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Current Issues in Molecular Biology (CIMB) (ISSN 1467-3045) is a peer-reviewed journal publishing original articles and reviews in all areas of molecular biology.

10/12/2025

🤔 Could a diabetes drug be the key to weight loss, anti-aging, and better metabolism?

Semaglutide, originally for blood sugar control, is showing promise far beyond diabetes:

👉 Appetite regulation and weight loss 🍽️

👉 Improved heart and metabolic health ❤️

👉 Boosting metabolism through adipose tissue browning 🔥

👉 Protecting muscles from age- and obesity-related decline 💪

👉 Anti-inflammatory and antioxidant effects 🧬

Most of these exciting mechanisms are still preclinical, but the potential is huge! Could semaglutide be the future of holistic metabolic health?

Discover the science here:

Initially intended to control blood glucose levels in patients with type 2 diabetes, semaglutide, a potent glucagon-like peptide 1 analogue, has been established as an effective weight loss treatment by controlling appetite. Integrating the latest clinical trials, semaglutide in patients with or wit...

10/12/2025

🦷 Highly Cited in Current Issues in Molecular Biology!

We are pleased to highlight the review “Plant-Derived Compounds: A Promising Tool for Dental Caries Prevention” by Konstantinos Tzimas, Maria Antoniadou, Theodoros Varzakas, and Chrysoula Voidarou.

With growing concerns about the environmental and health impacts of conventional oral care products, research has increasingly focused on herbal extracts and plant-based compounds as sustainable alternatives.

This comprehensive review explores recent findings (2019–present) on plant-derived compounds showing:

🌿 potent antibacterial activity against Streptococcus mutans
🌿 comparable efficacy to chlorhexidine in some extracts
🌿 promising results in vivo (including food-based applications like functional lollipops)
🌿 anti-adhesion, enzyme-inhibiting, and bactericidal properties

The article also highlights key challenges—especially evaluating safety, cytotoxicity, and clinical effectiveness—before widespread adoption.

📘 A valuable resource for researchers in oral biology, natural product chemistry, and dental therapeutics.

🔗

There is a growing shift from the use of conventional pharmaceutical oral care products to the use of herbal extracts and traditional remedies in dental caries prevention. This is attributed to the potential environmental and health implications of contemporary oral products. This comprehensive revi...

09/12/2025

🌱 Highly Cited in Current Issues in Molecular Biology!

We are pleased to highlight the review “A Review of Bioactive Compound Effects from Primary Legume Protein Sources in Human and Animal Health” by Zachary Shea et al.

Legumes—soybeans, peas, chickpeas, and mung beans—are rich in bioactive peptides, isoflavones, saponins, and other health-promoting compounds.
This comprehensive article examines how these molecules contribute to:

✨ antioxidant and anticancer activity
✨ diabetes and hypertension management
✨ improved metabolic and cardiovascular health
✨ enhanced nutritional profiles in both humans and animals

The authors emphasize soybeans’ well-studied bioactive components while revealing the untapped potential of other legume species—offering opportunities for the development of next-generation nutraceuticals and sustainable foods.

📚 This review sets the stage for future interdisciplinary research exploring mechanisms, synergies, and functional applications.

🔗 Read more:

The global demand for sustainable and nutritious food sources has catalyzed interest in legumes, known for their rich repertoire of health-promoting compounds. This review delves into the diverse array of bioactive peptides, protein subunits, isoflavones, antinutritional factors, and saponins found ...

09/12/2025

🧠 Highly Cited in Current Issues in Molecular Biology

We are excited to highlight the article “Mechanisms and Emerging Regulators of Neuroinflammation: Exploring New Therapeutic Strategies for Neurological Disorders” by Mi Eun Kim and Jun S*k Lee.

This comprehensive review explores how microglia, astrocytes, peripheral immune cells, and key pathways—such as NF-κB, JAK–STAT, and the NLRP3 inflammasome—shape the neuroinflammatory environment in conditions including Alzheimer’s, Parkinson’s, and Multiple Sclerosis.

🔬 The authors also discuss emerging regulators such as:
• non-coding RNAs
• epigenetic mechanisms
• gut–brain axis interactions
• metabolic modulation

💡 With growing interest in RNA-based therapeutics, immunomodulators, and microbiome-targeted strategies, this article offers a forward-looking perspective on future avenues for tackling chronic neuroinflammation.

📄 Read the full article:

Neuroinflammation is a complex and dynamic response of the central nervous system (CNS) to injury, infection, and disease. While acute neuroinflammation plays a protective role by facilitating pathogen clearance and tissue repair, chronic and dysregulated inflammation contributes significantly to th...

08/12/2025

🌍 Non-typhoidal Salmonella (NTS) remains a global health challenge, causing millions of illnesses yearly! 🦠

This highly cited review by Cristina Mihaela Sima et al. dives into NTS pathogenesis, rising antibiotic resistance, and promising new therapies—from probiotics to vaccines. 💉✨

Read the full article here:

Even with the intensive efforts by public health programs to control and prevent it, non-typhoidal Salmonella (NTS) infection remains an important public health challenge. It is responsible for approximately 150 million illnesses and 60,000 deaths worldwide annually. NTS infection poses significant....

