Embryoman

Embryoman πŸ”¬ Former embryologist sharing IVF research in simple terms on Remembryo.com
🌈 All IVF journeys welcome. Hateful comments get deleted/blocked.

How many euploid embryos do you need to have a baby?Large studies of patients transferring euploid embryos one at a time...
03/09/2026

How many euploid embryos do you need to have a baby?

Large studies of patients transferring euploid embryos one at a time suggest that the overall chance of having at least one live birth is about:

1 euploid: 63–65%
2 euploids: 83–84%
3 euploids: 92–93%
4 euploids: 96%
5 euploids: 98%

This helps explain the common rule of thumb that it takes about three euploid embryos per baby. But that's not exactly what the evidence shows.

Many patients won't need three. About 63–65% had a live birth after their first transfer, and these numbers are population averages, not predictions for an individual patient.

These studies estimated the chance of at least one live birth across groups of patients, but they can't predict how many embryos an individual patient will actually need. Some patients will have a live birth after their first transfer, while others may need several.

And if the first euploid transfer fails, the next embryo can still have a good chance of success. In the largest study, live birth rates remained around 50–58% per transfer from the second through fifth attempts.

Euploid embryos aren't all equivalent either. Developmental day, embryo grade, age, and other patient and clinic factors may affect the chance of success.

I've put together a new Evidence Guide that includes the evidence behind these estimates, what happens after failed transfers, factors that may change success, important evidence gaps, and interactive calculators for subscribers.

βœ… Check out more details on Remembryo, link is in the comments.

βœ‰οΈ Like this post? Get a free weekly summary of the latest IVF research (link in the comments).

𝑡𝒐𝒕𝒆 𝒕𝒉𝒂𝒕 π’•π’‰π’Šπ’” 𝒑𝒐𝒔𝒕 π’Šπ’” π’‡π’“π’π’Ž π’Žπ’š π’‘π’–π’ƒπ’π’Šπ’„-π’‡π’‚π’„π’Šπ’π’ˆ π’‘π’‚π’ˆπ’†. 𝑻𝒉𝒆 π’”π’‚π’Žπ’† 𝒑𝒐𝒔𝒕 𝒄𝒂𝒏 𝒃𝒆 𝒇𝒐𝒖𝒏𝒅 π’Šπ’ π’Žπ’š π’‘π’“π’Šπ’—π’‚π’•π’† π’ˆπ’“π’π’–π’‘, π’˜π’‰π’Šπ’„π’‰ 𝑰'𝒍𝒍 π’π’Šπ’π’Œ π’Šπ’ 𝒕𝒉𝒆 π’„π’π’Žπ’Žπ’†π’π’•π’”.

Many people going through IVF have issues with poor sleep, anxiety, or depression, but it's not clear if this has any af...
31/08/2026

Many people going through IVF have issues with poor sleep, anxiety, or depression, but it's not clear if this has any affect on the chance of success.

In a new study, Wang et al. (2026) evaluated 15,642 women before their first IVF or ICSI cycle using questionnaires on sleep quality, anxiety, depression, and physical symptoms.

Among the 11,986 women who went on to have an embryo transfer, women with better subjective sleep quality had a 2.6% higher relative chance of achieving a clinical pregnancy after adjusting for other factors. Note that this is a relative increase, not an absolute one. For example, if the chance of pregnancy was 50%, a 2.6% relative increase would raise it to about 51.3%, not 52.6%.

Anxiety, depression, and physical symptoms were not significantly associated with success rates.

The researchers also found that women who reported using sleep medication had a lower risk of late miscarriage. However, this was based on just three late miscarriages in sleep medication users, so it could have simply been due to chance.

This was an observational study, so it can't show that improving sleep will improve IVF outcomes. However, it adds to evidence that sleep may be one factor worth studying further during fertility treatment.

βœ… This post is a quick look at one study, rather than a full breakdown on Remembryo. Link to the study is in the comments.

