Retina

Retina Published monthly, RETINA® is the leading international peer-reviewed journal for anyone connected to vitreoretinal disorders.

RETINA® offers issue specific podcasts & a blog . RETINA® focuses exclusively on the growing specialty of vitreoretinal disorders. The Journal provides current information on diagnostic and therapeutic techniques. Its highly specialized and informative, peer-reviewed articles are easily applicable to clinical practice. In addition to regular reports from clinical and basic science i

nvestigators, RETINA® publishes special features including periodic review articles on pertinent topics, special articles dealing with surgical and other therapeutic techniques, and abstract cards. Issues are abundantly illustrated in vivid full color.

20/11/2025

TREATMENT OF CHOROIDAL METASTASIS WITH COMBINED PHOTODYNAMIC THERAPY AND BEVACIZUMAB AND COMPARISON WITH PHOTODYNAMIC THERAPY ALONE
Aykut, Aslan MD; Sarigul Sezenoz, Almila MD; Beser, Buse Guneri MD; Juntipwong, Sarinee MD; Alizade, Mehriban MD; Demirci, Hakan MD
Retina 45(11):p 2131-2141, November 2025
Combined photodynamic therapy and intravitreal bevacizumab treatment showed superior outcomes compared with photodynamic therapy alone for choroidal metastasis, with better visual acuity, higher fluid resolution, and greater tumor control rates at both early (6-week) and long-term follow-up.
https://ow.ly/Fm8k50XurWV

19/11/2025

INVESTIGATING CORRELATIONS BETWEEN MENTAL DISORDERS AND FUNDUS IMAGING DATA USING DEEP LEARNING
A Study From the UK Biobank
D**g, Jiadi PhD; Wang, Lisheng PhD; Zheng, Zhi MD; Xu, Xun MD; Qian, Tianwei MD
Retina 45(11):p 2119-2130, November 2025
This study uses the multimodality deep learning method on fundus imaging data to identify mental disorders.
https://ow.ly/kgnk50XurJB

14/11/2025

INTERNAL LIMITING MEMBRANE FLAP REPOSITION FACILITATES PRESERVATION OF THE INNER RETINA IN SURGICALLY CLOSED FULL-THICKNESS MACULAR HOLES
Darwisch, Warda MD; Weber, Dominik MSc; Wieczorek, Katarzyna MD; Trouvain, André M. MD; Boden, Karl MD; Roberts, Philipp K. MD; Szurman, Peter MD, PhD; Stanzel, Boris V. MD
Retina 45(11):p 2109-2118, November 2025
Macular hole surgery with internal limiting membrane peeling leads to retinal nerve fiber layer, ganglion cell layer, and inner plexiform layer thinning. Our study suggests superiority in preserving the inner retina with internal limiting membrane flap repositioning versus internal limiting membrane peeling.
https://ow.ly/BU9650XpKgs

EVALUATION OF FELLOW EYES IN IDIOPATHIC MACULAR HOLE CASES WITH OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHYUlusoy, Mahmut O...
14/11/2025

EVALUATION OF FELLOW EYES IN IDIOPATHIC MACULAR HOLE CASES WITH OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY
Ulusoy, Mahmut Oğuz MD; Sarıyeva-İsmayilov, Ayna MD; Can, Ramazan Burak MD
Retina 45(11):p 2104-2108, November 2025
The authors evaluated the fellow eyes of patients with idiopathic macular hole using optical coherence tomography angiography and observed microvascular changes in these eyes without any ophthalmological findings or clinical complaints.
https://ow.ly/k23q50XpK9Y

13/11/2025

OPTIC DISK PIT MACULOPATHY–LIKE RETINOSCHISIS WITHOUT A CLINICALLY VISIBLE OPTIC DISK PIT
Kim, Yeji MD; Ribarich, Nicolò MD; Querques, Giuseppe MD, PhD; Park, D**g Ho MD, PhD; Kim, Yong Joon MD, PhD; Choi, Eun Young MD; Byeon, Suk Ho MD, PhD; Kim, Sung Soo MD, PhD; Lee, Christopher Seungkyu MD, PhD
Retina 45(11):p 2096-2103, November 2025
Lamina cribrosa defects were observed in the eyes with optic disk pit maculopathy–like retinoschisis without a clinically visible optic disk pit. Vitrectomy may be effective for retinoschisis resolution in these eyes.
https://ow.ly/AVXS50XpK3v

