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One Day MD Health and Wellness media from www.onedaymd.com Health and Wellness site

12/12/2025

Sauna is one of the most effective health protocols I've done. Here is everything I've learned; it's the most robust characterization ever produced.

Results:

1) Fifteen sessions of sauna dramatically reduced environmental toxins in my body:

+ 65% drop in 2,4-D
+ 100% drop in MEP
+ 15% drop in MBP
+ 100% drop in MEHP (undetectable post sauna)
+ 56% drop in NAPR
+ 56% drop in HEMA
+ 100% drop in Perchlorate (undetectable post sauna)

2. Sauna eliminated 85% of microplastics from my ej*****te.

Nov 2024:
165 particles/mL
July 2025: 20 particles/mL

Nearly identical drop in my blood same time period:
Oct 2024: 70 particles/mL
May 2025: 10 particles/mL

3. Sauna, without ice on the boys, devastated my fertility markers.

Total Motile Count: –56%
Concentration: –30%
Motility: –50%
Morphology: –48%
Count: –9%

4. Sauna coincided with my fertility markers being at an all-time high. I have more total and motile s***m than 99.6% of men of any age, including men under 25.

+ total count: 600 M
+ concentration: 162 M
+ motility: 55%
+ total motile count: 330M
+ morphology (normal): 10%

We do not know what to make of these improvements. Was it the sauna? Sauna + ice? Ice only? We don't know but we did not identify any other protocols or lifestyle changes during this interval that would plausibly account for the change.

5. My vascular function improved by a ten year reduction in age. Now I have the vascular age of an elite 18-early 20s.

+ Central Systolic Blood Pressure: 96 mmHg
+ Central Pulse Pressure: 20 mmHg
+ Pulse Pressure Amplification: 160%
+ SEVR: 227%
+ Augmentation Pressure: 1 mmHg
+ Augmentation Index Wave: 3%
+ Traditional blood pressure: 107/75 mmHg

6. What type of sauna?
Use a dry sauna with high temperatures between 80-100°C (176 to 212°F) and 5-20% relative air humidity. Aim for the lower end of this spectrum, especially as a beginner. Higher temperatures closer to the boiling point can cause side effects like headaches and severely dried nose and eyes.

Note: Steam baths, hot tubs, and infrared saunas fail to replicate the same effects because they do not allow you to safely reach the required high temperatures and do not induce the same level of sweating, the necessary inverted (skin-to-core) temperature gradient, and the massive re-direction of blood to the skin with resulting vasodilation.

Dry sauna is unique, and very likely superior to wet (steam bath) and infrared saunas. By heating up your skin way faster than your core, dry hot sauna flips your core skin temperature gradient, eliciting the following hormetic benefits:

+ enhanced blood flow: the heart pumps up to 70% more blood, similar to intense aerobic exercise (zone 2-+ increased sweating for detoxification: to maintain a stable core temperature, the skin produces 0.6-1 liter of sweat per hour, facilitating significant detoxification.
+ improved heat tolerance: the body becomes better at handling heat, leading to a lower core body temperature (offering metabolic advantages)
+ safe activation of heat shock proteins: the skin experiences substantial heat shock protein activation, while a modest 1°C increase in core temperature is sufficient to activate these proteins without the risk of hyperthermia.
+ extended Exposure at higher temperatures: dry saunas are more tolerable for longer durations and at higher temperatures, maximizing the benefits.

7. Sauna protocol and frequency
Type: hot dry sauna
Temperature: 176–212°F ( I do 200°F)
Relative air humidity: very low, 5-20%
Duration: 20 min
Frequency: 4–7x a week

8. Heat Protection

If you'd like, you can protect your head from the heat by wearing a sauna hat or wrapping it with a towel (use only cotton or other 100% natural material). You can breathe through a towel or cloth if needed to protect your nose. I am personally fine not doing this.

Most importantly, ice the balls.

Icing the testicles is absolutely required to prevent heat from damaging fertility markers.

+ Ice the te**es during the sauna session.
+ Use a non-toxic, reusable ice pack material.
+ Wear cotton boxers and shorts.
+ Place ice packs in between the boxers and shorts.
+ Keep them in place for the entire session.

Men should care about preserving fertility markers even when they are not trying to conceive. S***m quality is tightly coupled to testicular function, which governs testosterone production, metabolic health, and long term endocrine stability. When fertility parameters decline, the same upstream dysfunction often drives lower testosterone, higher inflammation, and increased cardiometabolic risk.

9. Hydration

Dry sauna induces sweating as part of its beneficial mechanism. Be sure to hydrate properly. In general, you might need to rehydrate with up to 16–32 oz (0.5–1 L) of fluid after a sauna session. Be sure to add electrolytes.

