Science Translational Medicine

07/07/2025

Why do wounds in the mouth heal without scars?

New work shows that oral fibroblasts suppress fibrosis through the proteins AXL and GAS6, and finds stimulating AXL recapitulates these benefits in facial skin wounds in mice.

📄: https://scim.ag/3I9j2CR

04/07/2025

A new genome-wide CRISPR screen identifies BACE1 as a driver of lung cancer metastasis to the brain, suggesting that BACE1 inhibitors could be repurposed to prevent brain metastasis in non-small cell lung cancer.

📄: https://scim.ag/4lcdeqT

Beta-secretase 1 promotes the spread of lung cancers to the brain through epidermal growth factor receptor signaling.

03/07/2025

A modeling analysis of patients with clade I mpox in the Democratic Republic of the Congo identifies stratification groups and early markers that predict lesion length and severity, which may inform research into tailored therapies and control measures for outbreaks.

📄: https://scim.ag/44c8E5W

02/07/2025

A new classification system may predict outcomes in patients infected with severe mpox, scientists uncover the secret to rapid and scarless wound healing in the mouth, and more in the new issue of Science Translational Medicine.

https://scim.ag/4lxuI0x

01/07/2025

Older patients with lupus display a marked drop in the expression of interferon stimulated genes and shifts in methylation epigenetic patterns, according to a clinical study that may explain why the condition becomes milder with age.

📄: https://scim.ag/4nGIgsL

30/06/2025

Why does Roux-en-Y gastric bypass reduce the risk of colorectal cancer?

New work in mice and patients shows that the procedure diverts bile acids and shifts the bile acid profile in serum, leading to antitumor and antimetastatic effects.

📄: https://scim.ag/4nfDphI

27/06/2025

A new delayed delivery platform for malaria vaccines based on polymer microcapsules can deliver both prime and booster doses of the R21 vaccine in a single shot, leading to strong antibody responses in mice.

📄: https://scim.ag/4khrqh9

25/06/2025

Scientists decrypt why gastric bypass surgery can reduce the risk of colorectal cancer, a microcapsule platform for malaria vaccines yields strong immunity in mice with a single dose, and more this week in Science Translational Medicine.

https://scim.ag/3Gdd9DZ

23/06/2025

A new treatment platform for glioblastoma uses macrophages loaded with ferritin-drug conjugates to safely target tumor cells and reprogram the immunosuppressive tumor microenvironment, leading to tumor regression and longer survival times in mice.

📄: https://scim.ag/46752mV

20/06/2025

Leveraging synthetic biology techniques, researchers engineer a strain of Salmonella that can stimulate mature tertiary lymphoid structures to augment antitumor immunity and shrink colorectal cancer tumors in mice.

📄: https://scim.ag/4nb4eUj

18/06/2025

Synthetic bacteria reinvigorate immune cells to shrink colorectal cancer tumors in mice, a macrophage therapy can deliver powerful anticancer drugs to glioblastoma tumors, and more this week in Science Translational Medicine.

https://scim.ag/43Q8aCg

17/06/2025

mRNA vaccines for SARS-CoV-2 that use nonstabilized spike protein can still induce neutralizing antibodies against both variants of concern and related coronaviruses, show new experiments involving mice and macaques.

📄: https://scim.ag/3FRDvLL