Cardiology Journal

Cardiology Journal Editors-in-Chief:
Milosz J. Jaguszewski, Juan Luis Guttiérrez-Chico

Can inflammatory biomarkers help identify which overweight and obese patients are more likely to experience atrial fibri...
05/06/2026

Can inflammatory biomarkers help identify which overweight and obese patients are more likely to experience atrial fibrillation recurrence after catheter ablation?

This original study applies machine learning to a broad panel of inflammatory and clinical variables to predict both early and late AF recurrence. One of the most clinically interesting signals: late recurrence prediction became notably stronger when early recurrence was taken into account, suggesting that post-ablation rhythm behavior may carry major prognostic value.

A thought-provoking read for electrophysiology teams looking at recurrence risk through a more integrated lens.

Authors: Jan Budzianowski, Marcin Ostrowski, Raquel Fernandez-Peralta, Katarzyna Kaczmarek-Majer, Janusz Rzeźniczak, Dominika Kasprzak, Jarosław Hiczkiewicz, Paweł Burchardt

Could a short course of rifaximin help address high on-ticagrelor platelet reactivity after ACS?The FLORA-ACS study prot...
26/05/2026

Could a short course of rifaximin help address high on-ticagrelor platelet reactivity after ACS?

The FLORA-ACS study protocol explores the gut–platelet axis in a clinically relevant post-ACS population, combining platelet function testing with microbiome profiling. A thought-provoking research direction for interventional cardiology and personalized antiplatelet therapy.

Authors: Klaudyna Grzelakowska, Piotr Adamski, Michał Kasprzak, Piotr Michalski, Piotr Niezgoda, Małgorzata Ostrowska, Julia Umińska, Jakub Ratajczak, Kacper Strzelewicz, Tomasz Grzybowski, Katarzyna Skonieczna, Katarzyna Buszko, Jacek Kubica

OCT is a go-to tool for “stent healing” assessment—but how well do OCT patterns reflect *true* arterial healing on histo...
11/02/2026

OCT is a go-to tool for “stent healing” assessment—but how well do OCT patterns reflect *true* arterial healing on histopathology?

This original study tackles that gap using a histology-validated porcine coronary restenosis model (DES + BMS), asking a clinically relevant question: can OCT help identify a *completely healed* coronary stent (beyond simple strut coverage)?

What to look for:
• OCT phenotypes that track with “better healing” vs signals that may indicate ongoing adverse biology
• A decision-tree approach (see Figure 4) suggesting practical OCT feature combinations linked to persistent fibrin/inflammation

Authors: Maciej Pruski, Mateusz Kachel, Carlos Fernandez, Adam Janas, Aleksandra Błachut, Magdalena Michalak, Paweł Kaźmierczak, Paweł E Buszman, Krzysztof Milewski, Piotr P. Buszman

Angiography called it “mild” — physiology disagreed.A 76-year-old woman with antiphospholipid syndrome presented with dy...
30/01/2026

Angiography called it “mild” — physiology disagreed.

A 76-year-old woman with antiphospholipid syndrome presented with dyspnea and inferior LV wall abnormalities. Coronary angiography showed only a borderline mid-RCA lesion with linear/braided (“woven coronary artery”-like) structures. But FFR was markedly abnormal (0.63), prompting intracoronary imaging.

OCT revealed the striking “lotus root–like” multichannel pattern, consistent with a recanalized coronary thrombus — and the patient improved after PCI.

If you’re managing “hazy” or seemingly insignificant segments, this short Image-in-Cardiovascular-Medicine report is a sharp reminder: angiography alone can underestimate functional severity.

Authors: Tomoko Sekine, Tadao Aikawa, Iwao Okai, Tohru Minamino

🎉 Cardiology Journal — Vol. 32, No. 6 (2025) is out now!Dear Readers,We’re happy to announce the publication of the late...
30/12/2025

🎉 Cardiology Journal — Vol. 32, No. 6 (2025) is out now!

Dear Readers,
We’re happy to announce the publication of the latest issue of Cardiology Journal. The issue spans interventional and clinical cardiology, basic and translational science, reviews, technology notes, study protocols, and image cases.

