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Science Is Good

Welcome to SCIENCE IS GOOD by geneXplain proud owners of TRANSFAC. We spread verified science facts across many fields. "Let's Question Everything."

Like, follow, & share for more fascinating insights. The geneXplain GmbH distributes software solutions for genome, network and compound analysis, in short: everything you need for life sciences oriented towards personalized medicine.The tools we distribute are handpicked based on their functionality and proven reliability, they will not let you down. The online platform we have developed integrat

es public and private domain sources, the best of both worlds: Everyone is invited to contribute!With geneXplain products, your research is off to a good start.

02/12/2025

Researchers have identified a sophisticated molecular switch inside breast cancer cells that allows them to turn stress into a survival advantage. When the tumor environment becomes hostile due to lack of oxygen or oxidative stress, a protein called SIRT1 removes a chemical group (acetyl) from a key transcription factor called MED1. This deacetylation process acts as a survival switch, instantly reprogramming the cell's gene activity to activate protective programs that make the cells tougher and faster-growing. This discovery reveals how tumors co-opt generic cellular machinery to flourish and resist treatment, opening a promising new therapeutic avenue: targeting this specific MED1 regulatory pathway could disrupt a core survival mechanism in aggressive breast cancers.

02/12/2025

Screening Alert: Breast Cancer in Younger Women is More Aggressive Than Anticipated.
New data reveals a critical gap in health screening: nearly one-quarter (20% to 24%) of all breast cancer diagnoses analyzed over an 11-year span occurred in women aged 18 to 49. This research directly challenges current age-based screening cutoffs, finding that the under-50 age group carries a stable and substantial share of the breast cancer burden. Crucially, the vast majority of these cancers were invasive, and many were aggressive types like triple-negative, which are much harder to treat. The study strongly reinforces the need for physicians to perform risk assessments on women under 40 and implement earlier, risk-tailored screening approaches to catch these aggressive tumors sooner and improve treatment outcomes.

01/12/2025

Unlocking Novel Therapeutic Targets in Chronic Kidney Disease: geneXplain's Trans-Omics Powering Breakthrough Research. Huge congratulations to the authors Sho Nishida, Tamaki Ishima, Daiki Iwami, Ryozo Nagai, and Kenichi Aizawa, the participating institute JICHI MEDICAL UNIVERSITY, and MDPI on the publication of their groundbreaking study in the International Journal of Molecular Sciences. This research successfully leveraged a trans-omic approach, integrating transcriptomics and proteomics, to decipher the molecular pathogenesis of Tacrolimus-Induced Chronic Nephrotoxicity (TACN), a major obstacle to long-term kidney graft survival. The study represents the first comprehensive functional explanation for this challenging disease.

We're incredibly proud that the geneXplain platform was instrumental in driving this discovery. The Genome Enhancer conducted comprehensive in silico upstream network analysis, a first for TACN kidney tissue, employing the TRANSPATH® database and the Composite Module Analyst (CMA) algorithm. This powerful analysis pin-pointed PRMT1 (Protein Arginine Methyltransferase-1) and Integrins (αVβ6) as key upstream master regulators. Furthermore, using the Human PSD™ and PASS software, the platform confirmed these molecules as the most likely and most druggable therapeutic targets for TACN.

The integrated multi-omic results led to the proposal of a novel pathogenic mechanism: the 'PRMT1-STAT3-Integrin αVβ6 axis'. This axis explains how increased PRMT1 leads to vascular endothelial dysfunction and, via STAT3-regulated Integrin αVβ6 expression, drives renal fibrosis. Thank you to the entire research team for utilizing the Genome Enhancer to achieve this significant and insightful discovery.

Read the paper: https://www.mdpi.com/1422-0067/26/21/10282 -ijms-26-10282

26/11/2025

The Body Trait That Keeps Your Brain Young: It's All About the Ratio.
New research reveals a strong connection between body composition and cognitive health, finding that the balance between muscle and fat is a key predictor of your biological brain age. Scientists used whole-body MRI and AI to study over a thousand healthy adults and found that having more muscle mass and a lower ratio of visceral fat (the hidden fat stored deep in the abdomen) are linked to a significantly younger-looking brain. Visceral fat appears to accelerate brain aging, increasing the risk for diseases like Alzheimer's, while muscle mass offers a protective effect. This study provides actionable insights, suggesting that achieving the best brain health outcomes even with the use of new GLP-1 weight loss drugs requires focusing on maximizing muscle volume while specifically targeting the reduction of dangerous visceral fat.

