GigaScience

24/08/2025

Double Dragon Genomes Helping Explain S*x Determination of Reptiles. Two almost complete and gapless genomes of the s*x-changing central bearded dragon (Pogona vitticeps) have just been published back-to-back in GigaScience to help tackle the mystery of reptile s*x determination. Alongside a new gapless rice genome showcasing new BGI Group CycloneSeq nanopore sequencing technologies ability to complete animal and plant genomes.

https://gigasciencejournal.com/blog/double-dragon-genomes-helping-explain-s*x-determination-of-reptiles/

Read the papers in GigaScience:

Guo Q, Pan Y, Dai W et al., A near-complete genome assembly of the bearded dragon Pogona vitticeps provides insights into the origin of Pogona s*x chromosomes. GigaScience 2025. https://doi.org/10.1093/gigascience/giaf079

Patel HR, Alreja K, Reis AML, et al., A near telomere to telomere phased genome assembly and annotation for the Australian central bearded dragon Pogona vitticeps. GigaScience 2025. https://doi.org/10.1093/gigascience/giaf085

Guang X, Yang J, Zhang, S, et al., Telomere-to-telomere African wild rice (Oryza longistaminata) reference genome reveals segmental and structural variation. GigaScience 2025. https://doi.org/10.1093/gigascience/giaf074

Two almost complete and gapless genomes of the s*x-changing central bearded dragon (Pogona vitticeps) are published back-to-back to help tackle the mystery of reptile s*x determination. Alongside a new gapless rice genome showcasing new CycloneSeq nanopore sequencing technologies ability to complete...

12/08/2025

The s*x lives of sea buckthorns. Comparative genomics of male and female Hippophae angiosperms to understand its XY s*x determination system.

The genome of Hippophae salicifolia provides new insights into the s*xual differentiation of sea buckthorn https://doi.org/10.1093/gigascience/giaf046

11/08/2025

New open-source pipeline that can uncover hidden gene transfer patterns in microbiomes.

Integrating comparative genomics and risk classification by assessing virulence, antimicrobial resistance, and plasmid spread in microbial communities with gSpreadComp https://doi.org/10.1093/gigascience/giaf072

08/08/2025

Help! I need curation. Our write up of Birthdays, BOSC, Beatles and Bioinformatics at ISMB2025 in Liverpool https://gigasciencejournal.com/blog/help-i-need-curation-ismb-meets-the-beatles/

04/08/2025

04/08/2025

A new large-scale imaging dataset containing images of 4 staining types (DAPI, H&E, ssDNA and mIF) derived from >30 human and mouse tissues.

CellBinDB: a large-scale multimodal annotated dataset for cell segmentation with benchmarking of universal models

Abstract. In recent years, cell segmentation techniques have played a critical role in the analysis of biological images, especially for quantitative studi

01/08/2025

A new virus-focused assembler that does both assembly and polishing in a unified workflow.

PVGA: a precise viral genome assembler using an iterative alignment graph

AbstractBackground. Viral genome analysis is crucial for understanding virus evolution and mutation. Investigations into viral evolutionary dynamics and mu

28/07/2025

Investigating the potential of LLMs in improving the findability and reusability of experimental data

Extraction of biological terms using large language models enhances the usability of metadata in the BioSample database https://doi.org/10.1093/gigascience/giaf070

25/07/2025

A new tool designed to select sparse compositional predictors and predict continuous environmental factors

CODARFE: Unlocking the prediction of continuous environmental variables based on microbiome

AbstractBackground. Despite the surge in microbiome data acquisition, there is a limited availability of tools capable of effectively analyzing it and iden

17/07/2025

Sorry to keep carping on about our T2T genomes series...

The telomere-to-telomere gapless genome of grass carp provides insights for genetic improvement

AbstractBackground. The grass carp (Ctenopharyngodon idella) is a large herbivorous freshwater fish belonging to the Cyprinidae family. It is widely cultiv

15/07/2025

Transcriptome-wide association studies (TWAS) to identify candidate genetic variants for egg production traits

Identifying candidate genetic variants for egg number by analyzing over 1,000 fully sequenced layers

AbstractBackground. Egg production over a long laying cycle until 700 days of age is preferred for modern layer chicken breeding. It is influenced by the o

14/07/2025

A new tool for validating sample identities in whole-genome sequencing data without requiring reference information.

PISAD (Phased Intraspecies Sample Anomalies Detection): reference-free intraspecies sample anomalies detection tool based on k-mer counting

AbstractBackground. Genomic sequencing research often requires the simultaneous analysis of heterogeneous data types across single or multiple individuals,