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Current Issues in Molecular Biology (CIMB) (ISSN 1467-3045) is a peer-reviewed journal publishing original articles and reviews in all areas of molecular biology.

30/07/2025

🔬💥 Highly Cited Alert!
microRNAs meet lipedema: uncovering the epigenetic code behind a misunderstood disorder

🧬 Researchers identified specific miRNAs in lipedema-affected adipose tissue using advanced molecular and bioinformatics tools. Findings may pave the way for new biomarkers and improved diagnosis of this often-overlooked condition.

📈 A must-read for anyone working in epigenetics, women’s health, or metabolic diseases.

📖 Read the full study:

Lipedema is a chronic disorder affecting women with a 10% incidence worldwide. It is often confused with obesity. This study was undertaken to study microRNAs in lipedema tissue assessed by direct hybridization using the robust n-counter flex DX CE-IVD platform. The mean age of the subjects particip...

30/07/2025

📢 Highly Cited in Current Issues in Molecular Biology!

🔬 Development of Digital Droplet PCR Targeting the Influenza H3N2 Oseltamivir-Resistant E119V Mutation

💡 Authors developed and validated an RT-ddPCR assay for early detection of oseltamivir-resistant influenza strains—supporting better surveillance and public health response.

📖 Read more:

The monitoring of antiviral-resistant influenza virus strains is important for public health given the availability and use of neuraminidase inhibitors and other antivirals to treat infected patients. Naturally occurring oseltamivir-resistant seasonal H3N2 influenza virus strains often carry a gluta...

29/07/2025

📌 Highly Viewed in CIMB

Molecular Insights into Radiation Effects and Protective Mechanisms: A Focus on Cellular Damage and Radioprotectors
by Blanca Ibáñez, Ana Melero, Alegría Montoro, et al.

This in-depth review highlights the complex molecular damage caused by ionizing radiation and the potential of radioprotective agents to mitigate its effects. The authors examine direct DNA damage, oxidative stress via ROS, and the promising role of antioxidants and DNA repair stimulators in protecting healthy tissue.

Explore key findings in Current Issues in Molecular Biology:
👉

Ionizing radiation has been a critical tool in various fields, such as medicine, agriculture, and energy production, since its discovery in 1895. While its applications—particularly in cancer treatment and diagnostics—offer significant benefits, ionizing radiation also poses risks due to its pot...

29/07/2025

📌 Highly Viewed in CIMB

Zinc in Dermatology: Enhancing Botulinum Toxin Formulations and Clinical Efficacy
by Lacey Foster, Jose A. Foppiani, Helen Xun, et al.

This comprehensive review explores zinc’s emerging role in improving the performance and stability of botulinum toxin products in dermatology and aesthetic medicine. With implications for both cosmetic and therapeutic applications, the paper identifies opportunities for optimizing zinc delivery in non-invasive treatments.

Read the full article in Current Issues in Molecular Biology:
👉

This literature review provides a novel exploration of zinc’s multifaceted roles in dermatology, with a particular focus on its potential integration into botulinum toxin formulations—an area that remains relatively underexplored in clinical practice. Zinc is widely recognized for its critical f...

28/07/2025

🔬 Featured Paper | Current Issues in Molecular Biology
What genetic factors offer protection against chronic hepatitis B?

This study by Adriana Tălăngescu et al. analyzes HLA alleles and amino acid residues in Romanian patients with CHB, revealing key variants—such as DQB106:03:01 and DRB113:01:01—linked to protective effects.

🧬 Insights from next-generation sequencing may help improve CHB diagnostics and patient care.

📖 Read more:

Hepatitis B, a persistent inflammatory liver condition, stands as a significant global health issue. In Romania, the prevalence of chronic hepatitis B virus (CHB) infection ranks among the highest in the European Union. The HLA genotype significantly impacts hepatitis B virus infection progression,....

28/07/2025

🔬 World Hepatitis Day | Research Spotlight

Can genetics and microRNA expression help reduce acute cellular rejection (ACR) after liver transplantation in hepatitis C patients?

A recent study by King-Wah Chiu et al. explores how the IL-28B rs8099917 TT genotype and miRNA-122 expression may offer protective effects post-transplant.

📉 Patients with the TT genotype had lower ACR rates and higher miRNA-122 levels, suggesting a possible immunomodulatory role linked to anti-HCV antibody titers.

🔗 Read more: https://brnw.ch/21wUteY
📍 Published in Current Issues in Molecular Biology

This study aimed to investigate the relationship between the IL-28B SNP rs8099917 genotype, miRNA-122 expression, and the immune mechanism of ACR after LT using anti-HCV antibody calibration. A total of 45 patients with HCV received LT. IL-28B SNP rs8099917 genotyping was used to divide patients int...

25/07/2025

🔬 Highly Viewed in Current Issues in Molecular Biology!

Can metabolomics revolutionize prostate cancer diagnosis?
This study by Nitusca et al. combines untargeted and targeted metabolomic profiling to identify novel non-invasive biomarkers for PCa detection.

