19/12/2025
🚀Ahead of print🚀
Polymer matrix of biofilm in Klebsiella pneumoniae reduced by sub-MIC hydrogen peroxide enhances cefotaxime efficacy
Highlights
➡️Hydrogen peroxide enhances antibiotic efficacy by disrupting the biofilm matrix of cefotaxime-resistant Klebsiella pneumoniae at sub-minimum inhibitory concentrations (sub-MICs).
➡️Synergistic antimicrobial effect: hydrogen peroxide reduced the cefotaxime MIC from 1,000 μg/mL to 250 μg/mL in K. pneumoniae antibiotic-resistant isolates.
➡️Scanning electron microscopy analysis revealed hydrogen peroxide-induced pores and channels that weakened biofilm integrity and decreased biofilm formation.
➡️Combined hydrogen peroxide and cefotaxime therapy demonstrated significantly stronger biofilm inhibition than either treatment alone, suggesting a promising approach against antibiotic-resistant K. pneumoniae infections.
https://polimery.umw.edu.pl/en/ahead-of-print/207885/