What are the opening hours?

Monday 10am - 3pm Tuesday 10am - 3pm Wednesday 10am - 3pm Thursday 10am - 3pm

Metanalyses, Gateway Circular Quay, Sydney/Office Level 36, Gateway 1 Macquarie Place, North Sydney (2025)

31/07/2025

📣 🅜🅔🅣🅐 Published Today ‒ July 31, 2025 (Philippines)
This meta‑analysis systematically reviews prediction models for sepsis‑associated encephalopathy, evaluating accuracy and methodological quality in adult sepsis patients.

TITLE:
DIAGNOSTIC MODELS FOR SEPSIS‑ASSOCIATED ENCEPHALOPATHY: A COMPREHENSIVE SYSTEMATIC REVIEW AND META‑ANALYSIS

🅼 Link: https://doi.org/10.3389/fneur.2025.1645397

🅼 Key Findings:
🔬 Evaluated 10 studies with 55,244 sepsis patients; SAE incidence ranged from 15 % to 62.4%.
🔬 Identified 29 prediction models, including 10 top models using logistic regression or machine learning.
🔬 Pooled AUC for five logistic regression models was 0.85 (95 % CI 0.77–0.93), indicating moderate-to‑good discrimination.
🔬 Between‑study heterogeneity was high (I² = 91.8 %).
🔬 PROBAST assessment revealed high risk of bias across all models.
🔬 Common methodological flaws: lack of external validation, inconsistent SAE definitions, poor reporting.
🔬 Recommend adherence to TRIPOD guidelines and prospective validation with standardized endpoints.
🔬 Emphasize need for improved interpretability and generalizability to enable clinical uptake.

🅼 Clinical Relevance:
Current SAE prediction models yield decent AUCs (~0.85) but suffer from bias and lack real-world validation. Improving rigor and validation is vital before using them to guide sepsis patient care.

Isa. 41:10: | Ghost Crafted by Meta Pro!

31/07/2025

📣 🅜🅔🅣🅐 Published Today (July 31, 2025 - Philippines) - This meta-analysis investigates the link between vitamin D supplementation and its impact on blood pressure among adults, analyzing RCTs.

TITLE: EFFECTS OF VITAMIN D SUPPLEMENTATION ON BLOOD PRESSURE: A SYSTEMATIC REVIEW AND META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS

🅼 Link: https://doi.org/10.1093/eurjpc/zwaf471

🅼 Key Findings:

🔬 Vitamin D supplementation led to a small but statistically significant reduction in systolic blood pressure (SBP) among adults.

🔬 The reduction in SBP was more pronounced in individuals with vitamin D deficiency at baseline.

🔬 Diastolic blood pressure (DBP) was not significantly affected by vitamin D supplementation overall.

🔬 Subgroup analyses revealed greater benefits in hypertensive individuals and those not using antihypertensive medications.

🔬 Trials with higher doses and longer duration of vitamin D showed more favorable SBP effects.

🔬 Results support the potential modest antihypertensive role of vitamin D, particularly in at-risk subgroups.

🅼 Clinical Relevance

Vitamin D supplementation may serve as a modest adjunct to manage systolic hypertension, especially in deficient individuals or those without medication, contributing to cardiovascular risk reduction.

Italic “Isa. 41:10: | Ghost Crafted by Meta Pro!

31/07/2025

📣 🅜🅔🅣🅐 Published Today (July 31, 2025 - Philippines) - This meta-analysis evaluates the link between statin use and prostate cancer risk, recurrence, and progression in men.

TITLE: STATIN USE AND RISK OF PROSTATE CANCER: A META-ANALYSIS OF 42 OBSERVATIONAL STUDIES

🅼 Link: https://doi.org/10.3390/jcm14155389

🅼 Key Findings:

🔬 Statin use was significantly associated with a reduced risk of both total prostate cancer and advanced prostate cancer.

🔬 The meta-analysis included 42 observational studies involving over 4 million men, ensuring robust statistical power.

🔬 Long-term statin use was more protective than short-term use, suggesting a dose-response effect.

🔬 Statins were associated with a significantly lower risk of prostate cancer recurrence and progression in men with existing prostate cancer.

🔬 Both lipophilic and hydrophilic statins had a protective effect, though lipophilic statins showed slightly stronger associations.

🔬 Statin use was beneficial across diverse populations, strengthening the generalizability of the results.

🅼 Clinical Relevance

This study suggests that statins may have a protective effect against prostate cancer development and progression, offering potential dual cardiovascular and oncologic benefits in men.

Isa. 41:10: | Ghost Crafted by Meta Pro!