🧪 Key candidates:

Spermine

Acetylcarnitine

L-tryptophan

📈 High diagnostic accuracy (AUC up to 0.99!)
📖 Read the full article: https://brnw.ch/21wUqnQ
🧬 Special Issue: Advanced Molecular Solutions for Cancer Therapy

Prostate cancer (PCa) remains one of the leading causes of cancer mortality in men worldwide, currently lacking specific, early detection and staging biomarkers. In this regard, modern research focuses efforts on the discovery of novel molecules that could represent potential future non-invasive bio...

25/07/2025

🔬 Highly Viewed on Current Issues in Molecular Biology!

How do cancer-associated mutations impact the structure and function of p53?

In this study, Nicolini et al. explore the effects of representative cancer mutations on the oligomerisation of the p53 tetramerisation domain using advanced methods including native MS and high-field NMR.

🧬 Key insights into how these mutations destabilize p53 structure and alter its biological activity.

📖 Read the full paper: https://brnw.ch/21wUpNt
🔎 Published in the Special Issue Advances in Molecular Pathogenesis Regulation in Cancer

Tumour suppressor p53 plays a key role in the development of cancer and has therefore been widely studied in recent decades. While it is well known that p53 is biologically active as a tetramer, the tetramerisation mechanism is still not completely understood. p53 is mutated in nearly 50% of cancers...

24/07/2025

🧠 Highly Cited Paper in Current Issues in Molecular Biology!

🔍 Neuroprotective Effects of Geopung-Chunghyuldan Based on Its Salvianolic Acid B Content Using an In Vivo Stroke Model
📖 By Han-Gyul Lee, Seungwon Kwon, Sang-Kwan Moon et al.

🔗 https://brnw.ch/21wUozD

This study shows that Geopung-Chunghyuldan (GCD) with high salvianolic acid B helps reduce brain damage in a stroke model. The results highlight the importance of quality in herbal medicine ingredients.

👏 Well done to the authors for this highly cited work!

Background: Geopung-Chunghyuldan (GCD) has neuroprotective properties. Salviae miltiorrhizae Radix plays an essential role in GCD’s effect. The Salviae miltiorrhizae Radix marker compound is salvianolic acid B; however, its content is not uniform among samples. This study aimed to evaluate the neu...

24/07/2025

🌿 Nature’s Hidden Power: Methoxyfuranocoumarins (MFCs) 🌿
🧬 Anti-inflammatory, anticancer, neuroprotective... and more!

💡 This highly cited review reveals how these plant-derived compounds are making waves in modern medicine.

📄 Methoxyfuranocoumarins of Natural Origin – Updating Biological Activity Research and Searching for New Directions
👩‍🔬 By Dr. Magdalena Bartnik
📚 Current Issues in Molecular Biology
🔗 Read the full paper
https://brnw.ch/21wUoh2

✨ What’s inside:
✔️ Promising effects on cancer, diabetes, Alzheimer’s
✔️ Powerful natural enzyme inhibitors
✔️ Exciting new research directions

📊 Already cited by many—don’t miss what others are reading.

👉 Explore how MFCs could inspire the next generation of therapies.

Plant secondary metabolites, including furanocoumarins, have attracted attention for decades as active molecules with therapeutic potential, especially those occurring in a limited number of species as evolutionarily specific and chemotaxonomically important. The most famous methoxyfuranocoumarins (...

23/07/2025

🔬 A Rare Case of NSCLC with Both EGFR and KRAS Mutations

In a compelling case report, Abhimanyu Tushir, Israh Akhtar, and Anjali Seth (Temple University Hospital, USA) describe a patient with non-small cell lung cancer (NSCLC) harboring both EGFR and KRAS mutations—two mutations typically considered mutually exclusive.

📊 Identified through next-generation sequencing, this co-occurrence underscores the need for ongoing molecular testing, especially in patients showing resistance to tyrosine kinase inhibitors (TKIs).

💡 The case emphasizes the complexity of tumor heterogeneity and the importance of adaptive, mutation-informed treatment strategies.

🔗 Read more: https://brnw.ch/21wUn1A
🧬 Published in the Special Issue “Technological Advances Around Next-Generation Sequencing Application” in Current Issues in Molecular Biology.

Historically, EGFR and KRAS mutations were believed to be mutually exclusive. However, over the past few years, there have been emerging case reports showing the co-existence of both mutations in a single case. The majority of these co-occurring alterations were detected in samples collected from pa...

23/07/2025

🔬 How does tumor acidity drive drug resistance?

A recent study published in Current Issues in Molecular Biology uncovers how an acidic tumor microenvironment enhances cisplatin resistance in bladder cancer.

💥 Researchers found that BC cells exposed to acidic conditions (pH 6.0) required twice the cisplatin dose compared to neutral pH to achieve the same cytotoxic effect. The mechanism? Upregulation of Bcl-2 and XIAP, blocking both apoptotic and autophagic cell death pathways.

🧪 Targeting this acidity—possibly using agents like chloroquine and navitoclax—may improve chemotherapeutic responses.

📖 Read more:

Cisplatin (CDDP) remains a key drug for patients with advanced bladder cancer (BC), despite the emergence of new therapeutic agents; thus, the identification of factors contributing to CDDP treatment resistance is crucial. As acidity of the tumor microenvironment has been reported to be associated w...

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