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Current Issues in Molecular Biology (CIMB) (ISSN 1467-3045) is a peer-reviewed journal publishing original articles and reviews in all areas of molecular biology.

07/10/2025

Highly Cited and Viewed Article 🔬

🧪 Thioredoxin Domain Containing 5 (TXNDC5): Friend or Foe?
by Seyed Hesamoddin Bidooki, María A. Navarro, Susana C. M. Fernandes, and Jesus Osada*
(University of Zaragoza, Spain, and Université de Pau et des Pays de l’Adour, France)

This comprehensive review examines the dual role of TXNDC5 (ERp46)—a protein disulfide isomerase family member—across various diseases. Acting as both protector and promoter, TXNDC5 supports cellular defense under stress in normal tissues but may enhance survival and progression in cancer cells.

🧫 The study underscores TXNDC5’s complexity as both a potential biomarker and a therapeutic target in cancer and other pathologies.

📖 Read the full article in Current Issues in Molecular Biology:

This review focuses on the thioredoxin domain containing 5 (TXNDC5), also known as endoplasmic reticulum protein 46 (ERp46), a member of the protein disulfide isomerase (PDI) family with a dual role in multiple diseases. TXNDC5 is highly expressed in endothelial cells, fibroblasts, pancreatic β-cel...

07/10/2025

Highly Cited and Viewed Article 📈

🧬 Role of Filamin A in Growth and Migration of Breast Cancer—Review
by Patryk Zawadka, Wioletta Zielińska, Maciej Gagat*, and Magdalena Izdebska
(Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Poland)

This review explores the role of Filamin A (FLNa)—an actin-binding protein involved in cell migration, adhesion, and proliferation—in the progression and metastasis of breast cancer. The article highlights discrepancies in current research and emphasizes the need for further studies on FLNa as a potential therapeutic target.

📖 Read the full article in Current Issues in Molecular Biology:

Despite ongoing research in the field of breast cancer, the morbidity rates indicate that the disease remains a significant challenge. While patients with primary tumors have relatively high survival rates, these chances significantly decrease once metastasis begins. Thus, exploring alternative appr...

06/10/2025

📈 Highly Cited & Highly Viewed!

Discover “A Computational Approach for the Discovery of Novel DNA Methyltransferase Inhibitors” by Eftichia Kritsi et al. 🧬

This study employs a combination of structure- and ligand-based computational methods to identify potential natural-derived DNMT inhibitors, offering valuable insights into epigenetic drug discovery.

🔗 Read the full article:

Nowadays, the explosion of knowledge in the field of epigenetics has revealed new pathways toward the treatment of multifactorial diseases, rendering the key players of the epigenetic machinery the focus of today’s pharmaceutical landscape. Among epigenetic enzymes, DNA methyltransferases (DNMTs) ...

06/10/2025

📢 Highly Cited & Highly Viewed!

Check out our latest article: “The Biological Impact of Some Phosphonic and Phosphinic Acid Derivatives on Human Osteosarcoma” by Zakzak Khaled et al.

This study explores a newly developed phosphinic acid derivative with promising anti-osteosarcoma activity, showing strong biosafety on healthy cells and significant apoptosis induction in cancer cells. A potential breakthrough for future osteosarcoma therapy!

🔗 Read the full article:

Osteosarcoma malignancy currently represents a major health problem; therefore, the need for new therapy approaches is of great interest. In this regard, the current study aims to evaluate the anti-neoplastic potential of a newly developed phosphinic acid derivative (2-carboxyethylphenylphosphinic a...

03/10/2025

🔥 Hot Topic in Current Issues in Molecular Biology

Cytokine Therapy in Bladder Cancer: Mechanisms, Efficacy, and Future Prospects
by Hayden J. Oyler, Layne G. Bruton, Austin J. Maher, Darien A. Yu, Nicholas W. Shely, Mark R. Wakefield, and Yujiang Fang.