βœ‰οΈ Like this post? Get a free weekly summary of the latest IVF research (link in the comments).

𝑡𝒐𝒕𝒆 𝒕𝒉𝒂𝒕 π’•π’‰π’Šπ’” 𝒑𝒐𝒔𝒕 π’Šπ’” π’‡π’“π’π’Ž π’Žπ’š π’‘π’–π’ƒπ’π’Šπ’„-π’‡π’‚π’„π’Šπ’π’ˆ π’‘π’‚π’ˆπ’†. 𝑻𝒉𝒆 π’”π’‚π’Žπ’† 𝒑𝒐𝒔𝒕 𝒄𝒂𝒏 𝒃𝒆 𝒇𝒐𝒖𝒏𝒅 π’Šπ’ π’Žπ’š π’‘π’“π’Šπ’—π’‚π’•π’† π’ˆπ’“π’π’–π’‘, π’˜π’‰π’Šπ’„π’‰ 𝑰'𝒍𝒍 π’π’Šπ’π’Œ π’Šπ’ 𝒕𝒉𝒆 π’„π’π’Žπ’Žπ’†π’π’•π’”.

(Advertisement by IVF Media Ltd.)Check out the IVF Abroad - Patient's Guide 2026, showcasing the best countries for IVF ...
31/08/2026

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Check out the IVF Abroad - Patient's Guide 2026, showcasing the best countries for IVF treatment abroad! With this guide you can check clinic popularity, success rates, IVF treatment costs and legislation. The guide is comprehensive and includes 105 pages with 11 of the most popular countries, without ads.

Link in the comments.

Even when they were euploid, day 7 blastocysts had lower live birth rates than day 5 or day 6 blastocysts, but they stil...
27/08/2026

Even when they were euploid, day 7 blastocysts had lower live birth rates than day 5 or day 6 blastocysts, but they still had meaningful potential for success.

Day 7 blastocysts develop more slowly, and not all IVF labs routinely culture embryos to day 7. Extending culture to day 7 may allow some additional embryos to reach the blastocyst stage. Firmin et al. (2026) combined 17 studies to examine how these embryos perform compared with day 5 and day 6 blastocysts.

For untested blastocysts, live birth rates were 17% for day 7, compared with 44% for day 5 and 34% for day 6. Clinical pregnancy rates were also lower.

There was still a difference after PGT-A. Among euploid blastocysts, live birth rates were about 23% for day 7, 59% for day 5, and 45% for day 6. Day 7 blastocysts were also less likely to be euploid.

Miscarriage was also higher for day 7 than day 5 blastocysts. However, there was no significant difference in miscarriage between day 7 and day 6 blastocysts.

This research shows that day 7 blastocysts have potential, and the authors highlight their value for patients with few or no other embryos available, writing that they deserve consideration β€œrather than being dismissed outright.”

βœ… Check out more details on Remembryo, link is in the comments.

βœ‰οΈ Like this post? Get a free weekly summary of the latest IVF research (link in the comments).

𝑡𝒐𝒕𝒆 𝒕𝒉𝒂𝒕 π’•π’‰π’Šπ’” 𝒑𝒐𝒔𝒕 π’Šπ’” π’‡π’“π’π’Ž π’Žπ’š π’‘π’–π’ƒπ’π’Šπ’„-π’‡π’‚π’„π’Šπ’π’ˆ π’‘π’‚π’ˆπ’†. 𝑻𝒉𝒆 π’”π’‚π’Žπ’† 𝒑𝒐𝒔𝒕 𝒄𝒂𝒏 𝒃𝒆 𝒇𝒐𝒖𝒏𝒅 π’Šπ’ π’Žπ’š π’‘π’“π’Šπ’—π’‚π’•π’† π’ˆπ’“π’π’–π’‘, π’˜π’‰π’Šπ’„π’‰ 𝑰'𝒍𝒍 π’π’Šπ’π’Œ π’Šπ’ 𝒕𝒉𝒆 π’„π’π’Žπ’Žπ’†π’π’•π’”.