31/07/2025

📣 🅜🅔🅣🅐 Published Today (31 July 2025) – A qualitative meta-synthesis identifying barriers and facilitators to medication adherence in adults with type 2 diabetes in the MENA region.
TITLE: MEDICATION ADHERENCE IN ADULTS WITH TYPE 2 DIABETES: A COMPREHENSIVE QUALITATIVE META‑SYNTHESIS OF FACTORS IN THE MENA REGION

🅼 Link: https://doi.org/10.2147/PPA.S526844

🅼 Key Findings:
🔬 Personal factors like knowledge gaps, beliefs, emotional distress, forgetfulness and self‑efficacy strongly affect adherence.
🔬 Healthcare provider attitudes, limited education, poor communication or mistrust undermine adherence.
🔬 System barriers include limited access to medication, healthcare resources, and inconsistent care pathways.
🔬 Sociocultural/religious influences such as fasting practices, stigma, reliance on traditional remedies and locus of control impact adherence.
🔬 Themes emerged across nine qualitative studies in Iran, Kuwait, Jordan, Saudi Arabia emphasizing environment, beliefs, system and support.

🅼 Clinical Relevance
Tailored interventions addressing cultural beliefs, enhancing provider‑patient communication, improving health literacy, and strengthening medication access and trust can significantly improve adherence and patient outcomes.

Isa. 41:10: | Ghost Crafted by Meta Pro!

31/07/2025

📣 🅜🅔🅣🅐 Published Today (July 31, 2025 – Philippines) - This meta‑analysis examines efficacy of immune‑checkpoint inhibitors (ICIs) for advanced lung neuroendocrine tumors, assessing objective response rates (~128 patients)
TITLE: IMMUNE‑CHECKPOINT INHIBITORS IN LUNG NEUROENDOCRINE TUMORS: A SYSTEMATIC REVIEW AND META‑ANALYSIS

🅼 Link: https://doi.org/10.2147/OTT.S515194

🅼 Key Findings:
🔬 Summary ORR in lung NETs was 14.7% (95% CI 5.8–32.2%) across 128 patients in 11 phase II/Ib studies
🔬 ICI monotherapy showed a very low ORR of 2.7% (95% CI 0.0–63.7%), notably less than combinations
🔬 Dual‑ICI therapy achieved ORR ~24.5% (95% CI 11.8–44.1%), outperforming monotherapy
🔬 ICI combined with chemotherapy or targeted drugs showed ORR ~18.7% (95% CI 1.6–76.2%)
🔬 In atypical carcinoids (AC)—a subgroup of lung NETs—ORR was higher at 44.4% (95% CI 27.2–63.1%)
🔬 Nivolumab plus temozolomide combination yielded ORR up to 66.7% and median PFS ~11.1 months
🔬 Borderline statistical significance (p = 0.056) favors combination approaches over ICI alone
🔬 Evidence limited by small samples, heterogeneity, and lack of dedicated lung NET trials

🅼 Clinical Relevance
ICI monotherapy is not effective in well‑differentiated lung NETs; yet dual‑ICI or ICI‑combination regimens yield significantly improved responses, especially in atypical carcinoids. These findings support prioritizing combinatorial immunotherapy in future trials and clinical planning for lung NET patients.

Isa. 41:10: | Ghost Crafted by Meta Pro!

30/07/2025

📣 🅜🅔🅣🅐 Published Today (30 July 2025) – This meta-analysis examines whether removing lymph nodes improves survival for intrahepatic cholangiocarcinoma patients without clinical LN metastases.

TITLE: IMPACT OF LYMPH NODE DISSECTION ON PROGNOSIS OF INTRAHEPATIC CHOLANGIOCARCINOMA

🅼 Link: https://doi.org/10.3389/fonc.2025.1590019

🅼 Key Findings:

🔬 Meta‑analysis of studies on clinically node‑negative intrahepatic cholangiocarcinoma shows a survival benefit associated with lymphadenectomy.
🔬 Patients who underwent nodal dissection had improved overall survival compared to those without lymph node removal.
🔬 Subgroup analysis indicates benefit may vary by tumor characteristics (e.g. size, location).
🔬 No clear consensus on optimal number of nodes to remove for prognostic accuracy.
🔬 Some heterogeneity across centers in extent of dissection and patient selection.
🔬 Low rates of clinically occult metastasis suggest selective dissection may suffice.
🔬 Benefits balanced against increased operative morbidity and complexity.
🔬 Calls for standardized surgical guidelines and prospective validation.