This review highlights the rapidly evolving role of cytokine therapy in bladder cancer, covering:
✔️ Pro- and anti-inflammatory cytokines
✔️ Engineered cytokines and fusion proteins
✔️ Combination therapies

While challenges such as toxicity and immune suppression remain, cytokine-based strategies show strong promise for advancing safe, effective, and less invasive cancer treatments.

🔗 Read the article:

Cytokine therapy is a rapidly evolving field in bladder cancer research, with treatments designed to enhance immune responses, improve targeting, and promote tumor cell recognition and elimination. This review explores pro-inflammatory cytokines, anti-inflammatory cytokines, engineered cytokines and...

03/10/2025

🔥 Hot Topic in Current Issues in Molecular Biology

Emerging Tumor Biomarkers in Pancreatic Cancer and Their Clinical Implications
by Dimitrios Stefanoudakis, Maximos Frountzas, Nikolaos V. Michalopoulos, Dimitrios Schizas, Dimitrios Theodorou, and Konstantinos G. Toutouzas.

This review explores the potential of novel biomarkers in pancreatic cancer, including miRNAs, GATA6, L1CAM, and MUC1, highlighting their roles in diagnosis, prognosis, treatment response, and tumor progression.

While these biomarkers hold promise for personalized therapy, more clinical evidence is required before they can be routinely applied in practice.

🔗 Read the article:

Pancreatic cancer is one of the deadliest malignancies, and this is attributed to the fact that it is diagnosed at a late stage and there are limited treatment options. Tumor biomarkers are used to improve early diagnosis, treatment, and decision-making and to estimate patients’ outcomes. This rev...

02/10/2025

📢 Highly Cited & Viewed in Current Issues in Molecular Biology

Association between Donor Age and Osteogenic Potential of Human Adipose Stem Cells in Bone Tissue Engineering
by Md Abdus Sattar, Lara F. Lingens, Vincent G. J. Guillaume, Rebekka Goetzl, Justus P. Beier, and Tim Ruhl.

This review evaluates evidence on how donor age affects the osteogenic potential of human adipose stem cells (ASCs) in regenerative medicine. While ASCs are promising for bone tissue engineering, findings remain inconsistent due to donor-related factors (age, gender, lifestyle, metabolic state) and experimental variations in culture and differentiation protocols.

🔗 Read the article:

Adipose stem cells (ASCs) have multilineage differentiation capacity and hold great potential for regenerative medicine. Compared to bone marrow-derived mesenchymal stem cells (bmMSCs), ASCs are easier to isolate from abundant sources with significantly higher yields. It is generally accepted that b...

02/10/2025

🔥 Stress reimagined: Not all stress is harmful.

This Hot Topic in CIMB explores how the oxytocin–vasopressin system transforms stress into strength through hormesis—a process where small stressors precondition the body for resilience.

👉 Why do people often feel stronger after challenges like childbirth, vigorous exercise, or even psychedelic use? The answer may lie in oxytocin’s role in restoring balance and promoting healing.

This new perspective has profound implications for mental health, social connection, and chronic stress management.

🔗 Discover the full article:

The purpose of this article is to examine a previously unrecognized role for the vasopressin–oxytocin (VP-OT) system in mammalian “stress-response hormesis.” The current review adds hormesis to the long list of beneficial effects of OT. Hormesis, a biphasic adaptive response to low-level stres...

02/10/2025

📢 Highly Viewed in Current Issues in Molecular Biology

The Neuromuscular Disorder Mediated by Extracellular Vesicles in Amyotrophic Lateral Sclerosis
by Elisabetta Carata, Marco Muci, Simona Di Giulio, Tiziano Di Giulio, Stefania Mariano, and Elisa Panzarini.

This review highlights the role of extracellular vesicles (EVs) in the pathogenesis of amyotrophic lateral sclerosis (ALS), extending beyond central nervous system dysfunction to include skeletal muscle involvement. The authors discuss how EVs may influence neuromuscular junctions, muscle wasting, and regeneration—opening possibilities for novel therapeutic approaches in ALS.

