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Medical Sciences MDPI, Basel (2026)

15/01/2026

✨ New in Medical Sciences
Understanding prognostic markers in intrahepatic cholangiocarcinoma (iCCA) surgery:
📄 Preoperative Prognostic Score for Patients with Intrahepatic Cholangiocarcinoma Undergoing Curative-Intent Resection

👩‍💼 Authors:
Jarin Chindaprasirt, Thanachai Sanlung, Piyakarn Watcharenwong, Vasin Thanasukarn, Apiwat Jareanrat, Natcha Khuntikeo, Tharatip Srisuk, Prakasit Sa-Ngiamwibool, Chaiwat Aphivatanasiri & Watcharin Loilome

🏢 Institution:
Medical Oncology Program & Cholangiocarcinoma Research Institute, Khon Kaen University, Thailand

🔗 Access here: https://www.mdpi.com/2076-3271/14/1/23

📍 Core Insights:
✔ NLR (neutrophil-to-lymphocyte ratio), a marker of systemic inflammation, was strongly linked to shorter disease-free and overall survival.
✔ Prognostic significance was confirmed in margin-negative and recurrent patient subgroups.
✔ Accessible, cost-effective preoperative markers may aid surgical planning and personalized care.

📢 This study contributes valuable evidence for biomarker-based prognostic stratification in iCCA.

🔍

15/01/2026

📢 We are delighted to feature a new article in Medical Sciences!

Clinical Characteristics and Genetic Factors in Retinitis Pigmentosa
🧬 Authors: A. Demirkol, F. Kendir Uğuz, N. M. Cavuş, I. Demirkol, S. H. Tsang
🏥 Correspondence: Columbia University, New York, NY, USA
📍 https://www.mdpi.com/2076-3271/14/1/24

🧠 Study Focus:
This retrospective analysis characterizes RP in a Turkish cohort, with an emphasis on genetic and clinical patterns shaped by cultural and hereditary factors.

📊 What sets this work apart:
• Population-specific insight into RP inheritance
• Evidence of autosomal recessive dominance
• Correlation between family history & consanguinity
• Severe visual impairment as a common clinical feature
• Strategic implications for screening and early intervention

👁️ These results pave the way for tailored approaches in genetic screening and ophthalmic care within communities having high consanguinity.

15/01/2026

📢 New Review Alert in Medical Sciences!

We are pleased to highlight the publication:

👉 “From Glucose Transport to Microbial Modulation: The Impact of Sodium Glucose Co-Transporter-2 Inhibitors on the Gut Microbiota”

🧠 Authors:
Mina Y. George, Nada K. Gamal, Kerolos Safwat, Mohamed Mamdouh, Ahmed AbdElFatah, Abdelrahman Atallah, Claudio Cerchione

🏫 Correspondence:
Department of Pharmacology and Toxicology & PharmD Clinical Program, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt;
Hematology Unit, Istituto Romagnolo per lo Studio dei Tumori “Dino Amadori” – IRST IRCCS, Italy

🔬 This comprehensive review explores the multidimensional relationship between SGLT-2 inhibitors and the gut microbiome, extending beyond traditional glucose control. It synthesizes current evidence on how these agents modulate microbial composition and metabolites, strengthening barrier integrity and impacting inflammation, oxidative stress, and gut-organ communication axes (lung, heart, brain, liver, hematological system) for systemic benefits.

🌍 By bridging pharmacology and microbiome science, this work suggests novel mechanisms underlying the pleiotropic therapeutic effects of SGLT-2 inhibitors and identifies potential avenues for future microbiota-targeted strategies.

🔗 Read here: https://www.mdpi.com/2076-3271/14/1/22

✨

14/01/2026

🚀 Spotlight on Latest Research – Medical Sciences

Celebrating a new evidence synthesis by Carlos M. Ardila, Eliana Pineda-Vélez and Anny M. Vivares-Builes from Saveetha University and Universidad de Antioquia U de A on prognostic markers in oral squamous cell carcinoma (OSCC).

🌐 📌 Title: Computational Stemness and Cancer Stem Cell Markers in Oral Squamous Cell Carcinoma

📍 https://www.mdpi.com/2076-3271/14/1/21

✨ Key Takeaways:
✅ First dual meta-analysis that integrates molecular stemness signatures with IHC-based CSC markers in OSCC.
✅ Quantitative evidence shows that stemness predicts worse overall survival across multiple cohorts.
✅ Biological insights highlight EMT, extracellular matrix remodeling, redox balance, and ribosome activity in aggressive tumors.

📌 This work bridges computational biology and tumor immunophenotyping, paving the way for refined prognostic models and hypothesis-driven therapeutics in head and neck oncology.

14/01/2026

🔥 Featured Article — Medical Sciences

Does how you drink matter for cancer risk? Explore novel findings from the SUN cohort on Mediterranean alcohol-drinking patterns and cancer incidence.

