Pison Peak

11/08/2025

What are the chances of Genetic Variations in Serotonin Transporter Gene (SLC6A4) and Depression Risk Across Ethnicities: You will be amazed if you Examine how genetic variations in the serotonin transporter gene affect depression risk differently across various races and ethnic groups?

https://www.researchgate.net/publication/394431599_Genetic_Variations_in_Serotonin_Transporter_Gene_SLC6A4_and_Depression_Risk_Across_Ethnicities

18/07/2025

The “American Dream” vs. Reality

The U.S. promotes the idea that anyone can achieve success—wealth, status, stability—through hard work and determination. But:
- **Access to education, jobs, and resources isn’t equal** across race, class, and geography hence Delinquency Bizee , Colorado Secretary of State's Office Pison Peak .

- **Systemic barriers** like poverty, discrimination, and underfunded schools limit opportunities.
- **Social mobility** is lower than many believe, meaning people born into disadvantage often stay there.

This creates a **strain**: people internalize the dream but lack the legitimate means to reach it.

🔍 Merton’s Modes of Adaptation
When faced with this strain, people respond in different ways:
| Mode | Description |
|--------------|-----------------------------------------------------------------------------|
| Conformity | Accept goals and means—keep working hard, even if success is elusive. |
| Innovation | Accept goals but use **illegitimate means** (e.g., crime) to achieve them. |
| Ritualism | Abandon goals but stick to the rules—going through the motions. |
| Retreatism | Reject both goals and means—withdraw from society (e.g., addiction). |
| Rebellion | Replace societal goals and means with new ones—seek radical change. |

Innovation is often linked to delinquency or crime, especially when people feel **locked out** of legitimate paths to success.

💥 Why This Matters
- The **pressure to succeed** is intense, especially when failure is seen as personal weakness.
- **Cultural emphasis on wealth** can lead people to bypass rules to avoid being labelled a failure.
- **Social inequality** fuels frustration, resentment, and sometimes rebellion.

So it’s not that people don’t want to achieve goals legitimately—it’s that **the system doesn’t always give them a fair shot**. While China and India are ruling in billion population, America still rule in million with a system that doesn’t always give the populace a fair shot?

17/06/2025

Diabetes is a chronic metabolic disorder characterized by high blood sugar levels (hyperglycemia) over a prolonged period. It occurs due to problems with insulin production, insulin action, or both. Insulin, a hormone produced by the pancreas, helps regulate blood sugar by allowing glucose to enter cells for energy.

# # # **Types of Diabetes:**
1. **Type 1 Diabetes (T1D)**
- Autoimmune condition where the immune system attacks insulin-producing beta cells in the pancreas.
- Requires lifelong insulin therapy (injections or pump).
- Usually diagnosed in children/young adults but can occur at any age.

2. **Type 2 Diabetes (T2D)**
- Caused by insulin resistance (cells don’t respond to insulin) and/or reduced insulin production.
- Strongly linked to obesity, sedentary lifestyle, and genetics.
- Managed with diet, exercise, oral medications, and sometimes insulin.

3. **Gestational Diabetes (GDM)**
- Develops during pregnancy due to hormonal changes causing insulin resistance.
- Increases risk of Type 2 diabetes later in life for both mother and child.

4. **Other Types**
- Includes MODY (Maturity-Onset Diabetes of the Young), LADA (Latent Autoimmune Diabetes in Adults), and diabetes due to pancreatic disease or medications.

# # # **Symptoms of Diabetes:**
- Frequent urination (polyuria)
- Excessive thirst (polydipsia)
- Extreme hunger (polyphagia)
- Unexplained weight loss (common in Type 1)
- Fatigue
- Blurred vision
- Slow-healing wounds
- Tingling/numbness in hands/feet (neuropathy)

# # # **Complications (if uncontrolled):**
- **Short-term:** Hypoglycemia (low blood sugar), diabetic ketoacidosis (DKA, in Type 1), hyperosmolar hyperglycemic state (HHS, in Type 2).
- **Long-term:**
- Cardiovascular disease (heart attack, stroke)
- Kidney damage (nephropathy)
- Nerve damage (neuropathy)
- Eye damage (retinopathy, blindness)
- Foot ulcers, infections, amputations

# # # **Diagnosis:**
- **Fasting Blood Glucose** ≥ 126 mg/dL (7.0 mmol/L)
- **HbA1c** ≥ 6.5% (measures average blood sugar over 3 months)
- **Random Blood Glucose** ≥ 200 mg/dL (11.1 mmol/L) with symptoms
- **Oral Glucose Tolerance Test (OGTT)** ≥ 200 mg/dL after 2 hours

# # # **Management:**
- **Type 1:** Insulin therapy, blood sugar monitoring, carb counting.
- **Type 2:** Lifestyle changes (diet, exercise), metformin, other oral meds (e.g., SGLT2 inhibitors, GLP-1 agonists), insulin if needed.
- **Gestational:** Diet control, exercise, sometimes insulin.

# # # **Prevention (Type 2 & Gestational):**
- Healthy diet (low refined sugars, high fiber)
- Regular physical activity
- Weight management
- Avoiding smoking and excessive alcohol!

