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Today i Learned, Bangkok (2025)

01/08/2025

In September 2024, 35-year-old Tara Dower made history by conquering one of the most grueling endurance challenges on Earth: the 2,197-mile Appalachian Trail.

Stretching across 14 U.S. states and packed with punishing terrain, unpredictable weather, and nearly half a million feet of elevation gain, the trail is infamous even among elite athletes. But Tara didn’t just complete it she demolished the record, becoming the fastest person ever to finish the trail in an astonishing 40 days, 18 hours, and 6 minutes, beating the previous men’s record by a jaw-dropping 13 hours.

Averaging an unimaginable 54 miles per day, Tara pushed her body to the limit through rugged mountains, dense forests, and sleepless nights, all while braving freezing rain, physical exhaustion, and the emotional rollercoaster of extreme ultrarunning. But this wasn’t just a quest for personal glory. Tara’s mission was deeply rooted in purpose every painful step was taken to raise awareness and funds for Girls on the Run, a nonprofit that empowers young girls through running and confidence-building programs.

With every mountain she climbed, Tara carried a powerful message: strength isn't just physical it's fueled by heart, grit, and purpose. When she finally touched the finish marker at Springer Mountain, Georgia, she didn’t just set a world record she sparked a movement. A reminder to every girl watching that they are stronger, tougher, and more capable than they ever imagined. Tara Dower didn’t just run into the record books she ran into the hearts of dreamers everywhere.

01/08/2025

In a moment of sheer courage and quick thinking, Marine veteran Derrick Perry sprang into action during a terrifying stabbing rampage at a Walmart store. When a knife-wielding attacker allegedly stabbed 11 people, Perry didn’t hesitate. Armed and alert, he along with the help of several brave bystanders confronted and subdued the suspect, potentially saving numerous lives in the process..

Witnesses described the chaos as the suspect moved rapidly through the store, and many credit Perry’s decisive response for preventing even greater tragedy. Trained for high-stress situations, the Marine vet’s instinct to protect and serve kicked in immediately, bringing the violent spree to a halt before authorities arrived.

In a moment of sheer courage and quick thinking, Marine veteran Derrick Perry sprang into action during a terrifying stabbing rampage at a Walmart store. When a knife-wielding attacker allegedly stabbed 11 people, Perry didn’t hesitate. Armed and alert, he—along with the help of several brave bystanders confronted and subdued the suspect, potentially saving numerous lives in the process.

01/08/2025

In the Netherlands, creativity and sustainability come together on a mesmerizing glow-in-the-dark bike path inspired by Vincent van Gogh’s legendary painting, Starry Night.

Situated in the charming town of Nuenen Van Gogh’s hometown the path features thousands of solar-powered stones embedded directly into its surface. These innovative stones soak up sunlight throughout the day, illuminating the route at night with a gentle, swirling glow that beautifully mirrors the painting’s iconic star-filled sky.

Beyond its visual beauty, the bike path symbolizes a perfect blend of artistic legacy and environmental responsibility. By relying entirely on renewable solar energy, the stones eliminate the need for conventional electricity, making the pathway both eco-friendly and energy-efficient.

The glowing trail enhances nighttime safety for cyclists and pedestrians while turning an ordinary commute into an enchanting, unforgettable experience.

This unique project is part of a larger Dutch initiative focused on blending practical urban design with cultural storytelling and sustainable innovation. It stands as an inspiring example of how public spaces can simultaneously celebrate heritage, boost eco-awareness, and create moments of wonder all through the magic of a single illuminated path.

31/07/2025

Cutting back on added sugar even for a short period can produce remarkable and surprisingly rapid improvements in your health. A groundbreaking study led by Dr. Robert Lustig and his team at the University of California, San Francisco (UCSF), revealed that reducing sugar intake to just 10% of daily calories for nine days significantly lowered liver fat and improved insulin sensitivity in children. This powerful evidence highlights the body’s astonishing ability to repair and reverse metabolic damage much quicker than previously believed possible.

Beyond liver and insulin benefits, participants in the study experienced noticeable enhancements in overall health, including reduced blood pressure, better mood, improved sleep quality, and clearer, healthier skin. These findings underscore the wide-ranging effects of sugar consumption on the body, emphasizing that even brief dietary changes can yield impressive results.

Dr. Lustig's study serves as a clear reminder of the urgent need to limit added sugars for long-term health and wellness. Reducing sugar intake isn’t just about weight management it's about rapidly transforming your body’s internal health, vitality, and overall well-being.

Source: Lustig et al., University of California, San Francisco (UCSF)

31/07/2025

In an incredible display of quick thinking and genuine friendship, 17-year-old Aidan Jackson from the UK was saved by his gaming companion, Dia Lathora, who lived 5,000 miles away in Texas.