🧑‍🔬 Authors: María Barbería-Latasa, Estefanía Toledo, Maira Bes-Rastrollo, María Olmedo, Rafael Pérez-Araluce, Alfredo Gea & Miguel Ángel Martínez-González.

🏫 Institution:
Department of Preventive Medicine and Public Health, University of Navarra, 31008 Pamplona, Spain; Instituto de Investigación Sanitaria de Navarra (IdiSNA), Navarra Institute for Health Research, 31008 Pamplona, Spain; Biomedical Research Network Center for Pathophysiology of Obesity and Nutrition (CIBEROBN), Carlos III Health Institute, 28029 Madrid, Spain

📎 Access the article: https://doi.org/10.3390/medsci14010020

🔍 Key Insights:
• The Mediterranean drinking pattern, characterized by moderate wine intake with meals and avoidance of binge drinking, was studied in >19,000 participants.
• Men with higher MADP adherence had markedly lower risk of alcohol-related cancers.
• Findings suggest patterns of consumption may have implications beyond volume alone.

🎯 This work informs refined preventative advice in cancer and lifestyle medicine.

14/01/2026

📢 New Publication in Medical Sciences!

We are pleased to share the latest research exploring national trends in percutaneous renal biopsy (PRB) utilization across Australia over the past two decades. 🧠📊

📄 Article Title
A 24-Year Analysis of Percutaneous Renal Biopsy Trends in Australia

👩‍🔬 Authors:
Kieran Sandhu, Abdullah Al-Khanaty, Jonathon Carll, Declan G. Murphy, Nathan Lawrentschuk and Marlon Perera

🏥 Corresponding Author Institution:

Division of Cancer Services, Peter MacCallum Cancer Centre, Parkville, Australia; Department of Surgery, Austin Health, University of Melbourne, Melbourne , Australia

🔗 https://doi.org/10.3390/medsci14010019

🔍 Study Highlights:

• Comprehensive, population-based evaluation of PRB rates in Australia from 2000–2024.
• Demonstrates a sustained rise in PRB utilization, reflective of evolving clinical practice.
• Reveals marked variations by s*x, age group, and geographic region, underscoring disparities in access and clinical adoption.

This work offers valuable epidemiological insights that support optimized diagnostic pathways and equitable healthcare delivery.

13/01/2026

📣 Medical Sciences is excited to highlight this impactful research:
UniTope & TraCR: A Universal Tool to Tag, Enrich, and Track TCR-T Cells and Therapeutic Proteins

🧑‍🔬 Kanuj Mishra, Barbara Lösch & Dolores J. Schendel

📍 Medigene Immunotherapies GmbH & Champalimaud Foundation

📎 https://doi.org/10.3390/medsci14010018

Adoptive cell therapies are transforming cancer treatment — yet analytics for engineered receptors lag behind. This article introduces a versatile analytical platform that enables robust, reproducible detection of engineered TCRs without compromising cell function.

✨ Article insights:
📊 Quantitative evaluation of engineered TCR expression
🧬 High specificity with no cross-reaction to endogenous proteins
🛠️ Supports flow cytometry, Western blot, and immunoprecipitation assays

Connect with the forefront of T-cell engineering and analytics! 🔗

$🎉 Highlight from Medical Sciences: Understanding what predicts walking ability at discharge after hip fracture surgery! ...$

13/01/2026

🎉 Highlight from Medical Sciences: Understanding what predicts walking ability at discharge after hip fracture surgery!

Authors:
Thitirut Jongutchariya, Palanthorn Loomcharoen, Jittima Saengsuwan & Saowaluck Settheekul

Corresponding to: Faculty of Medicine, Khon Kaen University, Thailand

Study Insights:
• Ambulation training and hip arthroplasty = strong positive predictors of walking at discharge.
• Stroke history + rehabilitation delay = reduced ambulatory outcomes.
• Highlights how timely and targeted rehabilitation influences short-term functional recovery in older adults.

🔗 Read here: http://www.mdpi.com/2076-3271/14/1/17

13/01/2026

📢 New in Medical Sciences!
We are excited to highlight a significant clinical study on rhythm control in atrial fibrillation (AF) from the prestigious REGUEIFA Registry.

🫀 “The Clinical Safety and Efficacy of Sodium Channel Blocker Therapy for Rhythm Control in Atrial Fibrillation: Insights from the REGUEIFA Registry” investigates the real-world safety and effectiveness of sodium channel blockers (SCBs) in maintaining sinus rhythm over 2 years in nearly 1,000 patients with AF. Notably, SCB therapy was associated with improved sinus rhythm maintenance and no increase in adverse cardiovascular outcomes.

