18/07/2026
I truly wish no one needed medications, but that’s not a reality.
One class of medications, Statins, are probably the most hated medication on the market despite how important they are to reducing the risk of heart disease. But I get it. Some people have crazy muscle aches and other sides effects, and some patients won’t even try them just based on the bad reputation. That’s why people started flocking to PCSK9 inhibitors, but the problem was that they are super expensive AND they have been injection only.
In comes Enlicitide. FDA just approved it as the first ORAL PCSK9i, which is a game changer for how we can treat high cholesterol and other lipid markers. In combination with diet and exercise, the study showed that high risk people significantly reduced their LDL, Non-HDL, Apolipoprotein B, and Lipoprotein (a) levels by 6 months.
Some people will always refuse statins, some people would take them but just can’t tolerate the side effects: this new medication gives a great alternative option that is more effective than the oral alternatives we have now.
The outcome data isn’t out yet, but I’m expecting it to be very similar to the injectable PCSK9is , which have been excellent.
Study:
A Placebo-Controlled Trial of the Oral PCSK9 Inhibitor Enlicitide. The New England Journal of Medicine. February 5, 2026.