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Neural Regeneration Research (NRR) aims to duly report basic and clinical research in the field of neuroregeneration. 2023 JCR Impact Factor: 5.9, Q1 in Neurosience (ranking Top11%). 2023 CiteScore: 8.0.

Tired of limited options for peripheral nerve injury treatment? Galectin-1 gradient coating technology is here to change...
03/09/2025

Tired of limited options for peripheral nerve injury treatment? Galectin-1 gradient coating technology is here to change the game. This advanced method not only supports cell growth but also guides cells to migrate precisely where needed, enhancing nerve regeneration. With its unique structure and biological cues, this technology brings new hope for those suffering from nerve damage. Learn how it works: https://journals.lww.com/atn/fulltext/2024/12000/gradient_galectin_1_coating_technology__bionic.10.aspx

termined the concentration of galectin-1 (a member of the galactose lectin family) via the proliferation and morphology of Schwann cells and the viability, morphology, and axon length of PC12 cells. On this basis, nanofiber yarns coated with a uniform or unidirectionally linear gradient coating laye...

Mouse models reveal complement-dependent pathways as key mediators of progression. The study establishes a framework f...
03/09/2025

Mouse models reveal complement-dependent pathways as key mediators of progression. The study establishes a framework for future anti-inflammatory strategies targeting neuroinflammation mechanisms in SCI. Link: https://journals.lww.com/nrronline/fulltext/2025/05000/complement_dependent_neuroinflammation_in_spinal.8.aspx

stem in triggering and propagating cerebral neuroinflammation, a similar role for complement in spinal neuroinflammation is a focus of ongoing research. In this work, we survey the current literature investigating the role of complement in spinal cord injury including the sources of complement prote...

miR-146a levels in the brain rise in early Alzheimer’s, but its role isn’t clear-cut. Could it be both a culprit and a c...
02/09/2025

miR-146a levels in the brain rise in early Alzheimer’s, but its role isn’t clear-cut. Could it be both a culprit and a cure? Let’s unravel its contradictions. Read more: https://journals.lww.com/nrronline/fulltext/2025/05000/the_complex_effects_of_mir_146a_in_the.7.aspx

hosphorylated tau proteins, comprise two typical pathological features of Alzheimer’s disease. Besides symptomatic treatment, there are no effective therapies for delaying Alzheimer’s disease progression. MicroRNAs (miR) are small, non-coding RNAs that negatively regulate gene expression at the ...

The combination of cells and molecular agents is a promising approach in spinal cord injury treatment. For example, huma...
01/09/2025

The combination of cells and molecular agents is a promising approach in spinal cord injury treatment. For example, human neural stem cells co-administered with lithium chloride have shown potential in enhancing cell proliferation, differentiation, and survival. Other combinations like NSCs with tetrahedral framework nucleic acid also exhibited neuroprotective effects. Check out: https://journals.lww.com/nrronline/fulltext/2025/05000/combinatorial_therapies_for_spinal_cord_injury.6.aspx

l scarring. Unfortunately, currently, there are no effective treatments available that can fully repair the spinal cord and improve functional outcomes. Nevertheless, numerous pre-clinical approaches have been studied for spinal cord injury recovery, including using biomaterials, cells, drugs, or te...

Estrogen receptors: the unsung heroes of cellular energy and pregnancy! 💥 They're not just about reproduction; they're k...
01/09/2025

Estrogen receptors: the unsung heroes of cellular energy and pregnancy! 💥 They're not just about reproduction; they're key players in mitochondrial function and metabolic health. Dive into our review to uncover their fascinating roles!
https://journals.lww.com/aa/fulltext/2024/01020/estrogen_receptors_in_mitochondrial_metabolism_.10.aspx

reducing the production of reactive oxygen species in the electron transport chain, inhibiting apoptosis, and regulating mitochondrial DNA content. Moreover, estrogen receptors may be the key components in maintaining mitochondrial membrane potential and structure. Although estrogen plays a crucial....

When it comes to ischemic stroke, the interaction between T cells and microglia is a crucial plot. Upon stroke onset, mi...
28/08/2025

When it comes to ischemic stroke, the interaction between T cells and microglia is a crucial plot. Upon stroke onset, microglia spring into action, and T cells are summoned to the brain. Together, they secrete a mix of cytokines This intricate balance dictates the stroke's outcome. Read more: https://journals.lww.com/nrronline/fulltext/2025/05000/t_cell_interactions_with_microglia_in.5.aspx

ant immunomodulatory role in the progression of the condition. After an ischemic stroke, peripheral blood immune cells (mainly T cells) are recruited to the central nervous system by chemokines secreted by immune cells in the brain, where they interact with central nervous system cells (mainly micro...

Bones can regenerate in soft tissues in a pathological way. This abnormal bone formation, known as heterotopic ossificat...
28/08/2025

Bones can regenerate in soft tissues in a pathological way. This abnormal bone formation, known as heterotopic ossification, can occur due to various factors like genetic mutations, trauma, and nerve injuries. Understanding its mechanisms offers insights for developing therapeutic strategies to prevent or treat this condition. Read more: https://journals.lww.com/rmr/fulltext/2025/09000/pathological_bone_regeneration_in_soft_tissues__a.6.aspx

ic ossification is a form of pathological bone regeneration, and its treatment primarily focuses on inhibiting pathological bone formation. This review synthesizes the latest insights into the pathogenesis, risk factors, and clinical management of traumatic heterotopic ossification, highlighting cur...

The function of nerve cells in the central nervous system is closely related to potassium and calcium channels. Abnormal...
20/08/2025

The function of nerve cells in the central nervous system is closely related to potassium and calcium channels. Abnormalities in these ion channels can lead to neurological disorders like depression and Alzheimer’s disease. Read More: https://journals.lww.com/nrronline/fulltext/2025/05000/potassium_and_calcium_channels_in_different_nerve.4.aspx

rocytes and microglia belong to the glial cell family, which is the main source of cytokines and represents the main defense system of the central nervous system. Nerve cells undergo neurotransmission or gliotransmission, which regulates neuronal activity via the ion channels, receptors, or transpor...

Did you know axon guidance molecules might hold the key to tackling epilepsy? These molecules guide neuron growth and th...
19/08/2025

Did you know axon guidance molecules might hold the key to tackling epilepsy? These molecules guide neuron growth and their dysfunction could trigger seizures. Learn how they impact brain circuits and why they’re sparking interest for new treatments. Read more: https://journals.lww.com/nrronline/fulltext/2025/05000/the_role_of_axon_guidance_molecules_in_the.3.aspx

nce suggests that axon guidance molecules play a role in the structural and functional modifications of neural networks and that the dysregulation of these molecules is associated with epilepsy susceptibility. In this review, we discuss the essential role of axon guidance molecules in neuronal activ...

Say goodbye to peripheral nerve injury woes! Engineered exosomes are here to boost nerve repair. They act like tiny cour...
19/08/2025

Say goodbye to peripheral nerve injury woes! Engineered exosomes are here to boost nerve repair. They act like tiny couriers, delivering healing molecules directly to damaged nerves. Learn more: https://journals.lww.com/atn/fulltext/2025/09000/engineered_exosome_based_treatment_for_peripheral.6.aspx

enhanced, enabling efficient delivery of therapeutic molecules and significantly boosting their therapeutic potential. This review aims to explore exosome-based therapies in peripheral nerve repair and their mechanisms and summarizes recent advances in the roles of exosomes in neuroprotection, axona...

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