The Uterine Wall of Fame (UWOF) is a collection of real IVF success stories from people with difficult fertility journey...
26/08/2026

The Uterine Wall of Fame (UWOF) is a collection of real IVF success stories from people with difficult fertility journeys -- low-grade embryos, repeated failures, low AMH, mosaic results, and more.

UWOF #40 is one of those stories. Michelle conceived after 7.5 years, 8 egg retrievals, and 11 embryo transfers when a Day 5 4BC complex low-level mosaic embryo finally implanted. She was 17 weeks pregnant with a baby boy when she shared her story.

βœ… Visit the UWOF to read this story and others like it (link in the comments, free to access & no subscription required).

πŸ’Œ Have a story of your own? Can be anonymous or named -- link to the form is in the comments.

⚠️ These are personal stories, not medical advice or scientific evidence. A success story isn't proof of what made the difference. Always discuss treatment decisions with your fertility specialist.

𝑡𝒐𝒕𝒆 𝒕𝒉𝒂𝒕 π’•π’‰π’Šπ’” 𝒑𝒐𝒔𝒕 π’Šπ’” π’‡π’“π’π’Ž π’Žπ’š π’‘π’–π’ƒπ’π’Šπ’„-π’‡π’‚π’„π’Šπ’π’ˆ π’‘π’‚π’ˆπ’†. 𝑻𝒉𝒆 π’”π’‚π’Žπ’† 𝒑𝒐𝒔𝒕 𝒄𝒂𝒏 𝒃𝒆 𝒇𝒐𝒖𝒏𝒅 π’Šπ’ π’Žπ’š π’‘π’“π’Šπ’—π’‚π’•π’† π’ˆπ’“π’π’–π’‘, π’˜π’‰π’Šπ’„π’‰ 𝑰'𝒍𝒍 π’π’Šπ’π’Œ π’Šπ’ 𝒕𝒉𝒆 π’„π’π’Žπ’Žπ’†π’π’•π’”.

Correction: They started IVF in 2021, but had been trying for 7.5 years in total.

Childhood experiences can affect long-term health, but researchers are still learning whether they can also influence fe...
24/08/2026

Childhood experiences can affect long-term health, but researchers are still learning whether they can also influence fertility.

In a new study, Bromark et al. (2026) analyzed data from more than 22,000 women in Norway. Women reporting a difficult childhood had 35% higher odds of infertility (about 20% vs 16%), along with higher odds of preterm birth and having a baby born small for gestational age.

Childhood adversity included experiences such as parental divorce or death, growing up in a dysfunctional family, lack of support from a trusted adult, abuse, bullying, or struggling with bad childhood memories.

The authors shared several possible explanations for these results. Childhood adversity may lead to long-term stress that affects reproductive hormone regulation, or it may influence factors like smoking, body weight, education, and socioeconomic status, which can also affect fertility.

βœ… This post is a quick look at one study, rather than a full breakdown on Remembryo. Link to the study is in the comments.

βœ‰οΈ Like this post? Get a free weekly summary of the latest IVF research (link in the comments).

𝑡𝒐𝒕𝒆 𝒕𝒉𝒂𝒕 π’•π’‰π’Šπ’” 𝒑𝒐𝒔𝒕 π’Šπ’” π’‡π’“π’π’Ž π’Žπ’š π’‘π’–π’ƒπ’π’Šπ’„-π’‡π’‚π’„π’Šπ’π’ˆ π’‘π’‚π’ˆπ’†. 𝑻𝒉𝒆 π’”π’‚π’Žπ’† 𝒑𝒐𝒔𝒕 𝒄𝒂𝒏 𝒃𝒆 𝒇𝒐𝒖𝒏𝒅 π’Šπ’ π’Žπ’š π’‘π’“π’Šπ’—π’‚π’•π’† π’ˆπ’“π’π’–π’‘, π’˜π’‰π’Šπ’„π’‰ 𝑰'𝒍𝒍 π’π’Šπ’π’Œ π’Šπ’ 𝒕𝒉𝒆 π’„π’π’Žπ’Žπ’†π’π’•π’”.