🔹 Original articles — Interventional cardiology
• Comparison of angiographically derived coronary radial wall strain and superficial wall stress for the characterization of plaque vulnerability — explores biomechanical metrics of plaque instability (pp. 535–545).
• Clinical outcomes of intravascular lithotripsy according to the timing of stent failure: Insights from the COIL registry (p. 546).
• Preclinical safety and performance evaluation of a highly-flexible peripheral polytetrafluoroethylene-covered stent (p. 555).
• Successful experience of transcatheter residual right-to-left shunting closure after patent foramen ovale occlusion (p. 562).

🔹 Original articles — Clinical cardiology
• Swiss national cardiac device registry: Changing trends in implantation procedures over the last two decades (p. 569).
• Conventional versus hands-only cardiopulmonary resuscitation by bystanders for pediatrics with out-of-hospital cardiac arrest: A systematic review and meta-analysis (p. 579).
• Prognostic role of the serum uric acid-to-serum creatinine ratio in patients with ST-elevation myocardial infarction and multivessel coronary artery disease (p. 588).
• Plus: access strategy and obesity (KODRA registry), nurse education in heart failure, and a systematic review/meta-analysis of Eustachian valve endocarditis (pp. 598–615).

🔹 Original articles — Basic science & experimental cardiology
• Plasma levels of sirtuin 1 and sirtuin 2 in ascending aortic aneurysm patients — a comparative study (p. 625).
• Genetic insights into SGLT2 inhibition and atrial fibrillation: exploring the mediating role of inflammatory proteins (p. 635).
• Circulating microRNA-1 as a diagnostic biomarker for acute myocardial infarction: a meta-analysis (p. 643).

🔹 Review articles
• Artificial intelligence in heart failure — a comprehensive literature review (p. 655).
• Targeting factor XI as a compromise between thrombosis and bleeding (p. 666).
• Transfer RNA-derived small RNAs as novel players and biomarkers in cardiovascular disease (p. 678).

🔹 Technology note
• Nicotinamide adenine dinucleotide fluorescence monitoring as a potential tool for the microvascular and mitochondrial function assessment in heart failure (p. 692).

🔹 Study protocols
• ORItavancin as a therapeutic regimen for Cardiac Implantable Electronic Devices infections… (ORI-4-CIEDi) pilot study: rationale and design (p. 695).
• Characterization of patients and treatment outcomes in severe tricuspid regurgitation (CAPTURE) — study design (p. 704).

🔹 Images in cardiovascular medicine
• Lotus root-like appearance in angiographically mild coronary artery disease (p. 712).
• A rare case of cardiac sarcoidosis mimicking hypertrophic cardiomyopathy or a cardiac mass (p. 714).

Domain-specific knowledge on salt-related health risks and medical professional identity: Implications for cardi-ovascul...
12/12/2025

Domain-specific knowledge on salt-related health risks and medical professional identity: Implications for cardi-ovascular prevention.

An international PoLA/ILEP survey (n=668) mapped domain-specific knowledge about salt-related risks (CVD, neuro, renal, metabolic, bone) and linked it to medical professional identity using proportional-odds modeling. Top signal? Self-awareness of one’s BP/lipids/glucose was the strongest marker of medical affiliation (OR≈38). Meanwhile, metabolic/renal/bone effects were under-recognized—even among clinicians—pointing to concrete education targets for better prevention.

Authors: Stanisław Surma; Łukasz Lewandowski; Karol Momot; Michał Czapla; Tomasz Sobierajski; Joanna Lewek; Bogusław Okopień; Maciej Banach.

🎉 Cardiology Journal — Vol. 32, No. 5 (2025) is out now!Dear Colleagues,We’re pleased to announce that the new issue of ...
31/10/2025

🎉 Cardiology Journal — Vol. 32, No. 5 (2025) is out now!

Dear Colleagues,
We’re pleased to announce that the new issue of Cardiology Journal is now online. It highlights current trends in cardiovascular risk assessment and personalized treatment across clinical and interventional cardiology, with concise updates on evidence-based care, emerging technologies, and practical insights for everyday decision-making.