REAL-WORLD EFFICACY OF INTRAVITREAL METHOTREXATE FOR MANAGING PROLIFERATIVE VITREORETINOPATHY IN RECURRENT RHEGMATOGENOU...
13/11/2025

REAL-WORLD EFFICACY OF INTRAVITREAL METHOTREXATE FOR MANAGING PROLIFERATIVE VITREORETINOPATHY IN RECURRENT RHEGMATOGENOUS RETINAL DETACHMENT
Yun, Justin S. BA; Fortes, Blake H. MD; Yamamoto, Marcus H. BA; Au, Adrian C. MD, PhD; Prasad, Pradeep S. MD, MBA; McCannel, Colin A. MD; Tsui, Irena MD; McCannel, Tara A. MD, PhD; Hosseini, Hamid MD; Giral, David Lozano MD, MSc; Barzelay-Wollman, Aya MD, PhD; Pettenkofer, Moritz S. MD; Hou, Kirk K. MD
Retina 45(11):p 2086-2095, November 2025
To date, this is the largest real-world study on serial intravitreal methotrexate injections for complicated proliferative vitreoretinopathy, reporting no significant differences in outcomes between the patients treated with or without the modified GUARD protocol. The overall 75.6% retinal reattachment rate was better than previously reported rates without methotrexate for this population.
https://ow.ly/ZF1050XpJP6

OPEN ACCESS ArticleCURRENT STATUS AND DETERMINANTS OF POSTOPERATIVE VISUAL FUNCTION–RELATED QUALITY OF LIFE IN PATIENTS ...
13/11/2025

OPEN ACCESS Article
CURRENT STATUS AND DETERMINANTS OF POSTOPERATIVE VISUAL FUNCTION–RELATED QUALITY OF LIFE IN PATIENTS WITH RETINAL DETACHMENT
Zhao, Xiaojun BA; Fan, Chenjing BA; Chen, Huifang BA
Retina 45(11):p 2078-2085, November 2025
This study evaluated postoperative vision-related quality of life (VRQoL) in 120 patients with retinal detachment using NEI-VFQ-25. Key factors influencing VRQoL included gender, education, income, surgical method, preoperative delay, and visual acuity. Targeted interventions addressing these factors are critical to improving patient outcomes in resource-limited settings.
https://ow.ly/za7y50XpJEQ

12/11/2025

RETINAL DISPLACEMENT AFTER RHEGMATOGENOUS RETINAL DETACHMENT REPAIR
Diafas, Asterios MSc; Gray, Sandra BSN; Heimann, Heinrich PhD; Zheng, Yalin PhD; Groenewald, Carl MD; Pearce, Ian PhD; Tan, Shi Zhuan MD; Chua, Paul Y. MD; Sandinha, Teresa MD; Androudi, Sofia PhD; Haidich, Anna-Bettina PhD; Hussain, Rumana N. PhD
Retina 45(11):p 2066-2077, November 2025
This prospective nonrandomized study showed that scleral buckling was associated with less retinal displacement and metamorphopsia than pars plana vitrectomy in a real-world setting. Metamorphopsia is a vital determinant when assessing retinal detachment repair success. Scleral buckling should be considered more often for primary rhegmatogenous retinal detachments.
https://ow.ly/nOku50XpJpP

OPEN ACCESS ArticleCLINICAL OUTCOMES OF SCLERAL BUCKLING IN ELDERLY PATIENTS WITH RHEGMATOGENOUS RETINAL DETACHMENTA Ret...
11/11/2025

