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Advances in Clinical and Experimental Medicine

Strona główna
Polska
Wroclaw
Advances in Clinical and Experimental Medicine

5-Year IF 2.0, IF 1.9, JCI (2024) 0.43, Scopus CiteScore 4.3, H-index 49 (SJR)
Initial editorial assessment and first decision within 24 h

27/12/2025

📢Call for submissions of an Expression of Interest for an Adv Clin Exp Med Special Collection on

Application of stem cells in human medicine – from basic science research to clinical trials 📢

Medicine in the twenty-first century is closely associated with stem cell research, based on advanced in vitro analyzes, the use of model animals, and their application in clinical trials. Experimental research requires understanding the physiological and morphological properties of stem cells and analyzing their ability to divide and differentiate into other cell types. The best-known stem cells are those derived from bone marrow and umbilical cord blood. However, in recent years, stem cells have been discovered in, for example, adipose tissue and Wharton jelly. Stem cells isolated from these tissues, once properly differentiated, are increasingly used for the treatment of bone and neurodegenerative diseases. In recent years, the number of therapies using stem cells has increased significantly. The ability of stem cells to differentiate makes them an increasingly common therapeutic tool in regenerative and reconstructive medicine.

Key words:

mesenchymal stem cells, embryonic stem cells, iPSCs, cancer stem cells, cell proliferation and differentiation, small extracellular vesicles, exosomes, omics, animal models, preclinical and clinical trials, regenerative medicine, reconstructive medicine

Articles submitted should be related to the topic of stem cells and their use in basic and clinical research. Topics may include:

• molecular research involving advanced genomic methods
• tissue and cell research
• studies on the morphological and physiological properties of stem cells
• studies on the proliferative and multidirectional differentiation capacity of stem cells
• studies on model animals
• use of stem cells in preclinical and clinical research
• therapies with stem cell
• stem cells in regenerative and reconstructive medicine
• stem cells in translational medicine

Review articles describing recent achievements in stem cell medicine, as well as original articles will be accepted.

MORE INFORMATION:

https://advances.umw.edu.pl/en/application-stem

26/12/2025

Alma Mater (ca. 1900); Virginie Demont-Breton (1859–1935); private collection, Perpignan, France

25/12/2025

Nativity icon (early 18th century); unknown Russian painter; Ipatiev Monastery, Kostroma, Russia

24/12/2025

🎄Happy Christmas / Winter Holidays🎄

The world may feel no more stable than it did a year ago. In many regions, armed conflicts continue to affect societies and individuals alike, and even where peace has been achieved, it often remains fragile. At the same time, global cooperation appears increasingly challenged, reminding us how easily shared frameworks of trust and responsibility can be strained.
This sense of uncertainty was captured with striking clarity over a century ago by Irish poet William Butler Yeats in the opening lines of The Second Coming:

Turning and turning in the widening gyre
The falcon cannot hear the falconer;
Things fall apart; the centre cannot hold;
Mere anarchy is loosed upon the world,
The blood-dimmed tide is loosed, and everywhere
The ceremony of innocence is drowned;
The best lack all conviction, while the worst
Are full of passionate intensity.

Against such a backdrop, the work of the medical community acquires particular significance. Physicians, nurses and medical researchers continue to care for people affected by illness, suffering and displacement, irrespective of nationality, ethnicity, religion or worldview. Their commitment to alleviating human suffering remains one of the most stable and universal constants in an unstable world.
We wish our readers a deeply rooted confidence that their work matters, that it is meaningful and valued, and that choosing a profession dedicated to health and care was – and remains – a profoundly important decision. The Editorial Board of Advances in Clinical and Experimental Medicine extends its sincere appreciation to all those whose daily efforts sustain trust, dignity and compassion, especially in times of uncertainty.

A quieter, more intimate dimension of this season is evoked in a poem by the British poet Walter de la Mare, which reflects a sense of closeness and human connection:

Mistletoe

Sitting under the mistletoe
(Pale-green, fairy mistletoe),
One last candle burning low,
All the sleepy dancers gone,
Just one candle burning on,
Shadows lurking everywhere:
Someone came, and kissed me there.
Tired I was; my head would go
Nodding under the mistletoe
(Pale-green, fairy mistletoe),
No footsteps came, no voice, but only,
Just as I sat there, sleepy, lonely,
Stooped in the still and shadowy air
Lips unseen - and kissed me there.

May this season offer moments of calm, reflection and renewed connection, and may the year ahead bring strength and clarity in both professional and personal paths.

With warm regards,

The Editorial Board of Advances in Clinical and Experimental Medicine

[Sources: 1) William Butler Yeats, The Collected Poems of W.B. Yeats, Scribner 1996; 2) Walter de la Mare, The Collected Poems of Walter de la Mare, Faber & Faber 1986]

23/12/2025

🚀Ahead of print 🚀

Long-term exposure of indoxyl sulfate induces mesothelial-to-mesenchymal transition of peritoneal mesothelial cells via β-catenin-involved signaling pathway

➡️Indoxyl Sulfate Induces Mesothelial-to-Mesenchymal Transition in Peritoneal Dialysis. IS treatment significantly increased β-catenin and α-SMA expression while reducing E-cadherin, promoting MMT in human peritoneal mesothelial cells.

