The Analytical Scientist

17/12/2025

Standardizing veterinary drug testing in food matrices is tough. This AOAC-Official LC-MS/MS method package is designed to make it easier. 🧪🌍

In this “Story of Our App Note,” SCIEX experts Michael Scherer and Jianru Stahl-Zeng share how a single workflow was developed, validated across global QC labs, and accepted by AOAC to help screen ~150 compounds, with dedicated streams for challenging classes like beta-lactams, aminoglycosides, and tetracyclines.

Download the full technical note: https://ow.ly/KFSI50XCLKb

16/12/2025

🌊🔦 LIBS under pressure (literally). What happens when you try to do laser spectroscopy 4,000 meters beneath the ocean surface?

At Laser Zentrum Hannover, Marcel Rieck and team are adapting laser-induced breakdown spectroscopy (LIBS) for extreme environments, from the crushing pressure of the deep sea to the vacuum of space. The goal: real-time elemental analysis in places where traditional methods just do not work.

🌐 This is a great read, don't miss it: https://ow.ly/icAe50XGn1o

10/12/2025

CAR T vs solid tumors is still one of the biggest hurdles in cell therapy 🔬🧫

Joey Sheff of the National Research Council Canada, shares how mass spectrometry and proteomics can help close the gap, from cell-surface target discovery to epitope mapping, CAR/antibody characterization, and proteomic readouts that reveal the cell states linked to efficacy, exhaustion, and toxicity.

🔍 Read the full interview for more insights: https://ow.ly/chr450XBieP

Joey Sheff of the National Research Council Canada explains how mass spectrometry and proteomics could help CAR T therapies overcome the unique challenges of solid tumors

09/12/2025

Lipidomics is exploding. Clinical impact depends on one thing: getting quantitation right. 🔬📈

In this interview, Michal Holčapek (University of Pardubice) shares how high-resolution MS plus smart separation can reveal biology-relevant lipid detail, and why inter-lab harmonization is the make-or-break step for translation.

Read the full story: https://ow.ly/g2L550XBnFQ

05/12/2025

🧬⚗️ What happens when you revive a forgotten chromatography technique?

In this article, Fabrice Gritti shares how deep dives into DNA physics helped bring slalom chromatography back to life, and why it could change how we separate large DNA and RNA in cell and gene therapy workflows.

Full story: https://ow.ly/eJux50XvG39

03/12/2025

🧫✨ Biofilms just got a whole lot easier to map.

Researchers at Oak Ridge National Laboratory have developed an automated, large-area AFM platform that stitches together ultra-high-resolution scans across millimeter-scale surfaces — revealing biofilm architecture that has never been seen at this scale.

To learn more, we spoke with Liam Collins, senior author of the study, about the technical hurdles, interdisciplinary teamwork, and what comes next for large-area AFM.

Full feature:
https://ow.ly/KO0O50XtnUq

28/11/2025

The latest issue is ready to download 🚀

Download to explore the 2025 Innovation Awards, 4D metabolomics, single-molecule PCR, slalom chromatography, CLIRSPEC at 10, and more!

🔗 https://ow.ly/zif050XxvKX

27/11/2025

🪐 New research suggests some organics in Enceladus’s plumes may form through Saturn’s radiation, not the subsurface ocean.

We spoke with Grace Richards, postdoctoral researcher at INAF-IAPS in Rome working as part of the SERENA instrument team for BepiColombo, who led the research, to find out about what this means for finding biosignatures.

Full story:
https://ow.ly/s45550XtniU

26/11/2025

A giant of spectrochemical analysis, remembered.

Analytical science lost one of its most influential figures this year: Professor James D. Winefordner — a pioneer whose work shaped atomic spectrometry, laser spectroscopy, single-atom detection, instrumentation development, and generations of scientists around the world.

In a deeply personal remembrance, Gary Hieftje reflects on Winefordner’s legacy, his decades at the University of Florida, his profound mentorship, and the family-like lineage of scientists he helped inspire.

It’s a moving tribute to a scientist whose impact will continue echoing across analytical chemistry for decades.

Read the full reflection here: https://ow.ly/TMY750XxsZC

25/11/2025

⚡ Smarter science starts with the right tools.

The Product Book brings together the latest innovations in analytical science — from precision instruments to efficiency-boosting lab tech.

📖 Explore now: https://ow.ly/s7tl50X63KY

18/11/2025

🎉 The Analytical Scientist Innovation Awards 2025 continue!

We’re celebrating the breakthroughs pushing analytical science forward — from smarter separations to next-generation mass spectrometry.

Here are innovators #5 to #1:

✨ #5 Agilent Technologies 1290 Infinity III Hybrid Multisampler
Feed Injection for enhanced HPLC/UHPLC performance
https://ow.ly/yoQE50XtlKW

✨ #4 IonOpticks Aurora Series Capillary Flow Column Range
Proteomic depth combined with long-term stability
https://ow.ly/6N5650XtlKU

✨ #3 Waters Corporation BioResolve Protein A Affinity Columns
Biopharma innovation with insights from Beatrice Muriithi
https://ow.ly/1haU50XtlKR

✨ #2 Thermo Fisher Scientific Orbitrap Astral Zoom Mass Spectrometer
The story behind its development with Johannes Petzoldt
https://ow.ly/TrLW50XtlKS

✨ #1 Countable PCR from Countable Labs
🏆 Ranked first in our 2025 Innovation Awards
https://ow.ly/U1M950XtlKV

🚀 That concludes our 2025 Innovation Awards.
Congratulations to all the innovators pushing analytical science forward.

Read the full feature here: https://www.theanalyticalscientist.com/issues/2025/articles/november/the-analytical-scientist-innovation-awards-2025

17/11/2025

Start-ups live or die by their data. 📊

Alexander Böser explains why analytical science is the backbone of innovation — and why chemistry and materials start-ups can’t scale without it.

Read: https://ow.ly/kuSC50XgKfh