Viruses MDPI

12/09/2025

📢Excited to welcome our latest committee member: Dr. Yuntao Yun!

Share your research, gain insights from top virologists, and network with peers. Don’t miss this chance to grow and connect!

🔗 Submit your work: https://t.ly/tqe64
👉 Register here: https://t.ly/mtNvm

11/09/2025

Join us for the VirusesWebinar: "2025 The World HTLV Day"! 🤩

Dive into insights on HTLV-1—mark your calendar and don’t miss this key discussion.

🔎https://tinyurl.com/bd9kufx5

Viruses Webinar | 2025 The World HTLV Day

11/09/2025

Check out our successful Special Issue: "Advances in Antiviral Agents against SARS-CoV-2 and Its Variants"! Featuring 10 impactful papers with an average of 8.9 citations.

👉Dive into the latest research—link here: https://tinyurl.com/2vbcfxmb

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11/09/2025

Preclinical Profile of the HIV-1 Maturation Inhibitor VH3739937

by Brian McAuliffe et al.

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The HIV-1 maturation inhibitor (MI) VH3739937 (VH-937) inhibits cleavage between capsid and spacer peptide 1 and exhibits an oral half-life in humans compatible with once-weekly dosing. Here, the antiviral properties of VH-937 are described. VH-937 exhibited potent antiviral activity against all HIV...

11/09/2025

Redundancy in Innate Immune Pathways That Promote CD8+ T-Cell Responses in AAV1 Muscle Gene Transfer

by Ning Li et al.

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While adeno-associated viral (AAV) vectors are successfully used in a variety of in vivo gene therapy applications, they continue to be hampered by the immune system. Here, we sought to identify innate and cytokine signaling pathways that promote CD8+ T-cell responses against the transgene product u...

11/09/2025

Optimization of Cellular Transduction by the HIV-Based Pseudovirus Platform with Pan-Coronavirus Spike Proteins

by Syamala Rani Thimmiraju et al.

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Over the past three years, new SARS-CoV-2 variants have continuously emerged, evolving to a point where an immune response against the original vaccine no longer provided optimal protection against these new strains. During this time, high-throughput neutralization assays based on pseudoviruses have...

11/09/2025

📢Meet our newest committee member, Dr. Susan R. Weiss!

🌟 Join us to share your research , learn from leading virologists, and connect with experts in the field. Don’t miss this opportunity!
🔗 Submit: https://t.ly/tqe64
👉Register: https://t.ly/mtNvm

11/09/2025

AlphaFold2 Modeling and Molecular Dynamics Simulations of the Conformational Ensembles for the SARS-CoV-2 Spike Omicron JN.1, KP.2 and KP.3 Variants: Mutational Profiling of Binding Energetics Reveals Epistatic Drivers of the ACE2 Affinity and Escape Hotspots of Antibody Resistance

by Nishank Raisinghani et al.

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The most recent wave of SARS-CoV-2 Omicron variants descending from BA.2 and BA.2.86 exhibited improved viral growth and fitness due to convergent evolution of functional hotspots. These hotspots operate in tandem to optimize both receptor binding for effective infection and immune evasion efficienc...

09/09/2025

Higher Frequency of SARS-CoV-2 RNA Shedding by Cats than Dogs in Households with Owners Recently Diagnosed with COVID-19

by Michele Lunardi et al.

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Studies have demonstrated the susceptibility of companion animals to natural infection with SARS-CoV-2. Using quantitative reverse transcription polymerase chain reaction and sequencing analyses, this study investigated SARS-CoV-2 RNA excretion in pets in households with infected owners. Oropharynge...

09/09/2025

Interventions during Early Infection: Opening a Window for an HIV Cure?

by Christopher R. Hiner et al.

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Although combination antiretroviral therapy (ART) has been a landmark achievement for the treatment of human immunodeficiency virus (HIV), an HIV cure has remained elusive. Elimination of latent HIV reservoirs that persist throughout HIV infection is the most challenging barrier to an HIV cure. The....

09/09/2025

GPCR Inhibitors Have Antiviral Properties against JC Polyomavirus Infection

by Amanda L. Sandberg et al.

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JC polyomavirus (JCPyV) infects the majority of the population and initially establishes a persistent but asymptomatic infection of the kidneys. In healthy individuals, the infection remains controlled by the host immune system, but for individuals experiencing prolonged immunosuppression, the infec...

09/09/2025

A new systematic review dives into how congenital cytomegalovirus (CMV) links to intrauterine fetal demise and spontaneous abortion.

🔎Read more: https://tinyurl.com/mr24t52b

The objective was to review the existing literature reporting on spontaneous abortion (SA) and intrauterine fetal demise (IUFD) associated with cytomegalovirus (CMV) infection. A review using standardized terminology such as ‘intrauterine fetal death’, ‘congenital cytomegalovirus’ and ‘CMV...