➡️β-Catenin Signaling Pathway Identified as Key Driver of IS-Induced MMT. The β-catenin inhibitor ICG-001 reversed IS-induced molecular changes, confirming pathway involvement in peritoneal injury.

➡️Indoxyl Sulfate Enhances Cell Viability and Adhesion in Mesothelial Cells. IS and high-glucose PD fluid increased viable and adherent cell numbers, highlighting IS as a potential contributor to PD-related damage.

➡️ICG-001 Demonstrates Therapeutic Potential Against IS-Induced Peritoneal Injury. Blocking β-catenin signaling with ICG-001 mitigated MMT changes, suggesting a promising strategy for protecting peritoneal function in PD patients.

https://advances.umw.edu.pl/en/ahead-of-print/195869/

23/12/2025

🚀Ahead of print🚀

🚀A meta-analysis examining the impact of the continuous intervention for intraoperative pressure wound ulcers associated problems in women with breast cancer🚀

A recent meta-analysis explores how ongoing interventions influence pressure wound ulcers during surgery in women with breast cancer. Findings reveal that, compared to a control group, women receiving these interventions reported significantly higher Braden risk scores, improved quality of life, and fewer pressure wound ulcers during surgery.
However, due to the limited number of studies included in the meta-analysis, the results should be interpreted with caution.

https://advances.umw.edu.pl/en/ahead-of-print/197323/

22/12/2025

🚀Ahead of print 🚀

Identification of IGFBP3 and LGALS1 as potential secreted biomarkers for clear cell renal cell carcinoma based on bioinformatics analysis and machine learning

➡️IGFBP3 and LGALS1 Identified as Novel Secreted Biomarkers for ccRCC. Bioinformatics and machine learning revealed significant upregulation of IGFBP3 and LGALS1 in ccRCC tissues compared to normal kidney samples.

➡️High Expression of IGFBP3 and LGALS1 Predicts Poor Survival in ccRCC Patients. Survival analysis showed that elevated levels of these biomarkers were linked to shorter overall and disease-free survival.

➡️Machine Learning Models Achieve High Accuracy in ccRCC Diagnosis. Decision tree and random forest models based on IGFBP3 and LGALS1 expression reached 98.04% accuracy and an AUC of 0.98.

➡️Secretome-Based Approach Enhances Early Detection of Clear Cell Renal Cell Carcinoma. Integrating transcriptomics datasets with secretome analysis provides a powerful strategy for identifying diagnostic biomarkers in ccRCC.

https://advances.umw.edu.pl/en/ahead-of-print/194036/

22/12/2025

🚀Ahead of print 🚀

Experience with sodium glucose cotransporter-2 inhibitors in adult patients with Fontan circulation

➡️SGLT2 Inhibitors Improve Exercise Capacity in Adults with Fontan Circulation. Treatment with dapagliflozin or empagliflozin significantly increased VO₂ max, enhancing cardiopulmonary performance.

➡️High Safety Profile of SGLT2i in Fontan Patients. Over 11 months of observation, no adverse effects or complications were reported among 17 adult participants.

➡️Positive Hematological Changes with SGLT2i Therapy.Significant increases in erythrocytes (+6%), hemoglobin (+7%), and hematocrit (+7%) were observed after treatment.

➡️First Evidence Supporting SGLT2i Use in Fontan-Associated Heart Failure. Findings suggest flozins may be a promising pharmacological option for managing heart failure in Fontan adults.

https://advances.umw.edu.pl/en/ahead-of-print/194617/

21/12/2025

📢¡Únete al movimiento para avanzar en la salud mental y el bienestar!📢

Advances in Clinical and Experimental Medicine te invita a enviar tu investigación y artículos de vanguardia en el campo de la salud mental y el bienestar. Buscamos contribuciones innovadoras que amplíen los límites de la comprensión, el tratamiento y la promoción del bienestar mental.

Editores a cargo

Prof. Dr. Raúl Juárez-Vela (Grupo de Investigación en Cuidados (GRUPAC), Facultad de Ciencias de la Salud, Universidad de La Rioja, Logroño, España; ORCID 0000-0003-3597-2048) [email protected]

Los temas de interés incluyen, pero no se limitan a:

- Intervenciones terapéuticas innovadoras
- Estrategias para la prevención y promoción del bienestar mental
- Impacto de la salud mental en la calidad de vida
- Nuevos enfoques en el tratamiento de trastornos mentales
- Estudios sobre la relación entre la salud mental y las enfermedades físicas

¿Por qué publicar con nosotros?

- Visibilidad global: Alcanza una amplia audiencia internacional con tu trabajo.
- Revisión rigurosa: Benefíciate de nuestro proceso de revisión por pares de alta calidad.
- Impacto académico: Haz una contribución significativa a un campo vital y dinámico.