OPEN ACCESS Article
CLINICAL OUTCOMES OF SCLERAL BUCKLING IN ELDERLY PATIENTS WITH RHEGMATOGENOUS RETINAL DETACHMENT
A Retrospective Cohort Study
Zhu, Xinlei MD; Xu, Mengying MD; Chen, Nan MD, PhD; Lun, Lingxiao MD; Wan, Lei MD, PhD
Retina 45(11):p 2057-2065, November 2025
With proper surgical indications, scleral buckling achieves high anatomical and visual success in elderly rhegmatogenous retinal detachment with fewer complications. Key outcome predictors include initial visual acuity, macular attachment status, and proliferative vitreoretinopathy.
https://ow.ly/Mbnk50XpJ0G

11/11/2025

UNILATERAL RETICULAR PSEUDODRUSEN
Clinical Features and Potential Protective Factors
Ferro Desideri, Lorenzo MD; Anguita, Rodrigo MD; Sacconi, Riccardo MD, PhD; Beretta, Federico MD; Corradetti, Giulia MD; Feo, Alessandro MD; Dobovsek, Darja MD; Parravano, Mariacristina MD; Capuano, Vittorio MD; Souied, Eric MD, PhD; Sarraf, David MD; Zinkernagel, Martin MD, PhD; Querques, Giuseppe MD, PhD
Retina 45(11):p 2049-2056, November 2025
This study explores the clinical features of unilateral reticular pseudodrusen in age-related macular degeneration, emphasizing the role of choroidal vascular impairment. It highlights potential protective factors, including vascular retinal conditions such as retinal vein occlusion or macroaneurysms, which may enhance choroidal perfusion and mitigate reticular pseudodrusen formation, offering insights into age-related macular degeneration's asymmetric presentation.
https://ow.ly/y8Wz50XpIt9

COMPARISON OF OCULAR BLOOD FLOW CHANGES AT 30 MINUTES AFTER INTRAVITREAL INJECTION OF FARICIMAB, BROLUCIZUMAB, AND AFLIB...
11/11/2025

COMPARISON OF OCULAR BLOOD FLOW CHANGES AT 30 MINUTES AFTER INTRAVITREAL INJECTION OF FARICIMAB, BROLUCIZUMAB, AND AFLIBERCEPT 2 mg FOR NEOVASCULAR AGE-RELATED MACULAR
Kato, Nobuhiro MD; Haruta, Masatoshi MD, PhD; Matsuo, Yu MD, PhD; Dake, Shotaro MD; Kojima, Yoshiki MD; Arai, Rikki MD; Sato, Kazunori MD; Furushima, Kei MD, PhD; Yoshida, Shigeo MD, PhD
Retina 45(11):p 2042-2048, November 2025
We investigated ocular blood flow changes 30 minutes after injection of faricimab, brolucizumab, and aflibercept 2 mg in patients with age-related macular degeneration. Faricimab, brolucizumab, and aflibercept significantly decreased ocular blood flow. Brolucizumab showed a significantly greater reduction in choroidal blood flow than aflibercept 2 mg.
https://ow.ly/Y8uy50Xo7OX

PACHYCHOROID NEITHER PROMOTES NOR INHIBITS THE FORMATION OF FIBROSIS IN MACULAR NEOVASCULARIZATIONOka, Akari MD; Murakam...
10/11/2025

PACHYCHOROID NEITHER PROMOTES NOR INHIBITS THE FORMATION OF FIBROSIS IN MACULAR NEOVASCULARIZATION
Oka, Akari MD; Murakami, Ryuya MD; Machida, Akira MD, PhD; Hirata, Yuki MD, PhD; Miyagi, Sugao MD, PhD; Kurihara, Junko MD; Oishi, Akio MD, PhD
Retina 45(11):p 2035-2041, November 2025
This study investigates the impact of the pachychoroid phenotype on subretinal fibrosis development in macular neovascularization treated with antivascular endothelial growth factor therapy. Findings show that pachychoroid neither promotes nor prevents fibrosis, while subretinal hemorrhage, type 2 macular neovascularization, and taller pigment epithelium detachment are significant risk factors for fibrosis formation.
https://ow.ly/C9ZE50Xo7oB

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