30/05/2025

Abraham Maslow in 1943 proposed a theory which is depicted as a pyramid with five levels, where basic needs must be satisfied before higher-level needs can be pursued.

---

🔺 Maslow’s Hierarchy of Needs (from bottom to top):

1. Physiological Needs (Basic)

Air, water, food, shelter, sleep, clothing, reproduction

2. Safety Needs (Basic)

Personal security, employment, resources, health, property

3. Love and Belonging (Psychological)

Friendship, intimacy, family, sense of connection

4. Esteem Needs (Psychological)

Respect, self-esteem, status, recognition, strength, freedom

5. Self-Actualization (Self-Fulfillment)

Desire to become the most that one can be (personal growth, creativity, purpose)

---

🧠 Visual Tip

02/05/2025

Here are the top 10 Medtech ideas for 2025, incorporating current trends and potential advancements:
* AI-Powered Diagnostics and Imaging: Expect further integration of artificial intelligence (AI) and machine learning (ML) in medical imaging for faster, more accurate diagnoses, and improved workflow management for radiologists. AI algorithms will be crucial in analyzing complex scans (CT, MRI, X-ray) to detect diseases like cancer, cardiovascular conditions, and neurological disorders at earlier stages.
* Example: AI-powered software that can analyze retinal scans to detect early signs of diabetic retinopathy with higher accuracy than manual analysis.
* Wearable Health Technology Integration: The trend of sophisticated wearable devices (smartwatches, patches, continuous glucose monitors) will continue, focusing on seamless data integration with electronic health records (EHRs) for real-time monitoring and personalized care plans.
* Example: Smartwatches that continuously monitor vital signs and alert both the patient and healthcare provider to any anomalies, enabling proactive intervention.
* Telehealth and Remote Patient Monitoring: Building on the advancements spurred by recent needs, telehealth solutions and remote monitoring tools will become even more sophisticated, expanding access to healthcare, especially for underserved populations and chronic disease management.
* Example: Platforms that combine video consultations with data from wearable devices to provide comprehensive remote care for patients with heart failure.
* Cybersecurity for Medical Devices: With increased connectivity of medical devices and the Internet of Medical Things (IoMT), robust cybersecurity measures will be paramount to protect patient data and prevent unauthorized access to critical medical systems.
* Example: Advanced encryption and intrusion detection systems specifically designed for medical devices and hospital networks.
* Generative AI in Drug Discovery and Personalized Medicine: Generative AI will play a significant role in accelerating drug discovery, designing novel therapies, and personalizing patient care by analyzing vast amounts of data to identify patterns and predict treatment responses.
* Example: AI algorithms that can analyze a patient's genetic profile and medical history to predict their response to different cancer therapies, leading to more effective treatment strategies.
* Smart Surgical Instruments and Robotics: Surgical instruments with integrated sensors and AI capabilities will provide surgeons with real-time data and enhanced precision during procedures. Surgical robots will become more advanced, enabling minimally invasive surgeries with improved outcomes and faster recovery times.
* Example: Robotic surgery systems with haptic feedback and enhanced imaging that allow surgeons to perform complex procedures with greater dexterity and accuracy.
* Immersive Technologies (VR/AR/XR) in Healthcare: Virtual Reality (VR), Augmented Reality (AR), and Extended Reality (XR) will find increasing applications in medical training, surgical planning, pain management, and patient education by overlaying digital information onto the physical world or creating immersive simulated environments.
* Example: VR simulations that allow surgeons to practice complex procedures before operating on a patient, improving their preparedness and reducing errors.
* 3D Printing for Medical Devices and Personalized Implants: Additive manufacturing will continue to advance, enabling the creation of customized prosthetics, implants, and anatomical models for surgical planning, leading to better patient-specific solutions.
* Example: 3D-printed titanium implants designed to perfectly match a patient's bone structure, resulting in improved fit and integration.
* Minimally Invasive and Targeted Therapies: The focus on less invasive procedures and therapies that precisely target diseased tissues while leaving healthy cells unharmed will drive innovation in areas like advanced ablation techniques and micro/nanobots for targeted drug delivery.
* Example: Nanoparticles that can be loaded with chemotherapy drugs and guided to specific tumor sites using magnetic fields, minimizing systemic side effects.
* Focus on Sustainability in Medtech: There will be a growing emphasis on developing greener medical devices and reducing medical waste through the use of sustainable materials, optimizing device design for longevity, and implementing better waste management practices in healthcare settings.
* Example: Development of biodegradable surgical instruments or reusable medical device components to minimize environmental impact.

23/04/2025

📢 Did you know the UN does more than just peacekeeping? 🤔

Here are some surprising facts about the United Nations today!

* They're a major force in global health: The World Health Organization (WHO), a UN agency, plays a crucial role in coordinating international health responses, from eradicating diseases like polio to tackling global pandemics. They set health standards and guidelines used by countries worldwide.

* They feed millions: The World Food Programme (WFP), another UN agency, is the world's largest humanitarian organization addressing hunger and promoting food security. They provide food assistance in emergencies and work on long-term solutions to hunger.