26/11/2025

Imagine walking through a forest only to hear a thousand voices and see the landscape slowly rearrange itself. In this wild thought experiment from Endless Learning, we explore the immediate, disruptive, and total consequences if all trees suddenly gained the ability to walk and communicate vocally. The first crisis would be environmental chaos. Trees, which are essential for carbon sequestration and soil stability, would begin to migrate based on their own needs (seeking better sun, water, or mates). This massive, slow-moving upheaval would destroy infrastructure, erode massive amounts of topsoil, and catastrophically alter regional climates and water cycles. Furthermore, the initial human reaction would be one of terror and political panic. Governments would be forced to deal with the logistics of billions of sentient, moving organisms that literally underpin our entire ecosystem, leading to instant debates over their rights, land ownership, and their role in a now radically different civilization.

The long-term shift would redefine humanity’s place on Earth. The ability of trees to communicate vocally would unlock a vast, ancient, and interconnected intelligence, suddenly giving us access to millions of years of ecological knowledge. Would they cooperate with humanity, or see us as the primary threat to their survival? We explore the complex philosophical and biological hurdles of this change: how quickly would they learn human language, what would their voices sound like, and what would be their first, collective demand? This video is a fascinating and chilling look at the power dynamics between species and how the basic rules of nature would instantly change if our silent, rooted neighbors suddenly found their voice and their feet. Don't forget to like, share, and subscribe to Endless Learning for more deep-dive explorations into science, history, and global challenges!

́volutionprofessionnelle

25/11/2025

Imagine the clock suddenly ticks twice as fast: our 24-hour day shrinks instantly to a mere 12 hours. In this dizzying thought experiment from Endless Learning, we explore the immediate, disruptive, and total consequences if Earth's rotational speed suddenly doubled. The most visible change would be the extreme shortening of the day-night cycle, which would fundamentally disrupt the circadian rhythms of every living organism, severely impacting sleep, hunting, and feeding patterns globally. Far more dangerous is the increased centrifugal force. At the equator, this force would increase dramatically, making people feel lighter and slightly counteracting gravity. This reduction in effective gravity would cause significant changes in the atmosphere, making winds speed up to hundreds of miles per hour, creating perpetual, catastrophic storms and hurricanes across the planet, particularly near the equator.
The consequences for our planet's geography and infrastructure would be total. The increased centrifugal force would cause the oceans to swell dramatically around the equator and recede violently from the poles. Coastal cities in equatorial regions would be permanently submerged by massive, non-tidal equatorial bulges, while landmasses at the poles would see sea levels drop. This violent shift of immense water masses, combined with the extreme winds, would destroy coastal defenses, port infrastructure, and global shipping. The sheer momentum change would also introduce massive tectonic stresses on the Earth's crust, potentially increasing the frequency of large-scale earthquakes and volcanic eruptions. This video is a thrilling look at how perfectly balanced our planet's speed is and the chaos that would ensue if even a basic physical constant were altered. Don't forget to like, share, and subscribe to Endless Learning for more deep-dive explorations into science, history, and global challenges!

25/11/2025

We’re delighted to see that the TRANSFAC® database played a key role in the recent publication “Unveiling IRF4‑steered regulation of context‑dependent transcriptional networks in CD4 Th17 and iTreg cells” by A. Gabele et al. (2025) from the team at Johannes Gutenberg University Mainz, DKFZ and HI‑TRON.
In this pioneering work, the authors combined affinity‑purification mass‑spectrometry (AP‑MS) with ChIP‑seq to map the nuclear interactome of the transcription factor IRF4 in both Th17 and iTreg contexts (133 unique interacting proteins, 129 common across both cell types). TRANSFAC® was used to evaluate binding motifs associated with the IRF4 complex and to annotate transcription factor binding sites in the context of their composite motif analyses underlining the importance of curated motif databases in multi‑omics regulatory network modeling.
We extend our warm congratulations to the authors and collaborating institutions, and our thanks to Cell Reports for publishing this valuable contribution to the field of immune regulation and transcriptional network biology.
Read the Paper: https://doi.org/10.1016/j.celrep.2025.115407
Interested in how TRANSFAC® can support your regulatory‑network projects? Visit: https://genexplain.com/transfac-features-and-packages/

24/11/2025

Hot Tubs vs. Saunas: New Research Shows Hot Water Immersion Delivers Deeper Health Gains.
If you’re looking for measurable health benefits, new research suggests that hot tubs may significantly outperform both traditional and infrared saunas! Scientists compared the body’s acute responses to three types of passive heating and found that hot-water immersion was the most impactful method for raising core body temperature. Because the water prevents the body from sweating to cool down, the core temperature rises more effectively, which is the main stimulus for beneficial physiological responses. Crucially, hot-water immersion was the only method that produced measurable changes in inflammatory markers and increased immune cell populations. This suggests that soaking in a hot tub offers a more robust boost to blood flow and immune activity, providing a surprisingly effective health supplement for everyone, especially for those unable or unwilling to exercise.