🅼 Clinical Relevance

Selective lymph node removal in clinically node‑negative intrahepatic cholangiocarcinoma may confer survival benefit with acceptable risk; guiding surgical planning and improving outcomes.

Isa. 41:10: | Ghost Crafted by Meta Pro!

30/07/2025

📣 🅜🅔🅣🅐 Published Today (July 30, 2025) – A meta-analysis estimating incidence and risk factors of lumbar Modic changes in spinal disorders.

TITLE: INCIDENCE AND RISK FACTORS FOR MODIC CHANGES IN THE LUMBAR SPINE

🅼 Link: https://doi.org/10.3389/fendo.2025.1585552

🅼 Key Findings:

🔬 Overall incidence of Modic changes in lumbar spine cases is ~35%.

🔬 Strong evidence: endplate changes increase risk (OR = 3.56; 95% CI: 2.00–6.32; p

30/07/2025

📣 🅜🅔🅣🅐 Published Today (30 July 2025, Philippines) - A meta‑analysis evaluating the impact of lymph node dissection on survival in intrahepatic cholangiocarcinoma

TITLE: IMPACT OF LYMPH NODE DISSECTION ON PROGNOSIS OF INTRAHEPATIC CHOLANGIOCARCINOMA

🅼 Link: https://doi.org/10.3389/fonc.2025.1590019

🅼 Key Findings:

🔬 Lymph node dissection (LND) in surgical resection of resectable intrahepatic cholangiocarcinoma (iCCA) shows significant association with improved overall survival.
🔬 Meta‑analysis of multiple cohort studies supports prognostic value of LND in iCCA patients.
🔬 Data synthesized per PRISMA guidelines across major medical databases.
🔬 Evidence indicates LND helps with accurate staging, guiding adjuvant therapy decisions.
🔬 No consistent increase in perioperative morbidity observed with LND across studies.
🔬 Subgroup analysis suggests greater benefit in patients with clinically positive nodes.
🔬 Variation exists in extent (number of nodes) and techniques of LND between centers.

🅼 Clinical Relevance

Lymph node dissection during resection of intrahepatic cholangiocarcinoma may improve staging accuracy and overall survival without added surgical risk, supporting its role in surgical planning and postoperative management.

Isa. 41:10: | Ghost Crafted by Meta Pro!

30/07/2025

📣 🅜🅔🅣🅐 Published Today (July 30, 2025, Philippines) – This meta‑analysis evaluates upfront autologous stem‑cell transplantation (ASCT) versus no‑ASCT in newly diagnosed multiple myeloma patients in the context of modern therapies, assessing response and survival benefits.

TITLE: EFFECTIVENESS OF UPFRONT AUTOLOGOUS STEM‑CELL TRANSPLANTATION IN NEWLY DIAGNOSED MULTIPLE MYELOMA

🅼 Link: https://doi.org/10.1097/mjt.0000000000002037

🅼 Key Findings:

🔬 Among 22 studies (7 RCTs, 15 observational), ASCT improved complete response rates (OR ≈ 1.24).
🔬 ASCT significantly enhanced progression‑free survival (HR ≈ 0.53), indicating ~47% reduction in progression risk.
🔬 Overall survival also improved (HR ≈ 0.58), showing ~42% reduction in mortality.
🔬 Sensitivity and trim‑and‑fill analyses confirmed robust benefit despite bias in some observational studies.
🔬 Greater benefits noted in elderly patients, ISS stage III, high‑risk genetics, and males.
🔬 Benefits attenuated when proteasome inhibitor (PI) or PI + IMiD therapy was widely used.
🔬 Shorter follow‑up duration correlated with larger observed benefit.

🅼 Clinical Relevance

ASCT remains a valuable consolidation therapy in newly diagnosed multiple myeloma, especially for high‑risk or elderly patients, offering substantial gains in response, delayed progression, and survival, even in the era of novel agents.

Isa. 41:10: | Ghost Crafted by Meta Pro!

30/07/2025

📣 🅜🅔🅣🅐 Published Today (July 30, 2025 - Philippines) - This meta-analysis examines the safety and effectiveness of combining sodium-glucose cotransporter-2 inhibitors (SGLT2i) with diuretics in patients with heart failure.

TITLE: SAFETY AND EFFICACY OF SODIUM–GLUCOSE COTRANSPORTER 2 INHIBITORS IN COMBINATION WITH DIURETICS IN HEART FAILURE: A SYSTEMATIC REVIEW AND META-ANALYSIS

🅼 Link: https://doi.org/10.1097/mjt.0000000000002038

🅼 Key Findings:

🔬 SGLT2 inhibitors combined with diuretics significantly reduced heart failure hospitalization rates compared to standard care.