👩‍⚕️👨‍⚕️ Authors:
Javier García-Seara, Laila González Melchor, María Vázquez Caamaño, Emilio Fernández-Obanza Windcheid, Raquel Marzoa, Miriam Piñeiro Portela, Eva González Babarro, Pilar Cabanas Grandío, Olga Durán Bobín, Óscar Prada Delgado, Juliana Elices Teja, Evaristo Freire, Mario Gutiérrez Feijoo, Javier Muñiz, Francisco Gude, Carlos Minguito Carazo, Eduardo Barge-Caballero & Carlos González-Juanatey.

🏥 Correspondence/Lead Institution:
Cardiology Department, University Hospital of Santiago de Compostela, 15706 Santiago de Compostela, Spain; Cellular and Molecular Cardiology Unit, Institute of Biomedical Research of Santiago de Compostela (IDIS-SERGAS), 15706 Santiago de Compostela, Spain; Centro de Investigación Biomédica en Red Enfermedades Cardiovasculares (CIBERCV), Institute of Health Carlos III, 28029 Madrid, Spain

🔗 Read the full open-access article:
https://www.mdpi.com/2076-3271/14/1/16

✨ Key Takeaways:
• SCB therapy shows a safe profile in AF rhythm control.
• Improved sinus rhythm maintenance over long-term follow-up.
• Clinical insights relevant for electrophysiologists and cardiologists.

📌 📚

13/01/2026

🔥 Just Published — Medical Sciences
Seronegative Rheumatoid Arthritis: A Distinct Immunopathological Entity with Erosive Potential — redefining seronegative RA beyond classic biomarkers.

📚 Full Author List: Florent Lhotellerie, Ala Eddine Ben Ismail, Julie Sarrand, Muhammad Soyfoo*

🏥 Correspondence: Department of Rheumatology, Hôpital Universitaire de Bruxelles, Université libre de Bruxelles, Brussels, Belgium

📍 Why This Matters:
🔸 SNRA isn’t truly “invisible” — many patients harbour non-conventional autoantibodies undetected by routine tests.
🔸 Erosive disease can develop even in seronegative individuals, highlighting gaps in current classification.
🔸 The AMPA paradigm (anti-modified protein antibodies) may refine diagnosis and risk stratification.
🔸 Treatment efficacy varies by mechanism, underlining a precision-medicine approach.

📖 Explore the Review: https://www.mdpi.com/2076-3271/14/1/14

📊 Share with your network — advancing rheumatology knowledge together!

12/01/2026

📢 Medical Sciences is proud to feature this impactful trauma research!

📄 Article: Validation of an ICD‑9‑CM‑Based Monitoring Tool for Regional Trauma Systems: The PaTraME Study in Pavia Province, Italy

👨‍👩‍👧‍👦 Full Authorship: Paola Fugazzola, Leandro Gentile, Francesco Chiarolanza, Pietro Perotti, Mario Alessiani, Federico Capra Marzani, Lorenzo Cobianchi, Simone Frassini, Federico Alberto Grassi, Catherine Klersy, Alba Muzzi, Alessandra Palo, Stefano Perlini, Maurizio Raimondi, Luca Ansaloni (on behalf of the PaTraME Study Group)

🏥 Corresponding Affiliation: General Surgery, Fondazione IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico) Policlinico San Matteo, 27100 Pavia, Italy; Dipartimento di Scienze Clinico-Chirurgiche, Diagnostiche e Pediatriche, University of Pavia, 27100 Pavia, Italy

🧠 Why This Matters:
Trauma remains a global public health priority. This study presents a validated, automated monitoring solution that leverages routinely collected ICD‑9‑CM data to evaluate trauma severity, system centralization, and outcomes over time. It highlights the potential of administrative data to guide clinical benchmarking, resource distribution, and quality improvements in trauma care delivery.

🔗 Full text: https://www.mdpi.com/2076‑3271/14/1/13

📌

🏥📌🧬

12/01/2026

📣 Featured Article in Medical Sciences!

A retrospective cohort study by Fejes et al. investigates the comparative efficacy of empagliflozin, dapagliflozin, and allopurinol on serum uric acid (sUA) and kidney function in T2DM patients with hyperuricemia over a 36-month follow-up.

👥 Authors:
Roland Fejes, Tamás Jámbor, Tamás Lantos, Szabolcs Péter Tallósy (corresponding authors)

🏥 Institutions:

• Institute of Surgical Research & Department of Internal Medicine,
University of Szeged, Hungary
• Department of Medical Physics and Informatics, University of Szeged, Hungary

📌 Why This Matters:
✔ SGLT2 inhibitors delivered robust urate reduction and preserved eGFR, suggesting organ-protective advantages.
✔ Allopurinol’s urate lowering was accompanied by declining kidney function and higher all-cause mortality risk.
✔ Results emphasize the potential of SGLT2 inhibitors in comprehensive T2DM & CKD management.

Read more 👉 https://doi.org/10.3390/medsci14010012

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