
23/09/2025
A plant virus that reprograms the immune system to destroy cancer
By Morgan Nwanguma
Plant virus powers immune system to fight cancer—affordable, effective, and nearing clinical trials
A virus that normally infects black-eyed peas is emerging as a surprising weapon against cancer. Known as the cowpea mosaic virus (CPMV), it doesn’t infect people, but it can jumpstart the immune system in ways other plant viruses cannot—turning it into a cancer-fighting force.
Researchers at the University of California San Diego, writing in Cell Biomaterials, discovered that CPMV uniquely sparks strong interferon signals and immune activation, unlike related viruses. This finding helps explain its exceptional performance in preclinical studies, where direct injections of CPMV into tumours triggered waves of neutrophils, macrophages, and natural killer cells to attack cancer, while also priming B and T cells for long-term, body-wide protection.
So far, CPMV has shrunk tumours in multiple mouse models and even in dogs with naturally occurring cancers. Click the link to read more … https://pharmatimes.com.ng/a-plant-virus-that-reprograms-the-immune-system-to-destroy-cancer/