During an online gaming session, Aidan suddenly experienced a seizure, leaving him unable to call for help. Dia instantly sensed something was wrong when she heard unusual sounds through their online chat and acted without hesitation.

Despite the vast distance between them, Dia swiftly contacted UK emergency services, explaining the urgent situation from halfway around the world. Amazingly, her prompt action led emergency responders straight to Aidan’s home even before his own parents were aware of the emergency unfolding upstairs.

This extraordinary event serves as a powerful reminder that meaningful connections and friendships truly know no borders.

Dia's decisive action demonstrates how strong bonds can form through online friendships, highlighting that compassion and quick thinking can save lives, no matter how many miles separate us.

31/07/2025

In a groundbreaking development for Alzheimer’s research, scientists from Japan have achieved an exciting milestone: successfully reversing key symptoms of Alzheimer's disease in mice. Led by a team from the Okinawa Institute of Science and Technology, researchers created a special synthetic peptide a tiny, engineered protein delivered nasally to mice experiencing memory and learning impairments. Remarkably, the treatment restored their cognitive functions to levels comparable to healthy animals, sparking new hope in the global fight against Alzheimer’s.

This revolutionary peptide targets and repairs damaged synapses, the crucial communication points between brain cells often disrupted in Alzheimer’s sufferers. Alzheimer's disease is typically marked by the harmful buildup of tau proteins, which interfere with a vital enzyme called dynamin essential for normal cellular signaling. The Japanese team's innovative peptide works by effectively blocking this harmful interaction, halting further brain damage and allowing neural function to recover dramatically.

Although this promising treatment has so far only been demonstrated in animal studies, its potential is profound. If future research confirms its effectiveness in humans, it could represent a transformative breakthrough for millions affected by Alzheimer’s disease, fundamentally changing how this devastating illness is managed.

31/07/2025

In 2019, British wildlife photographer Sam Rowley captured an extraordinary moment that quickly became an iconic image: two tiny mice fighting over a scrap of food on a London Underground platform.

Aptly titled "Station Squabble," the photograph vividly shows the small rodents standing upright, locked in a brief but intense battle, against the blurred backdrop of a bustling train station. This unexpected snapshot highlighted the hidden struggles and resilience of urban wildlife, demonstrating just how fiercely even the smallest creatures fight to survive amidst human chaos.

Rowley's captivating image didn't come easily; it was the result of countless late nights spent patiently lying on cold subway platforms, observing and waiting for these overlooked animals to reveal their secret lives. His dedication and patience ultimately paid off, as the photo quickly went viral worldwide, resonating deeply with audiences fascinated by the unseen drama beneath their feet. It was awarded the prestigious People's Choice Award in the 2020 Wildlife Photographer of the Year competition, hosted by London's Natural History Museum.

Beyond its viral success, Rowley's photograph has become symbolic of the unnoticed daily struggles of wildlife in urban settings, inspiring viewers to appreciate the resilience and adaptability of nature amid modern city life. The image reminds us that remarkable stories often unfold quietly around us, waiting patiently for someone observant enough to capture them.

31/07/2025

A groundbreaking new mRNA vaccine, developed by scientists at the University of Florida, could transform cancer treatment forever no chemotherapy, surgery, or radiation required. Instead, it harnesses your body’s immune system, teaching it to recognize and eliminate nearly any type of cancer, even stubborn, resistant forms.

Unlike traditional cancer therapies targeting specific tumors, this vaccine triggers early immune signals called type-I interferons internal alarms that alert your immune system to attack cancer cells. Remarkably, this method also creates a powerful domino effect known as "epitope spreading," prompting your immune system to target multiple parts of a tumor simultaneously, delivering a more comprehensive assault on the disease.

The vaccine cleverly uses mRNA to instruct cancer cells to produce a protein named PD-L1, making previously hidden tumors highly visible to immune defenses. Tests in mice have shown astonishing results: stubborn tumors disappeared completely, with long-lasting protection against recurrence. Even better, immune responses to one tumor could be leveraged to battle other cancers, opening the possibility for a universal, ready-to-use cancer vaccine that provides new hope to countless patients.

Source:
Qdaisat, S., et al. (2025). Sensitization of tumours to immunotherapy by boosting early type-I interferon responses enables epitope spreading. Nature Biomedical Engineering. DOI: 10.1038/s41551-025-01380-1

31/07/2025

On the quiet Sunday morning of May 25, 1986, America witnessed something truly remarkable. Over six million people, from coast to coast, joined hands to create a human chain stretching nearly 6,600 miles across the country.

This historic event, known as Hands Across America, aimed to raise awareness and vital funds to combat hunger and homelessness. Ordinary citizens, including teachers, grandparents, children, and factory workers, stood shoulder-to-shoulder alongside celebrities like Michael Jackson and Oprah Winfrey, symbolizing unity and compassion on an unprecedented scale.

