10/08/2026
IrMn Cluster Based Artificial Metalloenzymes with Radiosensitized Systemic Antitumor Responses to Prevent Malignant Tumor Metastasis and Recurrence
Ruidan Li, Qinlong Wen, Zhenyu Xing, Ting Wang, Jing Yang, Yunfeng Tao, Shengdong Mu, Shuang Li, Zhigong Wei, Chong Cheng*, Xingchen Peng*
Nano Micro Lett. (2027) 19:4
https://doi.org/10.1007/s40820-026-02309-2
Bioinspired IrMn cluster artificial metalloenzyme (IMM) mitigates hypoxia induced radioresistance. Under X ray irradiation, its dual catalytic centers trigger immunogenic cell death and remodel the immunosuppressive tumor microenvironment. Combined with anti PD 1 therapy, it achieves abscopal antitumor effects and long term immune memory, validated in PDX and metastatic breast cancer models.