* They protect refugees: The UN Refugee Agency (UNHCR) works to protect and assist refugees, forcibly displaced communities, and stateless people. They provide vital aid, advocate for their rights, and help find durable solutions to their plight.

* They work on gender equality: UN Women is dedicated to gender equality and the empowerment of women. They work globally to develop and uphold standards and create an environment in which every woman and girl can exercise her human rights and live up to her full potential.

* They champion sustainable development: The UN is at the forefront of the global push for sustainable development through its Sustainable Development Goals (SDGs). These goals address a wide range of issues, including poverty, inequality, climate change, and environmental degradation.

* They promote international law: The International Court of Justice (ICJ), the principal judicial organ of the UN, settles legal disputes submitted to it by states and gives advisory opinions on legal questions referred to it by authorized UN organs and specialized agencies.

* They coordinate humanitarian aid: Beyond food, the UN coordinates a vast array of humanitarian efforts, providing shelter, clean water, sanitation, and other essential assistance to people affected by crises around the world.

The UN's work is incredibly diverse and impacts the lives of people everywhere in ways you might not even realize! Let's appreciate the vital role this organization plays in making our world a better place.

14/04/2025

According to a Goldman Sachs projection, the world's top 10 largest economies in 2075 are expected to be:

* China: $57.0 trillion
* India: $52.5 trillion
* United States: $51.5 trillion
* Indonesia: $13.7 trillion
* Nigeria: $13.1 trillion
* Pakistan: $12.3 trillion
* Egypt: $10.4 trillion
* Brazil: $8.7 trillion
* Germany: $8.1 trillion
* United Kingdom: $7.6 trillion (tied with Mexico)

Key Observations from this Projection:
* Asia's Dominance: The projection indicates a significant shift in global economic power towards Asia, with China and India leading the pack.
* Emerging Markets Rise: Countries like Nigeria, Pakistan, and Egypt are expected to break into the top 10, largely driven by rapid population growth leading to a substantial labor force.
* Europe's Declining Influence: European economies like Germany and the UK are projected to slip down the rankings compared to their historical positions.
* Similar GDP for Top Three: By 2075, China, India, and the United States are expected to have relatively similar GDPs, suggesting a more balanced distribution of economic power among these giants.
* Demographic Advantage: The rise of Nigeria, Pakistan, and Egypt is significantly attributed to their rapid population growth, which is expected to create a massive labor force.
It's important to remember that these are long-term projections and are subject to various factors and uncertainties that could influence the actual economic landscape in 2075. These factors include technological advancements, policy changes, geopolitical events, and demographic shifts.

According to a recent report by Goldman Sachs, the world’s economic landscape will undergo significant changes by 2075. The report predicts that the global GDP will grow by more than four times, reaching $280 trillion, and that the share of emerging markets will increase from 40% to 75%. The repor...

25/03/2025

AI as a transformational force in the workforce. Automation is expected to have a minimal impact on only a few industries, especially energy, biology, and AI system development. "AI has the potential to reduce working hours and allow us to focus on other creative or meaningful tasks that AI cannot do!" .

12/03/2025

https://www.researchgate.net/publication/389783475_A_project-work_that_accessed_the_Impact_of_Climate_Change_on_Public_Health_in_Barbados_by_Investigating_the_Effects_of_Rising_Sea_Levels_Increased_Temperatures_and_Extreme_Weather_Events_on_Disease_Pr

PDF | Abstract Climate change poses a significant threat to public health and healthcare systems, particularly in Small Island Developing States (SIDS)... | Find, read and cite all the research you need on ResearchGate

07/03/2025

Our reality has two dimensions: the one we can see — forests, animals, self, waters etc. (Environment)— and the “fictions” we invented — governments, companies, nations etc (Power). The fate of one dimension depends on what we imagine and the fate of the second dimension depends on how we picture it. ~ Yuval Noah Harari paraphrased by Joseph Ubine

11/02/2025

https://www.researchgate.net/publication/388874315_Evaluating_the_Impact_from_Wealth_to_Well-being_How_Economic_Disparities_Shape_Health_Trajectories_for_Black_and_White_Populations_in_the_UK_2025

PDF | The intricate relationship between economic disparities and health outcomes for Black and White populations in the UK, exploring how wealth and... | Find, read and cite all the research you need on ResearchGate

31/01/2025

The Active Directions or proposed steps of the Current Trump Administration?..;
1. Deportation 2. Tariffs 3. Military 4. Financial Deregulation 5. Space 6. Oil and Gas 7. Tax cuts....
These areas would have major influence on the flow of Policy, Wealth and Power in the Administration.... The list of the possible institutions who may be the major investors in these areas?....; Geo Group and CoreCivic, Owens Corning and Yum, Lockheed Martin, Boeing, and Northrop Grumman, Goldman Sachs and JPMorgan Chase, SpaceX, backed by investors such as Founders Fund, Fidelity Investments, and Google Ventures, BlackRock, KKR, and Brookfield Asset Management, SoftBank and Oracle etc...