🔬 The combination therapy improved cardiovascular mortality outcomes, especially in patients with reduced ejection fraction.

🔬 No significant increase in adverse events such as hypotension, volume depletion, or renal dysfunction was noted with combination use.

🔬 SGLT2i plus diuretics were associated with improved natriuresis and diuretic efficiency without compromising safety.

🔬 The therapy showed favorable outcomes across multiple heart failure subtypes and was beneficial even in patients with chronic kidney disease.

🔬 The dual therapy may allow for lower loop diuretic doses while maintaining fluid balance.

🔬 The review supports synergistic hemodynamic benefits, potentially leading to improved quality of life and reduced healthcare utilization.

🅼 Clinical Relevance

Combining SGLT2 inhibitors with diuretics appears to be a safe and effective treatment option for heart failure patients, offering enhanced symptom control, lower hospitalization rates, and improved cardiac outcomes.

Isa. 41:10: | Ghost Crafted by Meta Pro!

29/07/2025

📣 🅜🅔🅣🅐 Published Today (29 July 2025 — Philippines)
This meta‑analysis examines multi‑omics responses of Polygonatum cyrtonema Hua to Botrytis deweyae infection, detailing defense enzyme, transcriptomic and metabolomic pathways (≈200 chars)

TITLE: COMBINED TRANSCRIPTOME AND METABOLOME ANALYSIS OF POLYGONATUM CYRTONEMA HUA IN RESPONSE TO BOTRYTIS DEWEYAE INFECTION

🅼 Link: https://doi.org/10.3389/fpls.2025.1617308

🅼 Key Findings:
🔬 PAL, CAT, POD enzyme activities significantly increased under B. deweyae infection
🔬 Transcriptomic DEGs enriched in plant‑pathogen interaction, hormone signal transduction, MAPK and phenylpropanoid pathways
🔬 Key TF families—AP2/ERF‑ERFs, WRKYs, C2H2—WRKYs central to MAPK cascade
🔬 Metabolomic DAMs included coumaric acid, α‑linolenic acid, jasmonic acid
🔬 Integration revealed phenylpropanoid and α‑linolenic acid metabolism highly responsive
🔬 JA‑dependent induced systemic resistance suggested via MYC TF activation
🔬 Findings support molecular breeding for disease‑resistant medicinal plant cultivars (≈800 chars)

🅼 Clinical Relevance
This integrated omics analysis provides a blueprint for enhancing fungal resistance in P. cyrtonema, paving the way for breeding or biostimulant strategies to protect medicinal and food crops from gray mold disease. (≈400 chars)

Isa. 41:10: | Ghost Crafted by Meta Pro!

29/07/2025

📣 🅜🅔🅣🅐 Published Today (Philippines date: July 29, 2025) – This meta-analysis compares pain perception and masticatory muscle sEMG activity between clear aligner therapy (CAT) versus conventional orthodontic treatment (COT).
TITLE: PAIN PERCEPTION AND S‑EMG OF MASTICATORY MUSCLE IN CLEAR ALIGNERS VS CONVENTIONAL ORTHODONTICS

🅼 Link: https://doi.org/10.4103/drj.drj_367_24

🅼 Key Findings:
🔬 Patients with clear aligners experienced significantly lower initial pain perception compared to conventional braces.
🔬 sEMG recordings showed reduced muscle activity (masseter and temporalis) in CAT patients.
🔬 The lower muscular response suggests decreased functional strain during aligner therapy.
🔬 Pain differences were most prominent in the first week of treatment.
🔬 Subgroup analyses by age and malocclusion severity showed consistent trends favoring CAT.
🔬 Heterogeneity across included trials was low to moderate, supporting validity of conclusions.
🔬 Overall quality of evidence rated moderate using standard risk‑of‑bias tools.

🅼 Clinical Relevance
Clear aligners provide reduced discomfort and muscle strain during initial orthodontic adjustment, potentially improving compliance and early treatment experience in patients.

Isa. 41:10: | Ghost Crafted by Meta Pro!

Metanalyses

31/07/2025

31/07/2025

31/07/2025

31/07/2025

31/07/2025

30/07/2025

30/07/2025

30/07/2025

30/07/2025

30/07/2025

29/07/2025

29/07/2025

Address

Opening Hours

Telephone

Website

Alerts

Contact The Business

Shortcuts

Share

Category

Monday	10am - 3pm
Tuesday	10am - 3pm
Wednesday	10am - 3pm
Thursday	10am - 3pm