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The Lancet

The Lancet Group is a collection of 24 medical & health journals united by a shared vision – publishing the best science for better lives,

The Lancet began as an independent, weekly general medical journal founded in 1823 by Thomas Wakley. Since its first issue, the journal has addressed urgent medical and health-related topics, initiated debate, and influenced decision-makers around the world. In 2023, we celebrated The Lancet’s 200th year and its evolution into a Group of 24 journals spanning a wide range of fields and world region

s. After two centuries, The Lancet Group retains, at its core, the belief that medicine must serve society, that knowledge must transform society, and that the best science must lead to better lives. To find out more about, visit www.thelancet.com. The Lancet is a trade mark of RELX Intellectual Properties SA, used under license.

27/12/2025

A picture is worth a thousand words 📷

Explore the winning photos of The Lancet's 2025 Highlights competition, representing a year of pursuing health and hope in challenging conditions. Access via the link in comments ⤵️

26/12/2025

👀 Among our most-read in 2025:

What are the neuroprotective mechanisms of exercise? And just how important is fitness for healthy brain ageing?

Growing evidence suggests sedentary and unhealthy lifestyles accelerate brain ageing, while regular physical activity, high cardiorespiratory fitness—or a combination of both—can mitigate cognitive impairment and reduce dementia risk.

Read more via the link in comments ⤵️

📊 Figure: Molecular mechanisms whereby exercise safeguards brain health with a focus on exerkines

24/12/2025

In the 2025 Lancet Wakley Prize winning essay, Donna Wakefield explores how personal experiences and understanding of the social determinants of health can transform patient care and foster a more inclusive healthcare system.

Read now via the link in comments 💬

23/12/2025

Tetanus is a devastating neurological infection that remains a major cause of global morbidity and mortality, despite access to vaccines, antitoxin and intensive care.

A Review provides a summary of the causes of tetanus, its clinical features, and management options. Find out more via link in comments 💬

📊 Figure: Clinical features and complications of generalised tetanus.

21/12/2025

The therapeutic landscape for prostate cancer has evolved substantially in the past 5 years, resulting in improved patient outcomes.

A new Seminar provides an up-to-date overview of the management of prostate cancer at different stages of the disease. Link in comments 💬

Figure: Localised and locally advanced non-metastatic prostate cancer: different treatment options per risk group.

20/12/2025

A picture is worth a thousand words 📷

In our final issue of 2025, explore the winning photos of The Lancet's 2025 Highlights competition, representing a year of pursuing health and hope in challenging conditions.

Access the full issue 👉 https://hubs.li/Q03YJVmH0

19/12/2025

Peripartum cardiomyopathy is now the leading cause of maternal death in many parts of the world.

A recent Seminar summarises current knowledge of peripartum cardiomyopathy genetics, pathophysiology, diagnostic approaches, medical management, and outcome. Access via the link in comments ⤵️

📊 Figure: Multiple hit model.

18/12/2025

Research has found a strong link between hypertension in children & the effects of uncontrolled hypertension in later life, highlighting the need for early identification and interventions.

Coupled with cases of childhood hypertension increasing globally, prevention strategies & health policy changes are urgently needed.

A new Review discusses the risk factors, diagnosis, & management of paediatric hypertension. Access via the link in comments ⤵️

📊 Figure: Summary of non-pharmacological interventions in the management of paediatric hypertension.

17/12/2025

Use of ni****ne pouches has increased from 0.1% to 1% in the UK from 2020 to 2025, primarily driven by their use in young people, study suggests.

The study also found that ni****ne pouches are increasingly being used to help people quit or reduce smoking, being used in 6.5% of quit attempts in 2025.

Explore the research via the link in comments 💬

👇 Figure: Trends in current ni****ne pouch use in Great Britain overall among adults aged ≥18 years (A) and by age group among people aged ≥16 years (B).

16/12/2025

Ageing is associated with cognitive decline & an increased risk of neurodegenerative diseases.

A Review explores the neuroprotective mechanisms of endurance exercise & highlights the importance of cardiorespiratory fitness in healthy brain ageing. Find out more via the link in comments 💬

👇 Figure: The clinical, tissue, and molecular differences between healthy ageing and accelerated ageing.

15/12/2025

💊 New single dose oral treatment for gonorrhoea effectively combats drug-resistant infections, trial finds.

The study found that one dose of zoliflodacin was as effective as the current standard treatment, which combines two antibiotics: an injection of ceftriaxone followed by an oral dose of azithromycin.

Find out more via the link in comments 💬

Figure: Study RIC panel.

14/12/2025

Heterozygous familial hypercholesterolemia is a common genetic condition characterised by high LDL cholesterol levels from a young age.

A Review discusses the latest knowledge familial hypercholesterolaemia & its unmet clinical needs. Find out more via the link in comments 💬

👇 Figure: Implementation recommendations for familial hypercholesterolaemia models of care.

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