GigaScience

05/12/2025

How robust is your analysis? Our new study shows bioinformatics reprocessing choices matter less than you think.
The effects of bioinformatics preprocessing on cell-free DNA fragment analysis:

AbstractBackground. While cell-free DNA (cfDNA) is a promising biomarker for cancer diagnosis and monitoring, there is limited agreement on optimal cfDNA c

02/12/2025

The complete genome of a tiny liverwort unlocks secrets of genome evolution in early land plants.

Giant chromosomes of a tiny plant - the complete telomere-to-telomere genome assembly of the simple thalloid liverwort Apopellia endiviifolia (Jungermanniopsida, Marchantiophyta): https://doi.org/10.1093/gigascience/giaf145

13/10/2025

Dear Authors, Readers, Editorial Board Members and Colleagues in the Academic Community, we are delighted to announce that Dr. Xun Xu has officially been appointed as Editor-in-Chief of GigaScience. See the announcement here:

We are delighted to announce that Dr. Xun Xu has officially been appointed as Editor-in-Chief of GigaScience. As a distinguished expert in the fields of bioinformatics and genomics, Dr. Xu brings extensive research experience and has long been committed to promoting technological innovation and acad...

24/08/2025

Double Dragon Genomes Helping Explain S*x Determination of Reptiles. Two almost complete and gapless genomes of the s*x-changing central bearded dragon (Pogona vitticeps) have just been published back-to-back in GigaScience to help tackle the mystery of reptile s*x determination. Alongside a new gapless rice genome showcasing new BGI Group CycloneSeq nanopore sequencing technologies ability to complete animal and plant genomes.

https://gigasciencejournal.com/blog/double-dragon-genomes-helping-explain-s*x-determination-of-reptiles/

Read the papers in GigaScience:

Guo Q, Pan Y, Dai W et al., A near-complete genome assembly of the bearded dragon Pogona vitticeps provides insights into the origin of Pogona s*x chromosomes. GigaScience 2025. https://doi.org/10.1093/gigascience/giaf079

Patel HR, Alreja K, Reis AML, et al., A near telomere to telomere phased genome assembly and annotation for the Australian central bearded dragon Pogona vitticeps. GigaScience 2025. https://doi.org/10.1093/gigascience/giaf085

Guang X, Yang J, Zhang, S, et al., Telomere-to-telomere African wild rice (Oryza longistaminata) reference genome reveals segmental and structural variation. GigaScience 2025. https://doi.org/10.1093/gigascience/giaf074

Two almost complete and gapless genomes of the s*x-changing central bearded dragon (Pogona vitticeps) are published back-to-back to help tackle the mystery of reptile s*x determination. Alongside a new gapless rice genome showcasing new CycloneSeq nanopore sequencing technologies ability to complete...

12/08/2025

The s*x lives of sea buckthorns. Comparative genomics of male and female Hippophae angiosperms to understand its XY s*x determination system.

The genome of Hippophae salicifolia provides new insights into the s*xual differentiation of sea buckthorn https://doi.org/10.1093/gigascience/giaf046

11/08/2025

New open-source pipeline that can uncover hidden gene transfer patterns in microbiomes.

Integrating comparative genomics and risk classification by assessing virulence, antimicrobial resistance, and plasmid spread in microbial communities with gSpreadComp https://doi.org/10.1093/gigascience/giaf072

08/08/2025

Help! I need curation. Our write up of Birthdays, BOSC, Beatles and Bioinformatics at ISMB2025 in Liverpool https://gigasciencejournal.com/blog/help-i-need-curation-ismb-meets-the-beatles/

04/08/2025

04/08/2025

A new large-scale imaging dataset containing images of 4 staining types (DAPI, H&E, ssDNA and mIF) derived from >30 human and mouse tissues.

CellBinDB: a large-scale multimodal annotated dataset for cell segmentation with benchmarking of universal models

Abstract. In recent years, cell segmentation techniques have played a critical role in the analysis of biological images, especially for quantitative studi

01/08/2025

A new virus-focused assembler that does both assembly and polishing in a unified workflow.

PVGA: a precise viral genome assembler using an iterative alignment graph

AbstractBackground. Viral genome analysis is crucial for understanding virus evolution and mutation. Investigations into viral evolutionary dynamics and mu

28/07/2025

Investigating the potential of LLMs in improving the findability and reusability of experimental data

Extraction of biological terms using large language models enhances the usability of metadata in the BioSample database https://doi.org/10.1093/gigascience/giaf070

25/07/2025

A new tool designed to select sparse compositional predictors and predict continuous environmental factors

CODARFE: Unlocking the prediction of continuous environmental variables based on microbiome

AbstractBackground. Despite the surge in microbiome data acquisition, there is a limited availability of tools capable of effectively analyzing it and iden