24/11/2025

TRANSFAC® Enables Insight into ECM‑Driven Gene Expression during Human Cortical Development
We are pleased to share that TRANSFAC® binding motifs were leveraged in the recent open-access study Deciphering cell‑type‑and temporally specific matrisome expression signatures in human cortical development and neurodevelopmental disorders via scRNA‑seq meta‑analysis (published in Nature Communications, 2025) by Gim D.H., Assir M.Z.K., Soper O., Fowler P.A., Morgan M.D., Berg D.A., Kang E. et al.
In this impressive meta‑analysis of 37 human fetal cortex samples (gestational weeks 8–26) across six independent scRNA‑seq datasets, the authors chart the cell‑type‑ and time‑specific expression dynamics of the matrisome (ECM‑related genes) and link these signatures to neurodevelopmental disorder (NDD) risk.
TRANSFAC® motifs were used in the motif‑binding inference component of their workflow: after identifying genes of interest such as LGALS3 with pseudotime and co‑expression dynamics, the authors applied the IReNA framework and motif‑analysis using TRANSFAC® to encode TF–target relationships via promoter motif scanning. This enabled them to propose regulatory modules of transcription factors that may drive ECM‑gene expression changes during cortical development.
We thank the authors and congratulate them on producing a robust, open‑access dataset and analytic framework. Our appreciation also goes to the participating institutions—including University of Aberdeen, UK—and to Nature Portfolio Communications for disseminating this important work.
👏 We’re honoured to see TRANSFAC® included as a cited resource in their regulatory‑network toolkit.
Interested in how you can use TRANSFAC® for motif‑based analysis in your system? Visit us at: genexplain.com/transfac

24/11/2025

FOXO3: A single master regulator held the key to new therapies in Aging, Cancer, Metabolism, and Neurodegeneration. This influential transcription factor is the ultimate stress-response integrator. We've published a comprehensive breakdown of its molecular functions, revealing new therapeutic angles and connecting the dots across major disease areas.

🔗 Read the full scientific article and map your next steps here: https://genexplain.com/foxo3-key-regulator-in-aging-and-longevity/

FREE DATA OFFER: Interested in the full scope of FOXO3's impact?
Reply to this post or send us a quick DM with the phrase "Send me FOXO3 (free)" and we will send you the complete, curated list of 70 FOXO3 disease associations from our database, absolutely free of charge.

21/11/2025

Every single cell in your body has a unique molecular fingerprint that dictates its function and status, and scientists are racing to create a complete inventory of them all through the ambitious Human Cell Atlas project. This goal relies on single-cell RNA sequencing (scRNA-seq), a powerful tool that determines which genes are active in individual cells. Researchers recently completed the first comprehensive analysis comparing six different scRNA-seq methodologies based on their sensitivity, precision, and cost efficiency. Their findings revealed critical differences, such as commercial kits being up to ten times more expensive than home-made versions, and proving that the ideal method depends entirely on the specific demands of the experiment. This meticulous work is now providing scientists with the precise tools needed to revolutionize our understanding of human biology and disease processes one cell at a time.

21/11/2025

We are pleased to share that the latest publication by Tang et al. in Signal Transduction and Targeted Therapy (Nov 2025) makes extensive use of TRANSFAC® to identify transcription factor binding motifs critical to prostate cancer biology.
In this innovative study titled “β-catenin-TCF4-NANOG axis defines the core transcriptional network of cancer stem cells in prostate cancer”, the researchers uncover a pivotal regulatory circuit where Wnt/β-catenin signaling activates TCF4, which in turn upregulates NANOG, a key factor in maintaining stemness. To validate these interactions, they performed motif enrichment analysis at ChIP-seq peaks and promoter regions using TRANSFAC®, confirming the co-occurrence of TCF4 and NANOG motifs at target loci.
The authors cite our TRANSFAC® database and methodology across several sections of the study, applying it to define transcriptional modules associated with therapy resistance and metastasis. This work exemplifies how TRANSFAC® enables high-resolution dissection of transcriptional networks underlying aggressive cancer phenotypes.
We congratulate Yuqing Tang, Dan Wang, Yifan Zhang, and all co-authors on this impactful work. Special thanks to the contributing institutions: Sun Yat-sen University Cancer Center, Guangdong Provincial People’s Hospital, and Southern University of Science and Technology. Also, kudos to the editorial team at Nature’s Signal Transduction and Targeted Therapy for publishing this important contribution.
Read the paper: https://doi.org/10.1016/j.gene.2025.149890

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