well-being.

Keywords: : Herbal Cosmetics; Herbal Drug; Cosmeceuticals; Drugs used in Cosmetics

06/11/2024

Advancements in Antidiabetic Therapy: An extensive study on the use of Polypills to treat type 2 diabetes

https://medwinpublishers.com/BEBA/advancements-in-antidiabetic-therapy-an-extensive-study-on-the-use-of-polypills-to-treat-type-2-diabetes.pdf

Authors: Parimita Kalita*

DOI: 10.23880/beba-16000234

Abstract:

The hallmark of type 2 diabetes (T2DM) is elevated blood glucose levels brought on by insulin resistance or inadequate insulin synthesis. Oral hypoglycaemic medications and insulin therapy are two examples of pharmacological therapies used in conjunction with lifestyle changes like diet and exercise to manage type 2 diabetes. However, because T2DM is a complex disease and requires many drugs to regulate different risk factors, managing the condition can be difficult. Polypills, or cardiovascular fixed-dose combination pills, have the potential to alleviate the pervasive inaccessibility and noncompliance with established medications. Switching from existing individually taken drugs is usually required to begin polypill-based therapy. The impact of polypill treatment across various patterns of previous pharmaceutical regimen is of relevance due to the heterogeneity in usual care. Utilizing a polypill helps streamline drug schedules, lessening patients' burden with pills, and possibly increasing adherence. In type 2 diabetes, when controlling blood pressure, cholesterol, and blood glucose levels frequently necessitates the use of many drugs, this is especially crucial. Recommendations state that those with established cardiovascular disease are probably now receiving aspirin, a statin, and blood pressure (BP)-lowering drugs. It might be reasonable to combine these medications into a cardiovascular polypill for these patients in order to reduce prescription gaps and non-adherence. A sizable portion of individuals suffering from long-term cardiovascular conditions currently use a combination of prescription drugs. Introduce a polypill to high-risk patients to reduce prescription gaps and enhance adherence to recommended therapy.

Keywords: Polypill; Type2 Diabetes; Combination Pills

06/03/2024

Aspirin as an Independent Risk Factor for Hypertension
* (NSAID)
https://medwinpublishers.com/BEBA/aspirin-as-an-independent-risk-factor-for-hypertension.pdf

Authors: Sanyaolu A*

DOI: 10.23880/beba-16000233

Abstract:
Introduction: Hypertension is one of the most commonly occurring diseases throughout the world. Aspirin is the most recommended drug to prevent cardiovascular diseases in high-risk patients. As this may be true, Aspirin has shown to increase the risk of hypertension. The objective of our study is to see the correlation between Aspirin an NSAID and hypertension within the Anguillan population. Methods: This was a cross-sectional study comprising of males and females in Anguilla above the age of 20 years. Our study’s focus was those that took Aspirin as a self-directed medication or as physician-directed for the prevention of cardiovascular disease. The participants were given a survey to fill out. Surveys were formatted to include demographics, medical, family and social history. Consent for surveys was obtained and permission was granted by the ARB (Anguillan Review Board). Comorbidities were evaluated by self-reporting in the medical history. The goal of this study was to understand whether there was any correlation between Aspirin use and the increased risk of hypertension. Results: Primary outcome was significant with the p-value of 0.0008; however, secondary outcome was not statistically significant (p= 0.7) because whether the Aspirin was prescribed by physician or taken as a self-directed medication does not have influence in the mechanism of action of Aspirin. There was no statistical significance in the male gender between the control and the target groups (p= 0.054). Moreover, statistical significance was noted in female gender between the control and the target group (p= 0.004). Conclusion: The results showed that there was significance in the Blood Pressure of patients who were on Aspirin as compared to those who did not take Aspirin indicating that Aspirin plays a role in hypertension.