🔗 Read the article:

Amyotrophic lateral sclerosis (ALS) represents a neurodegenerative disorder characterized by the progressive loss of both upper and lower motor neurons, resulting in muscular atrophy and eventual paralysis. While much research has concentrated on investigating the impact of major mutations associate...

02/10/2025

📢 Highly Viewed in Current Issues in Molecular Biology

Expression and Functional Analysis of Immuno-Micro-RNAs miR-146a and miR-326 in Colorectal Cancer
by Ovidiu Farc, Liviuta Budisan, Florin Zaharie, Roman Țăulean, Dan Vălean, Elena Talvan, Ioana Berindan Neagoe, Oana Zănoagă, Cornelia Braicu, and Victor Cristea.

This study investigates the expression of miR-146a-5p and miR-326-5p in colorectal cancer, uncovering their regulatory transcriptional networks and biomarker potential. Results show both miRNAs are downregulated in tumor tissue, with miR-326 and its combination with miR-146a demonstrating promise as biomarkers in CRC.

🔗 Read the article:

Micro-RNAs (miRNAs) are non-coding RNAs with importance in the development of cancer. They are involved in both tumor development and immune processes in tumors. The present study aims to characterize the behavior of two miRNAs, the proinflammatory miR-326-5p and the anti-inflammatory miR-146a-5p, i...

01/10/2025

🧬 New Insights in Cancer Therapy
Modulation of Multidrug Resistance Transporters by Food Components and Dietary Supplements
by Agnieszka Brodzicka, Agnieszka Galanty & Paweł Paśko

Read here
https://brnw.ch/21wWgEa
Chemotherapy outcomes are often limited by multidrug resistance (MDR) transporters like MRP2, BCRP, and P-gp. This review shows how dietary compounds and supplements can influence these transporters:

🍇 Phytochemicals (catechins, quercetin, curcumin, resveratrol) may enhance or reduce drug efflux

🧪 Impact on drug bioavailability and intracellular drug accumulation

📌 Highlights the need to consider diet–drug interactions when planning cancer therapy

Optimizing nutrition and supplement intake could improve treatment efficacy and reduce side effects.

Published in Curr. Issues Mol. Biol. (Special Issue: Phytochemicals in Cancer Chemoprevention and Treatment).

The aim of this review is to explore how diet and dietary supplements influence the activity of key multidrug resistance (MDR) transporters—MRP2, BCRP, and P-gp. These transporters play a crucial role in drug efflux from cancer cells and significantly affect chemotherapy outcomes. This review focu...

01/10/2025

🌟 Highly Cited
Molecular Basis of Yeasts’ Antimicrobial Activity: Developing Innovative Strategies for Biomedicine and Biocontrol
by Ana-Maria Georgescu, Viorica Maria Corbu & Ortansa Csutak
👉 Read here https://brnw.ch/21wWgsn

With the rise of resistant pathogens, eco-friendly solutions are more important than ever. This review explores yeasts as natural antimicrobial agents and their molecular mechanisms:

🧬 Killer toxins from dsRNA, dsDNA, or chromosomal genes targeting fungi, yeasts, and bacteria

🌈 Red yeasts producing carotenoids and rhodotorulic acid to combat oxidative stress and inhibit pathogens

💧 Biosurfactants that prevent fungal growth, bacterial proliferation, and biofilm formation

These findings highlight yeasts’ potential in biomedicine, agriculture, and biocontrol, offering sustainable alternatives to synthetic biocides.

Published in Curr. Issues Mol. Biol. (Special Issue: Molecular Biology in Applied Biosciences).

In the context of the growing concern regarding the appearance and spread of emerging pathogens with high resistance to chemically synthetized biocides, the development of new agents for crops and human protection has become an emergency. In this context, the yeasts present a huge potential as eco-f...

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