22/10/2025
We are thrilled to share that our recent article titled “Exosomal pHERV-W ENV as a dynamic biomarker for relapse prediction and prognosis in multiple sclerosis “ has just been published in the Journal of Neuroinflammation.
In this study, our research team report that exosomal pHERV-W ENV expression is elevated during active MS and correlates with EBV activity (LMP2A expression), which may reflect coordinated immune activation. Notably, high baseline exosomal pHERV-W ENV levels were associated with greater long-term disease activity and earlier loss of NEDA status. This highlights the potential of exosomal pHERV-W ENV as a non-invasive biomarker with prognostic value in MS.
You can read the full article here: Saba, E.S., Mrad, M.F., Nakib, L. et al. J Neuroinflammation 22, 238 (2025). https://doi.org/10.1186/s12974-025-03567-4