Sclerosis MDPI

30/05/2025

World Multiple Sclerosis Day, officially observed each year on 30 May, aims to foster global understanding and recognition of the challenges faced by those affected by (MS). It brings the global MS community together to share stories, raise awareness, and campaign for change. World MS Day was initiated in 2009 by the Multiple Sclerosis International Federation (MSIF) and its global members, including the National MS Society. It unites individuals and organizations from around the world to spotlight the impact of MS and bring us closer to a world free of this disease. To mark this important day, we are proud to present a curated collection of articles and Special Issues dedicated to groundbreaking research and innovative approaches in multiple sclerosis. We invite readers to explore these contributions and join us in supporting the global fight against multiple sclerosis.

Sclerosis, an international, peer-reviewed Open Access journal.

12/02/2025

Apolipoprotein L1 (APOL1) genetic variations, notably the G1 and G2 alleles, have important roles in the pathophysiology of focal segmental (FSGS) and other kidney problems, especially in people of African descent. This review summarizes current understanding about the genetic, molecular, and clinical features of APOL1-associated and investigates new therapeutic options.

Read more: https://bit.ly/3CMYn5c

24/12/2024

🎄✨ Season's Greetings from the Sclerosis Editorial Office! ✨🎄

A heartfelt thank you to our authors, reviewers, editors, and collaborators for your incredible contributions in 2024. Your dedication has driven advancements in research and inspired global scientific progress. 🌍✨

Wishing you and your loved ones a joyful and peaceful holiday season. We look forward to achieving more together in 2025!

18/12/2024

Emerging evidence links dietary interventions to favorable multiple sclerosis (MS) outcomes; however, evidence for the efficacy of dietary interventions on functional disability remains sparse. A research by Allison R. Groux et al. pooled data from two 12-week, randomized, controlled pilot trials to investigate the efficacy of a modified Paleolithic diet (Paleo) on functional disability, as assessed by the MS Functional Composite (MSFC), among people diagnosed with MS.

Read more: https://bit.ly/4gDixwF

18/12/2024

This review "Biomarkers Differentiating RRMS and SPMS in Multiple Sclerosis—A Systematic Review" provides new insights into potential directions for future studies to investigate biomarkers as a diagnostic tool for SPMS.

Read more: https://bit.ly/3ZGnbmT

18/12/2024

Systemic sclerosis (SSc) is a rare, multifactorial autoimmune disease characterized by widespread vascular damage and fibrosis. Pulmonary involvement is a significant manifestation of SSc, contributing to considerable morbidity and mortality. Therefore, identifying reliable biomarkers is of the utmost importance. This review by Issa El Kaouri et al. explores emerging biomarkers to enhance diagnostic accuracy, prognostic assessment, and disease monitoring in SSc lung involvement. They discuss recent findings in immunological biomarkers, inflammatory indicators, and other parameters that can function as potential diagnostic and prognostic tools.

Read more: https://bit.ly/3VLTYWB

18/12/2024

A recent study examined how personality traits affect disease management in MS patients. Using the NEO-FFI and Lüscher Color Test, Prof. Pasquale Calabrese's team found that MS patients had higher neuroticism, openness, agreeableness, and conscientiousness, with no effect on extraversion. Neuroticism was linked to a preference for green-blue colors (indicating avoidance of stimulation) and predicted higher anxiety and fatigue. Openness showed a trend toward preferring lighter color shades. While no significant links were found between personality traits and cognitive function, their findings highlight the importance of personality assessments in MS care to improve treatment and address emotional challenges.

Learn more: https://bit.ly/3DvnnxK

18/12/2024

A recent study explored the relationship between caregiver burden and the quality of life in patients with Multiple Sclerosis (MS). Conducted between July 2021 and December 2023, the research involved 167 caregivers of 153 MS patients at a single center.

Learn more: bit.ly/3DplNha

18/12/2024

A review by Dr. Alexandros Tsoupras et al. examined the benefits of vitamin D including its anti-inflammatory promise against glomerulosclerosis and kidney diseases.

Read more: https://bit.ly/49JrORK

18/12/2024

Pseudobulbar Affect (PBA), an emotional disorder characterized by uncontrolled laughing or crying, affects 2% to 10% of multiple sclerosis (MS) patients. Clinicians should be prompted to consider PBA in the differential diagnosis of emotional disorders in the context of MS by using both clinical criteria and psychometric instruments. Further studies should be conducted to develop standardized diagnostic protocols and to optimize therapeutic approaches for the clinical management of this patient population.

Read this interesting systematic review at: https://bit.ly/49Ka6xw

Multiple sclerosis (MS) is associated with a high prevalence of emotional disorders affecting the health-related quality of life of patients and their families. Pseudobulbar affect (PBA), also referred to as pathological laughing and crying, is an under-recognized and under-treated co-morbidity. We....

18/12/2024

📚 Read our Opinion "The Conjecture of Poser on the Origins of : New Theoretical Considerations and Proposal" by Victor M. Rivera from Baylor College of Medicine.

🔺 Access the full text at: https://bit.ly/49GZ6AO

©️ Figure source: https://msif.org

18/12/2024

Following the success of the first edition, we're excited to announce the launch of the Special Issue "Neuropsychiatric and Quality of Life (QoL) Aspects of Multiple Sclerosis, 2nd Edition". We invite your submissions before the deadline 20 October 2025. Don't miss the opportunity to contribute! https://bit.ly/41GbYVT