Most children conceived through IVF appear to have similar long-term health to those conceived without fertility treatme...
13/08/2026

Most children conceived through IVF appear to have similar long-term health to those conceived without fertility treatment.

Many people worry about whether IVF could affect their child's health later in life. To help answer that question, two large reviews by Le et al. (2026) and Firmin et al. (2026) summarized nearly 150 studies examining the long-term health of children conceived through IVF and ICSI.

Overall, the evidence found:

β€’ Most birth defects and cardiovascular and metabolic outcomes were similar after IVF, although a few differences were reported.
β€’ Brain development, growth, asthma, diabetes, and cancer were generally similar.
β€’ Children conceived through ICSI had similar long-term health to those conceived through conventional IVF, with only some reported differences.
β€’ PGT wasn't associated with differences in children's growth, blood pressure, or metabolic health, but longer-term data are still needed.
β€’ Fresh and frozen embryo transfers differed in birth weight.

One important challenge is separating the effects of IVF itself from the effects of the parents' underlying infertility. Some of the reported differences may be related to infertility itself rather than the fertility treatment, but it's still not clear how much each contributes.

Overall, the evidence is reassuring. Importantly, most of the conditions studied were rare, affecting fewer than 1% of children. This means that even when an increased risk was found, the actual increase in the chance of developing the condition was very small.

βœ… Check out more details on Remembryo, link is in the comments.

βœ‰οΈ Like this post? Get a free weekly summary of the latest IVF research (link in the comments).

𝑡𝒐𝒕𝒆 𝒕𝒉𝒂𝒕 π’•π’‰π’Šπ’” 𝒑𝒐𝒔𝒕 π’Šπ’” π’‡π’“π’π’Ž π’Žπ’š π’‘π’–π’ƒπ’π’Šπ’„-π’‡π’‚π’„π’Šπ’π’ˆ π’‘π’‚π’ˆπ’†. 𝑻𝒉𝒆 π’”π’‚π’Žπ’† 𝒑𝒐𝒔𝒕 𝒄𝒂𝒏 𝒃𝒆 𝒇𝒐𝒖𝒏𝒅 π’Šπ’ π’Žπ’š π’‘π’“π’Šπ’—π’‚π’•π’† π’ˆπ’“π’π’–π’‘, π’˜π’‰π’Šπ’„π’‰ 𝑰'𝒍𝒍 π’π’Šπ’π’Œ π’Šπ’ 𝒕𝒉𝒆 π’„π’π’Žπ’Žπ’†π’π’•π’”.

The embryo is the biggest factor in whether implantation succeeds, but even after transferring a euploid embryo, many ot...
11/08/2026

The embryo is the biggest factor in whether implantation succeeds, but even after transferring a euploid embryo, many other factors can influence the chances of pregnancy.

Some of these include:

β€’ Endometrial receptivity: The uterine lining must be ready to receive the embryo during a short window of implantation.

β€’ The immune system: Implantation requires a carefully balanced immune response. In some patients, abnormal immune function may interfere with implantation.

β€’ Endometriosis and adenomyosis: These conditions can alter the uterine environment through inflammation, hormone signaling, and changes in uterine function.

β€’ Structural abnormalities: Fibroids, polyps, adhesions, hydrosalpinx, and uterine anomalies can reduce implantation by disrupting the uterine cavity or affecting endometrial function.

β€’ Endometritis: Infection or chronic inflammation of the endometrium can reduce implantation and increase the risk of miscarriage.

β€’ The microbiome: Changes in the bacteria living in the reproductive tract may also affect implantation, although the evidence is still evolving.