Keywords: : Hypertension; Aspirin; Nonsteroidal Anti-Inflammatory Drug (NSAID)

05/21/2024

Influence of Open Data Kit Application on Disease Surveillance and Notification

https://medwinpublishers.com/BEBA/influence-of-open-data-kit-application-on-disease-surveillance-and-notification.pdf

Authors: Uchendu IK*

DOI: 10.23880/beba-16000232

Abstract:

This project investigates the influence of Open Data Kit (ODK) on Disease Surveillance and Notification in Osun State, Nigeria.
Descriptive research design was used and 90 respondents were engage through total enumeration sampling technique. Open
Data Kit is an application that is used to capture data with designed template, allows the creation, distribution and filling of
questionnaire on mobile phone or tablet running the Android operating system which has the following discovered influences
on disease surveillance and notification: Facilitates adequate collection of morbidity and mortality data, enhances accurate
processing of morbidity and mortality statistics, facilitates uniformity in data capturing, enables orderliness in data registration
and contact tracing of contagious diseases, facilitates easy design of data collection tools. Descriptive survey research method
was adopted for this study to evaluate the influence of open data kit application on disease surveillance and notification
officer in Osun State. The findings show that a large proportion of DSNO and their assistance were strongly agreed and agreed
that Open Data Kit is an application that is used to capture data with designed template, allows the creation, distribution and
filling of questionnaire on mobile phone or tablet running the Android operating system and Real-time mapping of responses
in Google Maps is possible with the use of Open Data Kit which is similar to what has been found by (Open data kit history,
August 2019). There are positive influences of open data kit application on disease surveillance and notification in Osun State.

Keywords: Open Data Kit; Disease Surveillance and Notification; Morbidity; Mortality; Statistics; Application

05/10/2024

Applications of Artificial Intelligence in Pharmaceutical Research: An Extensive Review

https://medwinpublishers.com/BEBA/applications-of-artificial-intelligence-in-pharmaceutical-research-an-extensive-review.pdf

Authors: Pawar HA† and Nihalani G*

DOI: 10.23880/beba-16000231

Abstract:

Artificial Intelligence (AI) is transforming the pharmaceutical industry, revolutionizing drug discovery, development, and patient care. This comprehensive review explores the diverse applications of AI in the pharmaceutical sector, discussing its advantages, challenges, and future prospects. AI-driven techniques, including machine learning and deep learning, have accelerated drug discovery processes by expediting target identification, virtual screening, and drug repurposing. Predictive analytics optimize clinical trial design, while personalized medicine leverages patient-specific data for precise treatment plans. AI enhances drug formulation and manufacturing, improves pharmacovigilance and drug safety, and supports drug pricing and market access strategies. Despite its potential, challenges such as ethical considerations and data privacy concerns must be addressed. The integration of AI into existing workflows and regulatory compliance remain areas of focus. By overcoming these challenges, AI stands poised to reshape the pharmaceutical industry and pave the way for a more efficient, personalized, and impactful approach to drug development and healthcare

Keywords: Artificial Intelligence; Drug Development; Pharmaceutical Industry; Drug Discovery; Drug Repurposing

04/30/2024

Transferosomes: A Versatile and Ultradeformable Approach for Targeted Delivery of Anticancer Drugs in the Treatment of Diverse Cancers
# Transferosomes
https://medwinpublishers.com/BEBA/transferosomes-a-versatile-and-ultradeformable-approach-for-targeted-delivery-of-anticancer-drugs-in-the-treatment-of-diverse-cancers.pdf

Authors: Ali S*

DOI: 10.23880/beba-16000228

Abstract:

Nanoparticles, particularly transferosomes, have emerged as promising drug delivery systems in the field of cancer therapy.
With their unique properties and high adaptability, transferosomes have shown great potential in improving the targeted
delivery of chemotherapeutic drugs, including through transdermal applications. This article provides a comprehensive review
of the advancements and applications of transferosomes in cancer therapy and gene delivery; by highlighting the advantages
of nanoparticles in cancer treatment, such as their ability to passively target tumors through the enhanced permeation and
retention effect. It then focuses on the composition, preparation methods, and advantages of transferosomes over conventional liposomes, including their high stability, high carrier capacity, and ability to deliver drugs to deeper skin layers. The article further explores the applications of transferosomes in cancer therapy. It presents studies that demonstrate the effectiveness of transfersomes in delivering chemotherapeutic drugs, such as doxorubicin hydrochloride, carvedilol, and various natural compounds, for enhanced cancer treatment. Furthermore, it also discusses the use of transfersomes as adjuvant treatments to reduce the risk of cancer recurrence. Overall, this comprehensive review provides valuable insights into the advancements and applications of transferosomes in cancer therapy and gene delivery. The findings emphasize the potential of transferosomes as effective drug carriers, offering improved treatment outcomes and reduced side effect in the fight against cancer

Keywords: Transferosomes; Targeted Therapy; Nanoparticles; Advancements; Cancer

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