European Thyroid Journal

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European Thyroid Journal

The European Thyroid Journal publishes papers reporting original research in basic, translational and clinical thyroidology.

The official journal of the European Thyroid Association, publishing basic, translational and clinical thyroidology. 2025 Journal Impact Factor: 4.9/2025 CiteScore: 7.2 Original contributions cover all aspects of the field, from molecular and cellular biology to immunology and biochemistry, from physiology to pathology, and from pediatric to adult thyroid diseases with a special focus on thyroid cancer. Readers also benefit from reviews by noted experts, which highlight especially active areas of current research. The journal will further publish formal guidelines in the field, produced and endorsed by the European Thyroid Association.

24/09/2026

A new review by Linh T T Nguyen et al. summarises mechanisms of telomerase reverse transcriptase (TERT) activation in thyroid cancer, the biological consequences of promoter mutations, clinical utility as biomarkers, and emerging therapeutic strategies, including the most recent advances made in the field in the recent years.

Read the review: https://doi.org/10.1530/ETJ-26-0068

This paper forms part of the Novel Insights in Advanced Thyroid Carcinoma: From Mechanisms to Treatments Special Collection, edited by Efisio Puxeddu, Iwao Sugitani and Iñigo Landa

22/09/2026

A new review by Michaela Kuhlen et al. summarizes current evidence and practical management considerations for thyroid nodules in children and adolescents with cancer predisposition syndromes (CPSs), with a focus on follicular cell-derived nodules and non-medullary thyroid carcinoma (NMTC).

The review proposes a CPS-adapted, multidisciplinary risk-assessment framework to support evaluation and management and highlights the need for prospective multicentre registries and harmonized protocols to define syndrome-specific outcomes and evidence-based thresholds for surveillance and intervention.

Read the review: doi.org/10.1530/ETJ-26-0100

17/09/2026

Does progesterone luteal phase support (LPS) affect thyroid function?

New research investigates whether LPS with natural progesterone affects thyroid function in modified natural frozen embryo transfer (FET) cycles, as assessed by TSH and fT4.

Read the research: https://doi.org/10.1530/ETJ-26-0099

15/09/2026

New research investigates the dependence of murine thyroid cancer cell lines on COPZ1, a subunit of coatomer complex I, and the molecular mechanisms involved.

The study demonstrates that inflammatory responses following COPZ1 silencing are cell line-dependent. COPZ1 silencing impaired cell proliferation and induced ER stress in four cell lines, activated a transcriptional and secretory IFN-I-related program in two cell lines, and increased ROS production, lipid peroxidation, and Ca²⁺ levels in the other two cell lines.

Read the research: https://doi.org/10.1530/ETJ-25-0408

10/09/2026

What is the clinical value of intraoperative high-frequency ultrasound in assessing the capsular continuity of thyroid follicular neoplasms?

A new study explores the feasibility of using intraoperative high-frequency ultrasound to identify tumor capsular abnormalities and guide optimized sampling for intraoperative frozen section analysis, with the goal of improving sensitivity and accuracy in differentiating thyroid follicular neoplasms.

The study demonstrates that intraoperative high-frequency ultrasonography can effectively identify abnormalities in tumor capsular continuity, guide optimized sampling for intraoperative frozen section analysis, significantly improve the intraoperative detection of malignant tumors, and provide reliable intraoperative guidance.

Read the research: https://doi.org/10.1530/ETJ-26-0040

03/09/2026

✈️ See you in Porto!

The European Thyroid Journal will be attending the 47th Annual Meeting of the European Thyroid Association on 5-8 September.

If you're thinking about your next publication, stop by for a chat and learn more about publishing with the official journal of the European Thyroid Association.

We look forward to meeting you and hearing about your latest research.

27/08/2026

New Consensus Statement: Management of thyroid storm

This consensus statement provides practical recommendations for the diagnosis and treatment of thyroid storm, a rare but life-threatening endocrine emergency. It aims to standardise care, support clinical decision-making, and improve outcomes in patients presenting with thyroid storm.

Developed by an expert panel nominated by the European Thyroid Association, British Thyroid Association, Society for Endocrinology, and Welsh Endocrine and Diabetes Society, this document brings together current evidence and expert consensus to support the management of this critical condition.

🔗 https://doi.org/10.1530/ETJ-26-0043

25/08/2026

New research by Anke Daser et al. identifies tumor necrosis factor (TNFα) as a central regulator linking inflammation to adipogenic suppression, profibrotic signaling, and extracellular matrix (ECM) remodeling in a thyrotropin receptor (TSHR)-immunized mouse model of thyroid eye disease (TED).

TSHR-immunized mice exhibited marked orbital macrophage infiltration and elevated TNFα levels. TNFα induced a strong pro-inflammatory response in orbital fibroblasts (mOFs) and increased hyaluronic acid (HA) production and hyaluronan synthase 2 (HAS2) expression, particularly in TSHR-derived fibroblasts, demonstrating enhanced ECM synthesis under autoimmune conditions.

Enhanced HA/HAS2 induction underscores a disease-specific sensitivity of mOFs to TNFα. Targeting TNFα or its downstream IL-6/TGFβ-ECM axis may offer a promising therapeutic strategy to limit pathological tissue remodeling in TED.

Read the research: https://doi.org/10.1530/ETJ-25-0407

19/08/2026

August is Thyroid and Pregnancy Awareness Month 💙

As we mark Thyroid and Pregnancy Awareness Month, we recognise the importance of continuing to advance understanding of thyroid hormones and thyroid disease during pregnancy.

Supporting this area is a key aim of the European Thyroid Journal Special Collection: Thyroid Disease and Pregnancy, which is currently open for submissions.

The collection will explore the current state of the art in the management of maternal hypothyroidism and hyperthyroidism in pregnancy, with a clinical focus on diagnosis, treatment, and outcomes.

🔗 journals.bioscientifica.com/etj/pages/pregnancy/

18/08/2026

What role does MCT8 play in maternal-to-fetal T4 transport? And could this contribute to the neurodevelopmental features of MCT8 deficiency?

A recent study by Zhongli Chen et al. used an ex vivo human placental perfusion model to investigate whether MCT8 contributes to the transfer of thyroxine (T4) across the placenta. The study explores the possibility that impaired placental transport of maternal thyroid hormone may be an under-recognised mechanism in MCT8 deficiency, potentially affecting neurodevelopment before birth. The authors also examined the transplacental transport of TRIAC, providing further insight into its potential as a prenatal therapeutic approach for MCT8 deficiency.

Read the study: https://doi.org/10.1530/ETJ-26-0003

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