For a brief but powerful 15 minutes, differences faded away as Americans linked hands, bridging gaps both physical and emotional. While not every hand connected perfectly—some gaps were creatively filled with ribbons the imperfections only enhanced the event’s authenticity, highlighting genuine human connection rather than flawless ex*****on. The true magic lay in those simple gestures, where strangers, neighbors, and friends alike silently expressed their shared empathy and determination to make a difference.

The extraordinary moment successfully raised over $34 million, providing substantial support for food banks, shelters, and housing initiatives nationwide. Yet the greatest legacy of Hands Across America wasn’t the money alone; it was the lasting memory of an entire nation momentarily pausing to care. Though it didn't resolve every issue, for those unforgettable 15 minutes, millions of people stood united, reminding America of its potential for compassion and collective action.

31/07/2025

A Rare Genetic Mutation Offers Hope in the Fight Against Alzheimer’s

A new chapter in Alzheimer’s research is being written, thanks to a rare genetic twist known as the Christchurch mutation (APOE3-R136S). Unlike most headlines that focus on the “bad” genes that increase Alzheimer’s risk, this discovery shines a light on a mutation that does just the opposite protecting the brain by shutting down damaging inflammation.

Researchers found that this mutation dampens an immune pathway called cGAS-STING, notorious for getting overactive in Alzheimer’s and triggering destructive inflammation in the brain. Typically, cGAS-STING helps fight infection, but in people with Alzheimer’s, it stays stuck in overdrive leading to nerve cell damage and memory loss.

The breakthrough came when scientists introduced the Christchurch mutation into mice genetically programmed to develop Alzheimer’s-like symptoms. Despite still having high levels of amyloid (the sticky protein long blamed for the disease), these mice had less tau buildup, less brain damage, and fewer memory problems suggesting the real culprit might be runaway inflammation, not just amyloid alone.

Even more compelling, researchers gave a second group of Alzheimer’s-model mice a drug to block the cGAS-STING pathway. The results were just as promising: less brain damage, better memory. This points to a new frontier in Alzheimer’s treatment one focused on turning down the immune system’s harmful overreaction, especially in the brain’s microglia cells.

The Christchurch mutation was first identified in a remarkable woman from a Colombian family prone to early-onset Alzheimer’s. Despite heavy amyloid buildup, she remained cognitively sharp into her seventies, almost certainly due to this protective gene.

This discovery doesn’t just offer hope for future Alzheimer’s therapies it reframes our understanding of what really drives the disease and opens doors to treatments aimed at calming harmful brain inflammation.

Source: Nature, Study PMID: 38712164, PMCID: PMC11071490, International Alzheimer’s Research Updates 2024.

31/07/2025

A heartwarming moment featuring a baby elephant has captured India's attention and quickly gone viral on social media. In the short yet powerful clip, the young elephant effortlessly picks up a piece of trash and places it neatly into a dustbin, leaving viewers both charmed and inspired. The video has not only melted hearts but also sparked important nationwide conversations about respecting our environment.

This simple yet thoughtful action by the little elephant highlights an important lesson: if animals can instinctively care for our planet, there's no reason humans can't follow suit. Social media users across India praised the adorable creature's gesture, pointing out that nature itself might possess better manners and environmental awareness than many people today.

Ultimately, this viral clip serves as a gentle reminder that even small, considerate acts can create meaningful change. If a baby elephant can take responsibility for keeping the planet clean, it's undoubtedly within everyone's ability to do the same.

31/07/2025

Your Brain Thrives on Movement Even Gentle Workouts Like Yoga, Tai Chi, and Exergaming

If you’ve ever skipped the gym because you’re not into hardcore workouts, science has some uplifting news. A sweeping new review, published in The British Journal of Sports Medicine, reveals that even light to moderate exercise like yoga, Tai Chi, and active video games can work wonders for your brain health at any age.

Researchers examined data from over 258,000 people across 133 studies and discovered that regular movement supports general thinking skills, sharpens memory, and strengthens problem-solving abilities. Notably, low-intensity exercise was strongly linked to better overall brain function, while moderate movement stood out for boosting memory and higher-order skills like planning and reasoning.

Among all the options, active video games think Wii Sports, Dance Dance Revolution, or VR fitness stood out by blending fast reflexes, problem-solving, and physical motion into a fun package. Right behind were mind-body practices like yoga and Tai Chi, which keep your mind engaged by requiring you to remember movement sequences and focus, while also reducing stress—another big win for memory and decision-making.

Among all the options, active video games think Wii Sports, Dance Dance Revolution, or VR fitness stood out by blending fast reflexes, problem-solving, and physical motion into a fun package. Right behind were mind-body practices like yoga and Tai Chi, which keep your mind engaged by requiring you to remember movement sequences and focus, while also reducing stress another big win for memory and decision-making.

Source: The British Journal of Sports Medicine, Study PMID: 40049759, Cognitive Health & Physical Activity Research 2024.

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