Original articles — Clinical cardiology

🔸Neutrophil-lymphocyte ratio (NLR) as an independent factor of 1-year mortality in patients with chronic heart failure with reduced ejection fraction — In 140 clinically stable HFrEF patients, higher NLR independently predicted 1-year all-cause mortality (per-point HR ≈ 1.33) on top of natriuretic peptides and comorbidities; the effect persisted after excluding severe CKD/COPD. A practical, zero-cost prognostic marker for routine follow-up.

🔸Association between renal function and arterial stiffness among women with systemic lupus erythematosus or antiphospholipid syndrome — Study exploring links between eGFR and vascular stiffness indices in SLE/APS female cohorts (clinical cardiology focus as per ToC).

🔸The effect of P2Y12 receptor inhibitors on clinical outcomes in patients with acute coronary syndrome undergoing primary percutaneous intervention and receiving abciximab — Comparative outcomes in ACS patients on abciximab, stratified by P2Y12 choice (ToC).

Review articles

🔸(Interventional cardiology) Patient-tailored stent: Are we there yet? — State-of-the-art on matching stent platforms to anatomy/clinical context; evidence-based pointers include SES for small vessels, EES/ZES for bifurcations, EES for CTO, polymer-free options in HBR, and TiNO-coated/ultrathin DES in ACS; calls for more randomized data.

🔸(Clinical cardiology) Artificial Intelligence based fractional flow reserve — Critical overview of AI-derived FFR across CCTA, angiography and intravascular imaging; discusses cath-lab integration, accuracy versus invasive FFR/CFD methods, and current limitations.

Technology note — Interventional cardiology

🔸Reconstruction of inverted compression T-stenting for coronary bifurcation lesion: Double kissing inverted compression T-stenting — Procedural concept and stepwise reconstruction for complex bifurcations (technology note in this issue).

Study protocol — Interventional cardiology

🔸A protocol of ‘A post-market national POLish registry of biological prostheses with RESilia tissue (POLRES)’ — National post-market registry for surgical valves with RESILIA tissue (scope and endpoints defined).

Research letters

🔸(Interventional cardiology) Intracoronary adrenaline for the treatment of refractory no-reflow phenomenon: A single-centre experience — 10 NR cases during primary PCI; stepwise IC adrenaline (50 µg boluses) appeared feasible with acceptable tolerance; authors advocate randomized trials.

🔸(Interventional cardiology) Coronary microvascular dysfunction in symptomatic patients without significant epicardial stenosis — Prospective, 3-centre Polish cohort: IMR-defined dysfunction present in ~65% of patients; more frequent in women and in hypertension/diabetes; CFR–IMR discordance noted.

🔸(Clinical cardiology) Post-menopause women show age dependent increased levels in GRACE, PRECISE-DAPT and NCDR mortality risk prediction scores whereas the PARIS thrombotic score is reduced — Risk-score trajectories in postmenopausal women (letter; clinical cardiology).

Images in cardiovascular medicine

🔸(Interventional) Covert perforation caused by the edge of a drug-eluting coronary stent — Demonstrates an angiographically subtle, stent-edge–related perforation and management.

🔸(Clinical) Cardiac amyloidosis in a patient with severe chest pain: A wolf in sheep’s clothing; Early-onset severe cardiomyopathy in a Danon disease patient with a novel LAMP2 mutation; Ventricular arrhythmia aggravated by pregnancy — instructive visuals with concise clinical pearls.

🔗 Full table of contents & articles: Cardiology Journal — Vol. 32, No. 5 (2025): https://journals.viamedica.pl/cardiology_journal/issue/view/6716

Dilated cardiomyopathy without CAD: does the LV outgrow its coronary tree?In a CCTA cohort meticulously excluding any co...
22/10/2025

Dilated cardiomyopathy without CAD: does the LV outgrow its coronary tree?

In a CCTA cohort meticulously excluding any coronary atherosclerosis, patients with DCM showed larger total proximal+mid coronary volume—yet the left-ventricular mass rose even more, yielding higher LV mass-to-coronary volume and LV mass-to-coronary ostial area ratios vs controls. Segment-level differences were modest (e.g., wider mid-LAD and OM; slightly smaller distal RCA), while ostial area was similar between groups. In regression, DCM independently predicted higher LVMM/CAV and LVMM/COA, with male s*x also upping LVMM/COA (age lowered LVMM/CAV).
Why it matters: these altered LV–coronary scaling relationships may flag a perfusion mismatch phenotype in atherosclerosis-free DCM—worth considering for risk phenotyping and future outcomes work.