08/12/2025

✨Highly Cited Article Highlight
Title: Cadmium Stress Signaling Pathways in Plants: Molecular Responses and Mechanisms
Authors: Valentina Vitelli, Agnese Giamborino, Andrea Bertolini, Alessandro Saba, Andrea Andreucci
Journal: Current Issues in Molecular Biology, 2024, 46(6), 6052–6068
https://brnw.ch/21wYaHw

Special Issue: Latest Review Papers in Molecular Biology 2024

Why It Matters:
Cadmium (Cd) pollution is a serious threat to plants and ecosystems worldwide. This review dives into how plants fight back using clever molecular and physiological strategies. Key highlights:

✔️Phytochelatins (PCn) act like natural sponges, capturing and storing Cd ions to protect the plant.

✔️Glutathione (GSH) helps neutralize the oxidative damage caused by Cd, keeping cells safe.

✔️Transporter Proteins (ABCs and HMAs) carefully control Cd uptake, storage, and detoxification.

The paper provides a detailed map of the defense mechanisms plants deploy under heavy metal stress and offers a solid foundation for tackling pollution in agriculture and the environment.

Heavy metal (HM) pollution, specifically cadmium (Cd) contamination, is a worldwide concern for its consequences for plant health and ecosystem stability.

05/12/2025

🌟 Calling All Early Career Researchers!

Current Issues in Molecular Biology is recruiting Early Career Editorial Board Members! 🚀

Applications are now open until 31 July 2026. This is your chance to:

👉 Contribute to cutting-edge molecular biology research

👉 Collaborate with an international editorial team

👉 Gain valuable editorial experience

Don’t miss this opportunity—apply today!

More info 👇

Current Issues in Molecular Biology, an international, peer-reviewed Open Access journal.

05/12/2025

🔥 Cracking Drug Resistance in Prostate Cancer!

New research uncovers how ERK-Elk1, JNK-cJun, and JAK-STAT pathways drive autophagy and resistance to proteasome inhibitors in prostate cancer cells. 🧬⚡

Key insights:

🔑Resistant cells evade apoptosis and increase aggressiveness

🔑 Autophagy acts as a backup to the proteasome system

🔑 Novel therapeutic targets: transcription factors & kinases

🔑 Potential strategies to re-sensitize tumors to treatment

A must-read for anyone following cancer therapy breakthroughs!

Read more:

The rapid emergence of resistance limits the application of proteasome inhibitors against solid tumors, despite their effectiveness in the treatment of hematological malignancies.

05/12/2025

🤖🧬 AI Meets Genomics!

Discover how Artificial Intelligence is transforming Next-Generation Sequencing (NGS). From variant calling to single-cell analysis and cancer biomarker discovery, AI-driven tools are making genomic research faster, more accurate, and scalable.

This highly cited review dives into:

✔️Machine & deep learning in NGS workflows

✔️ AI-powered precision medicine and drug discovery

✔️ Challenges: data heterogeneity, interpretability & ethics

✔️ Future: federated learning, multi-omics integration, and third-generation sequencing

The future of genomics is intelligent—and here’s how we’re getting there. 🚀

Read the full review:

The integration of artificial intelligence (AI) into next-generation sequencing (NGS) has revolutionized genomics, offering unprecedented advancements in data analysis, accuracy, and scalability. This review explores the synergistic relationship between AI and NGS, highlighting its transformative im...

04/12/2025

🟡 Is Copper Still Safe for Us?

Copper is essential for many cellular processes, but too much—or too little—can harm almost every organ in the body. From the nervous system to the skin, subtle changes in copper levels can have serious effects. ⚖️🧬

This comprehensive review explores:

✨Safe vs. toxic copper levels

✨ How diet, lifestyle, and genetics affect copper absorption

✨ The impact of modern copper exposure, including copper nanoparticles

A must-read for anyone interested in trace elements, health, and safety.

Read more:

Copper (Cu) is a precious metal and one of the three most abundant trace elements in the body (50–120 mg). It is involved in a large number of cellular mechanisms and pathways and is an essential cofactor in the function of cellular enzymes. Both its excess and deficiency may be harmful for many d...

04/12/2025

🧬 Can we cure genetic disorders with a few edits?

This highly cited review explores how CRISPR, base editing, and prime editing are revolutionizing medicine. From monogenic diseases to complex conditions, these breakthroughs bring precision medicine closer to reality.

✨ How do delivery systems like nanoparticles and viral vectors make gene editing safer and more effective?
✨ What makes prime editing a game-changer compared to traditional CRISPR?

Discover the latest innovations shaping the future of healthcare: https://brnw.ch/21wY4Zd

Recent years have witnessed unprecedented progress in therapeutic gene editing, revolutionizing the approach to treating genetic disorders. In this comprehensive review, we discuss the progression of milestones leading to the emergence of the clustered regularly interspaced short palindromic repeats...

03/12/2025

Highly Cited Paper! 🌶️
Capsaicin: Emerging Pharmacological and Therapeutic Insights by Elena Madalina Petran et al. reviews the diverse pharmacological roles of capsaicin, the active compound in chili peppers. The article discusses its mechanisms via TRPV1, anti-inflammatory and anti-cancer effects, bioavailability depending on administration, traditional applications including acupuncture, and antimicrobial properties. While promising, capsaicin’s therapeutic use must consider tissue-specific toxicity. This comprehensive review highlights ongoing research and future potential of capsaicin in medicine.

📖 Read here:

Capsaicin, the most prominent pungent compound of chilli peppers, has been used in traditional medicine systems for centuries; it already has a number of established clinical and industrial applications. Capsaicin is known to act through the TRPV1 receptor, which exists in various tissues; capsaicin...

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