β€’ Lifestyle and metabolic health: Smoking, obesity, insulin resistance, and other health factors may reduce the chances of a successful pregnancy.

β€’ Clinical and lab factors: Embryo transfer technique and IVF laboratory performance can also influence outcomes.

Still, the exact reason a transfer failed often remains unknown. Implantation is one of the most complex processes in human reproduction, and researchers are still working to understand why some embryos implant while others don't.

βœ… This post covers the basics. The full article on Remembryo goes into more detail, link is in the comments.

βœ‰οΈ Like this post? Sign up for my free Friday newsletter to stay updated on the latest IVF research (link in the comments).

𝑡𝒐𝒕𝒆 𝒕𝒉𝒂𝒕 π’•π’‰π’Šπ’” 𝒑𝒐𝒔𝒕 π’Šπ’” π’‡π’“π’π’Ž π’Žπ’š π’‘π’–π’ƒπ’π’Šπ’„-π’‡π’‚π’„π’Šπ’π’ˆ π’‘π’‚π’ˆπ’†. 𝑻𝒉𝒆 π’”π’‚π’Žπ’† 𝒑𝒐𝒔𝒕 𝒄𝒂𝒏 𝒃𝒆 𝒇𝒐𝒖𝒏𝒅 π’Šπ’ π’Žπ’š π’‘π’“π’Šπ’—π’‚π’•π’† π’ˆπ’“π’π’–π’‘, π’˜π’‰π’Šπ’„π’‰ 𝑰'𝒍𝒍 π’π’Šπ’π’Œ π’Šπ’ 𝒕𝒉𝒆 π’„π’π’Žπ’Žπ’†π’π’•π’”.

After egg retrieval, some eggs are still immature and are often discarded.Rescue in vitro maturation (IVM) is a techniqu...
10/08/2026

After egg retrieval, some eggs are still immature and are often discarded.

Rescue in vitro maturation (IVM) is a technique where embryologists culture these immature eggs in the lab, often overnight, to give them time to mature before insemination.

In a new study, Cimadomo et al. (2026) performed rescue IVM on the most immature type of egg, called germinal vesicle (GV) oocytes.

Overall, 53.7% of GV eggs matured, but they were less likely to reach the blastocyst stage than eggs that were already mature when collected. However, blastocysts that did develop were just as likely to be euploid, and rescue IVM provided at least one additional euploid embryo in 11 of 47 patients. Overall, this contributed to a 20% relative increase in cumulative live birth rate.

This was a small retrospective study of patients with unexpectedly poor egg maturation. While larger studies are still needed, the results suggest that rescue IVM may provide another opportunity to obtain a transferable embryo instead of discarding these immature eggs.

βœ… This post is a quick look at one study, rather than a full breakdown on Remembryo. Link to the study is in the comments.

βœ‰οΈ Like this post? Get a free weekly summary of the latest IVF research (link in the comments).

𝑡𝒐𝒕𝒆 𝒕𝒉𝒂𝒕 π’•π’‰π’Šπ’” 𝒑𝒐𝒔𝒕 π’Šπ’” π’‡π’“π’π’Ž π’Žπ’š π’‘π’–π’ƒπ’π’Šπ’„-π’‡π’‚π’„π’Šπ’π’ˆ π’‘π’‚π’ˆπ’†. 𝑻𝒉𝒆 π’”π’‚π’Žπ’† 𝒑𝒐𝒔𝒕 𝒄𝒂𝒏 𝒃𝒆 𝒇𝒐𝒖𝒏𝒅 π’Šπ’ π’Žπ’š π’‘π’“π’Šπ’—π’‚π’•π’† π’ˆπ’“π’π’–π’‘, π’˜π’‰π’Šπ’„π’‰ 𝑰'𝒍𝒍 π’π’Šπ’π’Œ π’Šπ’ 𝒕𝒉𝒆 π’„π’π’Žπ’Žπ’†π’π’•π’”.

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