Authors: Jarosław Skowroński, Emilia Szudejko, Adam Banasiak, Kacper Milczanowski, Paweł Jelski, Ilona Michałowska, Cezary Kępka, Mariusz Kruk, Adam Witkowski, Jerzy Pręgowski.

📖 Open-access full text: https://journals.viamedica.pl/cardiology_journal/article/view/104850

🫀The latest issue of Cardiology Journal is out now! Vol. 32, No. 4 (2025)🔗 Explore the full table of contents: https://j...
05/09/2025

🫀The latest issue of Cardiology Journal is out now! Vol. 32, No. 4 (2025)
🔗 Explore the full table of contents: https://journals.viamedica.pl/cardiology_journal/issue/view/6672

For colleagues in and — this issue brings practice-shaping data and striking cases:

🔹Original articles — Interventional cardiology
• Aspiration thrombectomy compared to catheter directed thrombolysis in pulmonary embolism: Outcomes from a tertiary referral center — real-world head-to-head comparison of CBT in submassive/massive PE; greater RV/LV reduction and oxygenation gains with aspiration, with similar safety.
• Angiography-derived index of microcirculatory resistance predicts long-term outcomes in late-presenting patients with ST-segment elevation myocardial infarction — caIMR independently predicts long-term MACE after delayed PCI in late-presenting STEMI.

🔹Original articles — Clinical cardiology
• The impact of dilated cardiomyopathy in relation to coronary artery dimensions and left ventricle myocardial mass in a model with excluded coronary atherosclerosis.
• Diagnostic potential of increased Klotho and FGF23 protein concentrations after myocardial infarction in patients with acute coronary syndrome.

🔹Review articles — Clinical cardiology
• The use of imaging in the diagnosis and treatment of thromboembolic pulmonary hypertension.

🔹Technology note — Interventional cardiology
• Continuous mechanical aspiration thrombectomy for STEMI with high thrombus burden.
• Repeated stereotactic radioablation for recurrent ventricular tachycardia in a patient with lung cancer.

🔹Study protocol — Interventional cardiology
• Single-stage pulmonary vein isolation combined with percutaneous implantation of left atrial appendage occluder in patients with recent onset ischemic stroke and atrial fibrillation (PILOS-AF): A study protocol of randomized controlled trial.

🔹Research letters
• Rehabilitation in convalescent COVID-19 subjects improves right ventricular function.
• Temporal trends in incidence and mortality of infective endocarditis caused by oral streptococci.

🔹Images in cardiovascular medicine
• Percutaneous treatment of left ventricular free wall rupture and severe mitral regurgitation in a two-week myocardial infarction.
• Hoarseness caused by aneurysmal central pulmonary artery secondary to a giant patent ductus arteriosus associated with Eisenmenger’s syndrome.
• CMR-defined transmural myocardial infarction with area of microvascular obstruction in the MINOCA patient: How many undiagnosed cases are there?
• Utility of contrast-enhanced echocardiography in the diagnosis of left ventricular aneurysm.
• Unique coincidence of mitral valve prolapse and left ventricular hypertrabeculation in a patient with ventricular arrythmia.
• Hyperkalemia: Is it always about slow rhytm?

Can artificial intelligence revolutionize the assessment of coronary stenosis?This comprehensive review explores the cur...
22/08/2025

Can artificial intelligence revolutionize the assessment of coronary stenosis?

This comprehensive review explores the current role and future potential of artificial intelligence-derived fractional flow reserve (AI-FFR) in diagnosing and managing coronary artery disease. The authors examine AI-based solutions applied across modalities such as computed tomography, invasive angiography, and intravascular imaging, emphasizing both their clinical utility and limitations. The article also discusses promising future directions, including mixed reality integration and multimodal diagnostic strategies.

Authors: Adrian Bednarek, Paweł Gąsior, Miłosz Jaguszewski, Piotr P. Buszman, Krzysztof Milewski, Michał Hawranek, Robert Gil, Wojciech Wojakowski, Janusz Kochman, Mariusz Tomaniak

📖 Read the full article: https://journals.viamedica.pl/cardiology_journal/article/view/102635

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