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PAI - Pediatric Allergy and Immunology

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PAI - Pediatric Allergy and Immunology

PAI is the world's leading journal in Pediatric Allergy. Edited by Philippe Eigenmann
IF 4.4

30/12/2025

Still on , caregivers of younger children may feel greater worry and burden compared to caregivers of teenagers.
Reducing FA-worry and increasing FA-self-efficacy should be prime targets to improve FA-QoL in caregivers.

Take a peek at this 🔗 https://doi.org/10.1111/pai.70248, at

29/12/2025

This paper presents novel data on detectable bos d5 (β-lactoglobulin) and bos d11 (β-casein) in milk .
-> which contribute to our current understanding of milk ladders, a critical aspect in the management of Cow's .

See more about this 🔗 https://doi.org/10.1111/pai.70230

27/12/2025

When a Chromosomal Deletion Rewrites the Immune Script 🧬
New single-cell profiling reveals surprising players in .2 deletion syndrome.

1️⃣ Single-cell RNA-seq shows , , and also carry distinct transcriptional shifts.

2️⃣ Every cell type examined differed from controls - suggesting the deletion reshapes far beyond .

3️⃣ show elevated proliferative ; T cells shift further in children who had .

4️⃣ The syndrome may act through a -dosage ripple, altering the entire .

🔍 This study expands the paradigm - 22q11.2DS isn’t just a T-cell story, but a whole-immune-system rewrite.

🔗 https://doi.org/10.1111/pai.70237

26/12/2025

One more highlight, an article from last issue -> we present Chang Hoon Han & Seok-Jae Heo
the original article: 🔗 https://doi.org/10.1111/pai.70223

22/12/2025

Skin Barrier & Early Allergy 🔬 🔬
* Weak barrier = early trigger for ( ) & ( )
* Filaggrin mutations, changes, type-2 weaken the skin's defenses

🧴 AD : early & environment care (limited but promising)
🍽️ FA Prevention: early introduction of foods to build

Read more of this , here 🔗 https://doi.org/10.1111/pai.70238

20/12/2025

Turning Skin Prick Tests into a Better Experience 🕶️✨

What if testing felt less like a medical procedure… and more like an adventure?
In a new with 108 children, did exactly that.

With Virtual reality:
🎧 Anxiety, fear, and pain dropped significantly
🎧 100% compliance (yes, every single child!)
🎧 Happier staff, smoother testing
🎧 Zero adverse events

Know more at 🩺https://doi.org/10.1111/pai.70235

19/12/2025

Walnut Anaphylaxis on the Rise in Japan 🌰

📈 From 2011 → 2021, walnut-induced jumped from 3% to 26% in children
👶 Mostly first-time reactions in young kids (~4 years old)
🤢 Gastrointestinal symptoms more common than with other foods
⚠️ Prior allergy diagnosis less frequent in walnut cases

📌 is an emerging pediatric risk - and are key.
🔗 https://doi.org/10.1111/pai.70243

18/12/2025

Read the structured to standardize Primary Atopic Disorders and among subspecialists, aiming to improve patient outcomes through early intervention and tailored therapies.
- of the Italian Society of Pediatric Allergy and Immunology (SIAIP - Società Italiana di Allergologia e Immunologia Pediatrica

published at 🔗 https://doi.org/10.1111/pai.70225

17/12/2025

Feeding Allergens: What Holds Parents Back? 🍽️
* Many parents avoid allergenic foods by age 1
* Key barriers:
– Low awareness
– Cultural habits
– Conflicting advice
– Social media influence

📌 Takeaway: Clear, consistent guidance is essential to support early .

at 🔗 https://doi.org/10.1111/pai.70250

16/12/2025

One more highlight, an Task Force -> we present Stefania Arasi
the original article: 🔗 https://doi.org/10.1111/pai.70223

15/12/2025

There was an about and of chronic . 🔗 https://onlinelibrary.wiley.com/doi/epdf/10.1111/pai.70174.
In the November Issue, Polina Pyatilova, Agnes Leung & Philippe Eigenmann wrote an on this.
Learn more, here 🔗 https://doi.org/10.1111/pai.70244

13/12/2025

HLH in Children with CGD: Key Findings 🩸
* Among 60 CGD patients, 18.3% developed HLH
* HLH often triggered by infections
* was very high (72.7%)
* Treatment outcomes similar across vs. + immunosuppressive therapy

📌 Early recognition of HLH in CGD - especially during or - is critical for improving .
🔗 https://doi.org/10.1111/pai.70234

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Geneva

Webseite

https://onlinelibrary.wiley.com/journal/13993038

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