If you want to be precise, measure your sweat amount and electrolytes (saltiness) using a patch (e.g., from Gatorade) to quantify your liquid and electrolyte loss, and rehydrate accordingly. Some people have saltier sweat than others and must ensure they replenish electrolytes as well as water.

My results: my body sweats 18 oz during a 20 min sauna at 200 °F, with a sodium concentration of 25-39 mg/oz. A single sauna session flushes 450–700 mg of sodium out of my body.

#

I wish you all the best in life my friend. A new era or being human is here. One where existence is the highest virtue. Prioritize sleep, daily exercise and eat well and you'll be in a strong position. Try to avoid the bad stuff. Anything that takes away your agency.

Be a warrior and caretaker of existence. Don't Die.

12/12/2025

🔥 Your entire immune system starts with one cell.

Every red blood cell that carries oxygen
Every platelet that stops a cut from bleeding
Every neutrophil that attacks bacteria
Every T cell that hunts viruses
Every B cell that makes antibodies

All of them come from the same origin: a single pluripotent hematopoietic stem cell hidden inside your bone marrow.

🩸 What this stem cell can become

With the right signals from molecules like IL-3, GM-CSF, IL-7, SCF, and others, this stem cell divides and chooses a path:

• Red blood cells to deliver oxygen
• Platelets to form clots
• Neutrophils, eosinophils, and basophils to fight infection
• Monocytes and macrophages to clean up dead cells and debris
• B cells that produce IgG, IgA, IgM, and other antibodies
• T cells that orchestrate your immune defense
• Natural killer cells that recognize and destroy infected or malignant cells

Every branch in the diagram is a decision point based on the chemical signals surrounding the cell.

🧪 Why this matters

Your energy, your immunity, your ability to heal, and your resistance to infection depend on how well this system works.
When hematopoiesis is disrupted, it can lead to:

• anemia
• weakened immunity
• autoimmune problems
• slow healing
• susceptibility to infections
• blood cancers

Healthy blood begins with healthy stem cell signaling.

Inside your bone marrow, millions of stem cells are working every minute to build your immune system from scratch.
It is one of the most complex and elegant engineering systems in the human body.

In a landmark study published in the latest issue of Cell (2025;188:1–22), a 44-week trial in aged macaques, led by Guan...
02/12/2025

In a landmark study published in the latest issue of Cell (2025;188:1–22), a 44-week trial in aged macaques, led by Guanghui Liu, Si Wang, and Jing Qu, has delivered a scientific paradigm shift: genetically engineered human mesenchymal progenitor(stem) cells, termed senescence-resistant cells (SRCs), can not only halt aging but roll back its clinical and functions negative effects.
Delivered intravenously, these supercharged cells sparked a rejuvenation trifecta—sharper cognition, stronger bones, and revitalized reproductive health—all without identifiable adverse effects. The key seems to lie in their microscopic messengers, exosomes, which tackle the root of aging: cellular senescence.
The study’s implications are of high potential relevance, offering a glimpse into a future where aging is not a descent into frailty but a manageable condition. At the heart of this work are the SRCs, mesenchymal progenitor cells (MPCs) genetically modified to flourish in the harsh environment of an aging body, where chronic inflammation and oxidative stress dominate. Unlike conventional stem cells, SRCs are armed with the geroprotective gene FOXO3, identified by the same team as a powerhouse against aging.
This gene activates longevity pathways, fortifying the cells to resist deterioration and combat the ravages of time. In aged cynomolgus macaques, these cells did not just survive—they orchestrated a systemic rollback of aging’s hallmarks. The results seem to be staggering: enhanced brain function, fortified skeletal strength, restored reproductive vigor, and a dramatic reduction in cellular senescence and inflammation.
https://www.cell.com/cell/abstract/S0092-8674(25)00571-9

https://factcheck.afp.com/doc.afp.com.66V8364
25/11/2025

https://factcheck.afp.com/doc.afp.com.66V8364

Ni****ne, an addictive stimulant found in the to***co plant, can increase the release of dopamine and other neurotransmitters in the brain. But claims that the chemical is not addictive and can prevent or cure multiple neurological diseases -- such as Parkinson's, Alzheimer's and glioblastoma brain....

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NICE has recommended durvalumab for limited-stage small-cell lung cancer in England, marking the first major advance in more than 20 years.

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Head and neck cancer is the seventh most common cancer worldwide, responsible for more than 660 000 new diagnoses and 325 000 deaths each year.

This Review provides an overview of EGFR-targeted therapies in HNSCC, ranging from established traditional treatments, novel combination strategies, and emerging EGFR-targeting agents under clinical investigation.

https://ja.ma/4nTtcqR

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