Computational and Structural Biotechnology Journal

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Computational and Structural Biotechnology Journal

Computational and Structural Biotechnology Journal (ISSN 2001-0370) is an online journal publishing research articles and reviews after full peer review.

Computational and Structural Biotechnology Journal (CSBJ) is an open access journal (Impact Factor 4.5) and is composed of four specialty sections:
• General • Smart Hospital • Nanoscience and Advanced Materials • Quantum Biology and Biophotonics. All articles are published, without barriers to access, immediately upon acceptance. The journal places a strong emphasis on functional and mechanistic

understanding of how molecular components in a biological process work together through the application of computational methods. Structural data may provide such insights, but they are not a pre-requisite for publication in the journal. Specific areas of interest include, but are not limited to:

• Structure and function of proteins, nucleic acids and other macromolecules
• Structure and function of multi-component complexes
• Protein folding, processing and degradation
• Enzymology
• Computational and structural studies of plant systems
• Microbial Informatics
• Genomics
• Proteomics
• Metabolomics
• Algorithms and Hypothesis in Bioinformatics
• Computational Chemistry & Drug Discovery
• Microscopy and Molecular Imaging
• Nanotechnology

While all general topics related to Computational and Structural Biology are welcomed, the editors reserve the right to pre-screen submissions based on the suitability of the topic of a submission and, therefore, the right as whether a manuscript will be processed/reviewed or not. Even though experimental validation is not required for publication, reliability and significance of biological discovery are validated and enriched by experimental studies. The journal welcomes the submission of manuscripts that meet the general criteria of significance and scientific excellence, and enables the rapid publication of papers under the following categories:

• Research articles
• Review articles
• Mini Reviews
• Highlights
• Communications
• Software/Web server articles
• Methods articles
• Database articles
• Book Reviews
• Meeting Reviews

08/05/2026

CSBJ Smart Hospital (https://spj.science.org/journal/csbj/smarthospital), is inviting submissions for its upcoming special issue:

“Data Orchestration in Smart Health: From Raw Biomedical Data to AI-Ready Frameworks”

📌 Topics include (but are not limited to):
• Wearable physiological signal preprocessing (EEG, ECG, PPG, EMG, EDA, accelerometry)
• Medical imaging pipelines for AI (MRI, CT, ultrasound, histopathology)
• Multi-omics integration and AI-readiness
• EHR extraction, normalization, and clinical NLP
• FAIR data principles and benchmark dataset construction
• Annotation frameworks and weak supervision
• Federated learning, privacy-preserving AI, GDPR/HIPAA compliance
• Bias mitigation and reproducibility in biomedical AI
• Cloud-native biomedical AI workflows and clinical deployment pipelines

⏳ Submission Deadline: 30 December 2026

🔗 For more info about the Call for Papers, please visit: https://spj.science.org/journal/csbj/si/data-orchestration

🧠 Guest Editors:
• Eleni Kaldoudi, Δημοκρίτειο Πανεπιστήμιο Θράκης/Democritus University of Thrace, Greece
• Vaidotas Marozas, KTU Kauno technologijos universitetas/Kaunas University of Technology, Lithuania
• Antti Vehkaoja, Tampere University, Finland

Computational and Structural Biotechnology Journal, Science Partner Journals, AAAS - The American Association for the Advancement of Science

05/05/2026

🦠 Could we outsmart antibiotic resistance by turning bacteria against themselves?

This study introduces a systems biology driven CRISPR strategy to combat Pseudomonas aeruginosa, a major multidrug resistant pathogen, by enhancing its own quorum quenching mechanisms instead of relying on antibiotics. By combining metabolic modeling with rational gRNA design, the research opens a new path for antivirulence therapies that weaken bacteria without driving resistance.

📝 Javier Alejandro Delgado-Nungaray, Luis Joel Figueroa-Yáñez, Eire Reynaga-Delgado, Mario Alberto García-Ramírez, Orfil Gonzalez-Reynoso

🔗 Rational Targeting and gRNA Design for Enhancing Quorum Quenching in Pseudomonas aeruginosa PAO1. Computational and Structural Biotechnology Journal (CSBJ). DOI: https://doi.org/10.34133/csbj.0089

📚 CSBJ - A Science Partner Journal: https://spj.science.org/journal/csbj

Universidad de Guadalajara, Computational and Structural Biotechnology Journal, Science Partner Journals, AAAS - The American Association for the Advancement of Science

05/05/2026

🧠 What if the genes we blame for cancer aren’t actually in control — are we mistaking passengers for drivers?

