Viruses MDPI

13/01/2026

🚀 NEW Special Issue CALL FOR PAPERS!
Explore Viral Evolution & Diversity. How do viruses change within a single host? Contribute your research on quasispecies, persistence, and adaptation.
🗓️ Submission deadline: END OF THIS MONTH!
🔗 Details: https://tinyurl.com/2mevw8ze

13/01/2026

Genomic Analyses Uncover Evolutionary Features of Influenza A/H3N2 Viruses in Yunnan Province, China, from 2017 to 2022

by Meiling Zhang et al.

🔎

Influenza A viruses evolve at a high rate of nucleotide substitution, thereby requiring continuous monitoring to determine the efficacy of vaccines and antiviral drugs. In the current study, we performed whole-genome sequencing analyses of 253 influenza A/H3N2 strains from Yunnan Province, China, du...

13/01/2026

Chloride Intracellular Channel Protein 1 (CLIC1) Is a Critical Host Cellular Factor for Influenza A Virus Replication

by Mahamud-ur Rashid et al.

🔎

(1) Background: Influenza A Virus (IAV) uses host cellular proteins during replication in host cells. IAV infection causes elevated expression of chloride intracellular channel protein 1 (CLIC1) in lung epithelial cells, but the importance of this protein in IAV replication is unknown. (2) In this s...

13/01/2026

Arf GTPases Define BST-2-Independent Pathways for HIV-1 Assembly and Release

by Adam Smith et al.

👉

ADP-ribosylation factor (Arf) proteins are small GTPases that regulate intracellular membrane trafficking and actin remodeling through tightly controlled cycles of GTP binding and hydrolysis. Arf1, a central coordinator of Golgi and endosomal transport, and Arf6, which regulates plasma membranes and...

13/01/2026

HIV-1 Nef Uses a Conserved Pocket to Recruit the N-Terminal Cytoplasmic Tail of Serinc3

by Mohammad Karimian Shamsabadi et al.

🔎

Human transmembrane proteins Serinc3 and Serinc5 are antiviral restriction factors that inhibit HIV-1 infectivity. In the absence of viral antagonism, Serinc3 and Serinc5 incorporate into the envelopes of nascent virions and inhibit the fusion of virions to the target cells. The HIV-1 virus countera...

13/01/2026

Screening of the Pandemic Response Box Library Identified CRM1/XPO1 as an Anti-Mammarenavirus Druggable Target

by Chukwudi A. Ofodile et al.

👉

Mammarenaviruses (MaAv) cause persistent infection in their natural rodent hosts across the world and, via zoonotic events, can cause severe disease in humans.

12/01/2026

Cassava Congo cheravirus, a novel plant virus, has been silently circulating in African cassava fields.

🔬 This virus, with a unique genomic signature and wide distribution, highlights the hidden viral complexity in a crop feeding hundreds of millions.

👉Read the full study in Viruses: https://tinyurl.com/8j98v7a9

Cassava (Manihot esculenta) is a staple crop in sub-Saharan Africa threatened by several viral diseases.

12/01/2026

mRNA Vaccine Nanoplatforms and Innate Immunity

by Lai Wei et al.

🔥

mRNA-based vaccine technology has been significantly developed and enhanced, particularly highlighted by the authorization of mRNA vaccines for addressing the COVID-19 pandemic.

12/01/2026

Functional Analysis of KAP1/TRIM28 Requirements for HIV-1 Transcription Activation

by Keyera Randolph et al.

👉

HIV-1 latency maintenance and reactivation are regulated by several viral and host factors. One such factor is Krüppel-associated box (KRAB)-associated protein 1 (KAP1: also named TRIM28 or TIF1β). While initial studies have revealed KAP1 to be a positive regulator of latency reversal in transform...

12/01/2026

Exploring the Genetic Diversity and Molecular Evolution of Seoul and Hantaan Orthohantaviruses

by Atanas V. Demirev et al.

🔎

Seoul (SEOV) and Hantaan (HTNV) orthohantaviruses are significant zoonotic pathogens responsible for hemorrhagic fever with renal syndrome. Here, we investigated the molecular evolution of SEOV and HTNV through phylogenetic and bioinformatic analyses using complete genome sequences of their large (L...

12/01/2026

Characterization of a Thermostable Endolysin of the Aeribacillus Phage AeriP45 as a Potential Staphylococcus Biofilm-Removing Agent

by Natalia N. Golosova et al.

🔎

Multidrug-resistant Gram-positive bacteria, including bacteria from the genus Staphylococcus, are currently a challenge for medicine. Therefore, the development of new antimicrobials is required. Promising candidates for new antistaphylococcal drugs are phage endolysins, including endolysins from th...

12/01/2026

Mechanisms of Yellow Fever Transmission: Gleaning the Overlooked Records of Importance and Identifying Problems, Puzzles, Serious Issues, Surprises and Research Questions

by Goro Kuno

👉

In viral disease research, few diseases can compete with yellow fever for the volume of literature, historical significance, richness of the topics and the amount of strong interest among both scientists and laypersons. While the major foci of viral disease research shifted to other more pressing ne...