Proceso de envío

Como primer paso, solicitamos el envío de una Expresión de Interés con un resumen de artículos originales que aborden los temas mencionados al Editor de Sección de Adv Clin Exp Med: [email protected]

El Editor de Sección, junto con el Editor en Jefe, revisará todas las presentaciones y seleccionará aquellas que serán invitadas a enviar un artículo completo. El proceso de envío seguirá el proceso en línea regular de Adv Clin Exp Med. Todos los manuscritos serán enviados a al menos dos revisores independientes.

Fechas y tarifas

- Envío de la Expresión de Interés hasta el 31 de diciembre de 2025 a [email protected]
- Invitación para enviar un artículo completo antes del 31 de enero de 2026;
- Envío del artículo completo antes del 31 de marzo de 2026.

Si se acepta, los autores deberán pagar una tarifa (https://advances.umw.edu.pl/en/article-processing-charges/) para cubrir los costos de publicación;

Para autores seleccionados (expertos destacados), es posible reducir o incluso cancelar la tarifa de publicación.

Envía tu manuscrito hoy y únete a la conversación global sobre el mejoramiento de la salud mental y el bienestar. Para más detalles sobre el proceso de envío, visita nuestro sitio web.

¡Esperamos con ansias tus valiosas contribuciones!

21/12/2025

📢New call for submissions📢

📢Join the Movement to Advance Mental Health and Wellbeing!📢

Advances in Clinical and Experimental Medicine invites you to submit your cutting-edge research and articles in the field of Mental Health and Well-being. We are seeking groundbreaking contributions that push the boundaries of understanding, treating, and promoting mental wellbeing.

Handling Editors

Prof. Raúl Juárez-Vela (Group of Research in Care (GRUPAC), Faculty of Health Sciences, University of La Rioja, Logroño, Spain; ORCID 0000-0003-3597-2048) [email protected]

Topics of interest include, but are not limited to:

Innovative therapeutic interventions
Strategies for prevention and promotion of mental wellbeing
Impact of mental health on quality of life
New approaches in the treatment of mental disorders
Studies on the relationship between mental health and physical diseases

Why publish with us?

Global Visibility: Reach a wide international audience with your work
Rigorous Review: Benefit from our high-quality peer review process
Academic Impact: Make a significant contribution to a vital and dynamic field

Submission process

As a first step, we ask for submissions of an Expression of Interest with an Abstract of original papers outlining the themes above to Adv Clin Exp Med Section Editor: [email protected]

The Section Editor, jointly with the Editor-in-Chief, will review all submissions and select those who will be invited to submit a full paper. The submission process will then follow the regular Adv Clin Exp Med. online process. All manuscripts will be sent to at least two independent reviewers.

Dates and fees

Submission of Expression of Interest until December 31, 2025, to [email protected]
Invitation to submit a full paper by January 31, 2026;
Submission of full paper by March 31, 2026.
If accepted, Authors will be required to pay a fee (https://advances.umw.edu.pl/en/article-processing-charges/) to cover publication costs;

For selected Authors (outstanding experts), it is possible to reduce or even cancel the publication fee.

Submit your manuscript today and join the global conversation on enhancing mental health and well-being. For more details on the submission process, visit our website.

We eagerly anticipate your valuable contributions!

20/12/2025

📢Call for submissions of an Expression of Interest for an Adv Clin Exp Med Special Collection on Advances in Cardiovascular Care 📢

This Special Issue of the Advances in Clinical and Experimental Medicine will provide focused, comprehensive coverage of important clinical topics in cardiology. The issue will address selected clinical problems or conditions, including their pathophysiology, invasive and noninvasive diagnosis, drug therapy, surgical management, and rehabilitation.

This Special Issue aims to provide researchers with an opportunity to publish original research, meta-analyses and review articles related to recent advances in the cardiovascular field, with a particular focus on holistic and personalized management of patients with CVD.

Topic and format
Advances in Clinical and Experimental Medicine is therefore seeking original papers for a Special Collection focused on cardiovascular care.

MORE INFORMATION:

https://advances.umw.edu.pl/en/call-for-submissions-of-an-expression-of-interest-for-an-adv-clin-exp-med-special-collection-on-advances-in-cardiovascular-care

Izabella Uchmanowicz
Dr hab. Michał Czapla
Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu

19/12/2025

🚀Ahead of print🚀

Importance of single nucleotide polymorphism microarray in prenatal diagnosis

Highlights

➡️Single nucleotide polymorphism (SNP) array analysis is an important tool for screening chromosome deletions and replications, especially in fetuses with normal karyotypes.
➡️The success rate of SNP array analysis was 100%.
➡️The time for SNP array analysis is much shorter.
➡️SNP array analysis technology has the advantages of simple operation and fast speed.
➡️SNP array analysis technology has high throughput and resolution.

https://advances.umw.edu.pl/en/ahead-of-print/202728/

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