This study introduces a network-based computational framework to identify key driver genes in oligodendroglioma using single-cell transcriptomics, unlocking new precision insights into brain tumor biology. By moving beyond bulk data and focusing purely on tumor cells, the approach pinpoints genes that truly influence cancer-driving pathways, paving the way for more targeted therapies and deeper biological understanding.

📝 Michael Seifert

🔗 Network-Based Prediction of Oligodendroglioma Driver Gene Candidates within the Region of the 1p/19q Co-deletion Utilizing Single-Cell Transcriptomes. Computational and Structural Biotechnology Journal (CSBJ). DOI: https://doi.org/10.34133/csbj.0059

📚 CSBJ - A Science Partner Journal: https://spj.science.org/journal/csbj

TU Dresden, Computational and Structural Biotechnology Journal, Science Partner Journals, AAAS - The American Association for the Advancement of Science,

04/05/2026

CSBJ Quantum Biology and Biophotonics (https://spj.science.org/journal/csbj/qbio), is inviting submissions for its upcoming special issue:

“Quantum Effects in Biological Systems (QuEBS)”

📌 Topics include (but are not limited to):
• Quantum coherence, tunneling, and spin-dependent processes in biology
• Quantum effects in photosynthesis, photobiology, and bioenergetics
• Magnetoreception and biological quantum sensing mechanisms
• Theoretical and computational modeling of quantum biological systems
• Quantum-enabled sensing and measurement in biological environments
• Engineered proteins and biomolecular systems for quantum technologies
• Bio-inspired materials and concepts for quantum applications
• Quantum approaches in health and biomedical research

⏳ Submission Deadline: 31 January 2027

🔗 Guidelines for Authors: https://spj.science.org/page/csbj/for-authors

Guest Editor:
Gábor Vattay, Eötvös Loránd University, Hungary

Eötvös Loránd Tudományegyetem - ELTE, Computational and Structural Biotechnology Journal, Science Partner Journals, AAAS - The American Association for the Advancement of Science

03/05/2026

🧬 Could a single metric decode how genes are regulated across cells?

This study introduces a novel “Regulation Ratio (RR)”, a unified multi-omic metric that deciphers how genes are controlled across transcriptional and post-transcriptional levels, unlocking a deeper understanding of gene regulation and cellular behavior. By integrating ATAC-seq, RNA-seq, and POP-seq data across multiple human cell lines, the research uncovers fundamental principles governing gene expression and regulatory strategies.

📝 Alexander Krohannon, Mansi Srivastava, Neel Sangani, Sarath Chandra Janga

🔗 Regulation Ratio: A Singular Multi-Omic Measurement of Gene Regulatory Mechanisms. Computational and Structural Biotechnology Journal (CSBJ). DOI: https://doi.org/10.34133/csbj.0044

📚 CSBJ - A Science Partner Journal: https://spj.science.org/journal/csbj

IU Indianapolis, Indiana University School of Medicine, IU Luddy School of Informatics, Computing, and Engineering, Indianapolis, Indiana University Bloomington Department of Biology, Computational and Structural Biotechnology Journal, Science Partner Journals, AAAS - The American Association for the Advancement of Science

03/05/2026

🧠 Could the brain reveal vision loss more accurately than traditional eye tests?

This study explores how brain-based measurements can transform the way we assess vision loss in inherited retinal diseases, particularly CRB1-related retinopathy. By leveraging EEG-based steady-state visual evoked potentials (ssVEPs), the research introduces a powerful, objective, and patient-friendly approach to evaluating visual function across a wide spectrum of impairment.

📝 Kim Eliane Stäubli, Marc Pabst, Roni O. Maimon-Mor, Ana Catalina Rodriguez-Martinez, H. Steven Scholte, Mariya Moosajee, Tessa Marlijn Dekker

🔗 Using Steady-State Visual Evoked Potentials to Characterize Wide-Ranging Retinopathy Linked to CRB1: Implications for Clinical Trials. DOI: https://doi.org/10.34133/csbj.0042

📚 CSBJ - A Science Partner Journal: https://spj.science.org/journal/csbj

Computational and Structural Biotechnology Journal, Science Partner Journals, AAAS - The American Association for the Advancement of Science, UCL, Moorfields Eye Hospital, Great Ormond Street Hospital and Charity, University of Amsterdam / Universiteit van Amsterdam, The Francis Crick Institute

30/04/2026

CSBJ Smart Hospital (https://spj.science.org/journal/csbj/smarthospital), is inviting submissions for its upcoming special issue:

“Immersive Technologies in Surgery and Interventional Medicine”

📌 Topics include (but are not limited to):
• AR/VR/MR systems for surgical and interventional procedures
• Patient-specific 3D modeling and digital twins
• Multimodal imaging integration (CT, MRI, ultrasound, fluoroscopy)
• Intraoperative guidance and real-time visualization
• Immersive tech in robotic and image-guided interventions
• VR-based training, simulation, and skill assessment
• Human–computer interaction and clinical usability
• Collaborative and networked surgical systems
• Clinical validation and real-world deployment
• Regulatory, ethical, and safety considerations
• Emerging XR platforms and next-gen immersive systems

⏳ Submission Deadline: 30 November 2026

🔗 For more info about the Call for Papers, please visit: https://spj.science.org/journal/csbj/si/immersive-tech-surgery-intervention

Computational and Structural Biotechnology Journal, Science Partner Journals, AAAS - The American Association for the Advancement of Science,

29/04/2026

🦠 Does a hospital’s location shape the microbes in its air?

This study explores the hidden world of airborne bacterial microbiomes in hospitals, comparing environments in a metropolitan city (Bangkok) and a smaller city (Phitsanulok), Thailand. Using advanced 16S rRNA sequencing, the research reveals how hospital design, ventilation, and human activity shape microbial exposure, with important implications for infection control and air quality management.

📝 Piraya Chatthanathon, Doonyapong Wongsawaeng, Tassanee Chetwittayachan, Thanya Cheibchalard, Asada Leelahavanichkul, Ekasit Kowitdamrong, Jarun Sayasathid, Naraporn Somboonna

🔗 Air Bacterial Microbiomes in Hospitals: Case Studies from a Metropolis and a Small City of Thailand. DOI: https://doi.org/10.34133/csbj.0068

📚 CSBJ - A Science Partner Journal: https://spj.science.org/journal/csbj

มหาวิทยาลัยนเรศวร, Chulalongkorn University, Computational and Structural Biotechnology Journal, Science Partner Journals, AAAS - The American Association for the Advancement of Science

21/04/2026

🫧 Is there a point where hydration stops helping, and starts harming tissue integrity?

This study uncovers how hydration fundamentally reshapes collagen structure and mechanics, revealing why cartilage is flexible yet more vulnerable than tendon and bone. By developing a mesoscale energy model, the authors quantify how water weakens intermolecular cohesion in collagen fibrils and provide new insights into tissue mechanics, aging, and disease.

📝 Afif Gouissem, Malek Adouni

🔗 How Hydration Weakens Collagen: A Mesoscale Energy Decomposition of Type I and Type II Fibrils. Computational and Structural Biotechnology Journal (CSBJ). DOI: https://doi.org/10.34133/csbj.0050

📚 CSBJ - A Science Partner Journal: https://spj.science.org/journal/csbj

Computational and Structural Biotechnology Journal, Science Partner Journals, AAAS - The American Association for the Advancement of Science,

21/04/2026

🧩 Could RNA and proteins share the same “shape language” for binding drugs?

This study introduces a unified geometric framework to compare RNA and protein binding pockets, revealing that despite their biological differences, both share a common structural “shape language” critical for molecular recognition and drug design.

📝 Leïla Ziani, Anne Badel, Léa Dufay, Delphine Flatters, Leslie Regad, Anne-Claude Camproux

🔗 Eigenvalue Ratios Reveal Shared Binding Pocket Shapes in RNA and Protein Structures. Computational and Structural Biotechnology Journal (CSBJ). DOI: https://doi.org/10.34133/csbj.0022

📚 CSBJ - A Science Partner Journal: https://spj.science.org/journal/csbj

Université Paris Cité, Computational and Structural Biotechnology Journal, Science Partner Journals, AAAS - The American Association for the Advancement of Science,

20/04/2026

🧬 What if disease isn’t written in DNA, but in how RNA is edited and spliced?

This review explores how long-read RNA sequencing (lrRNA-seq) is transforming our ability to decode RNA splicing complexity, unlocking deeper insights into human diseases and advancing precision medicine.

📝 Xiangmin Tan, Ping Wang, Yang Li, Bo Yuan, Qiang Sun, Yaran Liu

🔗 Long-Read Sequencing Reveals RNA Splicing Complexity in Human Diseases. Computational and Structural Biotechnology Journal (CSBJ). DOI: https://doi.org/10.34133/csbj.0052

📚 CSBJ - A Science Partner Journal: https://spj.science.org/journal/csbj

Computational and Structural Biotechnology Journal, Science Partner Journals, AAAS - The American Association for the Advancement of Science

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